LOCUS       NM_001122759            6298 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Mus musculus phosphodiesterase 7A (Pde7a), transcript variant 2,
            mRNA.
ACCESSION   NM_001122759
VERSION     NM_001122759.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6298)
  AUTHORS   Liu,Z., Li,A., Ali,T., He,K., Gao,R., Liufang,H., Qiang,H., Li,T.,
            Li,N., Garcia,A., Gil,C., Martinez,A., Lipina,T.V. and Li,S.
  TITLE     Neuronal lack of PDE7a disrupted working memory, spatial learning,
            and memory but facilitated cued fear memory in mice
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 120, 110655 (2023)
   PUBMED   36220621
  REMARK    GeneRIF: Neuronal lack of PDE7a disrupted working memory, spatial
            learning, and memory but facilitated cued fear memory in mice.
REFERENCE   2  (bases 1 to 6298)
  AUTHORS   Isidori,A.M., Cornacchione,M., Barbagallo,F., Di Grazia,A.,
            Barrios,F., Fassina,L., Monaco,L., Giannetta,E., Gianfrilli,D.,
            Garofalo,S., Zhang,X., Chen,X., Xiang,Y.K., Lenzi,A., Pellegrini,M.
            and Naro,F.
  TITLE     Inhibition of type 5 phosphodiesterase counteracts beta2-adrenergic
            signalling in beating cardiomyocytes
  JOURNAL   Cardiovasc Res 106 (3), 408-420 (2015)
   PUBMED   25852085
REFERENCE   3  (bases 1 to 6298)
  AUTHORS   Medina-Rodriguez,E.M., Arenzana,F.J., Pastor,J., Redondo,M.,
            Palomo,V., Garcia de Sola,R., Gil,C., Martinez,A., Bribian,A. and
            de Castro,F.
  TITLE     Inhibition of endogenous phosphodiesterase 7 promotes
            oligodendrocyte precursor differentiation and survival
  JOURNAL   Cell Mol Life Sci 70 (18), 3449-3462 (2013)
   PUBMED   23661015
  REMARK    GeneRIF: PDE7 has roles in regulating oligodendrocyte precursor
            survival and differentiation during brain development and in
            adulthood
REFERENCE   4  (bases 1 to 6298)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   5  (bases 1 to 6298)
  AUTHORS   Goto,M., Murakawa,M., Kadoshima-Yamaoka,K., Tanaka,Y., Inoue,H.,
            Murafuji,H., Hayashi,Y., Miura,K., Nakatsuka,T., Nagahira,K.,
            Chamoto,K., Fukuda,Y. and Nishimura,T.
  TITLE     Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation
            and cytokine production of NKT cells
  JOURNAL   Cell Immunol 258 (2), 147-151 (2009)
   PUBMED   19477436
  REMARK    GeneRIF: PDE7A is involved in regulation of cell proliferation and
            cytokine production of NKT cells.
REFERENCE   6  (bases 1 to 6298)
  AUTHORS   Yang,G., McIntyre,K.W., Townsend,R.M., Shen,H.H., Pitts,W.J.,
            Dodd,J.H., Nadler,S.G., McKinnon,M. and Watson,A.J.
  TITLE     Phosphodiesterase 7A-deficient mice have functional T cells
  JOURNAL   J Immunol 171 (12), 6414-6420 (2003)
   PUBMED   14662840
  REMARK    GeneRIF: PDE7A is not essential for activation of T lymphocytes;
            its inactivation by targeted gene disruption appears to enhance in
            vivo humoral immune responses.
REFERENCE   7  (bases 1 to 6298)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 6298)
  AUTHORS   Wang,P., Wu,P., Egan,R.W. and Billah,M.M.
  TITLE     Cloning, characterization, and tissue distribution of mouse
            phosphodiesterase 7A1
  JOURNAL   Biochem Biophys Res Commun 276 (3), 1271-1277 (2000)
   PUBMED   11027622
REFERENCE   9  (bases 1 to 6298)
  AUTHORS   Han,P., Fletcher,C.F., Copeland,N.G., Jenkins,N.A., Yaremko,L.M.
            and Michaeli,T.
