LOCUS       NM_146086               4255 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus phosphodiesterase 6A, cGMP-specific, rod, alpha
            (Pde6a), mRNA.
ACCESSION   NM_146086 NM_008805 XM_001005843
VERSION     NM_146086.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4255)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4255)
  AUTHORS   Morshedian,A., Sendek,G., Ng,S.Y., Boyd,K., Radu,R.A., Liu,M.,
            Artemyev,N.O., Sampath,A.P. and Fain,G.L.
  TITLE     Reproducibility of the Rod Photoreceptor Response Depends
            Critically on the Concentration of the Phosphodiesterase Effector
            Enzyme
  JOURNAL   J Neurosci 42 (11), 2180-2189 (2022)
   PUBMED   35091503
REFERENCE   3  (bases 1 to 4255)
  AUTHORS   Yadav,R.P., Boyd,K. and Artemyev,N.O.
  TITLE     Molecular insights into the maturation of phosphodiesterase 6 by
            the specialized chaperone complex of HSP90 with AIPL1
  JOURNAL   J Biol Chem 298 (3), 101620 (2022)
   PUBMED   35065964
REFERENCE   4  (bases 1 to 4255)
  AUTHORS   Rowe,A.A., Patel,P.D., Gordillo,R. and Wert,K.J.
  TITLE     Replenishment of TCA cycle intermediates provides photoreceptor
            resilience against neurodegeneration during progression of
            retinitis pigmentosa
  JOURNAL   JCI Insight 6 (17), e150898 (2021)
   PUBMED   34292885
  REMARK    GeneRIF: Replenishment of TCA cycle intermediates provides
            photoreceptor resilience against neurodegeneration during
            progression of retinitis pigmentosa.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4255)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4255)
  AUTHORS   Johnson,K.R. and Davisson,M.T.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
REFERENCE   7  (bases 1 to 4255)
  AUTHORS   Danciger,M., Kozak,C.A., Adamson,M.C. and Farber,D.B.
  TITLE     Chromosomal localization of the murine genes for the alpha- and
            beta-subunits of calcium/calmodulin-dependent protein kinase II
  JOURNAL   Mamm Genome 3 (2), 122-125 (1992)
   PUBMED   1319776
REFERENCE   8  (bases 1 to 4255)
  AUTHORS   Baehr,W., Champagne,M.S., Lee,A.K. and Pittler,S.J.
  TITLE     Complete cDNA sequences of mouse rod photoreceptor cGMP
            phosphodiesterase alpha- and beta-subunits, and identification of
            beta'-, a putative beta-subunit isozyme produced by alternative
            splicing of the beta-subunit gene
  JOURNAL   FEBS Lett 278 (1), 107-114 (1991)
   PUBMED   1847109
REFERENCE   9  (bases 1 to 4255)
  AUTHORS   Sikela,J.M., Adamson,M.C., Wilson-Shaw,D. and Kozak,C.A.
  TITLE     Genetic mapping of the gene for Ca2+/calmodulin-dependent protein
            kinase IV (Camk-4) to mouse chromosome 18
  JOURNAL   Genomics 8 (3), 579-582 (1990)
   PUBMED   1981056
REFERENCE   10 (bases 1 to 4255)
  AUTHORS   Li,T.S., Volpp,K. and Applebury,M.L.
  TITLE     Bovine cone photoreceptor cGMP phosphodiesterase structure deduced
            from a cDNA clone
  JOURNAL   Proc Natl Acad Sci U S A 87 (1), 293-297 (1990)
   PUBMED   2153291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121903.2 and BC044892.1.
