LOCUS       NM_033614               2964 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus phosphodiesterase 6C, cGMP specific, cone, alpha prime
            (Pde6c), transcript variant 1, mRNA.
ACCESSION   NM_033614
VERSION     NM_033614.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2964)
  AUTHORS   Seidemann,S., Salomon,F., Hoffmann,K.B., Kurth,T., Sbalzarini,I.F.,
            Haase,R. and Ader,M.
  TITLE     Automated quantification of photoreceptor outer segments in
            developing and degenerating retinas on microscopy images across
            scales
  JOURNAL   Front Mol Neurosci 17, 1398447 (2024)
   PUBMED   38854587
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2964)
  AUTHORS   Singh,S., Srivastava,D., Boyd,K. and Artemyev,N.O.
  TITLE     Reconstitution of the phosphodiesterase 6 maturation process
            important for photoreceptor cell function
  JOURNAL   J Biol Chem 300 (1), 105576 (2024)
   PUBMED   38110033
  REMARK    GeneRIF: Reconstitution of the phosphodiesterase 6 maturation
            process important for photoreceptor cell function.
REFERENCE   3  (bases 1 to 2964)
  AUTHORS   Bachu,V.S., Kandoi,S., Park,K.U., Kaufman,M.L., Schwanke,M.,
            Lamba,D.A. and Brzezinski,J.A. 4th.
  TITLE     An enhancer located in a Pde6c intron drives transient expression
            in the cone photoreceptors of developing mouse and human retinas
  JOURNAL   Dev Biol 488, 131-150 (2022)
   PUBMED   35644251
  REMARK    GeneRIF: An enhancer located in a Pde6c intron drives transient
            expression in the cone photoreceptors of developing mouse and human
            retinas.
REFERENCE   4  (bases 1 to 2964)
  AUTHORS   Brunet,A.A., Fuller-Carter,P.I., Miller,A.L., Voigt,V.,
            Vasiliou,S., Rashwan,R., Hunt,D.M. and Carvalho,L.S.
  TITLE     Validating Fluorescent Chrnb4.EGFP Mouse Models for the Study of
            Cone Photoreceptor Degeneration
  JOURNAL   Transl Vis Sci Technol 9 (9), 28 (2020)
   PUBMED   32879784
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2964)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2964)
  AUTHORS   Omori,K. and Kotera,J.
  TITLE     Overview of PDEs and their regulation
  JOURNAL   Circ Res 100 (3), 309-327 (2007)
   PUBMED   17307970
  REMARK    Review article
REFERENCE   7  (bases 1 to 2964)
  AUTHORS   Cheng,H., Aleman,T.S., Cideciyan,A.V., Khanna,R., Jacobson,S.G. and
            Swaroop,A.
  TITLE     In vivo function of the orphan nuclear receptor NR2E3 in
            establishing photoreceptor identity during mammalian retinal
            development
  JOURNAL   Hum Mol Genet 15 (17), 2588-2602 (2006)
   PUBMED   16868010
REFERENCE   8  (bases 1 to 2964)
  AUTHORS   Lei,B., Yao,G., Zhang,K., Hofeldt,K.J. and Chang,B.
  TITLE     Study of rod- and cone-driven oscillatory potentials in mice
  JOURNAL   Invest Ophthalmol Vis Sci 47 (6), 2732-2738 (2006)
   PUBMED   16723493
REFERENCE   9  (bases 1 to 2964)
  AUTHORS   Chang,B., Hawes,N.L., Hurd,R.E., Wang,J., Howell,D., Davisson,M.T.,
            Roderick,T.H., Nusinowitz,S. and Heckenlively,J.R.
  TITLE     Mouse models of ocular diseases
  JOURNAL   Vis Neurosci 22 (5), 587-593 (2005)
   PUBMED   16332269
REFERENCE   10 (bases 1 to 2964)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112153.4.
            
            On Jan 6, 2023 this sequence version replaced NM_033614.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF411063.1, SRR17784650.1291433.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-654               AC112153.4         132165-132818       c
            655-807             AC112153.4         125467-125619       c
            808-897             AC112153.4         125278-125367       c
            898-1038            AC112153.4         124083-124223       c
            1039-1113           AC112153.4         114928-115002       c
            1114-1178           AC112153.4         113996-114060       c
            1179-1245           AC112153.4         113827-113893       c
            1246-1293           AC112153.4         111849-111896       c
            1294-1443           AC112153.4         108056-108205       c
            1444-1587           AC112153.4         107032-107175       c
            1588-1656           AC112153.4         105809-105877       c
            1657-1803           AC112153.4         103553-103699       c
            1804-1911           AC112153.4         103209-103316       c
            1912-2021           AC112153.4         102720-102829       c
            2022-2109           AC112153.4         96126-96213         c
            2110-2210           AC112153.4         89855-89955         c
            2211-2318           AC112153.4         87435-87542         c
            2319-2382           AC112153.4         87269-87332         c
            2383-2457           AC112153.4         85510-85584         c
            2458-2541           AC112153.4         85336-85419         c
            2542-2698           AC112153.4         84658-84814         c
            2699-2964           AC112153.4         81647-81912         c
FEATURES             Location/Qualifiers
     source          1..2964
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 32.77 cM"
     gene            1..2964
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /note="phosphodiesterase 6C, cGMP specific, cone, alpha
