LOCUS       NM_019971               3537 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus platelet-derived growth factor, C polypeptide (Pdgfc),
            transcript variant 1, mRNA.
ACCESSION   NM_019971 XM_982401 XM_982430 XM_982467 XM_982507
VERSION     NM_019971.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3537)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3537)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   3  (bases 1 to 3537)
  AUTHORS   Kumar,A. and Li,X.
  TITLE     PDGF-C and PDGF-D in ocular diseases
  JOURNAL   Mol Aspects Med 62, 33-43 (2018)
   PUBMED   29079201
  REMARK    Review article
REFERENCE   4  (bases 1 to 3537)
  AUTHORS   Lee,C., Zhang,F., Tang,Z., Liu,Y. and Li,X.
  TITLE     PDGF-C: a new performer in the neurovascular interplay
  JOURNAL   Trends Mol Med 19 (8), 474-486 (2013)
   PUBMED   23714575
  REMARK    Review article
REFERENCE   5  (bases 1 to 3537)
  AUTHORS   Lei,H. and Kazlauskas,A.
  TITLE     Focus on molecules: platelet-derived growth factor C, PDGF-C
  JOURNAL   Exp Eye Res 86 (5), 711-712 (2008)
   PUBMED   17904120
  REMARK    Review article
REFERENCE   6  (bases 1 to 3537)
  AUTHORS   Otrock,Z.K., Makarem,J.A. and Shamseddine,A.I.
  TITLE     Vascular endothelial growth factor family of ligands and receptors:
            review
  JOURNAL   Blood Cells Mol Dis 38 (3), 258-268 (2007)
   PUBMED   17344076
  REMARK    Review article
REFERENCE   7  (bases 1 to 3537)
  AUTHORS   Aase,K., Abramsson,A., Karlsson,L., Betsholtz,C. and Eriksson,U.
  TITLE     Expression analysis of PDGF-C in adult and developing mouse tissues
  JOURNAL   Mech Dev 110 (1-2), 187-191 (2002)
   PUBMED   11744381
  REMARK    GeneRIF: During development, PDGF-C expression was widespread and
            dynamic, and found in somites and their derivatives, in kidney,
            lung, brain
REFERENCE   8  (bases 1 to 3537)
  AUTHORS   Gilbertson,D.G., Duff,M.E., West,J.W., Kelly,J.D., Sheppard,P.O.,
            Hofstrand,P.D., Gao,Z., Shoemaker,K., Bukowski,T.R., Moore,M.,
            Feldhaus,A.L., Humes,J.M., Palmer,T.E. and Hart,C.E.
  TITLE     Platelet-derived growth factor C (PDGF-C), a novel growth factor
            that binds to PDGF alpha and beta receptor
  JOURNAL   J Biol Chem 276 (29), 27406-27414 (2001)
   PUBMED   11297552
REFERENCE   9  (bases 1 to 3537)
  AUTHORS   Ding,H., Wu,X., Kim,I., Tam,P.P., Koh,G.Y. and Nagy,A.
  TITLE     The mouse Pdgfc gene: dynamic expression in embryonic tissues
            during organogenesis
  JOURNAL   Mech Dev 96 (2), 209-213 (2000)
   PUBMED   10960785
REFERENCE   10 (bases 1 to 3537)
  AUTHORS   Li,X., Ponten,A., Aase,K., Karlsson,L., Abramsson,A., Uutela,M.,
            Backstrom,G., Hellstrom,M., Bostrom,H., Li,H., Soriano,P.,
            Betsholtz,C., Heldin,C.H., Alitalo,K., Ostman,A. and Eriksson,U.
  TITLE     PDGF-C is a new protease-activated ligand for the PDGF
            alpha-receptor
  JOURNAL   Nat Cell Biol 2 (5), 302-309 (2000)
   PUBMED   10806482
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF266467.1 and CD741441.1.
