LOCUS       NM_008810               2872 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus pyruvate dehydrogenase E1 alpha 1 (Pdha1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_008810 XM_980970 XM_981006
VERSION     NM_008810.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2872)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2872)
  AUTHORS   Li,H., Liuha,X., Chen,R., Xiao,Y., Xu,W., Zhou,Y., Bai,L.,
            Zhang,J., Zhao,Y., Zhao,Y., Wang,L., Qin,F., Chen,Y., Han,S.,
            Wei,Q., Li,S., Zhang,D., Bu,Q., Wang,X., Jiang,L., Dai,Y.,
            Zhang,N., Kuang,W., Qin,M., Wang,H., Tian,J., Zhao,Y. and Cen,X.
  TITLE     Pyruvate dehydrogenase complex E1 subunit alpha crotonylation
            modulates cocaine-associated memory through hippocampal neuron
            activation
  JOURNAL   Cell Rep 43 (8), 114529 (2024)
   PUBMED   39046876
REFERENCE   3  (bases 1 to 2872)
  AUTHORS   Marin-Valencia,I., Kocabas,A., Rodriguez-Navas,C., Miloushev,V.Z.,
            Gonzalez-Rodriguez,M., Lees,H., Henry,K.E., Vaynshteyn,J.,
            Longo,V., Deh,K., Eskandari,R., Mamakhanyan,A., Berishaj,M. and
            Keshari,K.R.
  TITLE     Imaging brain glucose metabolism in vivo reveals propionate as a
            major anaplerotic substrate in pyruvate dehydrogenase deficiency
  JOURNAL   Cell Metab 36 (6), 1394-1410 (2024)
   PUBMED   38838644
REFERENCE   4  (bases 1 to 2872)
  AUTHORS   Qiu,X., Jiang,Z., Luo,Y., Tian,D., Song,T. and Li,Q.
  TITLE     PPP3CB Inhibits Cell Proliferation and the Warburg Effect in
            Bladder Cancer by Blocking PDHK1
  JOURNAL   Front Biosci (Landmark Ed) 29 (2), 48 (2024)
   PUBMED   38420800
  REMARK    GeneRIF: PPP3CB Inhibits Cell Proliferation and the Warburg Effect
            in Bladder Cancer by Blocking PDHK1.
REFERENCE   5  (bases 1 to 2872)
  AUTHORS   Mishra,A., Tavasoli,M., Sokolenko,S., McMaster,C.R. and
            Pasumarthi,K.B.S.
  TITLE     Atrial natriuretic peptide signaling co-regulates lipid metabolism
            and ventricular conduction system gene expression in the embryonic
            heart
  JOURNAL   iScience 27 (1), 108748 (2023)
   PUBMED   38235330
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2872)
  AUTHORS   Zhou,E., Favor,J., Silvers,W. and Stambolian,D.
  TITLE     Exclusion of three candidate genes, Grpr, Cxn33, and Pdha1, for the
            X-linked cataract gene on the distal region of the mouse chromosome
            X
  JOURNAL   Mamm Genome 6 (5), 357-359 (1995)
   PUBMED   7626887
REFERENCE   7  (bases 1 to 2872)
  AUTHORS   Takakubo,F. and Dahl,H.H.
  TITLE     Analysis of pyruvate dehydrogenase expression in embryonic mouse
            brain: localization and developmental regulation
  JOURNAL   Brain Res Dev Brain Res 77 (1), 63-76 (1994)
   PUBMED   7510589
REFERENCE   8  (bases 1 to 2872)
  AUTHORS   Fitzgerald,J., Hutchison,W.M. and Dahl,H.H.
  TITLE     Isolation and characterisation of the mouse pyruvate dehydrogenase
            E1 alpha genes
  JOURNAL   Biochim Biophys Acta 1131 (1), 83-90 (1992)
   PUBMED   1581363
REFERENCE   9  (bases 1 to 2872)
  AUTHORS   Takakubo,F. and Dahl,H.H.
  TITLE     The expression pattern of the pyruvate dehydrogenase E1 alpha
            subunit genes during spermatogenesis in adult mouse
  JOURNAL   Exp Cell Res 199 (1), 39-49 (1992)
   PUBMED   1735460
REFERENCE   10 (bases 1 to 2872)
  AUTHORS   Brown,R.M., Dahl,H.H. and Brown,G.K.
  TITLE     Pyruvate dehydrogenase E1 alpha subunit genes in the mouse: mapping
            and comparison with human homologs
  JOURNAL   Somat Cell Mol Genet 16 (5), 487-492 (1990)
   PUBMED   2122529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY783593.1, AK148459.1 and BQ177075.1.
