LOCUS       NM_001360817            1472 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus phosphodiesterase 6D, cGMP-specific, rod, delta
            (Pde6d), transcript variant 3, mRNA.
ACCESSION   NM_001360817
VERSION     NM_001360817.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1472)
  AUTHORS   Collin GB, Gogna N, Chang B, Damkham N, Pinkney J, Hyde LF, Stone
            L, Naggert JK, Nishina PM and Krebs MP.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1472)
  AUTHORS   Ying G, Boldt K, Ueffing M, Gerstner CD, Frederick JM and Baehr W.
  TITLE     The small GTPase RAB28 is required for phagocytosis of cone outer
            segments by the murine retinal pigmented epithelium
  JOURNAL   J Biol Chem 293 (45), 17546-17558 (2018)
   PUBMED   30228185
REFERENCE   3  (bases 1 to 1472)
  AUTHORS   Kosling SK, Fansa EK, Maffini S and Wittinghofer A.
  TITLE     Mechanism and dynamics of INPP5E transport into and inside the
            ciliary compartment
  JOURNAL   Biol Chem 399 (3), 277-292 (2018)
   PUBMED   29140789
  REMARK    GeneRIF: It postulates a three-step mechanism regulating ciliary
            localization of INPP5E, consisting of farnesylation- and
            PDE6delta-mediated targeting, INPP5E-PDE6delta complex diffusion
            into the cilium with transfer to the IFT system, and retention
            inside cilia.
REFERENCE   4  (bases 1 to 1472)
  AUTHORS   Fansa EK, Kosling SK, Zent E, Wittinghofer A and Ismail S.
  TITLE     PDE6delta-mediated sorting of INPP5E into the cilium is determined
            by cargo-carrier affinity
  JOURNAL   Nat Commun 7, 11366 (2016)
   PUBMED   27063844
  REMARK    GeneRIF: the affinity to PDE6delta and the release by Arl2/3 in
            addition to a retention signal are the determinants for cargo
            sorting and enrichment at its destination.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1472)
  AUTHORS   Zhang H, Frederick JM and Baehr W.
  TITLE     Unc119 gene deletion partially rescues the GRK1 transport defect of
            Pde6d (- /-) cones
  JOURNAL   Adv Exp Med Biol 801, 487-493 (2014)
   PUBMED   24664735
  REMARK    GeneRIF: Knockout of Unc119 partially reversed the transport defect
            of GRK1 in cone photoreceptors caused by deletion of Pde6d.
REFERENCE   6  (bases 1 to 1472)
  AUTHORS   Nancy V, Callebaut I, El Marjou A and de Gunzburg J.
  TITLE     The delta subunit of retinal rod cGMP phosphodiesterase regulates
            the membrane association of Ras and Rap GTPases
  JOURNAL   J Biol Chem 277 (17), 15076-15084 (2002)
   PUBMED   11786539
REFERENCE   7  (bases 1 to 1472)
  AUTHORS   Linari M, Hanzal-Bayer M and Becker J.
  TITLE     The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE
            delta, interacts with the Arf-like protein Arl3 in a GTP specific
            manner
  JOURNAL   FEBS Lett 458 (1), 55-59 (1999)
   PUBMED   10518933
REFERENCE   8  (bases 1 to 1472)
  AUTHORS   Linari M, Ueffing M, Manson F, Wright A, Meitinger T and Becker J.
  TITLE     The retinitis pigmentosa GTPase regulator, RPGR, interacts with the
            delta subunit of rod cyclic GMP phosphodiesterase
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1315-1320 (1999)
   PUBMED   9990021
REFERENCE   9  (bases 1 to 1472)
  AUTHORS   Lorenz B, Migliaccio C, Lichtner P, Meyer C, Strom TM, D'Urso M,
            Becker J, Ciccodicola A and Meitinger T.
  TITLE     Cloning and gene structure of the rod cGMP phosphodiesterase delta
            subunit gene (PDED) in man and mouse
  JOURNAL   Eur J Hum Genet 6 (3), 283-290 (1998)
   PUBMED   9781033
REFERENCE   10 (bases 1 to 1472)
  AUTHORS   Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA and Baehr W.
