LOCUS       NM_012065                919 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus phosphodiesterase 6G, cGMP-specific, rod, gamma
            (Pde6g), transcript variant 1, mRNA.
ACCESSION   NM_012065 XM_994440
VERSION     NM_012065.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 919)
  AUTHORS   Nolan,N.D., Cui,X., Robbings,B.M., Demirkol,A., Pandey,K., Wu,W.H.,
            Hu,H.F., Jenny,L.A., Lin,C.S., Hass,D.T., Du,J., Hurley,J.B. and
            Tsang,S.H.
  TITLE     CRISPR editing of anti-anemia drug target rescues independent
            preclinical models of retinitis pigmentosa
  JOURNAL   Cell Rep Med 5 (4), 101459 (2024)
   PUBMED   38518771
REFERENCE   2  (bases 1 to 919)
  AUTHORS   Matalkah,F., Jeong,B., Sheridan,M., Horstick,E., Ramamurthy,V. and
            Stoilov,P.
  TITLE     The Musashi proteins direct post-transcriptional control of protein
            expression and alternate exon splicing in vertebrate photoreceptors
  JOURNAL   Commun Biol 5 (1), 1011 (2022)
   PUBMED   36153373
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 919)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 919)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 919)
  AUTHORS   Zhang,E., Ryu,J., Levi,S.R., Oh,J.K., Hsu,C.W., Cui,X., Lee,T.T.,
            Wang,N.K., Lima de Carvalho,J.R. and Tsang,S.H.
  TITLE     PKM2 ablation enhanced retinal function and survival in a
            preclinical model of retinitis pigmentosa
  JOURNAL   Mamm Genome 31 (3-4), 77-85 (2020)
   PUBMED   32342224
REFERENCE   6  (bases 1 to 919)
  AUTHORS   Tuteja,N., Tuteja,R. and Farber,D.B.
  TITLE     Cloning and sequencing of the gamma-subunit of retinal cyclic-GMP
            phosphodiesterase from rd mouse
  JOURNAL   Exp Eye Res 48 (6), 863-872 (1989)
   PUBMED   2543588
REFERENCE   7  (bases 1 to 919)
  AUTHORS   Danciger,M., Tuteja,N., Kozak,C.A. and Farber,D.B.
  TITLE     The gene for the gamma-subunit of retinal cGMP-phosphodiesterase is
            on mouse chromosome 11
  JOURNAL   Exp Eye Res 48 (2), 303-308 (1989)
   PUBMED   2538340
REFERENCE   8  (bases 1 to 919)
  AUTHORS   Farber,D.B., Kozak,C.A. and Danciger,M.
  TITLE     Assignment to mouse chromosomes of candidate genes for the rd
            mutation
  JOURNAL   Prog Clin Biol Res 314, 143-153 (1989)
   PUBMED   2558380
REFERENCE   9  (bases 1 to 919)
  AUTHORS   Yau,K.W. and Baylor,D.A.
  TITLE     Cyclic GMP-activated conductance of retinal photoreceptor cells
  JOURNAL   Annu Rev Neurosci 12, 289-327 (1989)
   PUBMED   2467600
  REMARK    Review article
REFERENCE   10 (bases 1 to 919)
  AUTHORS   Tuteja,N. and Farber,D.B.
  TITLE     Gamma-subunit of mouse retinal cyclic-GMP phosphodiesterase: cDNA
            and corresponding amino acid sequence
  JOURNAL   FEBS Lett 232 (1), 182-186 (1988)
   PUBMED   2835267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669855.20 and AK080735.1.
            
            On Oct 7, 2014 this sequence version replaced NM_012065.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG298486.1, AK080735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL669855.20        115289-115305       c
            18-916              AK080735.1         1-899
            917-919             AL669855.20        109412-109414       c
FEATURES             Location/Qualifiers
     source          1..919
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.14 cM"
     gene            1..919
                     /gene="Pde6g"
                     /gene_synonym="p3AT; Pdeg"
                     /note="phosphodiesterase 6G, cGMP-specific, rod, gamma"
                     /db_xref="GeneID:18588"
                     /db_xref="MGI:MGI:97526"
     exon            1..87
                     /gene="Pde6g"
                     /gene_synonym="p3AT; Pdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            88..309
                     /gene="Pde6g"
                     /gene_synonym="p3AT; Pdeg"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..427
                     /gene="Pde6g"
                     /gene_synonym="p3AT; Pdeg"
                     /EC_number="3.1.4.35"
                     /note="GMP-PDE gamma; cGMP phosphodiesterase gamma"
                     /codon_start=1
                     /product="retinal rod rhodopsin-sensitive cGMP
                     3',5'-cyclic phosphodiesterase subunit gamma"
                     /protein_id="NP_036197.1"
                     /db_xref="CCDS:CCDS36389.1"
                     /db_xref="GeneID:18588"
                     /db_xref="MGI:MGI:97526"
                     /translation="MNLEPPKGEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPK
                     KGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII"
     exon            310..350
                     /gene="Pde6g"
                     /gene_synonym="p3AT; Pdeg"
                     /inference="alignment:Splign:2.1.0"
     exon            351..919
                     /gene="Pde6g"
                     /gene_synonym="p3AT; Pdeg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      878..883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde6g"
                     /gene_synonym="p3AT; Pdeg"
                     /note="hexamer: AATAAA"
     polyA_site      900
                     /gene="Pde6g"
                     /gene_synonym="p3AT; Pdeg"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggataa attcctaggc cagtgttctg ctgacccagg tccagataac cggcgcctgt
       61 ggcttcctga gatctgtcca gtgcttgcct gcatgaggac accagcccag cctgacagag
      121 tccagaagct aagggtcact gcagtgtctc tgccagcctc accatgaacc tggagccacc
      181 caagggtgag attcggtcag ccacccgggt gataggagga ccagtcaccc ccaggaaagg
      241 accacctaag tttaagcagc ggcaaacaag gcagttcaag agcaagcccc ccaagaaagg
      301 cgtgcaaggg tttggggatg acatccctgg aatggaaggc ctggggacag atatcaccgt
      361 catctgccct tgggaggcct tcaatcacct agagctgcac gagctggccc agtatggcat
      421 catttagtca gatccctgct atgtgagccc tggggaagaa acctgctgaa gactccctcc
      481 cccctctgca aaccctgtcc aggacccaaa cctgagcctg agtccctagc caggttacca
      541 tggcctcccc cgggacaatc tcaggccctg acaccagcta ctgagagcct acagcctccc
      601 acaggatacc ctgttgacct gaagtcactg gtcagcagaa agaagggagt gggacccagc
      661 cccacttcct gtcctttttg tggctgtaat gcagggctcc cctttgttcc cctgaactgc
      721 cttctgaggg tgagaaagtt cctctgtctt gtagcccttc cagatgggtg tcttggggtg
      781 ggacactgtc ctggggtgag gtggcaagag agactaagct actccatccg ttataacaac
      841 cttcccaaca tactcttgtc ccttgtccct atttcaaaat aaagtcagca tgtccttgca
      901 tatgtgaggt gctctgaca
//
