LOCUS       NM_027924               3247 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus platelet-derived growth factor, D polypeptide (Pdgfd),
            transcript variant 1, mRNA.
ACCESSION   NM_027924
VERSION     NM_027924.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Wang,C., Huang,L., Li,J., Liu,D. and Wu,B.
  TITLE     MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by Targeting
            PDGFD in Diabetic Foot Ulcer
  JOURNAL   Biochem Genet 62 (4), 2437-2454 (2024)
   PUBMED   37950842
  REMARK    GeneRIF: MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by
            Targeting PDGFD in Diabetic Foot Ulcer.
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Bernard,M., Menet,R., Lecordier,S. and ElAli,A.
  TITLE     Endothelial PDGF-D contributes to neurovascular protection after
            ischemic stroke by rescuing pericyte functions
  JOURNAL   Cell Mol Life Sci 81 (1), 225 (2024)
   PUBMED   38769116
  REMARK    GeneRIF: Endothelial PDGF-D contributes to neurovascular protection
            after ischemic stroke by rescuing pericyte functions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Firat,E.A.M., Buhl,E.M., Bouteldja,N., Smeets,B., Eriksson,U.,
            Boor,P. and Klinkhammer,B.M.
  TITLE     PDGF-D Is Dispensable for the Development and Progression of Murine
            Alport Syndrome
  JOURNAL   Am J Pathol 194 (5), 641-655 (2024)
   PUBMED   38309427
  REMARK    GeneRIF: PDGF-D Is Dispensable for the Development and Progression
            of Murine Alport Syndrome.
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Kim,H.J., Cheng,P., Travisano,S., Weldy,C., Monteiro,J.P.,
            Kundu,R., Nguyen,T., Sharma,D., Shi,H., Lin,Y., Liu,B., Haldar,S.,
            Jackson,S. and Quertermous,T.
  TITLE     Molecular mechanisms of coronary artery disease risk at the PDGFD
            locus
  JOURNAL   Nat Commun 14 (1), 847 (2023)
   PUBMED   36792607
  REMARK    GeneRIF: Molecular mechanisms of coronary artery disease risk at
            the PDGFD locus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Saito,Y., Hojo,Y., Tanimoto,T., Abe,J. and Berk,B.C.
  TITLE     Protein kinase C-alpha and protein kinase C-epsilon are required
            for Grb2-associated binder-1 tyrosine phosphorylation in response
            to platelet-derived growth factor
  JOURNAL   J Biol Chem 277 (26), 23216-23222 (2002)
   PUBMED   11940581
REFERENCE   7  (bases 1 to 3247)
  AUTHORS   LaRochelle,W.J., Jeffers,M., Corvalan,J.R., Jia,X.C., Feng,X.,
            Vanegas,S., Vickroy,J.D., Yang,X.D., Chen,F., Gazit,G., Mayotte,J.,
            Macaluso,J., Rittman,B., Wu,F., Dhanabal,M., Herrmann,J. and
            Lichenstein,H.S.
  TITLE     Platelet-derived growth factor D: tumorigenicity in mice and
            dysregulated expression in human cancer
  JOURNAL   Cancer Res 62 (9), 2468-2473 (2002)
   PUBMED   11980634
REFERENCE   8  (bases 1 to 3247)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (bases 1 to 3247)
  AUTHORS   LaRochelle,W.J., Jeffers,M., McDonald,W.F., Chillakuru,R.A.,
            Giese,N.A., Lokker,N.A., Sullivan,C., Boldog,F.L., Yang,M.,
            Vernet,C., Burgess,C.E., Fernandes,E., Deegler,L.L., Rittman,B.,
            Shimkets,J., Shimkets,R.A., Rothberg,J.M. and Lichenstein,H.S.
  TITLE     PDGF-D, a new protease-activated growth factor
  JOURNAL   Nat Cell Biol 3 (5), 517-521 (2001)
   PUBMED   11331882
REFERENCE   10 (bases 1 to 3247)
  AUTHORS   Bergsten,E., Uutela,M., Li,X., Pietras,K., Ostman,A., Heldin,C.H.,
            Alitalo,K. and Eriksson,U.
