LOCUS       NM_001374003            4603 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus phosphodiesterase 8B (Pde8b), transcript variant 4,
            mRNA.
ACCESSION   NM_001374003 XM_006517585
VERSION     NM_001374003.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4603)
  AUTHORS   Madsen,J.F., Amoushahi,M., Choi,C.P., Bundgaard,S., Heuck,A. and
            Lykke-Hartmann,K.
  TITLE     Inhibition of phosphodiesterase PDE8B reduces activation of
            primordial follicles in mouse ovaries
  JOURNAL   Mol Reprod Dev 90 (6), 378-388 (2023)
   PUBMED   37499226
  REMARK    GeneRIF: Inhibition of phosphodiesterase PDE8B reduces activation
            of primordial follicles in mouse ovaries.
REFERENCE   2  (bases 1 to 4603)
  AUTHORS   Leal,L.F., Szarek,E., Berthon,A., Nesterova,M., Faucz,F.R.,
            London,E., Mercier,C., Abu-Asab,M., Starost,M.F., Dye,L.,
            Bilinska,B., Kotula-Balak,M., Antonini,S.R. and Stratakis,C.A.
  TITLE     Pde8b haploinsufficiency in mice is associated with modest adrenal
            defects, impaired steroidogenesis, and male infertility, unaltered
            by concurrent PKA or Wnt activation
  JOURNAL   Mol Cell Endocrinol 522, 111117 (2021)
   PUBMED   33338547
  REMARK    GeneRIF: Pde8b haploinsufficiency in mice is associated with modest
            adrenal defects, impaired steroidogenesis, and male infertility,
            unaltered by concurrent PKA or Wnt activation.
REFERENCE   3  (bases 1 to 4603)
  AUTHORS   Knoll,A.T., Halladay,L.R., Holmes,A.J. and Levitt,P.
  TITLE     Quantitative Trait Loci and a Novel Genetic Candidate for Fear
            Learning
  JOURNAL   J Neurosci 36 (23), 6258-6268 (2016)
   PUBMED   27277803
REFERENCE   4  (bases 1 to 4603)
  AUTHORS   Tsai,L.C., Chan,G.C., Nangle,S.N., Shimizu-Albergine,M.,
            Jones,G.L., Storm,D.R., Beavo,J.A. and Zweifel,L.S.
  TITLE     Inactivation of Pde8b enhances memory, motor performance, and
            protects against age-induced motor coordination decay
  JOURNAL   Genes Brain Behav 11 (7), 837-847 (2012)
   PUBMED   22925203
  REMARK    GeneRIF: Pde8b knockout mice demonstrate improvement in select
            behaviors, motor-coordination, attenuation of age-induced motor
            coordination decline and increased anxiety levels.
REFERENCE   5  (bases 1 to 4603)
  AUTHORS   Shimizu-Albergine,M., Tsai,L.C., Patrucco,E. and Beavo,J.A.
  TITLE     cAMP-specific phosphodiesterases 8A and 8B, essential regulators of
            Leydig cell steroidogenesis
  JOURNAL   Mol Pharmacol 81 (4), 556-566 (2012)
   PUBMED   22232524
  REMARK    GeneRIF: findings suggest that both PDE8A and PDE8B play essential
            roles to maintain low cAMP levels, thereby suppressing resting
            steroidogenesis by keeping CEH/HSL inactive and StAR protein
            expression low
REFERENCE   6  (bases 1 to 4603)
  AUTHORS   Sugamori,K.S., Brenneman,D. and Grant,D.M.
  TITLE     Liver-selective expression of human arylamine N-acetyltransferase
            NAT2 in transgenic mice
  JOURNAL   Drug Metab Dispos 39 (5), 882-890 (2011)
   PUBMED   21317369
REFERENCE   7  (bases 1 to 4603)
  AUTHORS   Tsai,L.C., Shimizu-Albergine,M. and Beavo,J.A.
  TITLE     The high-affinity cAMP-specific phosphodiesterase 8B controls
            steroidogenesis in the mouse adrenal gland
  JOURNAL   Mol Pharmacol 79 (4), 639-648 (2011)
   PUBMED   21187369
  REMARK    GeneRIF: Phosphodiesterase 8B is a major regulator of pools of
            cyclic AMP that promote steroidogenesis.
