LOCUS       NM_023898                574 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus phosphodiesterase 6H, cGMP-specific, cone, gamma
            (Pde6h), mRNA.
ACCESSION   NM_023898
VERSION     NM_023898.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 574)
  AUTHORS   Wei,W., Liu,B., Jiang,H., Jin,K. and Xiang,M.
  TITLE     Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the
            Differentiation and Maintenance of Non-photoreceptor Cell Types
            During Retinal Development
  JOURNAL   Mol Neurobiol 56 (3), 1719-1736 (2019)
   PUBMED   29922981
REFERENCE   2  (bases 1 to 574)
  AUTHORS   Brightman,D.S., Grant,R.L., Ruzycki,P.A., Suzuki,R., Hennig,A.K.
            and Chen,S.
  TITLE     MLL1 is essential for retinal neurogenesis and horizontal inner
            neuron integrity
  JOURNAL   Sci Rep 8 (1), 11902 (2018)
   PUBMED   30093671
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 574)
  AUTHORS   Schmidt,H., Peters,S., Frank,K., Wen,L., Feil,R. and Rathjen,F.G.
  TITLE     Dorsal root ganglion axon bifurcation tolerates increased cyclic
            GMP levels: the role of phosphodiesterase 2A and scavenger receptor
            Npr3
  JOURNAL   Eur J Neurosci 44 (12), 2991-3000 (2016)
   PUBMED   27740716
REFERENCE   4  (bases 1 to 574)
  AUTHORS   Omori,Y., Kitamura,T., Yoshida,S., Kuwahara,R., Chaya,T., Irie,S.
            and Furukawa,T.
  TITLE     Mef2d is essential for the maturation and integrity of retinal
            photoreceptor and bipolar cells
  JOURNAL   Genes Cells 20 (5), 408-426 (2015)
   PUBMED   25757744
REFERENCE   5  (bases 1 to 574)
  AUTHORS   Brennenstuhl,C., Tanimoto,N., Burkard,M., Wagner,R., Bolz,S.,
            Trifunovic,D., Kabagema-Bilan,C., Paquet-Durand,F., Beck,S.C.,
            Huber,G., Seeliger,M.W., Ruth,P., Wissinger,B. and Lukowski,R.
  TITLE     Targeted ablation of the Pde6h gene in mice reveals cross-species
            differences in cone and rod phototransduction protein isoform
            inventory
  JOURNAL   J Biol Chem 290 (16), 10242-10255 (2015)
   PUBMED   25739440
  REMARK    GeneRIF: Pde6h deficiency mice suggests no defects in
            cone/rod-driven retinal signaling and therefore preserved visual
            functions.
REFERENCE   6  (bases 1 to 574)
  AUTHORS   Omori,K. and Kotera,J.
  TITLE     Overview of PDEs and their regulation
  JOURNAL   Circ Res 100 (3), 309-327 (2007)
   PUBMED   17307970
  REMARK    Review article
REFERENCE   7  (bases 1 to 574)
  AUTHORS   Tsang,S.H., Woodruff,M.L., Chen,C.K., Yamashita,C.Y.,
            Cilluffo,M.C., Rao,A.L., Farber,D.B. and Fain,G.L.
  TITLE     GAP-independent termination of photoreceptor light response by
            excess gamma subunit of the cGMP-phosphodiesterase
  JOURNAL   J Neurosci 26 (17), 4472-4480 (2006)
   PUBMED   16641226
  REMARK    GeneRIF: Our results show that the PDE6gamma binding sites of PDE6
            alpha and beta are accessible to excess (presumably cytoplasmic)
            PDE6gamma in the light, once endogenous PDE6gamma has been
            displaced from its binding site by Talpha-GTP.
REFERENCE   8  (bases 1 to 574)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   9  (bases 1 to 574)
  AUTHORS   Tate,R.J., Arshavsky,V.Y. and Pyne,N.J.
