LOCUS       NM_001081070            1721 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus protein disulfide isomerase associated 2 (Pdia2),
            mRNA.
ACCESSION   NM_001081070 XM_128552
VERSION     NM_001081070.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1721)
  AUTHORS   Jazwiec,P.A., Patterson,V.S., Ribeiro,T.A., Yeo,E., Kennedy,K.M.,
            Mathias,P.C.F., Petrik,J.J. and Sloboda,D.M.
  TITLE     Paternal obesity induces placental hypoxia and sex-specific
            impairments in placental vascularization and offspring
            metabolismdagger
  JOURNAL   Biol Reprod 107 (2), 574-589 (2022)
   PUBMED   35377412
REFERENCE   2  (bases 1 to 1721)
  AUTHORS   Liu,J., Qi,Y., Chao,J., Sathuvalli,P., Y Lee,L. and Li,S.
  TITLE     CREG1 promotes lysosomal biogenesis and function
  JOURNAL   Autophagy 17 (12), 4249-4265 (2021)
   PUBMED   33966596
REFERENCE   3  (bases 1 to 1721)
  AUTHORS   Zhou,J., Wu,Y., Chen,F., Wang,L., Rauova,L., Hayes,V.M., Poncz,M.,
            Li,H., Liu,T., Liu,J. and Essex,D.W.
  TITLE     The disulfide isomerase ERp72 supports arterial thrombosis in mice
  JOURNAL   Blood 130 (6), 817-828 (2017)
   PUBMED   28576878
REFERENCE   4  (bases 1 to 1721)
  AUTHORS   Toldo,S., Boccellino,M., Rinaldi,B., Seropian,I.M., Mezzaroma,E.,
            Severino,A., Quagliuolo,L., Van Tassell,B.W., Marfella,R.,
            Paolisso,G., Rossi,F., Natarajan,R., Voelkel,N., Abbate,A., Crea,F.
            and Baldi,A.
  TITLE     Altered oxido-reductive state in the diabetic heart: loss of
            cardioprotection due to protein disulfide isomerase
  JOURNAL   Mol Med 17 (9-10), 1012-1021 (2011)
   PUBMED   21637911
  REMARK    GeneRIF: Data show that diabetic mice had a worse postinfarction
            remodeling associated with an altered protein disulfide isomerase
            (PDI). redox state.
REFERENCE   5  (bases 1 to 1721)
  AUTHORS   Calderon,M.N., Guerrero,C.A., Dominguez,Y., Garzon,E., Barreto,S.M.
            and Acosta,O.
  TITLE     [Interaction of rotavirus with protein disulfide isomerase in vitro
            and cell system]
  JOURNAL   Biomedica 31 (1), 70-81 (2011)
   PUBMED   22159485
  REMARK    GeneRIF: Rotavirus-protein disulfide isomerase interaction was
            demonstrated in vitro as well as inMA104 cells and intestinal villi
            from suckling mice.
REFERENCE   6  (bases 1 to 1721)
  AUTHORS   Lan,H., Rabaglia,M.E., Schueler,K.L., Mata,C., Yandell,B.S. and
            Attie,A.D.
  TITLE     Distinguishing covariation from causation in diabetes: a lesson
            from the protein disulfide isomerase mRNA abundance trait
  JOURNAL   Diabetes 53 (1), 240-244 (2004)
   PUBMED   14693722
  REMARK    GeneRIF: Elevated Pdi expression is cis regulated and is not linked
            to diabetes susceptibility.
REFERENCE   7  (bases 1 to 1721)
  AUTHORS   Meunier,L., Usherwood,Y.K., Chung,K.T. and Hendershot,L.M.
  TITLE     A subset of chaperones and folding enzymes form multiprotein
            complexes in endoplasmic reticulum to bind nascent proteins
  JOURNAL   Mol Biol Cell 13 (12), 4456-4469 (2002)
   PUBMED   12475965
REFERENCE   8  (bases 1 to 1721)
  AUTHORS   Turano,C., Coppari,S., Altieri,F. and Ferraro,A.
  TITLE     Proteins of the PDI family: unpredicted non-ER locations and
            functions
  JOURNAL   J Cell Physiol 193 (2), 154-163 (2002)
   PUBMED   12384992
  REMARK    Review article
REFERENCE   9  (bases 1 to 1721)
  AUTHORS   Ferrari,D.M. and Soling,H.D.
  TITLE     The protein disulphide-isomerase family: unravelling a string of
            folds
  JOURNAL   Biochem J 339 (Pt 1) (Pt 1), 1-10 (1999)
   PUBMED   10085220
  REMARK    Review article
REFERENCE   10 (bases 1 to 1721)
  AUTHORS   Desilva,M.G., Notkins,A.L. and Lan,M.S.
  TITLE     Molecular characterization of a pancreas-specific protein disulfide
            isomerase, PDIp
  JOURNAL   DNA Cell Biol 16 (3), 269-274 (1997)
   PUBMED   9115635
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC126438.3.
