LOCUS       NM_001402883            7476 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Mus musculus phosphodiesterase 4D, cAMP specific (Pde4d),
            transcript variant 2, mRNA.
ACCESSION   NM_001402883 XM_006517643
VERSION     NM_001402883.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7476)
  AUTHORS   Dorey,T.W., McRae,M.D., Belke,D.D. and Rose,R.A.
  TITLE     PDE4D mediates impaired beta-adrenergic receptor signalling in the
            sinoatrial node in mice with hypertensive heart disease
  JOURNAL   Cardiovasc Res 119 (17), 2697-2711 (2023)
   PUBMED   37643895
  REMARK    GeneRIF: PDE4D mediates impaired beta-adrenergic receptor
            signalling in the sinoatrial node in mice with hypertensive heart
            disease.
REFERENCE   2  (bases 1 to 7476)
  AUTHORS   Paes,D., Schepers,M., Willems,E., Rombaut,B., Tiane,A.,
            Solomina,Y., Tibbo,A., Blair,C., Kyurkchieva,E., Baillie,G.S.,
            Ricciarelli,R., Brullo,C., Fedele,E., Bruno,O., van den Hove,D.,
            Vanmierlo,T. and Prickaerts,J.
  TITLE     Ablation of specific long PDE4D isoforms increases neurite
            elongation and conveys protection against amyloid-beta pathology
  JOURNAL   Cell Mol Life Sci 80 (7), 178 (2023)
   PUBMED   37306762
  REMARK    GeneRIF: Ablation of specific long PDE4D isoforms increases neurite
            elongation and conveys protection against amyloid-beta pathology.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7476)
  AUTHORS   Tao,X., Chen,C., Huang,Z., Lei,Y., Wang,M., Wang,S. and Tian,D.
  TITLE     Genetic deletion of phosphodiesterase 4D in the liver improves
            kidney damage in high-fat fed mice: liver-kidney crosstalk
  JOURNAL   Cell Death Dis 14 (4), 273 (2023)
   PUBMED   37072403
  REMARK    GeneRIF: Genetic deletion of phosphodiesterase 4D in the liver
            improves kidney damage in high-fat fed mice: liver-kidney
            crosstalk.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7476)
  AUTHORS   Martinez,J.M., Shen,A., Xu,B., Jovanovic,A., de Chabot,J., Zhang,J.
            and Xiang,Y.K.
  TITLE     Arrestin-dependent nuclear export of phosphodiesterase 4D promotes
            GPCR-induced nuclear cAMP signaling required for learning and
            memory
  JOURNAL   Sci Signal 16 (778), eade3380 (2023)
   PUBMED   36976866
  REMARK    GeneRIF: Arrestin-dependent nuclear export of phosphodiesterase 4D
            promotes GPCR-induced nuclear cAMP signaling required for learning
            and memory.
REFERENCE   5  (bases 1 to 7476)
  AUTHORS   Pei,L., Xu,X. and Yuan,T.
  TITLE     Circ_0101874 overexpression strengthens PDE4D expression by
            targeting miR-335-5p to promote neuronal injury in ischemic stroke
  JOURNAL   J Stroke Cerebrovasc Dis 31 (12), 106817 (2022)
   PUBMED   36252429
  REMARK    GeneRIF: Circ_0101874 overexpression strengthens PDE4D expression
            by targeting miR-335-5p to promote neuronal injury in ischemic
            stroke.
REFERENCE   6  (bases 1 to 7476)
  AUTHORS   MacKenzie,S.J., Yarwood,S.J., Peden,A.H., Bolger,G.B., Vernon,R.G.
            and Houslay,M.D.
  TITLE     Stimulation of p70S6 kinase via a growth hormone-controlled
            phosphatidylinositol 3-kinase pathway leads to the activation of a
            PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A
            preadipocytes
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3549-3554 (1998)
   PUBMED   9520403
REFERENCE   7  (bases 1 to 7476)
  AUTHORS   Seymour,A.B., Yanak,B.L., O'Brien,E.P., Rusiniak,M.E., Novak,E.K.,
            Pinto,L.H., Swank,R.T. and Gorin,M.B.
  TITLE     An integrated genetic map of the pearl locus of mouse chromosome 13
  JOURNAL   Genome Res 6 (6), 538-544 (1996)
   PUBMED   8828042
REFERENCE   8  (bases 1 to 7476)
  AUTHORS   Cherry,J.A. and Davis,R.L.