  TITLE     PDGF-D is a specific, protease-activated ligand for the PDGF
            beta-receptor
  JOURNAL   Nat Cell Biol 3 (5), 512-516 (2001)
   PUBMED   11331881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV045274.1, AK003359.2 and AK141551.1.
            
            On Oct 26, 2017 this sequence version replaced NM_027924.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003359.2, AF335583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               DV045274.1         25-150
            127-1921            AK003359.2         3-1797
            1922-2845           AK141551.1         1806-2729
            2846-3247           AK141551.1         2731-3132
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..3247
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /note="platelet-derived growth factor, D polypeptide"
                     /db_xref="GeneID:71785"
                     /db_xref="MGI:MGI:1919035"
     exon            1..433
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1422
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; platelet-derived growth factor D; PDGF-D;
                     SCDGF-B; spinal cord-derived growth factor B"
                     /codon_start=1
                     /product="platelet-derived growth factor D isoform 1
                     precursor"
                     /protein_id="NP_082200.1"
                     /db_xref="CCDS:CCDS22801.1"
                     /db_xref="GeneID:71785"
                     /db_xref="MGI:MGI:1919035"
                     /translation="MQRLVLVSILLCANFSCYPDTFATPQRASIKALRNANLRRDESN
                     HLTDLYQREENIQVTSNGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHQFGLE
                     EAENDICRYDFVEVEEVSESSTVVRGRWCGHKEIPPRITSRTNQIKITFKSDDYFVAK
                     PGFKIYYSFVEDFQPEAASETNWESVTSSFSGVSYHSPSITDPTLTADALDKTVAEFD
                     TVEDLLKHFNPVSWQDDLENLYLDTPHYRGRSYHDRKSKVDLDRLNDDVKRYSCTPRN
                     HSVNLREELKLTNAVFFPRCLLVQRCGGNCGCGTVNWKSCTCSSGKTVKKYHEVLKFE
                     PGHFKRRGKAKNMALVDIQLDHHERCDCICSSRPPR"
     exon            434..638
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            639..819
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            820..882
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1081
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1296
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..3247
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3220..3225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3247
                     /gene="Pdgfd"
                     /gene_synonym="1110003I09Rik"
                     /note="major polyA site"
ORIGIN      
        1 gctgtgacgc cggctccctg cagcctgtgc tgcagccgct gtccaccgga ggggggcgaa
       61 tccacgtcaa cctgttgttt gcccagctcc tattgatcaa gtcagagcta caaggaaatg
      121 cggcacacac acgcgcttgg aaagtttagc ttacaggaag ttttgggaga gcagcgccag
      181 taactgggcg gccgggacaa cacaggcggt gaaggcgagg gactgtgcag tagaaatccg
      241 ccgactcaac cctttgggct ttatttattt acttttggag caacgcgatc cctaggtcgc
      301 tgagcccaaa tgcaacggct cgttttagtc tccattctcc tgtgcgcgaa ctttagctgc
      361 tatccggaca cttttgcgac tccgcagaga gcatccatca aagctttgcg caatgccaac
      421 ctcaggagag atgagagcaa tcacctcaca gacttgtacc agagagagga gaacattcag
      481 gtgacaagca atggccatgt gcagagtcct cgcttcccga acagctaccc aaggaacctg
