LOCUS       NM_007952               2658 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus protein disulfide isomerase associated 3 (Pdia3),
            mRNA.
ACCESSION   NM_007952
VERSION     NM_007952.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2658)
  AUTHORS   Luo,J.H., Wang,F.X., Zhao,J.W., Yang,C.L., Rong,S.J., Lu,W.Y.,
            Chen,Q.J., Zhou,Q., Xiao,J., Wang,Y.N., Luo,X., Li,Y., Song,D.N.,
            Chen,C., Zhang,C.L., Chen,S.H., Yang,P., Xiong,F., Yu,Q.L.,
            Zhang,S., Liu,S.W., Sun,F. and Wang,C.Y.
  TITLE     PDIA3 defines a novel subset of adipose macrophages to exacerbate
            the development of obesity and metabolic disorders
  JOURNAL   Cell Metab 36 (10), 2262-2280 (2024)
   PUBMED   39293433
  REMARK    GeneRIF: PDIA3 defines a novel subset of adipose macrophages to
            exacerbate the development of obesity and metabolic disorders.
REFERENCE   2  (bases 1 to 2658)
  AUTHORS   Liu,H., Zheng,Y., Li,F., Geng,B. and Liao,F.
  TITLE     Endoplasmic reticulum protein of 57 kDa sulfhydration promotes
            intestinal calcium absorption to attenuate primary osteoporosis
  JOURNAL   Nitric Oxide 149, 32-40 (2024)
   PUBMED   38830571
  REMARK    GeneRIF: Endoplasmic reticulum protein of 57 kDa sulfhydration
            promotes intestinal calcium absorption to attenuate primary
            osteoporosis.
REFERENCE   3  (bases 1 to 2658)
  AUTHORS   Czyzynska-Cichon,I., Giergiel,M., Kwiatkowski,G., Kurpinska,A.,
            Wojnar-Lason,K., Kaczara,P., Szymonski,M., Lekka,M., Kalvins,I.,
            Zapotoczny,B. and Chlopicki,S.
  TITLE     Protein disulfide isomerase A1 regulates fenestration dynamics in
            primary mouse liver sinusoidal endothelial cells (LSECs)
  JOURNAL   Redox Biol 72, 103162 (2024)
   PUBMED   38669864
  REMARK    GeneRIF: Protein disulfide isomerase A1 regulates fenestration
            dynamics in primary mouse liver sinusoidal endothelial cells
            (LSECs).
REFERENCE   4  (bases 1 to 2658)
  AUTHORS   Zhang,F., Liu,C., Chen,Z. and Zhao,C.
  TITLE     A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces
            osteogenic differentiation of preosteoblast in osteoporosis
  JOURNAL   Cell Biol Int 48 (4), 541-550 (2024)
   PUBMED   38321831
  REMARK    GeneRIF: A novel PDIA3/FTO/USP20 positive feedback regulatory loop
            induces osteogenic differentiation of preosteoblast in
            osteoporosis.
REFERENCE   5  (bases 1 to 2658)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2658)
  AUTHORS   Merrick,B.A., Patterson,R.M., Witcher,L.L., He,C. and Selkirk,J.K.
  TITLE     Separation and sequencing of familiar and novel murine proteins
            using preparative two-dimensional gel electrophoresis
  JOURNAL   Electrophoresis 15 (5), 735-745 (1994)
   PUBMED   7523108
REFERENCE   7  (bases 1 to 2658)
  AUTHORS   Burglin,T.R. and Barnes,T.M.
  TITLE     Introns in sequence tags
  JOURNAL   Nature 357 (6377), 367-368 (1992)
   PUBMED   1350660
REFERENCE   8  (bases 1 to 2658)
  AUTHORS   Hempel,W.M. and DeFranco,A.L.
  TITLE     Expression of phospholipase C isozymes by murine B lymphocytes
  JOURNAL   J Immunol 146 (11), 3713-3720 (1991)
   PUBMED   2033248
REFERENCE   9  (bases 1 to 2658)
  AUTHORS   Melero,J.A. and Smith,A.E.
  TITLE     Possible transcriptional control of three polypeptides which
            accumulate in a temperature-sensitive mammalian cell line
  JOURNAL   Nature 272 (5655), 725-727 (1978)
   PUBMED   643066
REFERENCE   10 (bases 1 to 2658)
  AUTHORS   Kirby,G.C.
  TITLE     The genetics of an electrophoretic variant of an erythrocytic
            protein in the house mouse (Mus musculus)
  JOURNAL   Anim Blood Groups Biochem Genet 5 (3), 153-157 (1974)
   PUBMED   4451294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ714617.1, AK133799.1, AK132459.1, AL845466.4 and BQ033063.1.