  TITLE     A mouse homolog of dunce, a gene important for learning and memory
            in Drosophila, is preferentially expressed in olfactory receptor
            neurons
  JOURNAL   J Neurobiol 28 (1), 102-113 (1995)
   PUBMED   8586960
REFERENCE   9  (bases 1 to 7476)
  AUTHORS   Milatovich,A., Bolger,G., Michaeli,T. and Francke,U.
  TITLE     Chromosome localizations of genes for five cAMP-specific
            phosphodiesterases in man and mouse
  JOURNAL   Somat Cell Mol Genet 20 (2), 75-86 (1994)
   PUBMED   8009369
REFERENCE   10 (bases 1 to 7476)
  AUTHORS   Repaske,D.R., Swinnen,J.V., Jin,S.L., Van Wyk,J.J. and Conti,M.
  TITLE     A polymerase chain reaction strategy to identify and clone cyclic
            nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA
            encoding the 63-kDa calmodulin-dependent phosphodiesterase
  JOURNAL   J Biol Chem 267 (26), 18683-18688 (1992)
   PUBMED   1326532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102805.6, AC161585.2 and AC163650.2.
            
            On Mar 23, 2022 this sequence version replaced XM_006517643.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.48928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-884               AC102805.6         15156-16039         c
            885-1076            AC161585.2         163553-163744
            1077-1113           AC161585.2         180743-180779
            1114-1187           AC161585.2         192700-192773
            1188-1237           AC161585.2         195797-195846
            1238-1350           AC163650.2         124578-124690
            1351-1444           AC163650.2         154869-154962
            1445-1617           AC163650.2         156307-156479
            1618-1716           AC163650.2         157678-157776
            1717-1881           AC163650.2         158968-159132
            1882-1981           AC163650.2         160263-160362
            1982-2136           AC163650.2         169241-169395
            2137-2259           AC163650.2         170415-170537
            2260-2442           AC163650.2         171210-171392
            2443-7476           AC163650.2         171932-176965
FEATURES             Location/Qualifiers
     source          1..7476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 59.69 cM"
     gene            1..7476
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /note="phosphodiesterase 4D, cAMP specific"
                     /db_xref="GeneID:238871"
                     /db_xref="MGI:MGI:99555"
     exon            1..884
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..2856
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /EC_number="3.1.4.53"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cAMP-specific 3',5'-cyclic phosphodiesterase 4D; dunce;
                     cyclic AMP specific phosphodiesterase PDE4D5A;
                     cAMP-specific phosphodiesterase 4D; 3',5'-cyclic-AMP
                     phosphodiesterase 4D"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 4D isoform 2"
                     /protein_id="NP_001389812.1"
                     /db_xref="GeneID:238871"
                     /db_xref="MGI:MGI:99555"
                     /translation="MEAEGSSVPARAVSEEGNDSAGGAALKAPKHLWRHEQHHQYPLR
                     QPQFRLLHPHHHLPPPPPPSPQPQLQPPPPPPLPPPPPPPGATRGRYASSGASRVRHR
                     GYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSP
                     LDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIV
                     TPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETL
                     EELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLD
                     KQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKE
                     LEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHY
                     HADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQF
                     LINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVL
                     ATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQ
                     LYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWA
                     DLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEEGRQGQTEKFQFELTLEEDCE
                     SDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPETCVPDD
                     CCPDT"
     exon            885..1076
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1113
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1187
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1237
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1350
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1444
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1617
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1716
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1881
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1981
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2136
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2259
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2442
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..7476
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6135..6140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /note="hexamer: ATTAAA"
     polyA_site      6180
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
     regulatory      6950..6955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /note="hexamer: AATAAA"
     polyA_site      6975
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /note="major polyA site"
     regulatory      7450..7455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /note="hexamer: AATAAA"
     polyA_site      7476
                     /gene="Pde4d"
                     /gene_synonym="9630011N22Rik; Dpde3"
                     /note="major polyA site"
ORIGIN      
        1 agagctccag ctggtcagtc gggagctgtc caacttttca gcagctctga gatccaggtt
       61 caggtgcccg gactcaagag aaggctactg ctgcgaagag cagattctat agagctagct
      121 gccaacagtc cctaatctca gcggaggaac gaagagaaaa gagaggggaa aaagaaaccg
      181 accatcagag aagcctcgcc tgccaatctt ggttacttgg gagcatccag cgcgcctttc
      241 tgcctctgct acggagcaag gatccctgtg gcgatcgctc ccgctaacag agccccctct
      301 cggtggccag gagcctctga ccgctacaag tcggaagctg agcccagcct ctggcgcctc
      361 ggcaagcggc ggcagcagga gccgggaggc gctcaggctg gtgtggtgga cccggcgggg
      421 cagcggggca cagagccggc caggatggag gcagagggca gcagcgtgcc ggcccgggcg
      481 gtcagcgaag agggcaatga cagcgctggc ggggccgctc tcaaagcccc taagcatctc
      541 tggaggcacg agcagcacca ccagtacccg ctccggcagc cccagttccg cctcttgcac
      601 ccccatcacc acctgccccc gccgccgcca ccctcgcccc agccccagct gcagccaccg
      661 ccaccgcccc cactgccacc acccccgcca ccacccggag ctacccgtgg tcgctacgcc
      721 tcaagcgggg ccagccgcgt ccggcaccgc ggctactcgg acaccgagcg ctacctgtac
      781 tgccgtgcca tggaccgcac ctcctacgcg gtggagacag gtcaccggcc gggcctgaag
      841 aaatctagga tgtcctggcc ctcgtctttc cagggactca gacgtttcga tgtggacaat
      901 ggcacatcag cgggacggag tcccttggat cccatgacca gcccagggtc tgggctgatt
      961 ctccaagcaa actttgtcca cagtcaacgc cgggagtcct tcctgtaccg atctgacagc
     1021 gactatgacc tctctccaaa gtctatgtcc aggaactcct cgattgccag tgatatacat
     1081 ggagatgact tgattgtgac cccgtttgct caggtcttgg ctagcctgcg aaccgtacgg
     1141 aacaactttg ctgcgttaac gaatttgcaa gaccgagcac ccagcaaaag atcacccatg
     1201 tgcaaccaac catccatcaa caaagccacc atcacagagg aggcctacca gaaactggcc
     1261 agcgagaccc tggaggagct ggactggtgt ctggaccagc tagagaccct gcagaccagg
     1321 cactccgtca gtgagatggc ctccaacaag ttcaaaagga tgctgaaccg ggagctcacg
     1381 catctctctg agatgagtcg gtctggcaac caggtgtcgg agtacatctc aaacacattt
     1441 ctcgataagc aacatgaagt ggaaatcccc tctccaactc agaaggaaaa ggagaagaag
     1501 aaaaggccga tgtcgcagat cagtggggtc aagaagttga tgcacagctc cagcctaact
     1561 aattcatgta tccccaggtt tggggttaaa acggagcagg aagatgtcct ggccaaggaa
     1621 ctagaagatg tgaacaagtg gggcctccac gttttccgaa tagcagagct gtctggtaac
     1681 cggcctctga ctgttatcat gcacaccatt tttcaggaac gagatttgtt aaaaacgttt
     1741 aaaatcccag tagacacttt gattacgtat cttatgactc tggaagacca ttaccatgct
     1801 gacgtggcct atcacaacaa catccatgct gcagacgtcg tccagtccac tcacgtgctg