            
            On Aug 25, 2015 this sequence version replaced NM_008810.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007142.1, AK145718.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BY783593.1         2-75
            75-2824             AK148459.1         2-2751
            2825-2872           BQ177075.1         1-48                c
FEATURES             Location/Qualifiers
     source          1..2872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 73.95 cM"
     gene            1..2872
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /note="pyruvate dehydrogenase E1 alpha 1"
                     /db_xref="GeneID:18597"
                     /db_xref="MGI:MGI:97532"
     exon            1..175
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            176..235
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..409
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..536
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..628
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..721
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..877
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..949
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1017
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1126
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..2855
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2837..2842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2855
                     /gene="Pdha1"
                     /gene_synonym="Pdha-1"
                     /note="major polyA site"
ORIGIN      
        1 gtcactgcgt tttgggcgtg gcttcggctc cgggcgcctc aaggagactt ggggacgccc
       61 gcaccactcc ttttgagtgc ctgggtgccg cggccgccgc gtgagtctgc tgcgctccat
      121 gaggaagatg cttgccgctg tatcccgcgt gttggcaggc tctgcgcaga agccggcaag
      181 ccgagtgctg gttgcttccc gtaattttgc aaatgatgct acatttgaga ttaagaaatg
      241 tgaccttcat cggctagaag agggcccccc agtcaccaca gtgctcacca gagaggatgg
      301 gctcaagtac tacaggatga tgcagactgt gcgccggatg gagctaaagg cggatcagct
      361 gtataagcag aaaatcattc gtggtttctg tcacttgtgt gatggtcagg aagcctgctg
      421 cgtgggcctg gaggctggca taaaccctac ggaccacctc atcactgcct atcgagcaca
      481 tggcttcacc ttcactcggg gcctgcctgt gcgagcaatt cttgcagagc taacaggacg
      541 aagaggaggt tgtgctaaag ggaaaggcgg gtcaatgcac atgtacgcca agaacttcta
      601 tggaggcaac ggcatcgttg gagctcaggt gcccctggga gcaggaattg ccctggcctg
      661 caagtacaat ggaaaagatg aggtctgttt gacattatac ggcgatggtg ctgctaatca
      721 gggtcagatc tttgaagctt acaatatggc agcactgtgg aaattacctt gcatttttat
      781 ctgtgagaac aaccgctatg gcatggggac gtctgttgag agagcagcag ccagcacgga
      841 ctactacaaa agaggagatt ttattcctgg actcagggta gatggaatgg atatcttgtg
      901 cgtccgagag gcaacaaagt ttgcggctgc ctattgcagg tctggtaagg ggcccatcct
      961 gatggagctc cagacttacc gctaccatgg acacagcatg agtgaccctg gagtaagcta
     1021 ccgcactcga gaagaaatcc aggaagtaag aagtaagagt gaccctatta tgcttctcaa
     1081 ggatagaatg gtgaacagca atcttgcaag tgttgaagaa ttaaaggaga ttgatgtgga
     1141 agtgaggaaa gaaatcgagg atgctgccca gtttgccacg gctgatcctg agcccccgtt
     1201 ggaggaacta ggctatcaca tctacagcag tgatcctccc tttgaagtgc gtggtgccaa
     1261 ccagtggatc aagtttaagt cagtcagtta atgggtgact gttaggtggg tggatgggtg
     1321 ttcccatcca gcgtaaggaa ctctgtgctc tcaacttgga caggaaatac ccagacaaca
     1381 aaaggcttga aaacatgtaa attaagggag agtaaaattg catgcagttt gtacattgct
     1441 gtatttggtg tattcattca tgtgaataag agtgtattgg atttgtatag gatttgagat
     1501 gggtattgca gagtttataa ccatccatca tatcccgggt taggtactaa aaaggaagaa
     1561 atctgccatt tggtggtgtg gtcctagctg tgaatgcctg ctggggaaat gcaaagcaga
     1621 ggtagaagtg tagcagccac caggaattgt ggaggcactg accatcatgt ctctgatcaa
     1681 aggctagaca aaatcatgtg tttcaaaata agggaacttc agtcacctca aaggtaaaat
     1741 agtttaattt tttccattta gacatttaac atacatgaaa ctgtactccc attgcaaggc
     1801 acacttttta acctttcaca tttaagtaat tacactagtt tataaaatac gtatgcttta
     1861 tctttccagc gatatgctga ctttttaaat attaggtcag ggctgacatt acttacaatc
     1921 ttgtttataa acaaggatgc tctacaatca cacgtgcttg aattaaatgg acaagggtct
     1981 ttctgtggaa actcggagtt tgtgagtaca ccaacagaag ctttaatcat gagcaggtgt
     2041 aggggacttt ttgcccattc tccccaggct tggctcactg tgaagactcc tgcatttgtc
     2101 ttctgtgctg ggagactgca tgccagagcc tacagaggac accacccctg caaaacaata
     2161 atttgcagaa gaaaagcaaa cttgaagcca gccatctact ctttaaatat aatctctaac
     2221 ttaaaagcaa aagtatgtcg cctttttctg aacatggtac cataggaatg ctggtggctc
     2281 tgtgtagagg tgtggatctt taaacaagag tgtaaagaaa ggtctatcac ttcatgcctt
     2341 gccaccctga acctgagaaa atgagctctg tttgctgtga cataggaaag ataggggaga
     2401 gctactagca tttttaagta ttcacatgaa aacaacccta agctgtcggg gaggctctct
     2461 taccgtagtc ggaggcacct taggtcttcc ttagtgatat cattgagaat atcagaaagt
     2521 gtatagtcct cttcaacaat ctgaaagatt caacgtatgg ataagcagct tttcaacaat
     2581 atcataggaa tactttgatt tagaaattta ccttttctat tgtattggca tccactcctt
     2641 gtagttgcaa ccagtctata agctctctgt cggttcccag tccatcaggg ggtggagggt
     2701 tctctgtacc acctataatg attccaattt tgttttattg tatagtaatg tataaccata
     2761 aaatgcttta aaagtaacaa cgtggatgta atgatgtatc gcaacagaaa tgtcatgtgc
     2821 tgtgaaaagg aaacgaatta aacttgtttg attcaaaaaa aaaaaaaaaa aa
//
