LOCUS       NM_008806               2831 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus phosphodiesterase 6B, cGMP, rod receptor, beta
            polypeptide (Pde6b), mRNA.
ACCESSION   NM_008806
VERSION     NM_008806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2831)
  AUTHORS   McBride,M.A., Caja,K.R., Patil,T.K., Owen,A.M., Luan,L.,
            Bohannon,J.K., Hernandez,A., Stothers,C.L., Trenary,I.A., Rahim,M.,
            Young,J.D., Calcutt,M.W., Stephens,V.R., Davis,X., Oliver,M.A.,
            Hao,D., Si,C., McRae,M., Nguyen,K.K., Davis,N.S., Wang,J.,
            Patil,N.K. and Sherwood,E.R.
  TITLE     Immunoresponsive Gene 1 Facilitates TLR4-agonist-Induced
            Augmentation of Innate Antimicrobial Immunity
  JOURNAL   J Leukoc Biol (2024) In press
   PUBMED   39351765
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2831)
  AUTHORS   Schwammle,M.E., Bucher,F., Schlunck,G. and Martin,G.
  TITLE     Genotyping single point mutations in rd1 and rd8 mice using melting
            curve analysis of qPCR fragments
  JOURNAL   Sci Rep 14 (1), 19909 (2024)
   PUBMED   39198547
  REMARK    GeneRIF: a simple and effective PCR based method for genotyping rd1
            (Pde6b) and rd8 (Crb1) in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2831)
  AUTHORS   Ayten,M., Straub,T., Kaplan,L., Hauck,S.M., Grosche,A. and
            Koch,S.F.
  TITLE     CD44 signaling in Muller cells impacts photoreceptor function and
            survival in healthy and diseased retinas
  JOURNAL   J Neuroinflammation 21 (1), 190 (2024)
   PUBMED   39095775
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2831)
  AUTHORS   Sung,C.Y.W., Hayase,N., Yuen,P.S.T., Lee,J., Fernandez,K., Hu,X.,
            Cheng,H., Star,R.A., Warchol,M.E. and Cunningham,L.L.
  TITLE     Macrophage depletion protects against cisplatin-induced ototoxicity
            and nephrotoxicity
  JOURNAL   Sci Adv 10 (30), eadk9878 (2024)
   PUBMED   39047106
REFERENCE   5  (bases 1 to 2831)
  AUTHORS   Leinonen,H., Zhang,J., Occelli,L.M., Seemab,U., Choi,E.H., L P
            Marinho,L.F., Querubin,J., Kolesnikov,A.V., Galinska,A.,
            Kordecka,K., Hoang,T., Lewandowski,D., Lee,T.T., Einstein,E.E.,
            Einstein,D.E., Dong,Z., Kiser,P.D., Blackshaw,S., Kefalov,V.J.,
            Tabaka,M., Foik,A., Petersen-Jones,S.M. and Palczewski,K.
  TITLE     A combination treatment based on drug repurposing demonstrates
            mutation-agnostic efficacy in pre-clinical retinopathy models
  JOURNAL   Nat Commun 15 (1), 5943 (2024)
   PUBMED   39009597
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2831)
  AUTHORS   Drager,U.C. and Hubel,D.H.
  TITLE     Studies of visual function and its decay in mice with hereditary
            retinal degeneration
  JOURNAL   J Comp Neurol 180 (1), 85-114 (1978)
   PUBMED   649791
REFERENCE   7  (bases 1 to 2831)
  AUTHORS   Carter-Dawson,L.D., LaVail,M.M. and Sidman,R.L.
  TITLE     Differential effect of the rd mutation on rods and cones in the
            mouse retina
  JOURNAL   Invest Ophthalmol Vis Sci 17 (6), 489-498 (1978)
   PUBMED   659071
REFERENCE   8  (bases 1 to 2831)
  AUTHORS   Blanks,J.C. and Bok,D.
  TITLE     An autoradiographic analysis of postnatal cell proliferation in the
            normal and degenerative mouse retina
  JOURNAL   J Comp Neurol 174 (2), 317-327 (1977)
   PUBMED   864040
REFERENCE   9  (bases 1 to 2831)
  AUTHORS   LaVail,M.M. and Mullen,R.J.
