LOCUS       NM_008801               1379 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus phosphodiesterase 6D, cGMP-specific, rod, delta
            (Pde6d), transcript variant 1, mRNA.
ACCESSION   NM_008801 XM_905951 XM_919582 XM_919593
VERSION     NM_008801.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Collin GB, Gogna N, Chang B, Damkham N, Pinkney J, Hyde LF, Stone
            L, Naggert JK, Nishina PM and Krebs MP.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Ying G, Boldt K, Ueffing M, Gerstner CD, Frederick JM and Baehr W.
  TITLE     The small GTPase RAB28 is required for phagocytosis of cone outer
            segments by the murine retinal pigmented epithelium
  JOURNAL   J Biol Chem 293 (45), 17546-17558 (2018)
   PUBMED   30228185
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   Kosling SK, Fansa EK, Maffini S and Wittinghofer A.
  TITLE     Mechanism and dynamics of INPP5E transport into and inside the
            ciliary compartment
  JOURNAL   Biol Chem 399 (3), 277-292 (2018)
   PUBMED   29140789
  REMARK    GeneRIF: It postulates a three-step mechanism regulating ciliary
            localization of INPP5E, consisting of farnesylation- and
            PDE6delta-mediated targeting, INPP5E-PDE6delta complex diffusion
            into the cilium with transfer to the IFT system, and retention
            inside cilia.
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Fansa EK, Kosling SK, Zent E, Wittinghofer A and Ismail S.
  TITLE     PDE6delta-mediated sorting of INPP5E into the cilium is determined
            by cargo-carrier affinity
  JOURNAL   Nat Commun 7, 11366 (2016)
   PUBMED   27063844
  REMARK    GeneRIF: the affinity to PDE6delta and the release by Arl2/3 in
            addition to a retention signal are the determinants for cargo
            sorting and enrichment at its destination.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Zhang H, Frederick JM and Baehr W.
  TITLE     Unc119 gene deletion partially rescues the GRK1 transport defect of
            Pde6d (- /-) cones
  JOURNAL   Adv Exp Med Biol 801, 487-493 (2014)
   PUBMED   24664735
  REMARK    GeneRIF: Knockout of Unc119 partially reversed the transport defect
            of GRK1 in cone photoreceptors caused by deletion of Pde6d.
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Nancy V, Callebaut I, El Marjou A and de Gunzburg J.
  TITLE     The delta subunit of retinal rod cGMP phosphodiesterase regulates
            the membrane association of Ras and Rap GTPases
  JOURNAL   J Biol Chem 277 (17), 15076-15084 (2002)
   PUBMED   11786539
REFERENCE   7  (bases 1 to 1379)
  AUTHORS   Linari M, Hanzal-Bayer M and Becker J.
  TITLE     The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE
            delta, interacts with the Arf-like protein Arl3 in a GTP specific
            manner
  JOURNAL   FEBS Lett 458 (1), 55-59 (1999)
   PUBMED   10518933
REFERENCE   8  (bases 1 to 1379)
  AUTHORS   Linari M, Ueffing M, Manson F, Wright A, Meitinger T and Becker J.
  TITLE     The retinitis pigmentosa GTPase regulator, RPGR, interacts with the
            delta subunit of rod cyclic GMP phosphodiesterase
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1315-1320 (1999)
   PUBMED   9990021
REFERENCE   9  (bases 1 to 1379)
  AUTHORS   Lorenz B, Migliaccio C, Lichtner P, Meyer C, Strom TM, D'Urso M,
            Becker J, Ciccodicola A and Meitinger T.
  TITLE     Cloning and gene structure of the rod cGMP phosphodiesterase delta
            subunit gene (PDED) in man and mouse
  JOURNAL   Eur J Hum Genet 6 (3), 283-290 (1998)
   PUBMED   9781033
REFERENCE   10 (bases 1 to 1379)
  AUTHORS   Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA and Baehr W.