  TITLE     Assignment of the mouse Pde7A gene to the proximal region of
            chromosome 3 and of the human PDE7A gene to chromosome 8q13
  JOURNAL   Genomics 48 (2), 275-276 (1998)
   PUBMED   9521885
REFERENCE   10 (bases 1 to 6298)
  AUTHORS   Bloom,T.J. and Beavo,J.A.
  TITLE     Identification and tissue-specific expression of PDE7
            phosphodiesterase splice variants
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 14188-14192 (1996)
   PUBMED   8943082
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062909.1, AC102756.8, AC127283.2 and AK036517.1.
            
            [WARNING] On Mar 13, 2024 this sequence was replaced by
            NM_001122759.3.
            
            On Nov 22, 2013 this sequence version replaced NM_001122759.1.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, lacks a portion of the 5' coding region and
            initiates translation at an alternate start codon compared to
            variant 1. The encoded isoform (2) has a distinct N-terminus and is
            longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062909.1, AK154521.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BC062909.1         1-16
            17-17               AC102756.8         153906-153906
            18-1362             BC062909.1         17-1361
            1363-1363           AC127283.2         144267-144267       c
            1364-2668           BC062909.1         1363-2667
            2669-2669           AC127283.2         140024-140024       c
            2670-3365           BC062909.1         2669-3364
            3366-4724           AK036517.1         3053-4411
            4725-6298           AC127283.2         136395-137968       c
FEATURES             Location/Qualifiers
     source          1..6298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 5.36 cM"
     gene            1..6298
                     /gene="Pde7a"
                     /note="phosphodiesterase 7A"
                     /db_xref="GeneID:18583"
                     /db_xref="MGI:MGI:1202402"
     exon            1..459
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1770
                     /gene="Pde7a"
                     /EC_number="3.1.4.53"
                     /note="isoform 2 is encoded by transcript variant 2; high
                     affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A;
                     cAMP-specific phosphodiesterase 7A; high affinity
                     3',5'-cyclic-AMP phosphodiesterase 7A"
                     /codon_start=1
                     /product="high affinity 3',5'-cyclic-AMP phosphodiesterase
                     7A isoform 2"
                     /protein_id="NP_001116231.1"
                     /db_xref="CCDS:CCDS50871.1"
                     /db_xref="GeneID:18583"
                     /db_xref="MGI:MGI:1202402"
                     /translation="MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPHPRQL
                     SQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFETERRGSHPYIDFRIFHSQSDIEAS
                     VSARNIRRLLSFQRYLRSSRVFRGATVCSSLDILDEDYNGQAKCMLEKVGNWNFDIFL
