LOCUS       NM_001347366            5080 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphodiesterase 7B (Pde7b), transcript variant 1,
            mRNA.
ACCESSION   NM_001347366 XM_006512758
VERSION     NM_001347366.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5080)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5080)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 5080)
  AUTHORS   Mathieu,M., Drelon,C., Rodriguez,S., Tabbal,H., Septier,A.,
            Damon-Soubeyrand,C., Dumontet,T., Berthon,A., Sahut-Barnola,I.,
            Djari,C., Batisse-Lignier,M., Pointud,J.C., Richard,D.,
            Kerdivel,G., Calmejane,M.A., Boeva,V., Tauveron,I.,
            Lefrancois-Martinez,A.M., Martinez,A. and Val,P.
  TITLE     Steroidogenic differentiation and PKA signaling are programmed by
            histone methyltransferase EZH2 in the adrenal cortex
  JOURNAL   Proc Natl Acad Sci U S A 115 (52), E12265-E12274 (2018)
   PUBMED   30541888
REFERENCE   4  (bases 1 to 5080)
  AUTHORS   Paul,A., Crow,M., Raudales,R., He,M., Gillis,J. and Huang,Z.J.
  TITLE     Transcriptional Architecture of Synaptic Communication Delineates
            GABAergic Neuron Identity
  JOURNAL   Cell 171 (3), 522-539 (2017)
   PUBMED   28942923
REFERENCE   5  (bases 1 to 5080)
  AUTHORS   Morales-Garcia,J.A., Aguilar-Morante,D., Hernandez-Encinas,E.,
            Alonso-Gil,S., Gil,C., Martinez,A., Santos,A. and Perez-Castillo,A.
  TITLE     Silencing phosphodiesterase 7B gene by lentiviral-shRNA
            interference attenuates neurodegeneration and motor deficits in
            hemiparkinsonian mice
  JOURNAL   Neurobiol Aging 36 (2), 1160-1173 (2015)
   PUBMED   25457552
  REMARK    GeneRIF: It is one of the enzymes responsible for controlling
            specifically the intracellular levels of cyclic adenosine 3',
            5'-monophosphate in the immune and central nervous systems.
REFERENCE   6  (bases 1 to 5080)
  AUTHORS   Chevalier,E., Lagente,V., Dupont,M., Fargeau,H., Palazzi,X.,
            Richard,V., Dassaud,M., Fric,M., Coupe,M., Carre,C., Leduc,S.,
            Bernardelli,P., Vergne,F., Berna,P. and Bertrand,C.P.
  TITLE     Lack of involvement of type 7 phosphodiesterase in an experimental
            model of asthma
  JOURNAL   Eur Respir J 39 (3), 582-588 (2012)
   PUBMED   22088971
  REMARK    GeneRIF: For the first time, it was demonstrated that the deletion
            of the PDE7B gene or the pharmacological inhibition of PDE7A and -B
            had no effect on ovalbumin-induced airway inflammation and airway
            hyperreactivity.
REFERENCE   7  (bases 1 to 5080)
  AUTHORS   Omori,K. and Kotera,J.
  TITLE     Overview of PDEs and their regulation
  JOURNAL   Circ Res 100 (3), 309-327 (2007)
   PUBMED   17307970
  REMARK    Review article
REFERENCE   8  (bases 1 to 5080)
  AUTHORS   Gardner,C., Robas,N., Cawkill,D. and Fidock,M.
  TITLE     Cloning and characterization of the human and mouse PDE7B, a novel
            cAMP-specific cyclic nucleotide phosphodiesterase
  JOURNAL   Biochem Biophys Res Commun 272 (1), 186-192 (2000)
   PUBMED   10872825
REFERENCE   9  (bases 1 to 5080)
  AUTHORS   Sasaki,T., Kotera,J., Yuasa,K. and Omori,K.
  TITLE     Identification of human PDE7B, a cAMP-specific phosphodiesterase
  JOURNAL   Biochem Biophys Res Commun 271 (3), 575-583 (2000)
   PUBMED   10814504
REFERENCE   10 (bases 1 to 5080)
  AUTHORS   Hetman,J.M., Soderling,S.H., Glavas,N.A. and Beavo,J.A.
