LOCUS       NM_011058               6625 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus platelet derived growth factor receptor, alpha
            polypeptide (Pdgfra), transcript variant 2, mRNA.
ACCESSION   NM_011058
VERSION     NM_011058.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6625)
  AUTHORS   Coren,L., Zaffryar-Eilot,S., Odeh,A., Kaganovsky,A. and Hasson,P.
  TITLE     Fibroblast diversification is an embryonic process dependent on
            muscle contraction
  JOURNAL   Cell Rep 43 (12), 115034 (2024)
   PUBMED   39636726
REFERENCE   2  (bases 1 to 6625)
  AUTHORS   Franks,N.E. and Allen,B.L.
  TITLE     Hedgehog-dependent and hedgehog-independent roles for growth arrest
            specific 1 in mammalian kidney morphogenesis
  JOURNAL   Development 151 (24) (2024)
   PUBMED   39629522
REFERENCE   3  (bases 1 to 6625)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   4  (bases 1 to 6625)
  AUTHORS   Khan,I.S., Molina,C., Ren,X., Auyeung,V.C., Cohen,M., Tsukui,T.,
            Atakilit,A. and Sheppard,D.
  TITLE     Impaired myofibroblast proliferation is a central feature of
            pathologic post-natal alveolar simplification
  JOURNAL   Elife 13, 94425 (2024)
   PUBMED   39660606
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6625)
  AUTHORS   Mueller,A.A., van Velthoven,C.T., Fukumoto,K.D., Cheung,T.H. and
            Rando,T.A.
  TITLE     Intronic polyadenylation of PDGFRalpha in resident stem cells
            attenuates muscle fibrosis
  JOURNAL   Nature 540 (7632), 276-279 (2016)
   PUBMED   27894125
  REMARK    GeneRIF: polyadenylation of a PDGFRalpha intron in resident stem
            cells attenuates muscle fibrosis
REFERENCE   6  (bases 1 to 6625)
  AUTHORS   Demoulin,J.B. and Essaghir,A.
  TITLE     PDGF receptor signaling networks in normal and cancer cells
  JOURNAL   Cytokine Growth Factor Rev 25 (3), 273-283 (2014)
   PUBMED   24703957
  REMARK    Review article
REFERENCE   7  (bases 1 to 6625)
  AUTHORS   Palmieri,S.L., Payne,J., Stiles,C.D., Biggers,J.D. and Mercola,M.
  TITLE     Expression of mouse PDGF-A and PDGF alpha-receptor genes during
            pre- and post-implantation development: evidence for a
            developmental shift from an autocrine to a paracrine mode of action
  JOURNAL   Mech Dev 39 (3), 181-191 (1992)
   PUBMED   1292572
REFERENCE   8  (bases 1 to 6625)
  AUTHORS   Do,M.S., Fitzer-Attas,C., Gubbay,J., Greenfeld,L., Feldman,M. and
            Eisenbach,L.
  TITLE     Mouse platelet-derived growth factor alpha receptor: sequence,
            tissue-specific expression and correlation with metastatic
            phenotype
  JOURNAL   Oncogene 7 (8), 1567-1575 (1992)
   PUBMED   1321404
REFERENCE   9  (bases 1 to 6625)
  AUTHORS   Altherr,M.R., Wasmuth,J.J., Seldin,M.F., Nadeau,J.H., Baehr,W. and
            Pittler,S.J.
  TITLE     Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase
            beta-subunit gene in mouse and human: tight linkage to the
            Huntington disease region (4p16.3)
  JOURNAL   Genomics 12 (4), 750-754 (1992)
   PUBMED   1315306
REFERENCE   10 (bases 1 to 6625)
  AUTHORS   Truslove,G.M.
  TITLE     A new allele at the patch locus in the mouse
  JOURNAL   Genet Res 29 (2), 183-186 (1977)
   PUBMED   863250
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120348.9, AK147267.1,
            BY628767.1 and CK627326.1.
            
            On Dec 10, 2016 this sequence version replaced NM_011058.2.