                     FDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMVKLRRFLVMIQEDYHSQNPYHNAVHAA
                     DVTQAMHCYLKEPKLASSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYK
                     NSSVLENHHWRSAVGLLRESGLFSHLPLESRQEMEAQIGALILATDISRQNEYLSLFR
                     SHLDKGDLHLDDGRHRHLVLQMALKCADICNPCRNWELSKQWSEKVTEEFFHQGDIEK
                     KYHLGVSPLCDRQTESIANIQIGFMTYLVEPLFTEWARFSDTRLSQTMLGHVGLNKAS
                     WKGLQRQQPSSEDANAAFELNSQLLTQENRLS"
     exon            460..520
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            521..604
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            605..756
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            757..820
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            821..916
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1017
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1149
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1241
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1386
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1483
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1564
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..6298
                     /gene="Pde7a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggggaggg gagggggcag ggctccggcg gccgaactgc tctacgctcc gcgcccgtgc
       61 tcgcggcccg ggccagctct cgcgccgcgg agcgcctggg cggcgggttc ccctttaacg
      121 ccgcccgccc ggcttcccga gcccgctgca gcccttcccg ccgccagccg cgcggagggc
      181 cgggaggcgt cggcggccac tagcgccgcc cgccccgcgc gcgcctcggc cccgggtccc
      241 cgcggcgcgg ccccctcgta gcgcaggggc gggcgaccgc ggactggcgg gcgccgcgcg
      301 gatccaaggc ggacgtgttc aatggaagta tgctaccagc tgccggtgct gcccctggac
      361 aggccggtcc cccagcacgt cctcagccgc cgaggagcca tcagcttcag ctccagctcc
      421 gcgctcttcg gctgcccgca tccccggcag ctctcgcaga gacgtggagc tatttcctat
      481 gacagttctg atcagactgc gttatatatt cgtatgctag gagatgtccg cgtgaggagc
      541 cgagcaggat ttgaaacaga aagaagaggt tcccatccgt acattgactt ccgtattttt
      601 cactctcaat ctgacattga agcatcagtc tccgccagga acatcagaag gttactaagt
      661 ttccagcgat atctcagatc ctcacgagtt tttcggggtg ccacagtttg tagttctcta
      721 gacattttag atgaggatta caatggacaa gccaagtgta tgctggaaaa agttggaaat
      781 tggaattttg atatctttct gtttgataga ctaacaaatg gaaatagtct agtaagccta
      841 acctttcatt tatttagtct tcatggattg attgagtact tccatttaga tatggtgaaa
      901 ctccgtcggt ttttagttat gattcaagaa gattaccaca gtcaaaatcc ttaccacaat
      961 gcagtccatg ctgcagacgt tactcaggcc atgcactgtt acttaaagga acctaagctt
     1021 gccagttctg tcactccttg ggatatcttg ctgagtttaa ttgcagccgc cactcacgat
     1081 ctggatcacc caggtgttaa tcagccgttt cttattaaaa ccaaccatta tctagcaact
     1141 ttatacaaga attcctcagt cctggagaat caccactgga gatctgcagt gggcttgtta
     1201 agagaatctg gtttgttctc acacttgcca ttggaaagca ggcaagagat ggaggctcag
     1261 ataggtgctt tgatattagc cacggatatc agtcgccaga acgagtacct gtcattgttt
     1321 agatctcact tggataaagg tgacttacac cttgacgatg gcagacatag gcatttggtt