REFERENCE   8  (bases 1 to 4603)
  AUTHORS   Omori,K. and Kotera,J.
  TITLE     Overview of PDEs and their regulation
  JOURNAL   Circ Res 100 (3), 309-327 (2007)
   PUBMED   17307970
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123034.5, AC147108.3 and AC134439.4.
            
            On Sep 6, 2019 this sequence version replaced XM_006517585.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.40144.1,
                                           SRR14995048.1777932.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-618               AC123034.5         129793-130410       c
            619-678             AC147108.3         109853-109912       c
            679-869             AC147108.3         94244-94434         c
            870-929             AC147108.3         91242-91301         c
            930-987             AC147108.3         87478-87535         c
            988-1076            AC147108.3         82225-82313         c
            1077-1155           AC147108.3         76867-76945         c
            1156-1296           AC147108.3         73317-73457         c
            1297-1385           AC147108.3         71762-71850         c
            1386-1446           AC147108.3         69703-69763         c
            1447-1489           AC134439.4         108279-108321       c
            1490-1567           AC134439.4         105317-105394       c
            1568-1644           AC134439.4         103128-103204       c
            1645-1809           AC134439.4         101713-101877       c
            1810-1855           AC134439.4         98818-98863         c
            1856-1991           AC134439.4         98291-98426         c
            1992-2190           AC134439.4         97256-97454         c
            2191-2408           AC134439.4         89560-89777         c
            2409-2529           AC134439.4         88221-88341         c
            2530-2697           AC134439.4         85704-85871         c
            2698-2827           AC134439.4         83009-83138         c
            2828-4603           AC134439.4         79845-81620         c
FEATURES             Location/Qualifiers
     source          1..4603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 49.22 cM"
     gene            1..4603
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /note="phosphodiesterase 8B"
                     /db_xref="GeneID:218461"
                     /db_xref="MGI:MGI:2443999"
     exon            1..618
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..2937
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /EC_number="3.1.4.53"
                     /note="isoform 4 is encoded by transcript variant 4; cell
                     proliferation-inducing gene 22 protein; high affinity
                     cAMP-specific and IBMX-insensitive 3',5'-cyclic
                     phosphodiesterase 8B"
                     /codon_start=1
                     /product="high affinity cAMP-specific and IBMX-insensitive
                     3',5'-cyclic phosphodiesterase 8B isoform 4"
                     /protein_id="NP_001360932.1"
                     /db_xref="GeneID:218461"
                     /db_xref="MGI:MGI:2443999"
                     /translation="MGCAPSIHVSQSGVIYCRDSDESNSPRQTSSVSQGPTAPLHGLF
                     VQTDAADAMPPSRAAGPPGAVRVRRSRAELGSGSSTGSSGPATTTCRGRRRHCCSSAE
                     AETQTSYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCN
                     IARTPESALECFLDKHHEIIVIDHRQSRNFDAEAVCRSIRATNPSEHTVILAVVSQAS
                     DDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALD
                     HCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTC
                     IKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDSNKQIHR
                     IHRDSGDNSQTEPHSFRHKSRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIE
                     APITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGL
                     MTDGLRRLSGNEYVFTKNVHHSHSHLSMPITINDVPPSIAQLLDNEESWDFNIFELEA