            
            On Feb 6, 2007 this sequence version replaced XM_128552.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007743.1, SRR5189685.44479.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AC126438.3         106165-106426
            263-469             AC126438.3         106992-107198
            470-603             AC126438.3         107287-107420
            604-741             AC126438.3         107498-107635
            742-858             AC126438.3         107703-107819
            859-984             AC126438.3         107965-108090
            985-1182            AC126438.3         108163-108360
            1183-1303           AC126438.3         108450-108570
            1304-1485           AC126438.3         108651-108832
            1486-1593           AC126438.3         108921-109028
            1594-1721           AC126438.3         109126-109253
FEATURES             Location/Qualifiers
     source          1..1721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.07 cM"
     gene            1..1721
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /note="protein disulfide isomerase associated 2"
                     /db_xref="GeneID:69191"
                     /db_xref="MGI:MGI:1916441"
     exon            1..262
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1638
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /EC_number="5.3.4.1"
                     /note="protein disulfide isomerase, pancreatic; protein
                     disulfide-isomerase A2; protein disulfide isomerase
                     (pancreas) like"
                     /codon_start=1
                     /product="protein disulfide-isomerase A2 precursor"
                     /protein_id="NP_001074539.1"
                     /db_xref="CCDS:CCDS37510.1"
                     /db_xref="GeneID:69191"
                     /db_xref="MGI:MGI:1916441"
                     /translation="MDKQLLPVLLLLLGVSGSWGQGEEPGGPSEVLPEEPTGEEVPKE
                     DGILVLNHRTLSLALQEHSALMVEFYAPWCGHCKELAPEYSKAAALLAAESAVVTLAK
                     VDGPAEPELTKEFEVVGYPTLKFFQNGNRTNPEEYAGPKTAEGIAEWLRRRVGPSATH
                     LEDEEGVQALMAKWDMVVIGFFQDLQGKDMATFLALAKDALDMTFGFTDQPQLFEKFG
                     LTKDTVVLFKKFDEGRADFPVDKETGLDLGDLSRFLVIHSMHLVTEFNSQTSPKIFAA
                     KILNHLLLFVNQTLAQHRELLTDFREAAPPFRGQVLFVMVDVAADNSHVLNYFGLKAE
                     EAPTLRLINVETTKKYAPTGVIAITAASVAAFCQAVLHGEIKHYLLSQEIPPDWDQGP
                     VKTLVSKNFEQVAFDETKNVFVKFYAPWCSHCKEMAPAWEALAEKYKDREDIVIAELD
                     ATANELEAFSVLGYPTLKFFPAGPDRKVIDYKSTRDLETFSKFLDSGGHLPKEEPKEP
                     AASAPEAQANSTLGPKEEL"
     exon            263..469
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     exon            470..603
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     exon            604..741
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     exon            742..858
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     exon            859..984
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1182
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1303
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1485
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1593
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1721
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1702..1707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /note="hexamer: AATAAA"
     polyA_site      1721
                     /gene="Pdia2"
                     /gene_synonym="1810041F13Rik; Pdip; Pdipl"
                     /note="major polyA site"
ORIGIN      
        1 gctgcttggt ccccaatctc tttatctgct ccagccttca gggcccagcg cgccatggac
       61 aagcagcttc tgccagtgtt gctgctcctg ctgggtgtct caggctcatg gggacaggga
      121 gaagagcctg ggggtccttc agaggtgctc cctgaggagc ccactgggga agaagtcccc
      181 aaggaggatg gtatcttggt cttgaaccac cgaaccctga gcctggcact gcaggagcat
      241 tcagccctga tggtggagtt ttatgcccca tggtgtggtc actgcaaaga actagctccc
      301 gagtacagca aggcggctgc cctgctggcg gctgagtcag ctgtggtcac cttggccaag
      361 gtggatggcc ctgcggaacc ggagctgacc aaggagtttg aagtggtagg gtaccctaca
      421 ctcaagttct tccagaatgg aaaccgcaca aacccagaag agtacgcagg gcccaagact
      481 gctgagggca ttgctgagtg gctgaggcgg cgagtggggc ccagtgccac acatctggag
      541 gatgaggaag gtgtccaggc actgatggcc aaatgggata tggtggtcat tggcttcttt
      601 caggatctac agggaaagga tatggcaact ttcctggcct tggccaagga tgccctggac
      661 atgacctttg gcttcactga ccagccacaa ctttttgaga agtttggcct caccaaggat
      721 actgtggtcc ttttcaagaa gtttgatgag ggtcgggccg acttcccggt agacaaggag
      781 actggcctgg acctggggga cctgtcccgc ttcctcgtca tacatagcat gcacctggtc
      841 acagaattca acagccagac atcacctaag atctttgcag ccaagatcct caaccacctg
      901 ctgctgtttg tgaaccagac actagctcaa cacagggaac tgctgacaga cttcagagag
      961 gcagctcctc cattcagggg gcaggtgttg ttcgtaatgg tggatgtggc tgctgacaac
     1021 agccatgtgc tgaattattt tggcctcaag gctgaggaag cccccaccct gcgtctgatc
     1081 aatgttgaga ctaccaagaa gtatgcacct acaggggtga tagccatcac tgcagcttct
     1141 gtggctgcct tctgccaggc agttctccat ggggaaatca agcactatct cctgagtcag
     1201 gagatacccc ctgactggga ccaggggcca gtcaagactc tcgtgagcaa gaattttgag
     1261 caggttgcct ttgatgaaac caagaatgtg tttgtcaagt tctatgcccc atggtgcagc
     1321 cactgcaagg agatggctcc agcctgggag gcattggcag agaagtacaa ggatcgtgag
     1381 gacattgtca ttgccgagtt ggatgctaca gctaatgagc tggaggcctt ctctgtgctc
     1441 ggctatccca ctctcaagtt ctttcctgca gggcctgacc gaaaggttat agactacaaa
     1501 agcactaggg acctagagac attctccaag ttcctggaca gcggaggtca cctgcctaag
     1561 gaggaaccca aggagcctgc agcctctgcc ccagaagcac aagccaattc caccttgggt
     1621 cccaaggagg agctgtagcc attgggacac tgtaatccag agagtggtgt tctcaggtgc
     1681 tggagggagc tgtgtactat gaataaacat gttgtcccag a
//