            
            On Aug 15, 2006 this sequence version replaced NM_007952.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132459.1, SRR1660815.40212.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BQ714617.1         1-43
            44-1622             AK133799.1         3-1581
            1623-1885           AK132459.1         1588-1850
            1886-2148           AL845466.4         144581-144843
            2149-2658           BQ033063.1         1-510               c
FEATURES             Location/Qualifiers
     source          1..2658
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.38 cM"
     gene            1..2658
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /note="protein disulfide isomerase associated 3"
                     /db_xref="GeneID:14827"
                     /db_xref="MGI:MGI:95834"
     exon            1..304
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            305..383
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            384..501
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            502..609
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            610..739
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            740..856
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            857..982
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1165
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1274
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1403
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1483
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1541
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..2643
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /note="hexamer: AATAAA"
     polyA_site      1936
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /note="major polyA site"
     regulatory      2613..2618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
                     /note="hexamer: ATTAAA"
     polyA_site      2643
                     /gene="Pdia3"
                     /gene_synonym="58kDa; Erp; ERp57; ERp60; ERp61; Grp58;
                     PDI; PDI-Q2; PI-PLC; Plca; PLC[a]"
ORIGIN      
        1 cgagcaggcc tagggggttg ggacctcggc agcgggtctg cccgggccag acgcgcgagc
       61 gcaggcaagc ggctgcagat tgcgggctct cccatctcat ttctccggtc ccggccctcc
      121 gaccgcgacc cgccgccatg cgcttcagct gcctagctct gctcccgggc gtggcgctgc
      181 tgctcgcctc ggcccgtctc gccgccgcct ccgatgtgtt ggaactgacg gacgaaaact
      241 tcgagagtcg cgtctccgac acgggctcgg cggggctcat gctagtcgag ttcttcgccc
      301 cctggtgtgg acattgcaag aggcttgccc ctgagtatga agctgcagca accagattaa
      361 aaggaatagt cccattagca aaggtggatt gcactgccaa cacaaacacc tgtaataagt
      421 atggggtcag tggctaccca actcttaaga tctttagaga tggtgaagaa gcgggtgctt
      481 atgatgggcc taggactgct gatggaattg tcagccactt gaagaaacaa gcaggaccag
      541 cttcagttcc tctcaggact gaggaagaat ttaagaagtt cattagtgat aaagatgcct
      601 cagtggtggg ttttttcagg gatttattca gtgatgggca ctctgaattc ctaaaagcag
      661 ccagcaactt gagagataac taccgatttg cacacaccaa cattgagtct ctggtgaagg
      721 agtacgatga taatggagag gggatcacta tattccgtcc attacatctt gctaacaagt
      781 ttgaagacaa aactgtggca tatactgaaa agaaaatgac cagtggcaag atcaagaaat
      841 ttattcagga tagcattttt ggtctctgtc ctcatatgac ggaagataat aaagatttga
      901 tacaaggcaa ggacttactc accgcttact atgatgtgga ctatgaaaag aatgctaaag
      961 gttctaacta ctggagaaac agggtcatga tggtggcaaa gaaattcctt gatgctggac
     1021 acaaactcaa ctttgctgta gctagccgta aaacctttag ccatgaactg tcagattttg
     1081 gcttagaaag cactactgga gaggttcctg ttgtggctat cagaactgct aaaggagaga
     1141 agtttgtcat gcaggaggag ttctcgcgag atggcaaggc tcttgaacag ttcctgcaag
     1201 aatactttga tggcaacttg aagagatacc tgaagtctga acccatccca gagtccaacg
     1261 aagggcctgt caaggttgtg gtagcagaga attttgatga catagtgaat gaagaagata
     1321 aggacgtgct gattgaattt tacgcccctt ggtgtggcca ctgtaagaat ctggaaccca
     1381 agtataaaga gctgggagaa aaactcagca aagatccaaa tattgtcata gccaagatgg
     1441 atgccacagc caatgatgtg ccttctccat atgaagtcaa gggttttcct accatctact
     1501 tctcaccagc caacaagaag ctaactccaa agaagtatga aggtggccgt gaattaaatg
     1561 attttattag ctatctacaa cgagaagcta caaacccccc tataattcaa gaagaaaaac
     1621 ctaagaagaa gaagaaggca caagaggacc tctaaagcaa cagccaaatg caccacttta
     1681 taaaaggact cttacaccag agaaggcaaa accagagagg acagaatgga tatactctga
     1741 atcctgttaa attttctcta aactgtttct tagctgcact gtttgaaaat acaaggacca
     1801 gtttatgttt gtggttttgg gagaaaatta tttgtgttgg gaagaatgtt gtgggggtgg
     1861 ggggaattga gttggggggt tattttctaa ttttttttgt acatttggaa cagtgacaat
     1921 aaatgtgccc cctttatact gtcgtttttt tcccctcatg ggatggagaa tcagggtctc
     1981 taaactgtaa tacagtaata gatagaagtg tttgagctat gctgttcaat gctgtagcta
     2041 aaccagatat gttatctcct ataatcgcaa cacttgggag gtgcaggcaa gagatctcaa
     2101 gttcaagatc ttccatggct acatagcagg ttttgaggct agcatcttaa acaggtttga
     2161 tctttcaaaa acaaagaaaa ccagctatgc tgattcctgt aacttgagac tgaataggtc
     2221 cagttaccat ctccaaattg tataatttat tagtttcttt ctgtagctca agctgtcctt
     2281 gaacttgtga tggtctccct ccctggccct gagatactga gatgacagtt gtttctagcc
     2341 tcattcatgt cctaaaggtg aatgcttact cttgccacac agccaagctt tctgcatgtg
     2401 catgcctcct gaggatggtt ctctgcccag aaatgccctg tgtgagtgac agcagtttgg
     2461 ggttccatcc aattttagga attattgaaa ctgctgggtg cagctctccc caaatcattg
     2521 ggtgtagcca tttacttccc tccagtgaac agggaaacag tatcaatcgc tggcaagaac
     2581 aagaacccac agagatgttt tcttttgaat ggattaaagt attgccctcc ttttatagct
     2641 aaaaaaaaaa aaaaaaaa
//