            
            On Nov 4, 2017 this sequence version replaced NM_019971.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF266467.1, AK042767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3512              AF266467.1         1-3512
            3513-3537           CD741441.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..3537
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 35.73 cM"
     gene            1..3537
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /note="platelet-derived growth factor, C polypeptide"
                     /db_xref="GeneID:54635"
                     /db_xref="MGI:MGI:1859631"
     exon            1..1139
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /inference="alignment:Splign:2.1.0"
     CDS             1022..2059
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fallotein; spinal cord-derived growth factor;
                     platelet-derived growth factor c"
                     /codon_start=1
                     /product="platelet-derived growth factor C isoform 1
                     precursor"
                     /protein_id="NP_064355.1"
                     /db_xref="CCDS:CCDS17425.1"
                     /db_xref="GeneID:54635"
                     /db_xref="MGI:MGI:1859631"
                     /translation="MLLLGLLLLTSALAGQRTGTRAESNLSSKLQLSSDKEQNGVQDP
                     RHERVVTISGNGSIHSPKFPHTYPRNMVLVWRLVAVDENVRIQLTFDERFGLEDPEDD
                     ICKYDFVEVEEPSDGSVLGRWCGSGTVPGKQTSKGNHIRIRFVSDEYFPSEPGFCIHY
                     SIIMPQVTETTSPSVLPPSSLSLDLLNNAVTAFSTLEELIRYLEPDRWQVDLDSLYKP
                     TWQLLGKAFLYGKKSKVVNLNLLKEEVKLYSCTPRNFSVSIREELKRTDTIFWPGCLL
                     VKRCGGNCACCLHNCNECQCVPRKVTKKYHEVLQLRPKTGVKGLHKSLTDVALEHHEE
                     CDCVCRGNAGG"
     exon            1140..1335
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1516
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1724
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1942
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..3521
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3486..3491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /note="hexamer: AATAAA"
     regulatory      3491..3496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /note="hexamer: AATAAT"
     polyA_site      3512
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /note="major polyA site"
     polyA_site      3515
                     /gene="Pdgfc"
                     /gene_synonym="1110064L01Rik; PDGF-C; SCDGF; VEGF-E"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcccagg ggaaaggaag ctgggggccg cctggcggca ttcctcgccg cagtgtgggc
       61 tccgtctgcc gcggggcccg cagtgccccc tgtctgcgcc agcacctgtt ggcccgccag
      121 ctggccgccc gcgccccccg cgccccccgc gcccgcccgg ccgccagccc cgcgccccgc
      181 gcgccgcccg ctgggggaaa gtggagacgg ggaggggaca agagcgatcc tccaggccag
      241 ccaggccttc ccttagccgc ccgtgcttag ccgccacctc tcctcagccc tgcgtcctgc
      301 cctgccttag ggcaggcatc cgagcgctcg cgactccgag ccgcccaagc tctcccggct
      361 tcccgcagca cttcgccggt acccgaggga acttcggtgg ccaccgactg cagcaaggag
      421 gaggctccgc ggtggatccg ggccagtccc gagtcgtccc cgcggcctct ctgcccgccc
      481 gggacccgcg cggcactcgc agggcacggt cccctccccc caggtggggg tggggcgccg
      541 cctgccgccc cgatcagcag ctttgtcatt gatcccaagg tgctcgcctc gctgccgacc
      601 tggcttccag tctggcttgg cgggaccccg agtcctcgcc tgtgtcctgt cccccaaact
      661 gacaggtgct ccctgcgagt cgccacgact catcgccgct cccccgcgtc cccacccctt