  TITLE     Role of the pigment epithelium in inherited retinal degeneration
            analyzed with experimental mouse chimeras
  JOURNAL   Exp Eye Res 23 (2), 227-245 (1976)
   PUBMED   976367
REFERENCE   10 (bases 1 to 2831)
  AUTHORS   Womack,J.E., Hawes,N.L., Soares,E.R. and Roderick,T.H.
  TITLE     Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to
            chromosome 5 markers
  JOURNAL   Biochem Genet 13 (9-10), 519-525 (1975)
   PUBMED   1203052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU505563.1, AK044364.1 and BE944318.1.
            
            On Sep 2, 2006 this sequence version replaced NM_008806.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044364.1, X55968.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BU505563.1         1-58
            59-2812             AK044364.1         2-2755
            2813-2831           BE944318.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2831
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.07 cM"
     gene            1..2831
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /note="phosphodiesterase 6B, cGMP, rod receptor, beta
                     polypeptide"
                     /db_xref="GeneID:18587"
                     /db_xref="MGI:MGI:97525"
     exon            1..535
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2638
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /EC_number="3.1.4.35"
                     /note="cGMP-phosphodiesterase beta-subunit; GMP-PDE beta;
                     retinal degeneration 1; phosphodiesterase, cGMP, rod
                     receptor, beta polypeptide"
                     /codon_start=1
                     /product="rod cGMP-specific 3',5'-cyclic phosphodiesterase
                     subunit beta"
                     /protein_id="NP_032832.2"
                     /db_xref="CCDS:CCDS19510.1"
                     /db_xref="GeneID:18587"
                     /db_xref="MGI:MGI:97525"
                     /translation="MSLSEEQVRSFLDGNPTFAHQYFGKKLSPENVAGACEDGWLADC
                     GSLRELCQVEESAALFELVQDMQESVNMERVVFKILRRLCTILHADRCSLFMYRQRNG
                     IAELATRLFSVQPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHF
                     SSFADELTDYVTKNILSTPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFATL
                     NLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVG
                     LLDMTKEKEFFDVWPVLMGEAQPYSGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPP
                     ADHWALASGLPTYVAESGFICNIMNASADEMFNFQEGPLDDSGWVIKNVLSMPIVNKK
                     EEIVGVATFYNRKDGKPFDDQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQD
                     MVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILKEELPGPTKFDIYEFHFSD
                     LECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGFNVA
                     QTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSI
                     LERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKI
                     VDESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEF
                     WEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFD
                     RLQNNRKEWKALADEYEAKVKALEEEKKKEEDRVAAKKVGTEVCNGGPAPKSSTCCIL
                     "
     exon            536..688
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            689..778
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            779..919
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            920..994
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1059
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1126
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1174
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1324
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1468
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1534
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1681
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1789
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1899
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1987
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2088
