LOCUS       NM_028295               1823 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus protein disulfide isomerase associated 5 (Pdia5),
            mRNA.
ACCESSION   NM_028295 XM_993211
VERSION     NM_028295.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1823)
  AUTHORS   Chen,Y., He,J., Chen,R., Wang,Z., Dai,Z., Liang,X., Wu,W., Luo,P.,
            Zhang,J., Peng,Y., Zhang,N., Liu,Z., Zhang,L., Zhang,H. and
            Cheng,Q.
  TITLE     Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential
            Target for Immunotherapy
  JOURNAL   Front Immunol 13, 881722 (2022)
   PUBMED   36003400
  REMARK    GeneRIF: Pan-Cancer Analysis of the Immunological Role of PDIA5: A
            Potential Target for Immunotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1823)
  AUTHORS   Villani,G.R., Chierchia,A., Di Napoli,D. and Di Natale,P.
  TITLE     Unfolded protein response is not activated in the
            mucopolysaccharidoses but protein disulfide isomerase 5 is
            deregulated
  JOURNAL   J Inherit Metab Dis 35 (3), 479-493 (2012)
   PUBMED   22002444
  REMARK    GeneRIF: protein disulfide isomerase 5 is deregulated in the
            mucopolysaccharidoses, although the unfolded protein response is
            not activated
REFERENCE   3  (bases 1 to 1823)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
REFERENCE   4  (bases 1 to 1823)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 1823)
  AUTHORS   Turano,C., Coppari,S., Altieri,F. and Ferraro,A.
  TITLE     Proteins of the PDI family: unpredicted non-ER locations and
            functions
  JOURNAL   J Cell Physiol 193 (2), 154-163 (2002)
   PUBMED   12384992
  REMARK    Review article
REFERENCE   6  (bases 1 to 1823)
  AUTHORS   Ferrari,D.M. and Soling,H.D.
  TITLE     The protein disulphide-isomerase family: unravelling a string of
            folds
  JOURNAL   Biochem J 339 (Pt 1) (Pt 1), 1-10 (1999)
   PUBMED   10085220
  REMARK    Review article
REFERENCE   7  (bases 1 to 1823)
  AUTHORS   Hayano,T. and Kikuchi,M.
  TITLE     Molecular cloning of the cDNA encoding a novel protein disulfide
            isomerase-related protein (PDIR)
  JOURNAL   FEBS Lett 372 (2-3), 210-214 (1995)
   PUBMED   7556671
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC009151.1.
            
            On May 4, 2006 this sequence version replaced XM_993211.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009151.1, SRR11927935.1416918.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1823
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.37 cM"
     gene            1..1823
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /note="protein disulfide isomerase associated 5"
                     /db_xref="GeneID:72599"
                     /db_xref="MGI:MGI:1919849"
     exon            1..145
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1663
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide-isomerase A5; protein disulfide
                     isomerase-related protein"
                     /codon_start=1
                     /product="protein disulfide-isomerase A5 precursor"
                     /protein_id="NP_082571.1"
                     /db_xref="CCDS:CCDS37323.1"
                     /db_xref="GeneID:72599"
                     /db_xref="MGI:MGI:1919849"
                     /translation="MARAWGLLLAIGVVLPTWLSSTKVSSLIERISDPKDLKKLLRTR
                     NNVLVLYSESEVAAESHLKLLSTVAQAVKGQGTVCWVDCGDAESRKLCKKMKVDLSPK
                     DKKIELFHYQDGAFHMQYDRAVTLKSIVAFLKDPKGPPLWEEDPGAKDVVHIDSEKDF
                     RRLLKREEKPLLMMFYAPWCSMCKRIMPHFQKAATQVRGHIVLAGMNVYPSEFENIKE
                     EYNVRGYPTICYFEKGRFLFPYENYGSTAEDIVEWLKNPLPPQPQVPETPWADEGGSV
                     YHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFESAAEVLHGDAESSGVLAAVD
                     ATVNEALAGRFHISAFPTLKYFKNGEQQAVPALRTKKKFIEWMQNPEAPPPPEPTWEE
                     QQTSVLHLVGDNFRDTLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKEDRKIACA
                     AVDCVKDKNQDLCQQEAVKAYPTFHYYHYGKLVEKYESDRTELGFTSFIRTLREGDLK
                     RLEKRREEL"
     exon            146..272
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            273..360
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            361..444
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            445..490
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            491..583
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            584..644
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            645..712
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            713..804
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            805..876
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1013
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1084
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1245
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1376
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1447
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1582
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1809
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1791..1796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /note="hexamer: AATAAA"
     polyA_site      1809
                     /gene="Pdia5"
                     /gene_synonym="2700053F16Rik; Pdir"
                     /note="major polyA site"
ORIGIN      
        1 ccgggaactc ggaggcgggg agcggctgtg aagtggccgt agctgttggc cgaggtggag
       61 ctggcaggcg tgcgcgggag ccgggtgcag acggcaggag gcggcgggga tggcgcgggc
      121 gtgggggctg ctactggcga ttggggtggt cctgccgaca tggctgtcct ccacaaaggt
      181 ctcttcgctc attgagagaa tctccgaccc taaggacttg aagaaacttc tcaggacccg
      241 caataacgtg ctggtgcttt actcggaatc cgaggtagca gctgaaagtc atcttaagct
      301 cctgtccacc gtggcccagg cagtgaaagg ccaaggcacc gtctgctggg tggactgcgg
      361 tgacgcagag agtagaaaat tgtgcaagaa gatgaaagtt gacctcagcc caaaggacaa
      421 aaagattgaa ttattccatt accaggacgg cgcctttcac atgcagtatg accgagctgt
      481 gacgttgaag tccatagtgg cctttctgaa agaccctaaa ggtcccccac tgtgggaaga
      541 agatcctgga gccaaagatg ttgtgcacat cgacagtgag aaggacttca gacgactcct
      601 gaagagagaa gagaagccac tgctcatgat gttctatgct ccctggtgca gcatgtgcaa
      661 gagaatcatg ccacatttcc agaaggctgc cacccaagtg cgaggccaca ttgtcctggc
      721 tgggatgaac gtctacccat cagagttcga gaacatcaag gaagagtaca atgtccgcgg
      781 ctaccctacc atctgctatt tcgagaaggg gcggtttctg ttcccgtatg agaactatgg
      841 gtccacggcc gaggacatcg tggagtggtt gaagaatcca ctgccaccac agccccaggt
      901 ccccgagact ccctgggcag atgagggcgg ctccgtttat cacctgaccg atgaagactt
      961 tgaccagttt gtgaaggagc actcctctgt cctcgtcatg ttccacgccc catggtgtgg
     1021 acattgtaag aaaatgaagc cagagtttga gagtgctgct gaagtcctcc acggagatgc
     1081 tgagagctct ggtgtacttg cagctgtcga tgccaccgtc aacgaggccc tggcaggaag
     1141 atttcacatc tcagcgtttc ctaccctgaa gtattttaag aatggcgagc agcaagcggt
     1201 gcctgcgctc agaacaaaga agaagtttat tgagtggatg cagaaccctg aggctccccc
     1261 acctccagag cccacgtggg aagaacagca gacaagcgtg ctacatctgg tgggggataa
     1321 cttccgggat accctgaaga agaagaaaca caccttggtc atgttctatg ccccttggtg
     1381 cccacactgt aagaaggtca tcccccactt cactgccaca gccgatgcct tcaaagagga
     1441 ccgcaagatt gcctgtgctg ctgtagactg tgtcaaggac aagaaccaag acctgtgtca
     1501 gcaggaggcc gtgaaggcct accccacctt ccactactac cactacggga agctcgtaga
     1561 aaagtatgag agcgaccgca cggagttggg atttaccagt ttcatccgaa ccctccggga
     1621 gggagacctc aagagactag agaaaaggag ggaagagctg taatcccgcc tcctgcaagg
     1681 ggcccttcct ttacactgtg aatgatacct attttgttct ttctgaattt ccatgtgtgc
     1741 tggagacaaa agttttttat agccatgtat ggccttttgt acaattttga aataaaatta
     1801 aaccatttaa aaaaaaaaaa aaa
//