            
            Summary: This gene encodes a member of the receptor tyrosine kinase
            family of proteins. Binding of platelet-derived growth factor
            protein ligands to this receptor triggers receptor dimerization and
            autophosphorylation, resulting in the activation of several
            downstream signaling pathways. Signaling through the encoded
            receptor plays a role in gastrulation and the development of nearly
            all organ systems. Mice lacking a functional copy of this gene
            reportedly exhibit defects in lung, skeleton, testis and the
            central nervous system, and die soon after birth. Alternative
            splicing and intronic polyadenylation of gene transcripts have been
            implicated in muscle regeneration and fibrosis in adult mice.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147267.1, M84607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC120348.9         75203-75297
            96-6438             AK147267.1         5-6347
            6439-6593           BY628767.1         221-375
            6594-6625           CK627326.1         8-39                c
FEATURES             Location/Qualifiers
     source          1..6625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.55 cM"
     gene            1..6625
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /note="platelet derived growth factor receptor, alpha
                     polypeptide"
                     /db_xref="GeneID:18595"
                     /db_xref="MGI:MGI:97530"
     exon            1..207
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            208..268
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..3489
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; alpha-type platelet-derived growth factor
                     receptor; platelet-derived growth factor receptor alpha;
                     PDGF-R-alpha; CD140 antigen-like family member A; PDGF
                     alpha chain; Alpha platelet-derived growth factor receptor
                     precursor (PDGF-R-alpha); PDGFR-alpha"
                     /codon_start=1
                     /product="platelet-derived growth factor receptor alpha
                     isoform 1 precursor"
                     /protein_id="NP_035188.2"
                     /db_xref="CCDS:CCDS19351.1"
                     /db_xref="GeneID:18595"
                     /db_xref="MGI:MGI:97530"
                     /translation="MGTSHQVFLVLSCLLTGPGLISCQLLLPSILPNENEKIVQLNSS
                     FSLRCVGESEVSWQHPMSEEDDPNVEIRSEENNSGLFVTVLEVVNASAAHTGWYTCYY
                     NHTQTDESEIEGRHIYIYVPDPDMAFVPLGMTDSLVIVEEDDSAIIPCRTTDPETQVT
                     LHNNGRLVPASYDSRQGFNGTFSVGPYICEATVKGRTFKTSEFNVYALKATSELNLEM
                     DARQTVYKAGETIVVTCAVFNNEVVDLQWTYPGEVRNKGITMLEEIKLPSIKLVYTLT
                     VPKATVKDSGEYECAARQATKEVKEMKRVTISVHEKGFVEIEPTFGQLEAVNLHEVRE
                     FVVEVQAYPTPRISWLKDNLTLIENLTEITTDVQKSQETRYQSKLKLIRAKEEDSGHY
                     TIIVQNEDDVKSYTFELSTLVPASILDLVDDHHGSGGGQTVRCTAEGTPLPEIDWMIC
                     KHIKKCNNDTSWTVLASNVSNIITELPRRGRSTVEGRVSFAKVEETIAVRCLAKNNLS
                     VVARELKLVAPTLRSELTVAAAVLVLLVIVIVSLIVLVVIWKQKPRYEIRWRVIESIS
                     PDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKV
                     AVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDL
                     VNYLHKNRDSFMSQHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYMDMKQADTT
                     QYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDDSEGLTLLDLLSF
                     TYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTF
                     LPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR
                     MAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKS
                     DHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPE
                     EEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSF
                     L"
     exon            269..586
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..847
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..978
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1150
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1340
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1456
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1583
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1777
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1872
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2005
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2110
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2221
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2375
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2542
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2658
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2781
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2893
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2993
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3099
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3341
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..6595
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4224..4229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /note="hexamer: AACAAA"
     polyA_site      4243
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /note="major polyA site"
     regulatory      6410..6415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /note="hexamer: AATAAA"
     polyA_site      6440
                     /gene="Pdgfra"
                     /gene_synonym="CD140a; Pdgfr-2"
                     /note="major polyA site"
ORIGIN      
        1 cagctattta ctttaagcaa atgattagtt tttggaggac ggactataac attgaatcaa
       61 ttacaaaatg cgggttttga gcccattact gttggagctt gagggagaga aacaaacgga
      121 ggagctgcgg ggaaggactg gaagcttggg gcttactttt cactccgggt atcggatttt
      181 ctttgcaaat tgacatagaa ggagaaggtc tcaggagcta tggggacctc ccaccaggtc
      241 tttctggtcc tcagctgtct cctcacaggg ccgggcctca tctcctgcca gctcttatta
      301 ccctctatcc tcccaaacga gaatgagaag attgtgcagc tgaattcgtc cttttctctg
      361 agatgcgttg gggagagtga agtgagctgg cagcacccca tgtctgaaga agacgacccc
      421 aacgtggaaa tcagaagtga ggagaacaac agtggcctct ttgtcacagt gctggaagtg
      481 gttaacgcct ccgcagccca caccggatgg tacacttgct actacaacca cactcagacg
      541 gatgagagtg agatcgaagg caggcacatt tacatctatg taccagaccc agacatggcc
      601 tttgtgcctc tcgggatgac cgattcctta gtcatcgtgg aagaggatga ctctgccatc
      661 ataccttgcc gcaccacaga tccggagact caagtaacct tgcacaataa cgggaggctg
      721 gtgcctgcct cctatgacag caggcagggc ttcaacggaa ccttcagcgt ggggccttac
      781 atctgtgagg ccaccgtcaa agggaggacg ttcaagacca gcgagtttaa tgtttatgcc
      841 ttgaaagcaa cgtcagaact gaatctggag atggacgcac gccagactgt gtataaggca
      901 ggagaaacga tcgtggtgac ctgtgccgtc tttaacaacg aggtcgttga cctgcagtgg
      961 acttaccctg gagaagtgag aaacaaaggt atcaccatgc tggaggagat caaactccca