      721 ctttcctccc tcgcctaccc ccaccccccg cacttcggca cagctcagga tttgtttaaa
      781 ccttgggaaa ctggttcagg tccaggtttt gctttgatcc ttttcaaaaa ctggagacac
      841 agaagagggc tctaggaaaa acttttggat gggattatgt ggaaactacc ctgcgattct
      901 ctgctgccag agccggccag gcgcttccac cgcagcgcag cctttccccg gctgggctga
      961 gccttggagt cgtcgcttcc ccagtgcccg ccgcgagtga gccctcgccc cagtcagcca
     1021 aatgctcctc ctcggcctcc tcctgctgac atctgccctg gccggccaaa gaacggggac
     1081 tcgggctgag tccaacctga gcagcaagtt gcagctctcc agcgacaagg aacagaacgg
     1141 agtgcaagat ccccggcatg agagagttgt cactatatct ggtaatggga gcatccacag
     1201 cccgaagttt cctcatacat acccaagaaa tatggtgctg gtgtggagat tagttgcagt
     1261 agatgaaaat gtgcggatcc agctgacatt tgatgagaga tttgggctgg aagatccaga
     1321 agacgatata tgcaagtatg attttgtaga agttgaggag cccagtgatg gaagtgtttt
     1381 aggacgctgg tgtggttctg ggactgtgcc aggaaagcag acttctaaag gaaatcatat
     1441 caggataaga tttgtatctg atgagtattt tccatctgaa cccggattct gcatccacta
     1501 cagtattatc atgccacaag tcacagaaac cacgagtcct tcggtgttgc ccccttcatc
     1561 tttgtcattg gacctgctca acaatgctgt gactgccttc agtaccttgg aagagctgat
     1621 tcggtaccta gagccagatc gatggcaggt ggacttggac agcctctaca agccaacatg
     1681 gcagcttttg ggcaaggctt tcctgtatgg gaaaaaaagc aaagtggtga atctgaatct
     1741 cctcaaggaa gaggtaaaac tctacagctg cacaccccgg aacttctcag tgtccatacg
     1801 ggaagagcta aagaggacag ataccatatt ctggccaggt tgtctcctgg tcaagcgctg
     1861 tggaggaaat tgtgcctgtt gtctccataa ttgcaatgaa tgtcagtgtg tcccacgtaa
     1921 agttacaaaa aagtaccatg aggtccttca gttgagacca aaaactggag tcaagggatt
     1981 gcataagtca ctcactgatg tggctctgga acaccacgag gaatgtgact gtgtgtgtag
     2041 aggaaacgca ggagggtaac tgcagccttc gtagcagcac acgtgagcac tggcattctg
     2101 tgtaccccca caagcaacct tcatccccac cagcgttggc cgcagggctc tcagctgctg
     2161 atgctggcta tggtaaagat cttactcgtc tccaaccaaa ttctcagttg tttgcttcaa
     2221 tagccttccc ctgcaggact tcaagtgtct tctaaaagac cagaggcacc aagaggagtc
     2281 aatcacaaag cactgccttc tagaggaagc ccagacaatg gtcttctgac cacagaaaca
     2341 aatgaaatga atgtagatcg ctagcaaact ctggagtgac agcatttctt ttccactgac
     2401 agaatggtgt agcttagttg tcttgatatg ggcaagtgat gtcagcacaa gaaaatggtg
     2461 aaaaacacac acttgattgt gaacaatgca gaaatacttg gatttctcca acctgtttgc
     2521 atagatagac agatgctctg ttttctacaa actcaaagct tttagagagc agctatgtta
     2581 ataggaatta aatgtgccat gctgaaagga aagactgaag ttttcaatgc ttggcaactt
     2641 ctccgcaatt tggaggaaag gtgcggtcat ggtttggaga aagcacacct gcacagagga
     2701 gtggccttcc cttcccttcc ctctgaggtg gcttctgtgt ttcattgtgt atatttttat
     2761 attctccttt tgacattata actgttggct tttctaatct tgttaaatat ttctattttt
     2821 accaaaggta tttaatattc ttttttatga caacctagag caattatttt tagcttgata
     2881 attttttttt ctaaacaaaa ttgttatagc cagaagaaca aagatgattg atataaaaat
     2941 cttgttgctc tgacaaaaac atatgtattt cttccttgta tggtgctaga gcttagcgtc
     3001 atctgcattt gaaaagatgg aatggggaag tttttagaat tggtaggtcg cagggacagt
     3061 ttgataacaa ctgtactatc atcaattccc aattctgttc ttagagctac gaacagaaca
     3121 gagcttgagt aaatatggag ccattgctaa cctacccctt tctatgggaa ataggagtat
     3181 agctcagaga agcacgtccc cagaaacctc gaccatttct aggcacagtg ttctgggcta
     3241 tgctgcgctg tatggacata tcctatttat ttcaatacta gggttttatt acctttaaac
     3301 tctgctccat acacttgtat taatacatgg atatttttat gtacagaagt atatcattta
     3361 aggagttcac ttattatact ctttggcaat tgcaaagaaa atcaacataa tacattgctt
     3421 gtaaatgctt aatctgtgcc caagttttgt ggtgactatt tgaattaaaa tgtattgaat
     3481 catcaaataa aataatctgg ctattttggg gacaagtgta aaaaaaaaaa aaaaaaa
//