  TITLE     Cloning and characterization of PDE7B, a cAMP-specific
            phosphodiesterase
  JOURNAL   Proc Natl Acad Sci U S A 97 (1), 472-476 (2000)
   PUBMED   10618442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049910.1, AJ251859.1, AK035385.1, AC153845.10 and CX215057.1.
            
            On Nov 24, 2016 this sequence version replaced XM_006512758.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.274521.1,
                                           SRR6116558.90274.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AK049910.1         1-137
            138-324             AK049910.1         139-325
            325-438             AK049910.1         327-440
            439-2623            AJ251859.1         507-2691
            2624-3308           AK035385.1         2652-3336
            3309-4111           AK035385.1         3338-4140
            4112-4964           AC153845.10        187624-188476       c
            4965-5080           CX215057.1         236-351
FEATURES             Location/Qualifiers
     source          1..5080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.75 cM"
     gene            1..5080
                     /gene="Pde7b"
                     /note="phosphodiesterase 7B"
                     /db_xref="GeneID:29863"
                     /db_xref="MGI:MGI:1352752"
     exon            1..438
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1697
                     /gene="Pde7b"
                     /EC_number="3.1.4.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cAMP-specific 3',5'-cyclic phosphodiesterase 7B;
                     cAMP-specific phosphodiesterase 7B; 3',5'-cyclic-AMP
                     phosphodiesterase 7B"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 7B isoform 1"
                     /protein_id="NP_001334295.1"
                     /db_xref="CCDS:CCDS83686.1"
                     /db_xref="GeneID:29863"
                     /db_xref="MGI:MGI:1352752"
                     /translation="MPVLERYFHSAELGRRWTAPEAVLPSSLSSRPGCQQGPLPWDLP
                     EMIRMVKLVWKSKSELQATKPRGILENEDASHSFPGDVRLRGQTGVPAERRGSYPFID
                     FRLLNNTTHSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHM
                     LSKVGTWDFDIFLFDRLTNGNSLVTLLCHLFNSHGLIHHFKLDMVTLHRFLVMVQEDY
                     HGHNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPF
                     LIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILAT
                     DINRQNEFLTRLKAHLHNKDLRLENVQDRHFMLQIALKCADICNPCRIWEMSKQWSER
                     VCEEFYRQGDLEQKFELEISPLCNQQKDSIPSIQIGFMTYIVEPLFREWARFTGNSTL
                     SENMLSHLAHNKAQWKSLLSNQHRRRGSGQDLAGPAPETLEQTEGATP"
     exon            439..522
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            523..674
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            675..738
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            739..834
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            835..935
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1067
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1159
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1304
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1401
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1482
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..5063