  TITLE     Characterization of human and mouse rod cGMP phosphodiesterase
            delta subunit (PDE6D) and chromosomal localization of the human
            gene
  JOURNAL   Genomics 49 (1), 76-82 (1998)
   PUBMED   9570951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158132.6, AK165701.1 and AK141209.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by
            NM_001360817.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (3) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1290916.1, AK165701.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               AC158132.6         129452-129804       c
            354-1057            AK165701.1         202-905
            1058-1060           AC158132.6         90443-90445         c
            1061-1462           AK165701.1         906-1307
            1463-1472           AK141209.1         1092-1101
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..1472
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /note="phosphodiesterase 6D, cGMP-specific, rod, delta"
                     /db_xref="GeneID:18582"
                     /db_xref="MGI:MGI:1270843"
     exon            1..486
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
     exon            487..668
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
     exon            669..794
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
     CDS             740..982
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /EC_number="3.1.4.17"
                     /note="isoform 3 is encoded by transcript variant 3;
                     retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic
                     phosphodiesterase subunit delta; GMP-PDE delta"
                     /codon_start=1
                     /product="retinal rod rhodopsin-sensitive cGMP
                     3',5'-cyclic phosphodiesterase subunit delta isoform 3"
                     /protein_id="NP_001347746.1"
                     /db_xref="GeneID:18582"
                     /db_xref="MGI:MGI:1270843"
                     /translation="MEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPE
                     SQMMPASVLTGNVIIETKFFDDDLLVSTSKVRLFYV"
     exon            795..900
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1472
                     /gene="Pde6d"
                     /gene_synonym="PrBP/delta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccactag tgtgcccggc aacaagagca ggcatctcaa acgcctctga agatttcaag
       61 ccatcgctcc tctgggacaa actctaggca acaacacgaa agaaaattct gtcctccggg
      121 actctccaag agggcctttc ccactgacgc tctccgtccc cgagcgaagc cgctgagcgt
      181 tgctattggc tactcaagat gccaatcgcc aaggctggct tgtcattggt ttcaaggcgg
      241 gagctccacg actagaggga aggagaaggg atcaggagcg ggagctgagg ggagggagag
      301 gccggttcgg gtctggccgc caccgctgtt cacctgaggt gtccggccgg gctgcggctg
      361 tcctcggttc ctgggtaccg tctgcgaggc cccgcggagc cagcgtggga gggccgcggg
      421 cggcaggcgc cgcatcatgt cagccaagga cgagcgggcc agggatatcc tgagaggctt
      481 caaactaaat tggatgaacc ttcgggatgc cgaaacaggg aagatactct ggcaaggaac
      541 agaagacctg tctgtccctg gtgtggaaca tgaaggtact ttgcagcccc ttgagtgtac
      601 aaactatgcc cactgccaga acagaccctg gcatcaagga gctaagtaag cacgcagcta
      661 ctagacagcc cgtgtgccca agaaaatcct caagtgcaag gcagtgtctc gagaattgaa
      721 cttttcttca gcagaacaaa tggaaaaatt ccgcctggaa caaaaagttt acttcaaagg
      781 acaatgccta gaagagtggt tcttcgagtt tggctttgtg atccctaact ccacaaacac
      841 ctggcagtcc ttgatagaag cagcgcctga gtcccagatg atgcccgcca gcgtcctaac
      901 gggcaatgtc atcatagaga caaagttctt tgacgatgat cttcttgtca gcacatccaa
      961 agtgaggctt ttctatgttt gagagaattt gtgtgcactt ctaagaattt ggccgggggc
     1021 aggaggaagc tgaacttgtt ctctgcacac ctgactggga tactccagct gactcactcc
     1081 ttcaacacag aacccacctg tgcaccagga aaccagctct gaatagacgg ccagtggctt
     1141 ttctcccaaa acctccatct tcactgacaa gactaaactc ccaaccccag ccaaaggcag
     1201 ggataagcct cgactccttc ctggcgcaaa catgggaaca aaccctccca ggagccacgc
     1261 tgcgcctgtc acctgcctgc ctcctccttg ggccccacag gctttcttta gcctctggtt
     1321 ttgaaaaaat tttacctttc tgacccattt aggtttttcc taccacttgt atttcataca
     1381 ttctcatacc tttaacttgt aaaatagact atgatattat tattacataa tgtaattaag
     1441 gcattaaaat attcctacag tctttagcat gc
//