     1381 ctacagatgg ccttgaaatg tgctgatatt tgtaacccat gtcggaactg ggaattaagc
     1441 aagcagtgga gtgaaaaagt aacggaggaa ttcttccacc aaggagatat agaaaaaaag
     1501 taccatttgg gtgtgagtcc actttgtgat cgtcagactg agtctattgc caacatccag
     1561 attggtttta tgacttacct agtggagcct ttatttacag agtgggccag gttttcagac
     1621 acacggctgt cacagacgat gcttggacat gtggggctga ataaagccag ctggaaggga
     1681 ctgcagagac aacagcccag cagcgaggat gccaatgctg catttgagtt gaactcacag
     1741 ttactaactc aggaaaatcg gttatcataa ccctgaacca gtgggacaac tccctcctgc
     1801 aacattgtgg aaatgtgaaa tggtcttgag tggaagaact ggttctgact gctgaggttt
     1861 ccaaggggat gatgccagca ttatctatca agatgtcttc tgttagatca tacgagcgca
     1921 cgttttaatg gtaagacatg aatatacagc aatatgcatc ttgcttttgt atgaaacctt
     1981 aagtctgtaa agctcagcag gagaaccaca aagggttctt aacgaaggaa gatgatgttt
     2041 taggtgtgcc atgtgctttc agagtgtgtg tccttcaagc cctgaaactt gaactcaacc
     2101 tcagcagcaa tcttgatgca accagtccag tccaacagcg catccgtccc ttccactaca
     2161 ttctctctga gaaaacagaa atgtgaagtg cccagcctct gctgcctctg gcaagaatca
     2221 atcaaatgtt tacaaatcaa atctgaacta ttggttctaa attgcctcgg agcatcgttg
     2281 tgaaggaacc actgaccgtt ctcagctgag ctggagactg cagctcttcg cagcatttgc
     2341 cttttcttct tcggatgtca atgtcatcat cgcctcccac ctgctgctct gctctgtgcc
     2401 tggagactga gcatttattt accacagacg ccacacgaag cttttcactc cagcgtggtt
     2461 ggcaatgcag attccttttt taactgttag tttttaacat ggggtgggag ggaaggaaca
     2521 ccactgtcct agctgtgttc tgactctgca gtgaagacac tgcatgttgt tttcactact
     2581 gtacacttga cctacacatg caagcaaaag gtggaatgtt taacatacca taatcagctc
     2641 aggggatttg ccaatctgaa ataaagtggg ctagggaagt gtgtccttca aatcaagggt
     2701 actaaagtcc ctttcgctgc agtgtgtgag aggtatgttg tgtatggctg tatggatgtg
     2761 tgtttgcgtg catgtttgtg catgtatggc tgtgcatgtt ctgtccatcc atgtgggaaa
     2821 ggattagaag tgtaagttct tatttattgt tctagaatgt gacatagtga gcagccacac
     2881 ttgggggagg ggaaggtagg tgaagctgta agattgctcc agatgcctta aactatgcac
     2941 aaagctaagt gaccaaactt ctcattttga tttgaaaagt gcattgtttt cttgtccccc
     3001 ctcccccact ttgatgaaac attacccttt ggcggacctt ttgatgtgag tagatgtttt
     3061 ctaggataaa atttaaggac taattttaga cttaaaacat tccacttttg taagttgttt
     3121 tcagtggtct tatgtagagc aagcacaact gtaacctagt ttaagagaaa cggtgctttc
     3181 ttttagttac cttctatttc ccttgttact gtttaagact gttcattatg tttacagttt
     3241 gttgcaacag ccatcttggg agagaacttg agtgtaaagc catgtgtgaa ggcttgggca
     3301 cactcgttta aacacgtgcc tgttgcttca ccttctgatt gacaaataaa accggtcttt
     3361 gctcattggt taatctttgc actctacctt accactcagt cctttggaag tgacatgctg
     3421 gattcttagg tgatcagtta gctgctgcct ctcccgttca gtcctgggta ttttgaagtc
     3481 taagttgtat gcagactttg tcttcctgga gtgtatgagc ctcactctgc accgtacaag
     3541 tgtggcaagg tctggttccg tttggtcatt cttgtatagc atttgttgga aattgcctaa
     3601 gaaatcacac ccttgaaagg gataaaaata gcagttgtgt ttgtattcct ggccttttac
     3661 agcagtaagt aataaccact taattctttc tttcagatag cctggtaaca atgtagacag
     3721 actggcctca actcagatac ctccctgctt ctgggtccta ctattaaagg tgtatgccac
     3781 catccacagt gccaatagag tggccttact gccctcccag gcctaactca tgagaaggga