                     VTHKRPLVYLGLKVFSRFGVCEFLNCTETTLRAWLQVIEANYHSSNAYHNSTHAADVL
                     HATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTA
                     VLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFV
                     NSINKPLAAESEGSDCECNPTGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGR
                     ISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPA
                     LMQHLADNYKHWKTLDDLKCKTLRLPSDS"
     exon            619..678
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            679..869
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            870..929
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..987
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1076
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1155
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1296
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1385
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1446
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1489
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1567
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1644
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1809
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1855
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1991
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2190
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2408
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2529
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2697
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2827
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..4603
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3100..3105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3121
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /note="major polyA site"
     regulatory      4522..4527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      4554
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
     polyA_site      4603
                     /gene="Pde8b"
                     /gene_synonym="B230331L10Rik; C030047E14Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcggccgct ggggcgcgcg ggccgtgtgt gcgcgctctg ccgctccggg aggaagatgg
       61 cccgggaggg aaagttgggg tgacgcgcgc tgcccccgga cgctcgccag ggggcacgga
      121 ggcgagcccg acagagcggt ggccacccag actggggggc gcgcagtctg ggcaccaccg
      181 tcaccacgcc cgccccctca ctgcaggtgg ccgtgggagc tccgagtccg ggtggcccgg
      241 gggcgcgggc gggcgcgcgc gggggagccc ggctgaggga tgggctgcgc ccccagcatc
      301 catgtctcgc agagcggtgt gatctactgc cgggactcgg atgagtccaa ctcgccccgc
      361 cagaccagca gcgtgtcgca gggccccacg gcgcccctgc acggcctctt cgtgcagacc
      421 gacgccgccg acgccatgcc cccgagtcgc gcggcgggac ccccgggcgc tgtccgagtc
      481 cgcagatccc gggctgaact gggcagcggc agcagcacgg ggtcctcggg ccccgccacg
      541 accacctgcc ggggccggag gcgccactgc tgcagcagcg ccgaggccga gacccagact
      601 agctacacca gcgtcaagca ggtgtcttct gcagaggtgc gcattgggcc catgagactg
      661 acacaggacc ctatccaggt tctgctaatc ttcgcaaagg aagatagcca gagtgatggc
      721 ttctggtggg cctgtgacag agctggctac agatgcaaca tcgctcgcac tccagagtcg
      781 gccctcgagt gctttctgga caagcatcat gaaattattg tgatcgatca caggcagagc
      841 cggaactttg atgcagaagc cgtgtgcagg tcaatccggg ccacgaaccc ctctgagcac
      901 acggtgatcc tggctgtcgt ttcacaagca tctgatgacc atgaagaggc ctcagtcctt
      961 cctcttcttc atgcaggctt caaccggaga tttatggaga acagcagcat aattgcttgc
     1021 tataatgaac tgattcaaat agaacacggg gaagttcgct cacagttcaa attacgggcc
     1081 tgtaattcag tgtttacagc gttagaccac tgtcacgaag ccatagaaat aacaagtgat
     1141 gaccatgtga ttcagtatgt caaccctgcc tttgagagga tgatgggcta ccacaaaggg
     1201 gagctcctgg ggaaggaact cgctgaccta cctaagagtg acaagaaccg ggcagacctc
     1261 ctggacacca tcaacacgtg catcaagaag ggaaaggagt ggcagggggt ttactatgcc
     1321 agacggaaat ccggggacag catccaacag cacgtgaaga tcaccccagt gattggccaa
     1381 ggagggaaaa ttaggcactt tgtctccctc aagaagctgt gctgtaccac tgacagtaac
