LOCUS       NM_009787               2610 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein disulfide isomerase associated 4 (Pdia4),
            transcript variant 2, mRNA.
ACCESSION   NM_009787
VERSION     NM_009787.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Li,Y., Xu,X., Wang,H.J., Chen,Y.C., Chen,Y., Chiu,J., Li,L.,
            Wang,L., Wang,J., Tang,Z., Ren,L., Li,H., Wang,X., Jin,S., Wu,Y.,
            Huang,M., Ju,L.A. and Fang,C.
  TITLE     Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1 Activity
            to Influence Neutrophil Recruitment
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (3), e82-e98 (2024)
   PUBMED   38205640
  REMARK    GeneRIF: Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1
            Activity to Influence Neutrophil Recruitment.
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Su,S.C., Chien,C.Y., Chen,Y.C., Chiang,C.F., Lin,F.H., Kuo,F.C.,
            Huang,C.L., Li,P.F., Liu,J.S., Lu,C.H., Ho,L.J., Hsieh,C.H.,
            Hung,Y.J., Shieh,Y.S. and Lee,C.H.
  TITLE     PDIA4, a novel ER stress chaperone, modulates adiponectin
            expression and inflammation in adipose tissue
  JOURNAL   Biofactors 48 (5), 1060-1075 (2022)
   PUBMED   35674710
  REMARK    GeneRIF: PDIA4, a novel ER stress chaperone, modulates adiponectin
            expression and inflammation in adipose tissue.
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Di Minin,G., Holzner,M., Grison,A., Dumeau,C.E., Chan,W.,
            Monfort,A., Jerome-Majewska,L.A., Roelink,H. and Wutz,A.
  TITLE     TMED2 binding restricts SMO to the ER and Golgi compartments
  JOURNAL   PLoS Biol 20 (3), e3001596 (2022)
   PUBMED   35353806
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2610)
  AUTHORS   Kuo,T.F., Hsu,S.W., Huang,S.H., Chang,C.L., Feng,C.S., Huang,M.G.,
            Chen,T.Y., Yang,M.T., Jiang,S.T., Wen,T.N., Yang,C.Y., Huang,C.Y.,
            Kao,S.H., Tsai,K.C., Yang,G. and Yang,W.C.
  TITLE     Pdia4 regulates beta-cell pathogenesis in diabetes: molecular
            mechanism and targeted therapy
  JOURNAL   EMBO Mol Med 13 (10), e11668 (2021)
   PUBMED   34542937
  REMARK    GeneRIF: Pdia4 regulates beta-cell pathogenesis in diabetes:
            molecular mechanism and targeted therapy.
REFERENCE   6  (bases 1 to 2610)
  AUTHORS   Briquet-Laugier,V., Xia,Y.R., Rooke,K., Mehrabian,M., Lusis,A.J.
            and Doolittle,M.H.
  TITLE     Mapping of three members of the mouse protein disulfide isomerase
            family
  JOURNAL   Mamm Genome 9 (2), 176-177 (1998)
   PUBMED   9457688
REFERENCE   7  (bases 1 to 2610)
  AUTHORS   Srinivasan,M., Lenny,N. and Green,M.
  TITLE     Identification of genomic sequences that mediate the induction of
            the endoplasmic reticulum stress protein, ERp72, by protein traffic
  JOURNAL   DNA Cell Biol 12 (9), 807-822 (1993)
   PUBMED   8216852
REFERENCE   8  (bases 1 to 2610)
  AUTHORS   Urade,R., Takenaka,Y. and Kito,M.
  TITLE     Protein degradation by ERp72 from rat and mouse liver endoplasmic
            reticulum
  JOURNAL   J Biol Chem 268 (29), 22004-22009 (1993)
   PUBMED   8408057
REFERENCE   9  (bases 1 to 2610)
  AUTHORS   Mazzarella,R.A., Srinivasan,M., Haugejorden,S.M. and Green,M.
