LOCUS       NM_011057               3113 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus platelet derived growth factor, B polypeptide (Pdgfb),
            transcript variant 1, mRNA.
ACCESSION   NM_011057 XM_906227 XM_919724
VERSION     NM_011057.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3113)
  AUTHORS   Wu,Y., Korobeynyk,V.I., Zamboni,M., Waern,F., Cole,J.D., Mundt,S.,
            Greter,M., Frisen,J., Llorens-Bobadilla,E. and Jessberger,S.
  TITLE     Multimodal transcriptomics reveal neurogenic aging trajectories and
            age-related regional inflammation in the dentate gyrus
  JOURNAL   Nat Neurosci 28 (2), 415-430 (2025)
   PUBMED   39762661
REFERENCE   2  (bases 1 to 3113)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   3  (bases 1 to 3113)
  AUTHORS   Lund,H., Hunt,M.A., Kurtovic,Z., Sandor,K., Kagy,P.B.,
            Fereydouni,N., Julien,A., Goritz,C., Vazquez-Liebanas,E.,
            Andaloussi Mae,M., Jurczak,A., Han,J., Zhu,K., Harris,R.A.,
            Lampa,J., Graversen,J.H., Etzerodt,A., Haglund,L., Yaksh,T.L. and
            Svensson,C.I.
  TITLE     CD163+ macrophages monitor enhanced permeability at the
            blood-dorsal root ganglion barrier
  JOURNAL   J Exp Med 221 (2) (2024)
   PUBMED   38117255
REFERENCE   4  (bases 1 to 3113)
  AUTHORS   Weng,Y., Chen,N., Zhang,R., He,J., Ding,X., Cheng,G., Bi,Q.,
            Lu,Y.M., Shen,X.Z., Wan,S. and Shi,P.
  TITLE     An integral blood-brain barrier in adulthood relies on
            microglia-derived PDGFB
  JOURNAL   Brain Behav Immun 115, 705-717 (2024)
   PUBMED   37992789
  REMARK    GeneRIF: An integral blood-brain barrier in adulthood relies on
            microglia-derived PDGFB.
REFERENCE   5  (bases 1 to 3113)
  AUTHORS   Miller,C.R. and Hjelmeland,A.B.
  TITLE     Breaking the feed forward inflammatory cytokine loop in the tumor
            microenvironment of PDGFB-driven glioblastomas
  JOURNAL   J Clin Invest 133 (22), e175127 (2023)
   PUBMED   37966120
  REMARK    GeneRIF: Breaking the feed forward inflammatory cytokine loop in
            the tumor microenvironment of PDGFB-driven glioblastomas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3113)
  AUTHORS   Hameister,H., Schulz,W.A., Meyer,J., Thoma,S., Adolph,S., Gaa,A.
            and von Deimling,O.
  TITLE     Gene order and genetic distance of 13 loci spanning murine
            chromosome 15
  JOURNAL   Genomics 14 (2), 417-422 (1992)
   PUBMED   1358803
REFERENCE   7  (bases 1 to 3113)
  AUTHORS   Gorman,D.M., Itoh,N., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Miyajima,A.
  TITLE     Chromosomal localization and organization of the murine genes
            encoding the beta subunits (AIC2A and AIC2B) of the interleukin 3,
            granulocyte/macrophage colony-stimulating factor, and interleukin 5
            receptors
  JOURNAL   J Biol Chem 267 (22), 15842-15848 (1992)
   PUBMED   1386365
REFERENCE   8  (bases 1 to 3113)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   9  (bases 1 to 3113)
  AUTHORS   Hutchins,J.B. and Jefferson,V.E.
  TITLE     Developmental distribution of platelet-derived growth factor in the
            mouse central nervous system
  JOURNAL   Brain Res Dev Brain Res 67 (2), 121-135 (1992)
   PUBMED   1324805
REFERENCE   10 (bases 1 to 3113)
  AUTHORS   Rorsman,F. and Betsholtz,C.
  TITLE     Characterization of the mouse PDGF A-chain gene. Evolutionary
            conservation of gene structure, nucleotide sequence and alternative
            splicing
  JOURNAL   Growth Factors 6 (4), 303-313 (1992)
   PUBMED   1340209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113595.11.