            
            On Jul 20, 2018 this sequence version replaced NM_146086.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044892.1, X60664.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC121903.2         136432-136456       c
            26-4255             BC044892.1         1-4230
FEATURES             Location/Qualifiers
     source          1..4255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..4255
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /note="phosphodiesterase 6A, cGMP-specific, rod, alpha"
                     /db_xref="GeneID:225600"
                     /db_xref="MGI:MGI:97524"
     exon            1..605
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..2714
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /EC_number="3.1.4.35"
                     /note="GMP-PDE alpha"
                     /codon_start=1
                     /product="rod cGMP-specific 3',5'-cyclic phosphodiesterase
                     subunit alpha"
                     /protein_id="NP_666198.1"
                     /db_xref="CCDS:CCDS29283.1"
                     /db_xref="GeneID:225600"
                     /db_xref="MGI:MGI:97524"
                     /translation="MGEVTAEEVEKFLDSNIGFAKQYYNFHYRGKVISDLLGAKEAAV
                     DFSNYHDVNSVEESEIIFDLLRDVQENLQAEKCTFNVMKKLCFLLRADRMSLFMYRTR
                     NGIAELATRLFNVHKDAVLEDCLVMPDSEIVFPLDMGVVGHVAHSKKIANVPNTEEDE
                     HFCDFVDNLTEYQTKNILASPIMNGKDVVAIIMAVNKIDEPHFTKRDEEILLKYLNFV
                     NLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYS
                     VGLLDMTKQKEFFDVWPVLMGEAPAYSGPRTPDGREINFYKVIDYILHGKEDIKVIPN
                     PPADHWALVSGLPTYVAQNGLICNIMNAPAEDFFEFQKEPLDESGWMIKNVLSMPIVN
                     KKEEIVGVATFYNRKDGKPFDDMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIF
                     QDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQGELPDAESYEINKFHF
                     SDLPLTELELVKCGIQMYYELRVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFN
                     VGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGS
                     SILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQ
                     KIVDQSKTYESTQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAA
                     EFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPM
                     LDGITNNRKEWKALADEYEAKMKALEEEKQKQQAAKQAASGNQPGGNPTPGGAPASKS
                     CCIQ"
     exon            606..758
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            759..848
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            849..989
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1064
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1129
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1196
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1244
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1394
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1538
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1604
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1751
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1859
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1969
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2057
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2158
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2266
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2330
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2405
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2489
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2637
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..4255
                     /gene="Pde6a"
                     /gene_synonym="nmf282; Pdea"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatttgcaga caagacccag agaacctcag attgacgtgg ggcctattga actcaatttg
       61 cttggaaact gcccaggaaa ggctgagagc ctgaaccccc tccttgggag cagctaaagg
      121 gagtcttcac catgggtgag gtgacagcag aggaggtaga aaagttcctg gattcaaata
      181 ttggctttgc caaacagtac tataactttc actaccgggg gaaggtcatc tcagacctcc
      241 tcggggccaa ggaggcagcc gtggacttca gcaactacca cgatgtgaac agcgtagagg
      301 agagtgagat catctttgac ctcctgcggg acgttcagga gaacttacag gctgagaaat
      361 gcacattcaa tgtcatgaag aagctctgct tcctcctgcg ggctgaccgc atgagcctgt
      421 tcatgtacag gacccgcaac gggatcgccg agttggccac taggctcttc aatgtccaca
      481 aggatgccgt cctagaggac tgcttggtga tgcccgactc cgagattgtc ttccctctgg
      541 acatgggtgt cgtgggccac gtcgcacact ccaaaaagat tgccaatgtc cccaacacag