  TITLE     ERp72, an abundant luminal endoplasmic reticulum protein, contains
            three copies of the active site sequences of protein disulfide
            isomerase
  JOURNAL   J Biol Chem 265 (2), 1094-1101 (1990)
   PUBMED   2295602
REFERENCE   10 (bases 1 to 2610)
  AUTHORS   Gough,N.M., King,J.A. and Dunn,A.R.
  TITLE     An mRNA sharing sequences with a variant granulocyte-macrophage
            colony stimulating factor cDNA clone
  JOURNAL   Nucleic Acids Res 15 (24), 10584 (1987)
   PUBMED   3320970
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF165880.1, AK161534.1 and BC066857.1.
            
            On Jan 31, 2006 this sequence version replaced NM_009787.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148801.1, AK150566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               CF165880.1         1-163
            164-2434            AK161534.1         2-2272
            2435-2610           BC066857.1         2032-2207
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 22.94 cM"
     gene            1..2610
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /note="protein disulfide isomerase associated 4"
                     /db_xref="GeneID:12304"
                     /db_xref="MGI:MGI:104864"
     exon            1..296
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2134
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /EC_number="5.3.4.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; calcium binding protein, intestinal; protein
                     disulfide-isomerase A4; ER protein 72; endoplasmic
                     reticulum resident protein 72; endoplasmic reticulum
                     protein 72"
                     /codon_start=1
                     /product="protein disulfide-isomerase A4 isoform 2
                     precursor"
                     /protein_id="NP_033917.2"
                     /db_xref="CCDS:CCDS20097.1"
                     /db_xref="GeneID:12304"
                     /db_xref="MGI:MGI:104864"
                     /translation="MKLRKAWLLVLLLALTQLLAAASAGDAHEDTSDTENATEEEEEE
                     EEEDDDDLEVKEENGVWVLNDGNFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIAS
                     TLKDNDPPIAVAKIDATSASMLASKFDVSGYPTIKILKKGQAVDYDGSRTQEEIVAKV
                     REVSQPDWTPPPEVTLSLTKDNFDDVVNNADIILVEFYAPWCGHCKKLAPEYEKAAKE
                     LSKRSPPIPLAKVDATEQTDLAKRFDVSGYPTLKIFRKGRPFDYNGPREKYGIVDYMI
                     EQSGPPSKEILTLKQVQEFLKDGDDVVIIGLFQGDGDPAYLQYQDAANNLREDYKFHH
                     TFSPEIAKFLKVSLGKLVLTHPEKFQSKYEPRFHVMDVQGSTEASAIKDYVVKHALPL
                     VGHRKTSNDAKRYSKRPLVVVYYSVDFSFDYRAATQFWRNKVLEVAKDFPEYTFAIAD
                     EEDYATEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKP
                     VIKSQPVPKNNKGPVKVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGK
                     KYKGQKDLVIAKMDATANDITNDQYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLS
                     KFIDEHATKRSRTKEEL"
     exon            297..465
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            466..671
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            672..810
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1016
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1175
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1327
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1484
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1718
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..2481