     1021 tccatcaaac tggtgtacac tttgaccgtc cccaaggcca cggtgaagga cagtggagag
     1081 tatgaatgtg ctgcccgtca ggccactaaa gaggtcaagg aaatgaagag agtcaccatt
     1141 tctgtccacg agaaaggctt cgtcgagatt gagcccacct ttggccagct ggaagctgtc
     1201 aacttgcacg aagtcagaga gttcgtggtg gaggtgcagg cctacccgac gcccaggata
     1261 tcgtggctga aggacaactt gactctgata gagaatctca ccgagatcac cactgatgta
     1321 cagaagagtc aggaaacaag gtatcagagc aaattaaagc tgatccgggc taaggaagaa
     1381 gacagtggcc attacaccat tatagttcaa aatgaggatg acgtgaagag ttacacgttt
     1441 gagctgtcaa ccctagttcc tgcatccatt ttggatctcg tagatgacca ccatggctct
     1501 ggcgggggac agactgtgag gtgtacagcc gaaggcaccc ctcttccaga aatcgactgg
     1561 atgatctgca agcatattaa gaaatgtaat aatgacactt cgtggacagt tttggccagc
     1621 aatgtctcaa atattatcac agagctccct cgccgtggca ggagtaccgt ggagggacga
     1681 gtgtccttcg ccaaagtgga agagaccatc gcagttcgat gcctggcaaa gaacaacctc
     1741 agcgttgtgg cccgtgagct gaagctggtg gctcccactc tgcgatctga actcacagtg
     1801 gcggccgcag tgttggtgct gttggtgatt gtcattgtct ctctcatcgt cctggtggtc
     1861 atttggaagc agaaaccacg gtatgaaatt cgctggaggg ttatcgagtc aatcagcccc
     1921 gatggacatg agtatatcta tgtggacccc atgcagttgc cttacgactc cagatgggaa
     1981 ttcccgagag atggcctcgt gcttggtcgg attttgggat ccggtgcatt tgggaaagtg
     2041 gtcgaaggta cagcttatgg attaagccgg tcccaacctg taatgaaggt ggctgtgaag
     2101 atgctcaaac ccacagccag gtctagtgaa aagcaggctc tcatgtctga gctgaagata
     2161 atgactcacc tggggccaca tttgaacatt gtgaacttgc tgggagcctg caccaagtca
     2221 ggtcccattt acatcatcac agaatactgc ttctatgggg atttggtcaa ctacttgcat
     2281 aagaacagag atagcttcat gagccaacac ccagagaagc cgaagaaaga cctggacatc
     2341 tttggattga atcctgcaga cgagagcaca agaagttatg tgattttgtc ttttgaaaat
     2401 aacggcgact acatggacat gaagcaagct gataccacac agtatgtccc catgcttgaa
     2461 aggaaagagg tttctaaata ctctgacatc cagagatcgc tgtacgatcg gccagcctcc
     2521 tacaagaaga aatccatgct agactcagaa gtcaaaaacc tcctttcgga cgatgactcc
     2581 gagggtctga ctttgctgga tctattgagc ttcacctatc aagttgctcg aggaatggaa
     2641 tttttggctt cgaaaaattg tgtccaccgg gacctggctg cccgcaacgt cctcctggcg
     2701 caaggaaaaa ttgtgaagat ctgtgatttt ggcctggcca gagacatcat gcacgattcc
     2761 aactacgtgt caaaaggcag tactttcctg cctgtgaagt ggatggcacc cgagagcatc
     2821 ttcgacaacc tctacaccac gctgagtgac gtctggtcct atggcattct gctctgggaa
     2881 atcttttccc ttggtggcac accctatcct ggcatgatgg tcgattctac tttctacaat
     2941 aagatcaaga gtggataccg gatggccaaa cctgaccatg ccaccagtga agtctatgag
     3001 atcatggtgc agtgctggaa cagtgagccc gagaagagac cctccttcta ccacctcagc
     3061 gagatagtgg agaacctgtt gccgggacaa tacaagaaga gttatgaaaa gattcacctg
     3121 gacttcctaa agagtgacca tccggccgtg gcacgcatgc gggtggactc tgataatgcg
     3181 tacatcggtg tcacttacaa aaatgaagag gataagctga aggactggga aggtggcctg
     3241 gacgaacaga gactgagcgc tgacagtggc tacatcatcc ccctgccaga cattgaccct
     3301 gttccagagg aggaagacct gggcaagagg aacagacaca gctcacagac ttcggaagag
     3361 agtgccatcg agacaggttc cagtagttcc accttcatca agagagagga cgagaccatc
     3421 gaggacatcg acatgatgga tgacattggt atagattcct cggacctggt ggaggacagc
     3481 ttcctgtaac tgacacgctc cgggtatcat cttctccggg agcctcctcg ggataacctt
     3541 aagaaaacca cttcattgca atgcaaaagt tgagaagagg acttgggtga tgtggagaga
     3601 gaaagttccc gaggccgagg gccttggtaa gcctgtgtgg atgactggga tacttggatt
     3661 gaactttatc cgtgttgcct cttgcaacgc gtcagtagca tctcagcggc gtgtgcggtt
     3721 tggaaatgga tggacaagag agtgactggc cacagaagac gggctttgtg tttccagggc
     3781 atgggtgaga gtcccacacg cgccaacttg tactgcagac aactccagca ttgtaattat