  TITLE     Characterization of human and mouse rod cGMP phosphodiesterase
            delta subunit (PDE6D) and chromosomal localization of the human
            gene
  JOURNAL   Genomics 49 (1), 76-82 (1998)
   PUBMED   9570951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158132.6 and AK141209.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_008801.4.
            
            On Feb 15, 2018 this sequence version replaced NM_008801.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005636.1, AK170067.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AC158132.6         129526-129804       c
            280-598             AK141209.1         2-320
            599-599             AC158132.6         93778-93778         c
            600-1379            AK141209.1         322-1101
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1379
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /note="phosphodiesterase 6D, cGMP-specific, rod, delta"
                     /db_xref="GeneID:18582"
                     /db_xref="MGI:MGI:1270843"
     exon            1..486
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
     CDS             437..889
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /EC_number="3.1.4.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic
                     phosphodiesterase subunit delta; GMP-PDE delta"
                     /codon_start=1
                     /product="retinal rod rhodopsin-sensitive cGMP
                     3',5'-cyclic phosphodiesterase subunit delta isoform 1"
                     /protein_id="NP_032827.1"
                     /db_xref="CCDS:CCDS15121.1"
                     /db_xref="GeneID:18582"
                     /db_xref="MGI:MGI:1270843"
                     /translation="MSAKDERARDILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVE
                     HEARVPKKILKCKAVSRELNFSSAEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNST
                     NTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSKVRLFYV"
     exon            487..575
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
     exon            576..701
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
     exon            702..807
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1379
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccactag tgtgcccggc aacaagagca ggcatctcaa acgcctctga agatttcaag
       61 ccatcgctcc tctgggacaa actctaggca acaacacgaa agaaaattct gtcctccggg
      121 actctccaag agggcctttc ccactgacgc tctccgtccc cgagcgaagc cgctgagcgt
      181 tgctattggc tactcaagat gccaatcgcc aaggctggct tgtcattggt ttcaaggcgg
      241 gagctccacg actagaggga aggagaaggg atcaggagcg ggagctgagg ggagggagag
      301 gccggttcgg gtctggccgc caccgctgtt cacctgaggt gtccggccgg gctgcggctg
      361 tcctcggttc ctgggtaccg tctgcgaggc cccgcggagc cagcgtggga gggccgcggg
      421 cggcaggcgc cgcatcatgt cagccaagga cgagcgggcc agggatatcc tgagaggctt
      481 caaactaaat tggatgaacc ttcgggatgc cgaaacaggg aagatactct ggcaaggaac
      541 agaagacctg tctgtccctg gtgtggaaca tgaagcccgt gtgcccaaga aaatcctcaa
      601 gtgcaaggca gtgtctcgag aattgaactt ttcttcagca gaacaaatgg aaaaattccg
      661 cctggaacaa aaagtttact tcaaaggaca atgcctagaa gagtggttct tcgagtttgg
      721 ctttgtgatc cctaactcca caaacacctg gcagtccttg atagaagcag cgcctgagtc
      781 ccagatgatg cccgccagcg tcctaacggg caatgtcatc atagagacaa agttctttga
      841 cgatgatctt cttgtcagca catccaaagt gaggcttttc tatgtttgag agaatttgtg
      901 tgcacttcta agaatttggc cgggggcagg aggaagctga acttgttctc tgcacacctg
      961 actgggatac tccagctgac tcactccttc aacacagaac ccacctgtgc accaggaaac
     1021 cagctctgaa tagacggcca gtggcttttc tcccaaaacc tccatcttca ctgacaagac
     1081 taaactccca accccagcca aaggcaggga taagcctcga ctccttcctg gcgcaaacat
     1141 gggaacaaac cctcccagga gccacgctgc gcctgtcacc tgcctgcctc ctccttgggc
     1201 cccacaggct ttctttagcc tctggttttg aaaaaatttt acctttctga cccatttagg
     1261 tttttcctac cacttgtatt tcatacattc tcataccttt aacttgtaaa atagactatg
     1321 atattattat tacataatgt aattaaggca ttaaaatatt cctacagtct ttagcatgc
//