      541 cttctgacat ggtggctccg ttcccaggag aaaacacgga tacaactgtc ctttgaccat
      601 caattcggac tagaggaagc agaaaatgac atttgtaggt atgactttgt ggaagttgaa
      661 gaagtctcag agagcagcac tgttgtcaga ggaagatggt gtggccacaa ggagatccct
      721 ccaaggataa cgtcaagaac aaaccagatt aaaatcacat ttaagtctga tgactacttt
      781 gtggcaaaac ctggattcaa gatttattat tcatttgtgg aagatttcca accggaagca
      841 gcctcagaga ccaactggga atcagtcaca agctctttct ctggggtgtc ctatcactct
      901 ccatcaataa cggaccccac tctcactgct gatgccctgg acaaaactgt cgcagaattc
      961 gataccgtgg aagatctact taagcacttc aatccagtgt cttggcaaga tgatctggag
     1021 aatttgtatc tggacacccc tcattataga ggcaggtcat accatgatcg gaagtccaaa
     1081 gtggacctgg acaggctcaa tgatgatgtc aagcgttaca gttgcactcc caggaatcac
     1141 tctgtgaacc tcagggagga gctgaagctg accaatgcag tcttcttccc acgatgcctc
     1201 ctcgtgcagc gctgtggtgg caactgtggt tgcggaactg tcaactggaa gtcctgcaca
     1261 tgcagctcag ggaagacagt gaagaagtat catgaggtat tgaagtttga gcctggacat
     1321 ttcaagagaa ggggcaaagc taagaatatg gctcttgttg atatccagct ggatcatcat
     1381 gagcgatgtg actgtatctg cagctcaaga ccacctcgat aaaacactat gcacatctgt
     1441 actttgatta tgaaaggacc tttaggttac aaaaacccta agaagcttct aatctcagtg
     1501 caatgaatgc atatggaaat gttgctttgt tagtgccatg gcaagaagaa gcaaatatca
     1561 ttaatttcta tatacataaa cataggaatt cacttatcaa tagtatgtga agatatgtat
     1621 atatacttat atacatgact agctctatgt atgtaaatag attaaatact ttattcagta
     1681 tatttactga agtcccctag aggcaaatga tattacttga tattttgcta aaataaggga
     1741 atgtgtcaag catataaaat atctttcaaa aattcaaaag gtaagtttat tctaaagctt
     1801 tgtatgacaa aatatatcag attttgctca cttaaagaag gcacttgtcc attaaatgaa
     1861 agatgagact ttcttctgtg aataaatcta attatgtgaa gacaaataca tagtttctgg
     1921 caataaaaac aagttttgaa atattttctt catgagatgt actactcacc taccaatgtg
     1981 gacagttatt atctgtctcc acaactatgc caaagtaata caggatattt aacaatcaag
     2041 tcaatcaagt cattaagtcc tcttccatgt attttctcaa tgcaagctaa gtaactgagc
     2101 acccttctca atgaattgct cagggacttg tggtgataat tggcaagaga tattcaatag
     2161 gcaagcaata ggttgctgta gaatttttga attttttttt ttattttaaa gtctgcagaa
     2221 aagcaagtgt tttcaggaag aacatgatat ttattacaca tgagccttta aatatggtag
     2281 tcatggcaag acttgggtga tagaaagtca gaaataagca aatgttgaca taactggaaa
     2341 tcaaatgggc tgtttgataa ggtctacatt taaaagtggg tcaaaatctt ctaaactgtg
     2401 ccaataattt ttctgtgttt tgctcttgca tttctatctt ttcaatatat acacataaac
     2461 ttatattgtg ctatatgaga caagctatca tggaatattt atagcctaaa atatttatgt
     2521 attaacaaaa caactagagc cagctaagtt gtggaggcac agatttggtc ctgctgttcc
     2581 actggaaagc tttttgttct gatttttagg agtgagttaa gtttccccag tggtgcctct
     2641 atatcttttc taaagagatt gagtccagaa acaggaagtt gctcattgtt ctccaaacaa
     2701 aatgtttagg agggaatcct gaagtcaagt taacttggtt ctgctactag gaaactatat
     2761 ttttcttcct gcctttagag tagaaaagaa aactgattta ttcggtgagt ctaacactac
     2821 cctgagcaca aagtgttttt tttttctgaa tctgtgcaca ggcccctttg gtctggtgtc
     2881 agatgaatag cttatacaca cttacattgc taaggatgat gctgtctaag ccaagttatc
     2941 agctgtgtgc tcaacaaatc tatgcttact gacacatata ttctaaaggt tctatgcagt
     3001 caattacctg ccagttctac ttaaatgatt attaaaatta aatagtatat tgttgtcaag
     3061 catgccacag aacaataaga agtaagccag gcccaatttg caagcttcct gtgaaacaat
     3121 ggctcctata aaaaacacca aaatgtacat tatcttactc acttgtaaag ggcacagatc
     3181 aatcataact gtacatatga aatgttagag ggttttttca ataaaccttc taggtggtga
     3241 taaccaa
//