            
            On Aug 29, 2022 this sequence version replaced NM_011057.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053430.1, SRR7652917.1172637.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1042              AC113595.11        228837-229878       c
            1043-1139           AC113595.11        220370-220466       c
            1140-1229           AC113595.11        218226-218315       c
            1230-1435           AC113595.11        216583-216788       c
            1436-1580           AC113595.11        215230-215374       c
            1581-1729           AC113595.11        212457-212605       c
            1730-3113           AC113595.11        210775-212158       c
FEATURES             Location/Qualifiers
     source          1..3113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..3113
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /note="platelet derived growth factor, B polypeptide"
                     /db_xref="GeneID:18591"
                     /db_xref="MGI:MGI:97528"
     exon            1..1042
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /inference="alignment:Splign:2.1.0"
     CDS             980..1705
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; platelet-derived growth factor subunit B; PDGF
                     subunit B; platelet-derived growth factor B chain;
                     platelet-derived growth factor beta polypeptide;
                     proto-oncogene c-Sis"
                     /codon_start=1
                     /product="platelet-derived growth factor subunit B isoform
                     1 preproprotein"
                     /protein_id="NP_035187.2"
                     /db_xref="CCDS:CCDS27656.1"
                     /db_xref="GeneID:18591"
                     /db_xref="MGI:MGI:97528"
                     /translation="MNRCWALFLPLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDL
                     QRLLHRDSVDEDGAELDLNMTRAHSGVELESSSRGRRSLGSLAAAEPAVIAECKTRTE
                     VFQISRNLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRASQVQMRPVQVRKIEIVR
                     KKPIFKKATVTLEDHLACKCETVVTPRPVTRSPGTSREQRAKTPQARVTIRTVRIRRP
                     PKGKHRKFKHTHDKAALKETLGA"
     exon            1043..1139
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1229
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1435
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1580
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1729
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..3113
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3107..3112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /note="hexamer: AACAAA"
     polyA_site      3113
                     /gene="Pdgfb"
                     /gene_synonym="c-sis; PDGF-2; PDGF-B; Sis"
                     /note="major polyA site"
ORIGIN      
        1 aacttctcct gcagccggga gcagcctgcc tgcctccccc gctgcctccc tgagggcttc
       61 cctccggccg ccagcgccca tctttctcca gagagatatt ttgcgcacac acacatacac
      121 acacgcgcaa aagggaaagg aggaaaaaaa aaaaaagccc accctctagc ttcgttgcaa
      181 cgagaaagcc ggagcagccg cagctcgaaa cccgcagagg aagcccagag tggcgagcga
      241 gtgggtagat agacagactg acccgagccg cgtccacctg tcggcccgga ccagcccagc
      301 gcgcagtggg cgcgccgcgc tctcggagca gccgtgcccg ccgcttgggc cctgcgccag
      361 ggcgcacacg ctcccgcccc gccacccggc ccgggcggga gtttgcacct ctccctgccc
