LOCUS       NP_032834                196 aa            linear   ROD 11-MAR-2025
DEFINITION  platelet-derived growth factor subunit A isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_032834
VERSION     NP_032834.1
DBSOURCE    REFSEQ: accession NM_008808.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 196)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 196)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   3  (residues 1 to 196)
  AUTHORS   Kumar,N., Prakash,P.G., Wentland,C., Kurian,S.M., Jethva,G.,
            Brinkmann,V., Mollenkopf,H.J., Krammer,T., Toussaint,C.,
            Saliba,A.E., Biebl,M., Jurgensen,C., Wiedenmann,B., Meyer,T.F.,
            Gurumurthy,R.K. and Chumduri,C.
  TITLE     Decoding spatiotemporal transcriptional dynamics and epithelial
            fibroblast crosstalk during gastroesophageal junction development
            through single cell analysis
  JOURNAL   Nat Commun 15 (1), 3064 (2024)
   PUBMED   38594232
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 196)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   5  (residues 1 to 196)
  AUTHORS   Singh,N., Singh,D., Bhide,A., Sharma,R., Bhowmick,S., Patel,V. and
            Modi,D.
  TITLE     LHX2 in germ cells control tubular organization in the developing
            mouse testis
  JOURNAL   Exp Cell Res 425 (1), 113511 (2023)
   PUBMED   36796745
REFERENCE   6  (residues 1 to 196)
  AUTHORS   Palmieri,S.L., Payne,J., Stiles,C.D., Biggers,J.D. and Mercola,M.
  TITLE     Expression of mouse PDGF-A and PDGF alpha-receptor genes during
            pre- and post-implantation development: evidence for a
            developmental shift from an autocrine to a paracrine mode of action
  JOURNAL   Mech Dev 39 (3), 181-191 (1992)
   PUBMED   1292572
REFERENCE   7  (residues 1 to 196)
  AUTHORS   Orr-Urtreger,A. and Lonai,P.
  TITLE     Platelet-derived growth factor-A and its receptor are expressed in
            separate, but adjacent cell layers of the mouse embryo
  JOURNAL   Development 115 (4), 1045-1058 (1992)
   PUBMED   1451656
REFERENCE   8  (residues 1 to 196)
  AUTHORS   Hutchins,J.B. and Jefferson,V.E.
  TITLE     Developmental distribution of platelet-derived growth factor in the
            mouse central nervous system
  JOURNAL   Brain Res Dev Brain Res 67 (2), 121-135 (1992)
   PUBMED   1324805
REFERENCE   9  (residues 1 to 196)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   10 (residues 1 to 196)
  AUTHORS   Rorsman,F. and Betsholtz,C.
  TITLE     Characterization of the mouse PDGF A-chain gene. Evolutionary
            conservation of gene structure, nucleotide sequence and alternative
            splicing
  JOURNAL   Growth Factors 6 (4), 303-313 (1992)
   PUBMED   1340209
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117698.19.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003817.1, SRR15390195.743997.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..196
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 77.65 cM"
     Protein         1..196
                     /product="platelet-derived growth factor subunit A isoform
                     1 precursor"
                     /note="platelet-derived growth factor subunit A; PDGF
                     subunit A; platelet-derived growth factor alpha
                     polypeptide; PDGF A-chain; platelet-derived growth factor
                     A-chain"
                     /calculated_mol_wt=20122
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2177
     Region          21..95
                     /region_name="PDGF_N"
                     /note="Platelet-derived growth factor, N terminal region;
                     pfam04692"
                     /db_xref="CDD:461394"
     Region          94..181
                     /region_name="PDGF"
                     /note="Platelet-derived and vascular endothelial growth
                     factors (PDGF, VEGF) family; smart00141"
                     /db_xref="CDD:197537"
     Site            order(94..97,133,135..138,153..156)
                     /site_type="active"
                     /note="receptor binding interface [active]"
                     /db_xref="CDD:238079"
     Site            order(96,129,133,140,177,179)
                     /site_type="other"
                     /note="cysteine knot motif"
                     /db_xref="CDD:238079"
     Site            order(123,132)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238079"
     Site            134
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P20033.3)"
     Region          158..162
                     /region_name="Receptor binding site.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P20033.3)"
     CDS             1..196
                     /gene="Pdgfa"
                     /gene_synonym="PDGF-1"
                     /coded_by="NM_008808.5:174..764"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS19802.1"
                     /db_xref="GeneID:18590"
                     /db_xref="MGI:MGI:97527"
ORIGIN      
        1 mrtwacllll gcgylahala eeaeipreli erlarsqihs irdlqrllei dsvgaedale
       61 tslrahgsha inhvpekrpv pirrkrsiee aipavcktrt viyeiprsqv dptsanfliw
      121 ppcvevkrct gccntssvkc qpsrvhhrsv kvakveyvrk kpklkevqvr leehlecaca
      181 tsnlnpdhre eetdvr
//