     1441 aagcagattc accggattca tcgtgactcc ggggacaact ctcagacaga gcctcattcg
     1501 ttcagacaca agagcaggag gaaagagtcc attgatgtga aatcaatatc ttctcggggc
     1561 agtgatgcgc caagcctaca gaatcgccgc tacccctcca tggccaggat ccactccatg
     1621 accattgagg ctcccatcac aaaggttata aatataatca atgcagctca ggagaacagc
     1681 ccagttacag tagcagaggc cttggacaga gtcctagaaa ttttacggac cacagaactg
     1741 tattcccctc agctgggaac caaagatgag gatccccaca ccagtgacct tgttgggggc
     1801 ctgatgactg atggcttgag gagactgtca gggaacgagt atgtgtttac aaagaatgtg
     1861 caccacagtc acagtcacct ctcgatgccc atcaccatca atgatgtccc cccaagtatc
     1921 gcccagctcc ttgataatga ggaaagctgg gacttcaaca tctttgaatt ggaagccgtt
     1981 acacataaaa ggccacttgt gtacctgggc ttaaaggtct tctctcggtt tggagtatgt
     2041 gaatttttaa actgtactga aaccactctt cgggcctggc tgcaagtgat tgaagccaac
     2101 taccactcct ccaacgccta ccacaactcc acccatgctg ccgatgtact gcatgccacg
     2161 gctttcttcc ttggaaagga aagagtgaag ggaagcctgg accagctgga tgaggtggct
     2221 gctctgattg ctgccacagt ccacgacgtg gatcaccccg gaaggaccaa ctctttcctg
     2281 tgcaacgccg gcagcgagct cgctgtgctc tacaatgaca ctgcagtctt ggagagtcac
     2341 cacacagccc tggccttcca gctcacagtc aaggacacca agtgcaacat tttcaagaat
     2401 attgacagga accactatcg aacgctgcgc caggctatta tcgacatggt tttggctaca
     2461 gagatgacaa aacacttcga gcacgtgaac aaattcgtga acagcatcaa caagccactg
     2521 gcagctgaga gtgagggcag tgattgtgaa tgcaacccta ccgggaagaa ctttcctgag
     2581 aaccaaatcc tcatcaaacg catgatgatt aagtgtgccg acgtggccaa cccgtgccgg
     2641 cccttggacc tgtgcattga atgggctgga aggatctccg aggagtactt tgctcagact
     2701 gatgaagaga agaggcaggg gctgcctgtg gtgatgccag tgttcgaccg caatacctgc
     2761 agcatcccca agtcccagat ctccttcatc gactacttca taacagacat gtttgatgct
     2821 tgggatgcct tcgctcacct gcctgccctg atgcagcacc tggccgataa ctataaacac
     2881 tggaagacac tggatgacct caagtgcaaa actctgagac ttccatctga cagctgaagc
     2941 cacgcccgag aaggggacac tgtgaatcac agggtagaac aagcaagagg gtttccttta
     3001 aaatggaaat gacaggcgga cactaagggg atggtgttta atttccgacc tgaatcatgc
     3061 acgcccccaa acttcatttc cagaaagtta tattccatca ataaaaatat gttcctttga
     3121 atcactcagt gacaaaacga gctgcctggc agcttcttct gccaagctgt tagcctgcgt
     3181 gcccttgtaa agccggagct gactgactta ctgacggtac aagcaggaca cgagaagcaa
     3241 aggcctgttg tgtgtccatc ctcctgacgg aggtcaggta gcttagccag agttcagctc
     3301 aactgttacc agaaaactaa cgacggaggc tttcctcagt ggcaaaagga tgaaggattc
     3361 ctaaacatct tctctgagca aatggatgtg aggaaggagc tcattaaaat gagcagaatg
     3421 agaatgagat ggtcagtaaa ctaattagtt agcactgtgg ttcccatggc tacatgggag
     3481 acagtgtgat atccaagtca gaacacatcc tgggcctgcc gggtgtcccg tggatgggtg
     3541 cccgtcaccc gtggagcccc ctttcctccg tggaacccgc cttttggaag ccagctgata
     3601 gggaaggagt aggatctcag ttaggggagt ccttgagcac cccttacttc aggctcaagg
     3661 acacagccac aagtcagagt atctataaag ccattaagtc tgaatgctcg tgggtaaggt
     3721 tttttttaaa aaaaaaaaat taagagaaga taaatttata tatatttgct gttcaaagat
     3781 ttttattaaa ataatctaaa tgtcccgaat cttcacccct agtttgctgg gcattacctg
     3841 tctgtctata tctggggagg aaatggggaa gttccaaggt tcggatatcc ttaatttata
     3901 tttgagatca tgccatttgc tttaatgatg taaaaagaga ctgcaagaag tgtaaatatg
     3961 tcgggcggga caaaggcatg gagaggcagt aaatactatt ttatgctacc gcccgtacgc
     4021 tgacattcct gaagcacaag ggcatatttt tatacaactt ttcacaaggc tctgtgctct
     4081 gcatacggtc agacagatct cccctctctc ttgtcagccg tcccgcctct atgtgttacg
     4141 aacatcagaa accaagtaaa caaaatacct tacttttatt ttatctgtac tccacgatgc
     4201 attttaaaga tgtatagaaa ctgaactgat agaatcagta gctacatttt tttttccaag
     4261 tgaacattgg accttggagt atgtggaaat tggtacatgg ggaagaaaga gacaacttat
     4321 cgctacgtaa tgtgccaatg tttttttttt ctatgttttg taccaaagtg taaacatata
     4381 tgacaattcc atgcaaagaa atgcatctaa attatttttg ttagatggtg agagggcttg
     4441 cttgctcagg acaggagatg gctttctatt gtactgctgc gttatctaca tgtgatgaaa
     4501 tgtttttgtg aagtacttgt aactaaattc ttacagccat tttttcattc ccaacagctg
     4561 tttttatttt atctctttgg cctaaacttt tcacaatttc aaa
//