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2196
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2260
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2335
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2419
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2576
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2817
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde6b"
                     /gene_synonym="Pdeb; r; rd; rd-1; rd1; rd10"
                     /note="putative"
ORIGIN      
        1 acagggtttg cagaatccat gtgtacctgg gggtggagaa agccccgggc acagcagcag
       61 gaacaccatg agcctcagtg aggaacaggt acgcagcttc ctggatggga accccacgtt
      121 tgcccatcaa tactttggga agaagttgag ccctgaaaat gtggcagggg cctgtgaaga
      181 tggttggctg gcggactgtg gcagcctgcg agagctgtgc caggtggaag agagtgcagc
      241 actttttgaa ctggtgcagg acatgcagga gagtgtcaat atggaacgtg tggtcttcaa
      301 gatcctgcgg cgcctctgca ccatcctgca tgccgaccgc tgcagcctct ttatgtaccg
      361 ccagcgcaat ggcatagctg aacttgctac gcggctcttc agcgtgcagc ctgacagcct
      421 tctggaggat tgcctggtgc cccctgactc tgagatcgtc ttccccctgg acattgggat
      481 tgtgggccat gtggctcaga ccaagaagat gataaacgtg caggatgtgg cagagtgtcc
      541 ccacttcagc tcattcgccg atgagctcac cgactatgtg acaaagaaca ttttgtccac
      601 accaatcatg aatggcaaag atgtcgtggc tgtgatcatg gcagtgaata aactggatgg
      661 cccatgcttc acgagtgaag atgaagatgt tttcacgaag tacctgaatt ttgctacatt
      721 aaacctgaag atctatcacc taagctacct ccacaactgt gagacacgca gaggccaggt
      781 gctcctctgg tcagccaata aggtgtttga agagctgaca gacatcgaaa gacagttcca
      841 caaggccttc tatactgtcc gggcctatct aaactgcgaa cggtattcag tgggcctcct
      901 ggacatgacc aaggagaagg agttctttga tgtgtggcct gtgctgatgg gagaagccca
      961 gccatactca ggcccacgaa cacctgatgg ccgggaaatt gtcttctaca aagtcatcga
     1021 ttatatcctc cacggcaaag aagacatcaa agtcattccc acacccccgg ctgatcactg
     1081 ggccctggcc agtggccttc caacctacgt agcagaaagt ggctttatct gtaacatcat
     1141 gaatgcttca gctgatgaaa tgttcaactt tcaggagggg cccctggatg attcaggatg
     1201 ggtgatcaag aatgtcctct ctatgcccat tgtcaacaag aaagaggaga ttgtgggggt
     1261 ggcaaccttc tacaacagga aagatggaaa gcccttcgat gatcaagatg aagtccttat
     1321 ggagtctctg acacagttcc tggggtggtc agtgctgaac acagacacct atgacaagat
     1381 gaacaagctg gagaaccgta aggacatcgc ccaggacatg gttctgtacc atgtgagatg
     1441 tgacaaagat gaaatccagg aaatcctgcc aacaagggat cgccttggga aagagcctgc
     1501 tgactgtgag gaggatgagc tggggaaaat cttgaaggaa gaacttccag ggccgaccaa
     1561 gtttgacatc tatgagttcc acttctctga tctggagtgt acagagctgg agctagtcaa
     1621 atgtggcatc cagatgtact atgagctggg tgtagtccga aagttccaga ttccccagga
     1681 ggtcttggtg cgctttctat tctctgtcag caaagcctat cgaagaatca cctaccacaa
     1741 ctggcgccac ggcttcaatg tagcccagac catgtttacc ctactcatga caggcaaact
     1801 gaagagctat tacactgacc tagaggcctt cgccatggtt acagctggct tgtgccacga
     1861 catcgaccac cgtggcacca acaacctgta ccagatgaaa tcgcagaatc ctctagccaa
     1921 gttacatggc tcctcaattc tggaaaggca ccacctggaa tttgggaagt ttctgttggc
     1981 agaggagagc ctgaacatct atcagaacct gaaccggcgg cagcatgaac atgtgatcca
     2041 cctcatggac attgccatca ttgccaccga cctggccctc tacttcaaga agagaacaat
     2101 gttccagaag attgtggatg agtctaagaa ctatgaagat aagaagagtt gggttgagta
     2161 cttatcctta gagaccacac gaaaggagat agtcatggcc atgatgatga ctgcatgtga
     2221 cctgtctgct atcaccaaac cctgggaagt ccagagcaag gttgctcttc tggtggctgc
     2281 tgagttctgg gaacaggggg acttggagag gactgtcttg gatcaacagc ccattcccat
     2341 gatggaccgg aacaaagcag ctgagctccc taagctgcaa gttggtttca ttgacttcgt
     2401 atgtactttc gtatacaagg aattttctcg atttcacgaa gagatcctgc ccatgtttga
     2461 ccgactgcaa aataacagaa aggagtggaa agcactagct gacgagtatg aggccaaagt
     2521 caaggccctg gaggaagaaa agaagaagga agaagacaga gtcgcagcca agaaagtggg
     2581 cacagaagtt tgcaatggtg gtccagcacc caagtcctcg acctgctgta tcctataagc
     2641 cgtgtttcat ggctttgggt ccctcctgcc actcacccac tgcatacgga ctctgcctat
     2701 agcaatttgg tataagccat taggaacagg aaaaaaaaaa agatcgaatg taactttgga
     2761 tattttgaaa ttttaaaggt gtttttacaa attaaaaaca actatgaata agttaaaaaa
     2821 aaaaaaaaaa a
//