      601 aagaggatga gcatttctgt gacttcgtgg acaatctcac agaatatcag accaaaaaca
      661 tcctggcttc ccccatcatg aatgggaagg atgtggtagc cataatcatg gctgtgaata
      721 aaatagatga accccacttc accaagagag atgaagagat tcttctcaag tacctcaact
      781 ttgtgaacct gatcatgaag gtattccacc tgagctacct gcacaactgt gagactcgtc
      841 gcggccagat attgctgtgg tctgggagca aggtctttga ggagctcacg gatatagaga
      901 ggcagttcca caaggccctg tacacggtcc gggctttcct caactgtgac agatactccg
      961 taggactctt agacatgacc aaacagaagg aattttttga tgtgtggcca gttctgatgg
     1021 gcgaggctcc agcttactct ggtcccagga ctccagacgg aagggaaatt aacttctaca
     1081 aggtcattga ctacatcctg cacggcaaag aagacatcaa agtcatcccg aacccacccg
     1141 ctgaccactg ggctctagtg agtggtctcc ccacttacgt ggctcaaaat ggtctgatct
     1201 gcaatataat gaatgcgcct gcagaggact tttttgaatt ccagaaagag cctctggatg
     1261 agtctgggtg gatgattaaa aatgtactct ccatgcccat cgtcaacaag aaggaagaga
     1321 tcgtcggcgt ggccacattt tacaaccgca aagatgggaa gcccttcgac gatatggacg
     1381 agaccctcat ggagtctttg actcagtttc tgggatggtc agtcttaaac cctgacacct
     1441 acgagtccat gaacaagctc gagaacagga aggatatctt ccaggacatc gtgaaatatc
     1501 acgtgaagtg tgataacgaa gaaatccaga agatcttgaa aaccagagag gtgtacggca
     1561 aagagccgtg ggaatgcgag gaggaggagc tggctgagat cctgcaagga gaacttccag
     1621 acgcggagtc atacgaaatc aacaagttcc acttcagcga cctgccactc acggagctgg
     1681 agctggtgaa gtgcggcatc cagatgtact acgagctcag agtggtggac aagttccaca
     1741 tcccgcaaga ggccctggtg cgcttcatgt attcgctaag caaaggctac cggagaatca
     1801 cttaccacaa ctggcggcat ggcttcaacg tggggcagac catgttctcc ttgctggtga
     1861 caggaaagct gaaacggtac ttcactgatc tagaggcctt ggccatggtc actgctgcct
     1921 tctgtcatga catcgaccac agaggcacga acaacctcta ccagatgaaa tcacagaacc
     1981 ccctggccaa gctccatggg tcctccatct tggaaaggca tcatttggag tttggcaaaa
     2041 cactcctgag agatgagagc ctgaatatct tccagaacct gaatcgccgg cagcatgagc
     2101 acgcgatcca catgatggac atcgcgatca ttgccacaga ccttgccttg tatttcaaga
     2161 aaaggaccat gttccagaag attgtggatc agtcaaagac atatgagagt acccaggagt
     2221 ggacccagta catgatgctg gagcagacac ggaaggaaat tgtgatggcc atgatgatga
     2281 ccgcctgtga tctctcagcc atcaccaaac cctgggaggt acagagcaag gtggctctgc
     2341 tggtggctgc tgaattctgg gagcaaggtg acctggagcg cacagtgctg cagcagaatc
     2401 ccattcccat gatggacaga aacaaggcgg atgagctccc caagcttcaa gtcggcttca
     2461 tcgactttgt gtgcactttt gtctataagg agttctcccg atttcatgag gagattacac
     2521 ccatgctgga tgggatcact aacaaccgca aggaatggaa ggcgctggct gatgagtacg
     2581 aagccaagat gaaggccctg gaggaggaga agcagaagca gcaggcagcc aagcaagctg
     2641 cttccgggaa ccagccagga gggaacccca ctccaggggg tgcacctgca tctaagtcct
     2701 gttgcatcca gtagctgact gcactgcgag cagggggcac agccctcagg aaggaggagg
     2761 tcaccctggc actggacagt taaagaacca ggagcttgga agtggtggca aacacagcag
     2821 gcatctatat catcaaatgg tcttagacat tggttctgtt ctgttctgtt ctgttctgtt
     2881 ctgttctgtt ctgttctgtt ctgttctgtt ctgttctgtc ctgtcctgtt ctgttctgtt
     2941 ttagacagct ctggctggcc tggaactctc tatgtagact gggctggcct caaactcaca
     3001 ggcctccacc tgcctctgtg tcctgagttc tgagttaata agcaagcacc atcacacagg
     3061 gcttagagat tgtgtttaat tctaaaaagt ctatcgagtc tagcctaata ttctagactt
     3121 catatactga cttgataatt ttttgttctt ataatgcttg taattcttat aagcttttta
     3181 aacttagtgt tttattataa aagtgttcgc taattcccaa aagtacagaa ttatacatca
     3241 aatacccaca aacttacccc agatttgaac atcaagctct ggtcatgtat acttcatgtg
     3301 tcttcacgtt ccttttcaat ttctctctcc cttttctcct tcatctagtc ctccctccct
     3361 ccttccccct acttcctccc tccctccttc ccttccttcc ttcctttctg attcccacca
     3421 tgtagtccca tgaagcccca gcttgcttta aactctccat ccactgacct ctatgttcac
     3481 taccaccctt ggcttagccg agctatttat gaaaaatttc catacacatg gcttcactcc
     3541 tccacagtct ttagagttta tgtatcttta caggaataag cagcatcttt aaaggtcacg
     3601 catcttatgt ggtagcacat tcgggcaatc ccagcactag gaaaagagag agggggaggt
     3661 caggagtttc aaaggtctca gtctatacaa cacgaccaaa cctcaagggg aaagttaccc
     3721 atccttaaag gaacagagct ttttctagca caacactgtc acacggaagt gaaggcttca
     3781 cacccagctg tggagtaaat tcagatgagc cacaaacgga ggactcagag gactgggggg
     3841 tggggtggag gggtgggggt ggggcttcag cagacatcgc cttcaggggt ttcctcagct
     3901 gcaggatatt ctgcattttt cagggggatc tatgcctgag atggacaagt atggtcacgt
     3961 tgcctaacct ggatcaactg tggaaggcca gtccaactcc aggttagagc ctgtttccta
     4021 ggaaacccag ctgtgatgaa aactcagaat caaggacccc tatggtccca aaactcttta
     4081 agagattatt tgtgctgggg gtggtagtcc cagcatgcag gaggtagagg caagagcatg
     4141 tccgtaaatt ccaggccagc ctggtttaca cagaaagttc caggctgggc tacagtatgc
     4201 taccttgttt caaacaaggg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
