LOCUS       NM_026840               1545 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus platelet-derived growth factor receptor-like (Pdgfrl),
            mRNA.
ACCESSION   NM_026840
VERSION     NM_026840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1545)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1545)
  AUTHORS   Kawata,K., Kubota,S., Eguchi,T., Aoyama,E., Moritani,N.H., Oka,M.,
            Kawaki,H. and Takigawa,M.
  TITLE     A Tumor Suppressor Gene Product, Platelet-Derived Growth Factor
            Receptor-Like Protein Controls Chondrocyte Proliferation and
            Differentiation
  JOURNAL   J Cell Biochem 118 (11), 4033-4044 (2017)
   PUBMED   28407304
  REMARK    GeneRIF: These findings suggest that PDGFRL plays the different
            roles, depending upon cell types. Particularly, in chondrocytes,
            PDGFRL may play a new and important role which is distinct from the
            function previously reported.
REFERENCE   3  (bases 1 to 1545)
  AUTHORS   Ashley,R.L., Henkes,L.E., Bouma,G.J., Pru,J.K. and Hansen,T.R.
  TITLE     Deletion of the Isg15 gene results in up-regulation of decidual
            cell survival genes and down-regulation of adhesion genes:
            implication for regulation by IL-1beta
  JOURNAL   Endocrinology 151 (9), 4527-4536 (2010)
   PUBMED   20660068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132625.1.
            
            On Mar 25, 2008 this sequence version replaced NM_026840.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058275.1, AK132625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1545              AK132625.1         2-1546
FEATURES             Location/Qualifiers
     source          1..1545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..1545
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /note="platelet-derived growth factor receptor-like"
                     /db_xref="GeneID:68797"
                     /db_xref="MGI:MGI:1916047"
     exon            1..193
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1266
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /note="platelet-derived growth factor receptor-like
                     (MGD|MGI:1916047 GB|BC058275, evidence: BLASTN, 99%,
                     match=1537); putative; platelet-derived growth factor
                     receptor-like protein; PDGFR-like protein"
                     /codon_start=1
                     /product="platelet-derived growth factor receptor-like
                     protein precursor"
                     /protein_id="NP_081116.3"
                     /db_xref="CCDS:CCDS22259.1"
                     /db_xref="GeneID:68797"
                     /db_xref="MGI:MGI:1916047"
                     /translation="MKFWLLLGLLLLHEALEDVGGQHSPKNKRPKEQGENRIKPTNKK
                     AKPKIPKVKDRDSTDSTAKSQSIMMQAMGNGRFQRPAATVSLLAGQTLELRCKGSKVE
                     WSYPAYLDTFKDSRLTVKQSERYGQLTLVNSTAADTGEFSCWEQLCNGYICRRDEAKT
                     GSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTAPSAKVTLHREFPAKEIPA
                     NGTDIVYDMKRGFVYLQPHSDHQGVVYCKAEAGGKSQISVKYQLLYVEVPSGPPSTTI
                     LASSNKVRGGDDISVLCTVLGEPDVEVEFRWLFPGQKDERPVTIQDTWRLIHRGLGHT
                     TRISQSVIIVEDFETIDAGYYICTAQNLRGQTTVATTVEFS"
     exon            194..491
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            492..643
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            644..937
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1077
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1545
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1414..1419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /note="hexamer: TATAAA"
     polyA_site      1436
                     /gene="Pdgfrl"
                     /gene_synonym="1110039P19Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttcccc cagtgaaacc gaatcctcca gctgtggtgt cccaggcgcc gcctcccctc
       61 tgcgcccctg ccctgccctg gacagcctgt cgcgccgtct gcagtcctga actattctgc
      121 aggtcaccag ccctgaagat gaagttttgg ctgctgctcg gacttctgtt gctacacgaa
      181 gcgctggaag atgttggtgg tcagcattct cctaagaaca agcgtccaaa ggagcaggga
      241 gaaaacagga tcaaaccaac caacaaaaag gccaaaccca agattcctaa ggtaaaggac
      301 agggactcca ctgactcaac cgcaaagagc cagtccatca tgatgcaagc gatgggcaac
      361 ggtcgcttcc agaggcctgc tgccacagtg agtctcctgg cagggcaaac tctagagcta
      421 cgatgtaagg ggagcaaagt ggaatggagt taccccgcct acttggacac cttcaaggac
      481 tcccgcctca ctgtgaagca gagtgaacgc tatgggcagt tgactctggt caactccacc
      541 gcggccgaca ccggtgaatt cagctgctgg gagcaactgt gcaatggcta catctgcaga
      601 cgggatgaag ccaaaacagg ctccacctat atcttcttca cagagaaagg agagctgttt
      661 gtgccttctc ccagttactt tgatgttgtc tacctgaacc cggacagaca agctgtggtt
      721 ccttgtcgag tgacagcccc gtcagccaaa gtcacgctcc acagggagtt tcccgccaaa
      781 gaaatccctg ccaatggcac ggacattgtg tacgacatga agagaggttt cgtgtacctt
      841 cagcctcatt ccgatcacca gggtgtggtc tactgcaaag cggaagccgg gggcaagtct
      901 cagatctcag tcaagtatca gctgctctat gtagaggttc ctagtggccc tccatcaaca
      961 accatcttgg cctcctctaa caaagtgagg ggcggtgatg acatcagcgt gctctgcact
     1021 gtcctcgggg agcctgatgt ggaggttgaa ttcaggtggc tctttcctgg gcagaaggac
     1081 gaaaggcctg tgaccatcca ggacacctgg agactgattc acagaggact gggacacacc
     1141 acaagaatct cccagagtgt cattatcgtg gaagactttg agaccattga tgcgggctac
     1201 tacatatgca cagctcagaa tctccgagga cagaccacag tagcgaccac tgttgagttt
     1261 tcctgatttg gaaagtgaag agtagtggac caatgggatg cccatctgca cacacagctt
     1321 ccaggtgctt tataggaggc caaggaccaa cccctgccag tgggtcagac agacatccga
     1381 attaaaagga agtcactagt ctattaatag aagtataaac tttcctaact aaagtatgta
     1441 ttttgactca gccatgtttc tactttttat actgagaaaa catgtcaaca actttgtatc
     1501 aatcgtttct attaaatgag caagatttta taaaaaaaaa aaaaa
//