                     /gene="Pde7b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5040..5045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde7b"
                     /note="hexamer: AATAAA"
     polyA_site      5063
                     /gene="Pde7b"
                     /note="major polyA site"
ORIGIN      
        1 agaaaggctg tgccaggctg gaggaggctt gtctttccaa ggctggagag gatttcacgc
       61 gggtttgcct gcagctgccc gggaagaaat tcccctctgg tggcagcagc agcagcaaca
      121 acaacagcag cagcagcagg aacagcagca gcagcagcga cggcggcagc cctacctctt
      181 cttctgggga acagggcaga atgcctgtgc tagagcggta cttccactct gcagaactag
      241 gcaggaggtg gacggcccca gaagctgtgc taccctcttc cctcagcagc aggccggggt
      301 gccagcaggg gccgctaccc tgggacttgc cagagatgat caggatggta aagctggttt
      361 ggaagtccaa aagtgagcta caggcaacca aaccgagagg cattctggaa aatgaagatg
      421 cttcccacag cttcccagga gatgtacgac taaggggtca gacgggggtt cctgccgaac
      481 gccgtggctc ctacccattc attgacttcc gtctacttaa caatacaaca cactcagggg
      541 aaattggcac caagaaaaag gtgaaacgac tgttaagttt ccaaagatac ttccatgcat
      601 ctaggcttct ccgggggatt ataccgcagg cccctctcca cctgctggat gaagactacc
      661 ttggacaagc aaggcacatg ctctccaaag ttggaacgtg ggactttgac attttcttgt
      721 ttgatcgctt gacaaatggg aacagtctgg taactctgtt gtgtcacctc ttcaactccc
      781 atgggctcat ccaccatttc aagctcgata tggtgacctt gcacaggttt ctggttatgg
      841 ttcaggaaga ttaccacggt cacaacccat accacaatgc tgttcacgca gccgacgtca
      901 cccaggccat gcactgttac ctgaaggagc caaagttggc aagcttcctc acacctctgg
      961 acatcatgct tggactactg gctgcagcag ctcatgacgt ggaccaccca ggggtcaacc
     1021 agccattttt gatcaaaact aaccaccatc ttgccaacct gtatcagaat atgtctgtac
     1081 tggagaatca ccactggcga tctacaattg gcatgcttcg agaatcacgg ctcctggctc
     1141 acttgccaaa ggaaatgaca caggatatcg aacagcagct gggctccctc atcttggcca
     1201 cggatatcaa cagacagaat gagtttctga cccgcttaaa agctcacctc cacaataaag
     1261 atttgagact ggagaatgta caggacagac actttatgct tcagatcgcc ttgaagtgtg
     1321 ctgacatttg caatccttgt cgtatctggg agatgagcaa gcagtggagt gaaagggtct
     1381 gtgaggaatt ctacagacaa ggtgaccttg aacagaagtt tgaactggaa atcagtcctc
     1441 tttgtaatca acagaaagat tcaatcccta gcatacaaat tggtttcatg acttacatcg
     1501 tggagccgct gttccgggag tgggcccggt ttactgggaa cagcaccctg tcggagaaca
     1561 tgctaagcca tctcgcgcac aacaaagccc agtggaagag cctgctgtcc aatcagcaca
     1621 gacgcagggg cagcggccag gacctggcgg gccccgcacc tgagaccctg gagcagacag
     1681 aaggtgccac gccctaaggt agctgtctgc tgatgcacgg ccatctgtcc gtccacagga
     1741 gcacggccat ccgtccgact gccctcgcaa caagcccatc acgctgggtt tcgatgccat
     1801 ccgcctgcca cttaccgcct cccttcgttg atccaagtgt acaaaagcca ttgtcacctc
     1861 agcattagct gccgaaatgg gcggctctat cccgtcattg gagctgattc tggggcggct
     1921 gccccaaccg aaacgcctgg aagtaagaaa ggggtgcttc tgccgtgttc gcctctggcc
     1981 cttggtcacg ctgactggca gtagctccta agtccagagc attttaacgt ttgccatcgg
     2041 acagctgacc tgcatgacac cagcatactt ggaactgcaa aactggtctt gcgtgccaga
     2101 gcacaaacga gagtgtgaga gaaagtacct tctattttaa taataattat tattataaaa
     2161 taataaatct ttttaacttt tatatttcat gcaccagaca atgggtctaa aactttggac
     2221 aagtaatact ctgcgtaccc aaacctaaga gggggttcat tattttgcta ttgactctat
     2281 gccacattgg gtccgagatg tggcaccatt gcgatttctg aaaccacgcg tcccctccca
     2341 tctggtggaa ggtgctgtac agcccgtccc tttgcaccgt tagccaatcc gtcttttacg