                     prime"
                     /db_xref="GeneID:110855"
                     /db_xref="MGI:MGI:105956"
     exon            1..654
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..807
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..897
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1038
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1113
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1178
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1245
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1293
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1443
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1587
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1656
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1803
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1911
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2021
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2109
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2210
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2318
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2382
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2457
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2541
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2698
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2964
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2942..2947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /note="hexamer: AATAAA"
     polyA_site      2964
                     /gene="Pde6c"
                     /gene_synonym="cpfl1"
                     /note="major polyA site"
ORIGIN      
        1 cttgtgttac atacaggcag cttggaggaa ctactaaaca accttcctgc ttcacatagc
       61 cacctggggc ttccttggcg attttgacca ggatgtattt ccttggtatg gtgctcaggg
      121 tatcactctg agaaaccctc cactctgggt agcagcagca acacaagcca cagcatgggt
      181 gagatcagcc aagaggccgt ggagcgctac ctggagaaga acccttgttt tgccaaagag
      241 tattttgaca agaaactacg ggtggaggca ctgggggtga tcttcaaaaa cagccatgca
      301 ggggtccaga ccggcttgtc gctccctgag atgacacagg tggaggagtc ggccgtgtgc
      361 ctggagctac tgcagtgtat gcaggacgag gccggaagcg cggagcagat ggctcaccgg
      421 gcactgcaga ggctcgctca acttctgcag gctgattgct gcagtatgtt ctcgtgcaga
      481 gcaagaaacg gcataccaga ggtggcctcc aggctgctga acgtcacccc aacttctaag
      541 tttgaggaca acctcgtggc ccctgacaga gaagttgtat ttccgttgga cattgggata
      601 gttggctggg tcgctcatgt gaagaaagcc cttaatgtct cagatgtcaa aaagaacagc
      661 catttttctg actttatgga caagcaaact ggatatgtca ccaggaatct gctagcagtc
      721 ccgatcgtgg caggcaagga ggtccttgct gtggtcatgg cagtgaacaa aatcagcgct
      781 cccgagtttt ccaaacagga tgaggaggtc ttttctaagt acctcagctt tgttgctgtc
      841 gcactaaggc tgcagcacac cagttacctg tacagtgtgg agtcccggag aagccagatc
      901 cttatgtggt cagccaataa agtattcgaa gagctcactg atgttgagcg acagtttcac
      961 aaggcactgt acaccatcag gacgtacctg aactgcgatc gctactccat tggtcttctg
     1021 gacatgacca aggagaagga attttacgat gagtggccaa tcaagcttgg agaagttgag
     1081 ccttataaag gaccaaagac tccagatggc agggaaatca tcttctataa aatcatcgat
     1141 tacattttac atggaaaaga agagatcaac gtgattccgt cacctccagc agaccactgg
     1201 acgcttgtta gtggattgcc aacatacgtt gcagaaaatg gatttatctg taacatgctg
     1261 aatgcccctg cagatgagta cttcacattt cagaaaggac cggtagatga gactggctgg
     1321 gtcattaaaa atgtcttgtc cctgcctatt gtcaacaaga aagaagacat cgtgggtgta
     1381 gctacgtttt acaaccggaa ggatgggaaa ccctttgatg agcatgatga acatatcact
     1441 gagactttaa cccagtttct tggatggtct cttttaaaca ccgataccta tgagcgagtg
     1501 aacaagctgg aaagcagaaa ggacattgct caggaaatgg ttatgaacct cacaaaagcc
     1561 accccggatg aaatcagctc tattctgaag tttaaagaga agttaaatgt agaggtaatt
     1621 gaagagtgtg aagagagaca gctcctggcc atattgaagg aggacttgcc ggacccgaga
     1681 acagcagacc tgtacgagtt ctgtttcagc gacttcccca ttacggagca cgagttggtt
     1741 aaatgcgggc tgaggctgtt tttggagata aacgtggtgg agaaattcaa agtccctgta
     1801 gaggttctta caaggtggat gtacacagtc cggaaagggt accgtcctgt cacctaccac
     1861 aactggcggc acggattcaa cgtggggcag accatgttca ctttgttaat gacaggaaga
     1921 ctaaagaaat actatacaga ccttgaagcc tttgccatgc tcgctgctgc tttctgccat
     1981 gacattgacc acagaggcac caataacttg taccaaatga agtccacatc tccacttgca
     2041 aggcttcatg ggacttccat tttagagcga catcacctgg aatatagcaa gactctcttg
     2101 caggatgaga gtttaaacat cttccagaat ctaaacaagc ggcagtttga aacggtgatc
     2161 catttgttcg aggttgcaat aatagcaact gacctggcac tctatttcaa gaagagaacc
     2221 atgtttcaaa agatcgttga tacctgcgag cagatgcaaa gtgaagaaga aaccatcaaa
     2281 tacgtaacct ccgacccgac caaaaaggaa gtcatcatgg ccatgatgat gactgcctgt
     2341 gacctgtctg ccatcaccaa gccctgggag gtgcagagtc aggtagcact tctggttgca
     2401 aatgaatttt gggaacaagg agatctggaa agaacagtgc tgcagcagca accaattcct
     2461 atgatggaca gaagcaaaaa ggatgaactc ccgaaacttc aagtgggatt tattgatttt
     2521 gtttgtactt tcgtatataa ggagttctct cggtttcatg gagagatcac acccatgctg
     2581 aacggccttc agaataacag ggtggaatgg aaatccctgg cggaggagta cgaggcgaag
     2641 gtgaaggtga ctgaagaaga ggcgggaaag caggaagaag aagcctcaga tggaaaagct
     2701 gccacagatt taggaggcag cgccgaagac aaaaagtcca aaacatgctt aatgttataa
     2761 tctaactggt ctgtatttca agtatcatct tagtttccac gaaaaaaaaa catccaaaag
     2821 agcctccttg attgagttct gtccagtgac caagaagtga cagaagagga agagccccag
     2881 agattctgcc atgtgactac ccacagatta tccattgctg acctggaaac cctgtgagct
     2941 aaataaagtt tagtaaaaac aaaa
//