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2481
                     /gene="Pdia4"
                     /gene_synonym="Cai; ERp-72; Erp72"
                     /note="major polyA site"
ORIGIN      
        1 gctcaggcag cggggcgggg cggtgtaggc ggggcgccac ggctctcgcc ctgattcgtg
       61 cggggattgg acgggccgcg gcttccttac ctccaaccaa tcaccggcct gaacttcctg
      121 gaggctttgg tgcgctccgg cgtcgctcgg gaggtcggcg agtgctctgc ggtggccggt
      181 gtctgcaggc ccagctctgc acccaatcat gaagctccgg aaagcttggc tgttggtcct
      241 gctcttggcg ctgacacagc tgctggctgc tgcgagcgcc ggagatgcac acgaagatac
      301 ttcagataca gaaaatgcca ctgaggagga agaggaggaa gaggaagagg atgacgatga
      361 cttggaagtt aaggaagaaa atggtgtttg ggtcttaaat gatgggaact ttgataactt
      421 tgtggctgac aaagatacag tgctactgga gttctatgca ccatggtgtg gacactgcaa
      481 gcagtttgct ccagaatatg agaaaattgc cagtactttg aaggataatg atcctcccat
      541 tgctgtagcg aagatcgatg caacctcagc atccatgcta gccagcaaat ttgatgtgag
      601 tggctacccc accatcaaga tcctgaagaa gggacaggcc gttgactatg atggctccag
      661 gacccaggaa gaaattgttg ccaaagtcag agaagtttcc cagcctgatt ggacacctcc
      721 acctgaagtc actctttcat tgactaaaga taactttgac gatgttgtaa ataatgcaga
      781 cattattttg gtggagttct atgccccgtg gtgtggacac tgcaagaaac ttgcccctga
      841 gtatgagaaa gctgccaagg agctcagcaa gcgctctccc ccaattccct tagccaaagt
      901 ggacgccacc gaacagacag acctggctaa gaggtttgat gtctctggct acccgacttt
      961 gaaaattttc cgcaaaggaa ggccttttga ctacaatggc ccacgagaga aatatgggat
     1021 tgttgactac atgattgagc agtctgggcc tccctcaaag gagatcctga ccctgaagca
     1081 ggtccaggag ttcctgaagg atggagatga tgtggtcatc attgggctct ttcagggaga
     1141 tggtgacccg gcctacttgc agtatcagga tgctgctaac aacctgagag aagattacaa
     1201 gtttcaccac actttcagcc ctgaaatagc caagttcctg aaagtctccc tggggaagtt
     1261 ggtgctgaca caccctgaga agttccagtc caagtatgag cccaggttcc acgtgatgga
     1321 tgttcagggc tctacagaag catcagccat taaggactat gtagtgaaac atgccttgcc
     1381 cctggtgggc catcgtaaga cttctaatga tgctaagcgg tacagcaaac gccccctggt
     1441 ggttgtatac tacagtgtgg acttcagctt tgattacaga gctgctactc agttttggcg
     1501 taacaaagtc ctagaggtgg ccaaggactt ccctgagtat accttcgcca ttgctgacga
     1561 ggaagactat gccacggagg tgaaggacct ggggctcagt gagagtggag aggatgtcaa
     1621 tgcagccatc ctagacgaga gcgggaagaa gtttgccatg gagccagagg agtttgattc
     1681 agacactctc cgggaatttg tcacagcttt taaaaaagga aaactaaagc cagtcatcaa
     1741 atcacagcca gtacccaaga acaacaaggg accagtcaag gtggtggtgg gaaagacctt
     1801 tgatgccatt gtgatggacc ccaaaaagga cgtcctcatt gaattctatg caccctggtg
     1861 tgggcactgc aagcagctag agcctatcta taccagccta ggcaagaaat acaagggcca
     1921 gaaggacctg gtcatcgcca agatggatgc tactgccaac gacatcacca acgaccaata
     1981 taaggtggag ggcttcccta ccatctattt tgctcccagt ggggacaaaa agaacccaat
     2041 taaatttgag ggtggcaaca gagatctgga gcatttgagc aagtttatag atgaacatgc
     2101 cacaaagagg agcaggacca aggaagagct ttaaaggcct ggctgtgtgc agaaggtgga
     2161 ggcaccaggc actagtggac agcattggcc accaagcatg tgagccatca gtgaaatggc
     2221 aggatcttga ctttttttta tattttgtta atgccacctc atgctctgaa tactgaatag
     2281 ccacgagtga cttgatgata gtttagatca gatttttatg gaggatacat ctatttttat
     2341 cattttgggt cttctttttt tttttttttt tttttaacta tttacttcag tatctcttca
     2401 gacaaataag ttttggatct tctgtttaag aatctttttt tttttttttt aatttaaact
     2461 ttaaaagtct ttgccaaatc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2521 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2581 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