     3841 taccgttcac gttttagatc agacgtatct gctcctactt cctagaagaa agtacaagtg
     3901 ttagtgaacc cactcaaatg tttgcccagt tttctagaaa agctgaaact ttagtaattc
     3961 taatatatcc aaaatatttt cttttagtat aattaaagtg ggttgctaag tctctgaaat
     4021 ccagtgtgtg ttttaaactt acagtacatc tcaatttata ctagcctcat ttcaagtggt
     4081 cacccatgcc cacattcggc tctcctatta gcatgggtac aggataatag tcattaccca
     4141 aagacagcca ctggcccctc ctaaagtgac agcatatttg accgtccggg gtctgaggaa
     4201 gtctcctgca agctaacatt accttaaaca agttcacaca gtatctgata actgcaaaga
     4261 aaagtcttgg tattttaatt tgcaatgaaa aacataacta ccaatctttc tccctttagg
     4321 taaatcttca gaagccaaat taggatcagc tggtttcctc agcaagaatt ctgagcaagg
     4381 gacacaaagt ttcctaaagc atccatctcc ctgtggagat agctgctact atcatatctg
     4441 tgaactgggt tcctcctccc ctggatgcta gaggttctct gccgctagcg gcttctatac
     4501 attggcttga ttggcagctc cattgtgttc aagtttaata gcaggaaggt ttagctttcc
     4561 tgactcagct tctcaaaggg tcaccttagt ggtgcttgca aacccatcac atttgttttc
     4621 tgcagctgtg ggaattacct gcctcaacct attttccttg atcagctggg ttttctacaa
     4681 gaatttaagg aaccatttag gtcacttttt aaaaagcaaa ttcattaaaa aaaaaaaaaa
     4741 aagcaaattc agagtagcac aaaattcatg gtatttcatg atatattgga cacttcaaag
     4801 aatttttgag tatgtagcag ccatttggga atctgggccc actgctgaag gggcgctggg
     4861 gtaggttagg gagtctctgc tctagaggtg agaaaaaatt ttaacaagtc ttgtcctaac
     4921 atggtcatca acactgtact ctaaacatat tagtttgtaa tgaatctccg tattaaaaga
     4981 aaaaagcaaa atttacattt tttttgtcct ttgcaaactt ggaaaaaaat atcctgtacc
     5041 tgagatatag gttagaggtg cactaatccc ttcacagctc tgaaaatgaa tgccttttct
     5101 aaatttagtt agttagttag ttttttgttt ttgttttgtt ttttcaagac agggtttctc
     5161 tgtgtgtccc tggctgtcct ggaactctgt agaccaggct ggcctcgaac tcagaaatac
     5221 acctgcctct gcctcccaag tgctgggata aaaggtgtgc gccaccgctg ccggactcaa
     5281 gcttatgtct tacggtcagt aacttaaatg tgcaaactag ttgccacact tttgccatgt
     5341 ttttgaagca taactttgaa actgcagcca ttgtgtccta agaacctgcg tagcatcgag
     5401 aggaccccca agggtcttca ggagagagag ccaccactga ggagcagcat gggggtgaac
     5461 tgacaggaac ataaaaggtc tctcacattc ttcagtgtgc agggtagtgg gcagatgtaa
     5521 attgggctat cagtaaacaa gttactgtgg agttctatgt accctttatc acgttattgc
     5581 taagacattt atttactgga agtagttcag taatgtaatg ctgaagttgt atagtaaatg
     5641 aatgcagaac atggaactag gtgttcaatt tttagagagc attaaaagtt acaagccagg
     5701 gtctctgttc aaattgtctt ggtaaaagaa aaatgtgtac aaagtgcttg taattagttt
     5761 tcagaactga ctaggagggg taatgctggg atattgtttg agagactagc ttaataagga
     5821 aacttatacc atgtgtgtct tttgatgcta agtcacttag cattcaaatt tgaatataca
     5881 gtttcaagta ttgaaaatga tactttgagt aaaatactaa ctttatcaat tacattttaa
     5941 actttatgtc taagttttgt aagttatctt ggaatccatc tttagaacct ggtaggatgg
     6001 aaaggtaaag acaaacactg ttcttttcaa tatttagctt cttgttggct gttgacttaa
     6061 attgaaacct gttgacttag tcatttgtgg ctttcacttg attcagtagt atctgttaaa
     6121 aaaaaaaagc tatcttttac ttgtctttaa gagtgagtgg gtgtgtgtgt gggtgtatag
     6181 caaatttgaa gtattcgttg tttggacatg tcttgtaaaa aatttcagga aactgtaata
     6241 gtatcaaagt tttttatctt atctaaaatt tataaaatat ataaagtttt gaaggaaa
//