  TITLE     The identification of the inhibitory gamma-subunits of the type 6
            retinal cyclic guanosine monophosphate phosphodiesterase in
            non-retinal tissues: differential processing of mRNA transcripts
  JOURNAL   Genomics 79 (4), 582-586 (2002)
   PUBMED   11944991
  REMARK    Erratum:[Genomics. 2004 Feb;83(2):346]
REFERENCE   10 (bases 1 to 574)
  AUTHORS   Wan,K.F., Sambi,B.S., Frame,M., Tate,R. and Pyne,N.J.
  TITLE     The inhibitory gamma subunit of the type 6 retinal cyclic guanosine
            monophosphate phosphodiesterase is a novel intermediate regulating
            p42/p44 mitogen-activated protein kinase signaling in human
            embryonic kidney 293 cells
  JOURNAL   J Biol Chem 276 (41), 37802-37808 (2001)
   PUBMED   11502744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK020922.1 and BE983779.1.
            
            On Sep 8, 2006 this sequence version replaced NM_023898.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY742316.1, AK020922.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-434               AK020922.1         2-435
            435-574             BE983779.1         1-140               c
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 66.72 cM"
     gene            1..574
                     /gene="Pde6h"
                     /gene_synonym="A930033D18Rik; PDEgamma"
                     /note="phosphodiesterase 6H, cGMP-specific, cone, gamma"
                     /db_xref="GeneID:78600"
                     /db_xref="MGI:MGI:1925850"
     exon            1..57
                     /gene="Pde6h"
                     /gene_synonym="A930033D18Rik; PDEgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            58..226
                     /gene="Pde6h"
                     /gene_synonym="A930033D18Rik; PDEgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..344
                     /gene="Pde6h"
                     /gene_synonym="A930033D18Rik; PDEgamma"
                     /EC_number="3.1.4.35"
                     /note="cone phosphodiesterase 6 gamma; GMP-PDE gamma;
                     cone-like cGMP-phosphodiesterase 6 gamma subunit type 2"
                     /codon_start=1
                     /product="retinal cone rhodopsin-sensitive cGMP
                     3',5'-cyclic phosphodiesterase subunit gamma"
                     /protein_id="NP_076387.2"
                     /db_xref="CCDS:CCDS39686.1"
                     /db_xref="GeneID:78600"
                     /db_xref="MGI:MGI:1925850"
                     /translation="MSDSPSLSPPAPSQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVK
                     GFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQFGII"
     exon            227..267
                     /gene="Pde6h"
                     /gene_synonym="A930033D18Rik; PDEgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            268..558
                     /gene="Pde6h"
                     /gene_synonym="A930033D18Rik; PDEgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      521..526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde6h"
                     /gene_synonym="A930033D18Rik; PDEgamma"
                     /note="hexamer: AATAAA"
     polyA_site      558
                     /gene="Pde6h"
                     /gene_synonym="A930033D18Rik; PDEgamma"
                     /note="major polyA site"
ORIGIN      
        1 gtcagcgact agacaactta cgggaacaca ttcggctctg ggggatttta actcgtgcct
       61 gaaagcaaag cacgggccat tcaaggaccg agatgagtga cagcccttcc ctgagtcctc
      121 cagcaccaag ccagggccct actaccccac gcaaagggcc ccccaagttc aagcagaggc
      181 agactcgaca gttcaagagc aagcctccca agaaaggggt gaaagggttt ggagatgaca
      241 tcccaggcat ggaggggcta ggaacagata tcacggtcat ctgtccctgg gaagcgttca
      301 gccatctgga gctgcatgag cttgctcagt tcgggatcat atgaggagcc cagaggctcg
      361 gctgctctcg agagcgactg ctgctcttga gagtgtcatt gctttaccta attggtcttt
      421 ctgagtcttg aaacccagta tttggaagga ccgtatatgg ccctgaccca tgagttatgg
      481 tacgtgttct ttcctgaatg gtagttcagt ttcattgttg aataaaacgg cagtttttgg
      541 ggggtttccc caactttaaa aaaaaaaaaa aaaa
//