     3841 gtaaataact cttaaccgag gatgggttta gatctgtgtt aactctcctc tccggacctc
     3901 tgaagagacc actcagtcca cccgtgtgct tccttccttc ttggaatccg gtaccagctg
     3961 ctgttgaatt ttctcatgaa gtacatgcaa aaccactttg aactttggaa ggtactggaa
     4021 ccgtcgtgtt ttactgtctt gtaagtgtta aagaggcaaa aagataaaaa ctaaccaacc
     4081 gtgagtagta ggtttgggtc ttttagggca cccaagaatt cctctgtatc ttgtaatctg
     4141 tacttataac actactactg tttaacaaga atgctaaata tgtaatccgt aacatgattt
     4201 ctttacagag aaagcacaat taaaacaaaa cccttactaa gaaggtgaca agtttggcag
     4261 tttttgacat ttatattaag taacacgttt ctcaataaag tataataggt ttagcggatt
     4321 aaagttagca aacactagag agcagagtgt aagtagttat ccagaaagtc aaaccttttt
     4381 gttttgttct aagcagtctc cctaatccaa ggcactagga acagttaatg acctctgaag
     4441 tactgggata agcaaagcag aaacccggtg ggtgtcctaa gtgttctcag tagaaaggcg
     4501 tacgcctgag cccagtgtga ctcctcacgc tgtgtgcgac cttctggaag agactcattc
     4561 acaaaaagga ctcagatggg cagaatgtcc atcagatggg actcagatgt ctctcctgac
     4621 cagtgatggc ttggatggat cccgcccata cctactttta aagtctgtga cttttaagga
     4681 tgcttcaaca tcagcacctt actttttctc tcttgtctca gacgagaaag aactgcaaac
     4741 cctgagacca caatggtgct gttgaatgaa ggctatgtgg gcatcagctt ggctcttccc
     4801 ttcccaccat taactacagc tacagttact agcctcaatg gtgtcagacc tttgccccag
     4861 agatttggaa ttacaaggtc tgacgggagc aggaagctat atatatgaac tgcctggtgc
     4921 tcttgaatag tcagtgttca gaaacactgg cttgggttac tgttggggga gggcaacttt
     4981 gaaatttgga acggggctag aagtcaacca tgcaggaagg ctactgttta agttcttggc
     5041 ttcatgtcaa taacatgtca atgccacgta tgcagctatt cctacccttg atttaagttt
     5101 ccaggcttgg ctgaggctga gaaagcaaac atcttgactt gggaacatct tcccattcta
     5161 gtcaacgtgg gtaccacttc cccctggatg ggagaacctg agcttgctcg cctcaaagtg
     5221 tgtccgggaa tgatgcaagt ctgtgtgtca ggtctttgtg caaccagctc catattcggt
     5281 ggagaagatt aaaaaaaaag ttttctgaat ttggggcctt taggtggtag gctatcagga
     5341 gcatccgaac tgtcaaagtg gttagtgtga gttcattggc attctctgcc atgtgtctaa
     5401 ttgctgactc tgtatgaatg aaacatgggc tatgattact gcaatcactg tattgcttct
     5461 agcaggtgac gctttggaag gcacagaagc aataacaagg tacttgacta cctactggca
     5521 taatctcaat gcaaacccca actttccctt ttcacagtaa gtgtgaagac tgagccagat
     5581 tggccaattg aaaaacaaaa acctgactag agtctttcga gccaattaga cttgaactac
     5641 atccgtcttt ctagactcgt ggctggagca gtctgtttac cactcatttg cacagcctct
     5701 gtttgttgct tctttttatt ctgatgtcgc tttgggcctt gcatgacacc atgaagttgg
     5761 atgatacttc tcagaccagc agtttcccat ctttagctgt acccacctct gagattcaat
     5821 gggaatacgt tcacttttgt tttttgagac agggtctttc tacgcagccc tggctgccct
     5881 ggaactcact gtgtaaacca ggctagcctt gaactctcag agatccactg tctctgtacc
     5941 cccagtgctg ggattacagg catgcaccac cacactcagc agggatacat ttttattttt
     6001 aaacagtgtt ttgactgtat cctgatttgt tttctttctg gcctcctgca gagtccctgg
     6061 aagaaaattt accaatcttt cctgctttct atttttatga tgacaatcaa agcttgcccg
     6121 aggaacacaa tttgtgactt ttaaaaaaat gatcaatgat gtccttaaaa aaatgtggtc
     6181 tgccaacctg tacaaaatgg tcctatattt gtgaagaggg acgtaagata aaacgatgtt
     6241 atacatcgat atgtatatat ctgttgctat gtagacttgg agaatactgc caaaatgtgt
     6301 atgacaagct gtatcactgc ctttgtttat atttttttta actgtgatat tccccacagg
     6361 cacgttaact gttgcacttt tgaatgtcca aaatttatat tttagaagta ataaagagaa
     6421 aaatactgac atgttcccaa catggtggtg tggtaagtgt gtgagagcga cttactccat
     6481 aggaagggtc ttccaataca agatggcttc cagatacccc tgttcatgtt ttgttttaaa
     6541 aagtgtaaat ggagatcttt atatttcaat aaatgattta ttatatatga cttaaaaaaa
     6601 aaaaaaaaaa aaaaaaaaaa aaaaa
//