     2401 gattcagtga cctgtttata ttcacaagtg tacattttct gtaaatacca aacgctactg
     2461 attcccatgc caaaatacac gagtattatg ggattgctac ctgtataaac aatggcactg
     2521 tgaacagaat actgttagtt ttaatacaag agaatgcatt tgtaaatatg gtatagagtt
     2581 tattaatata ctgttgttcg cagataaagg ccttaacttt aaacattttt cctctttcca
     2641 aaactgccca acctaaatcc tgacagatgt ctttctgaac tgcctgcccc tagtgaccat
     2701 ctctgcttcc ctgctaaggt cacaagccaa aactgagtac catcttgaag gaaacttttt
     2761 tcgaaaacct ctcatgcatt gggaacgtag tttttaatct atggcactaa gtttggtttc
     2821 ctcagattaa tgagcaagat gtaaatcact ttccagcaca gcaatgctgc acacagtttt
     2881 aacaagctgg ctgagaagct cgtgtttttg tgactcctgt tgtggaacac ggggtacatc
     2941 cacctcacgg aagacacagc aggtttcctg tcacctaacc atcagggaac tccctgcccc
     3001 catgccacac atttgtctga tatggctaca ataccaaagt ccctttggtc cgtggacggt
     3061 tggtgtgcgt ttctttggcg ttgacagtaa ctgaattatt tacttttttc tatagtttca
     3121 tgtgaacaac tgcccagctg tttggctgaa tttaatctta tttaagtaaa gaagctattt
     3181 cagttttatc agagacttta gctttctagc agattaatgt ggttcatcac agctgcagcc
     3241 agcagacgca gcttggaatt gttgtcatct gtctgcagat gcttggctgt aaaatccagt
     3301 gtgtacgcat tcttacccag ctgaactatg cattgagcct tttcttcgtg agctctagca
     3361 taattaatgt tatatggaaa ctgccaatgc ttctttctct ttatcttaag tagtgggaga
     3421 gggggcattt ctgccatgat caagccactt ctcaaactga cagcaacagc tagctcttac
     3481 ttcctaagtg caactaatgt ggggctctct gtttctccta ataacgcaag tgaaacatta
     3541 aaaacttgct tggcttggaa cacgttccta cagagagatt ggggcttaca gagttaaggt
     3601 tgtggaagga attggaaagt tgattatatt ttcactagta taagcaagat tgtcagatgg
     3661 gactaaagaa agtctgaaga atttgcgaag tgggtggatg gcgctgacgt cactgatatg
     3721 ggtgagaagg gaagttgtga acacagcact aacttctgtt ttctgaagca gctacggact
     3781 gacatacatc ttcattgcta tggtattctg aagctctgaa cttaagcaag gcctcacatg
     3841 agaatacagc agaaagattc ctgcttcaaa acctcttatt ttggattgta gccatctgtt
     3901 tttatgcata tgagatcaaa acaaggagat caattgttca ggatgacaaa atagaaacag
     3961 taaagaaaac attgtcttta gccagtggag tttaggaaat agatttgctt aagctacaat
     4021 tatattataa ttgaattagg atagggcatt cttggtagtt ccaggtttat agggaaagat
     4081 tttcatctac caaacatcta atagttaaaa cacaagaata ataaaaatca gaaatagaat
     4141 ggaggtagac gtgcctgcat gcttctactg tctggaaatt ttgtgagatc ctcatgtgtt
     4201 gagaaaaaat taactgtgaa aactcttttc tgcctgctaa tggctctctt ggaataattt
     4261 aatacaagtt gtccaataag tcttggagac acggtccatg tgtcaatatc gttttaacgc
     4321 ttttagtctt agtctgctag cccacctagg tcgtggatca tcaattgatg actttagaaa
     4381 ggaagaattc agagagctac tttcttaata atacataaag atctcagaga caaagagaga
     4441 gagagaggaa gaaagggagg gagggaggga gagagagggg gagggggaga gggagagaga
     4501 gagagagaga gcgagagaga gcgagagagg gagagggaga gagagagaga gacagagaga
     4561 gagagagaga gagagagaga gagagagaga gagagaggtg aacatgaata catcactatc
     4621 aggtctgatg atcaaagcct acttttcttt gctgccatcc aatccgcagt cagacctgat
     4681 acctgaaacc ctgacaaccc atacttccgg gttaggttaa gtaaaaacta gttgtttctc
     4741 ctcttcctgc tttcagcttc ccacaaaggg ccttggaggg catctgcaac cctgccttca
     4801 aatagccctt cctgtaaaac atggagatgt gtggcctttt gtgtcgaatc acatctgctc
     4861 agtggcgttg acttggttat gagcttgtat tcctcatgct ttcttctttt aagactgtaa
     4921 aattgtgtca tcttgtgtac acatgtaagt ttgggggggg ggggaacaaa ccttgtgagt
     4981 tttgctcaaa aatgtggcct aaatattcat tggcatgtct atccagatga acatttaaaa
     5041 ataaagataa tttctttaaa ataaaaaaaa aaaaaaaaaa
//