      421 gggtgttcgg gccgccgctg caaagccaac tttggaaaaa gttttttttt ggagacttgg
      481 gcttggaggt ccccagctct gcgctttctg atctgggggt ccgttccaga aaatgttgca
      541 aaaaagctaa gccagcaggc agaggaacac gcctttagcg ggcgagtgaa gacgaaccat
      601 cggctgccgt gttccttttc ctctctgagg ttggagtccc ctgcgcgccc ccacacggct
      661 agacgccttg gctggttcgc gacgcagccc ccagactgtg gatgctcgcg tgggctcggg
      721 atccgcccag gtagcggctt tggaccccgg tcccttgtcc aggtcctccc cagcccccca
      781 gcgacggagc cggggccggg ggcggcggcg cccgggggcc atgcgggtga gccgcggcgg
      841 cggctgcagc ggcctgatcg cctgatcgcg ggggacccga gcggagccca ccctcctccc
      901 cagcccccaa ccctggccgc gggggcggcg cgctccgtct acgcgtccgg ggccccgcgg
      961 ggccgggccc ggagtcggca tgaatcgctg ctgggcgctc ttccttcctc tctgctgcta
     1021 cctgcgtctg gtcagcgccg agggggatcc cattcctgag gaactgtatg aaatgctgag
     1081 cgaccactcc atccgctcct ttgatgatct tcagcgcctg ctgcacagag actccgtaga
     1141 tgaagatggg gctgagctgg acttgaacat gacccgagca cactccggag tcgagttgga
     1201 aagctcatct cgagggagga ggagcctagg gtccctggca gcagcagagc ctgctgtaat
     1261 cgccgagtgc aagacgcgca cagaggtgtt ccagatctct cggaacctca tcgatcgcac
     1321 caacgccaac ttcctggtgt ggccgccctg tgtggaggtg cagcgctgct ccggctgctg
     1381 caataaccgc aatgtgcaat gccgggcctc gcaggtgcag atgcggccgg tccaggtgag
     1441 aaagattgag attgtgcgaa agaagcccat cttcaagaag gccacagtga ccttggagga
     1501 ccacctcgcc tgcaagtgtg agacagtagt gacccctcgg cctgtgacta gaagtcctgg
     1561 gacatccagg gagcagcgag ccaagacgcc tcaagctcgg gtgaccattc ggacggtgag
     1621 aatccgccgg ccccccaaag gcaagcaccg aaagtttaag cacacccatg acaaggcggc
     1681 cctgaaggag accctcggag cctaggggcg tcggcaagag tgtgggcagg gttatttaat
     1741 atggtatttg ctgtattgcc cccatggggt ccttggagtg ataatgttgt tcccctcgtc
     1801 cgtctgtctc gatgcctgat tcggacggcc aatggtgctt ccctcacccc gtgtgcccgg
     1861 ccacctccac cagcagcgat tcctcagccc gccctgcagc tccagatgca aaggactcca
     1921 ctccaggctg caggcttctc ttgactccaa gaacctggaa caagtgtgca ggagccttgc
     1981 cgggggacgt ggactgtgga ctggccccag agcctggcac ttagcccgag gacctctgca
     2041 tgtcctgcct ggttcctgga ccactggcca gccagcaggg aacatgttca ggcaggctag
     2101 ggtcccttgc agtcctgtgg cagggagcac agactggagg aactctgatg gcacccagat
     2161 ctgccacgca ctcatctctt cctgtcccct cagcccacag tggcttttca ttttataaga
     2221 catgaactcc tctgggcagg tggccacaca ccttctctga tggattagag gtgcagtgtg
     2281 cgtgtgacct gggccgtgtc cctgcctctt tccacttccc ctacgttcac ttccggttca
     2341 tttctctacc tccactctgt gtcttcttcc tcatgtgccc ttcagtctgc tcctccacgg
     2401 ggtgttcgga tcccgattga ggccctgaat gcccgccatt cctccctagg gcaggagacc
     2461 tgtctcttat attccactcc agccaagcag ggtgagcaag gttgtaatgg gatgtatatt
     2521 gcacatgatg cactgcgtgt ggagactgct gttcacaccc taaatatggc caacttgcct
     2581 attatgacgt tctggccaat gtaggtcaaa cctctgagga aagggaacct tgtttaattc
     2641 ataccgaggc cctctgtgga gtggctgtgt gtgccctggc ccagcctgaa gctcagaatg
     2701 agcccatggt actggggaag caaccctgtt gtctgtccat tgcctccact tcctgggtct
     2761 cagctgtccc cttcctgaca ggtgaggggc actaggagac ctccaaggga ggaacagccc
     2821 tcgctgcaca ggtgtccctc tgatcttttg cggttctacc cgatggctcc ttcaaggaag
     2881 ctagccagta gattggaagt gggggagaga gggagagccc tagagccctt gggaggacgg
     2941 attgacctgg cccgcctccc ttcccacact ttcccgtccc cgttccttct gcttccttca
     3001 gtttgtaaag ttggtgatta tatttttggg ggctttcttt ttatttttta aatgtaaagt
     3061 ttatttatat tccgtattta aagttgtaaa aaaaaaaaag ccacaaaaca aaa
//