     1861 ctctctacac ccgctttgga ggctgtgttc acagacttgg agattctcgc ggccattttt
     1921 gccagtgcaa tacatgatgt ggaccatcct ggggtgtcaa atcaatttct gatcaataca
     1981 aactcggaac tcgctctgat gtacaacgac tcctcggtcc tagagaacca tcacttggcg
     2041 gtgggcttta agttgctcca ggaagaaaac tgtgacattt tccagaatct gaccaaaaag
     2101 caaagacaat ctttaaggaa aatggtcatt gacattgtcc tggcgacaga catgtcgaag
     2161 cacatgaacc tgctggctga tctgaaaacc atggttgaaa ccaagaaggt gacaagctcc
     2221 ggcgtcctcc tcctggataa ctactccgac aggatccagg tccttcagaa tatggtgcac
     2281 tgtgcagacc tgagcaaccc cacaaagcca ctccagctgt accgccagtg gacggaccgg
     2341 ataatggagg agttcttccg ccagggggac cgagagcggg agcgtggcat ggagataagt
     2401 cccatgtgtg acaagcacaa cgcctctgtg gaaaaatcac aggtgggctt catagactat
     2461 atcgttcatc cactctggga gacgtgggca gacctcgtac atcccgatgc ccaggacatc
     2521 ttggacactt tggaggacaa tcgtgagtgg taccagagca caatccccca gagcccctcc
     2581 cctgcacctg atgaccaaga ggagggccgg cagggacaga ctgaaaaatt ccagtttgaa
     2641 ctaaccttgg aggaagactg cgagtcagac actgaaaagg acagtggaag tcaggtggag
     2701 gaagacacta gctgcagtga ctctaagact ctgtgcaccc aagactcaga gtccactgaa
     2761 attccccttg acgagcaggt tgaggaggaa gctgtagcgg aagaggaaag ccagcctgaa
     2821 acttgcgtcc cagatgactg ctgtcctgat acgtaacagc ataaaggctg tcccactctt
     2881 tctgtttttt tggttttttg tttttttttt aaagtagaaa aatattgttt ccaaagtgca
     2941 tgtcacatgc cacaaccatg gtcacacctc actgtcatct gccaggacgt ttgttgaaca
     3001 aaactgacct tgaactactc agtctggcgc tcaggaatat tgtaaccagt tctctcaccc
     3061 accccacccc cccatgtcat cggagaagag agatgtcttc acgtacagga cgtggacgtg
     3121 acgtcagctt ggcagagctg acaaagcgga taaaattgac tccaactgtt ttcaagggag
     3181 cctgtggccc atccagctgc ccagacgcta agatcggatt gcagggttcc tttctggttt
     3241 gcttgcaaac gtgttaagaa gaaagaaggc atttgatgac gcgtgtgaac tcacagagga
     3301 agcaatgaga gcgtcatgaa caggacacag cttggatctg tcccctggag gaggatgagc
     3361 cacagaaatt gcatactttt ctaatttcaa gtcttcctga taacatgact gaacagtgtg
     3421 gttcagtgag ccacactcac ctctctctac attttgtatg atatgtaaaa cagatttttt
     3481 gtagagctta cttttattat taaatgtatt gaggtattat atttaaaaaa caaaacaaaa
     3541 ctctgttcag aacttcatct accactggtt tttgtttttt tgttttgttt tgtttttttg
     3601 ggtttttttt tttttttcta agaagtaact tgcaagtttt cagtacagat cagtactaca
     3661 ctggagaaat ctcatttacg aattttactc gcaccttaga ggtcatagca atgaactgat
     3721 ttgtagtgat tcattctttt atataccgat gacttccata ctctaaaaca gagaaacaaa
     3781 tttatgttgc gggaaaaccc cttttgtaag tgtccattgg ctcctccttt acttccactc
     3841 ctccacctgc caggggagtc tgctctccca cattgctccc ctcactgtgt gcaaagtgag
     3901 tatttattct gtaatacgtt aatgtgcatt acgtccagtg ttgtcttaaa cctcatagga
     3961 gctcagtcgt cagcctctgt tgtctgaagt aaatgggaga tatataaata cccagtagct
     4021 aaaacagtca ggtcttttcc aggcattttc ctacccactg ccttctggta atttcctccc
     4081 cccccccccc ccccgccctg tctcaggaga catgcattca caaatgctgt ccttgtagtc
     4141 acccgaacat ttcaccatca ttttattgtt gctcacagcc agttacagga agaaaaacat
     4201 tttcgcatcc tgttgcttgg tttaatgcct atgccagcct ctgcacttgt tcacttgatg
     4261 ggggtcttac caagtctgtc actaccattc tgaccgagga aaaagaaaca ggttgtcagg
     4321 gtagggctga agttcaattc ttctacatgg ttctgtcttc tctagctttt tcctctgagg
     4381 ttgcagagga aaagcatgct aagtgttata taggcaggtc ttaagactgt cagctgtctc
     4441 tatcgacaaa taccaggaca gctgttgttt gaactgccca gggaagcgag acctccgtga
     4501 ggagcagccc tgggaagtgg ttctgagtgt cgaagctgct ctctcctaat ggacagtctg
     4561 gtaacatgtg gactttgcta ttgattcttc ttgctccatc agcttgtccc ataggaagga
     4621 ctgctgcaga cacactaaag gagagtggat gataccgctg gctccaggcg gatcgttatg
     4681 cgatgggatc taaaccagtg gattgtgtga gtctgcctca gtagaacatt aagagaggaa
     4741 tccagatttc agctccagga actctgtgaa tttatggctt agttcccagg gttaacttgc
     4801 tgataccagt cagcctcgtg cagcatgtgt ctagcctaga ccttagttgt cttcttggtg
     4861 taaggtttgg agcccatgct aattttcctt tatggcaccc aaatggggac taaaggagag
     4921 ggtggtatat gaccaaatgg aaaaggaaac gtttaagaaa agtcctaagt ctggaaaaaa
     4981 aatatgaata aaacttctcc aggaagttgg aggctagtga ctgagaaagt aagtcatcag
     5041 ccagggagat cacccaggct gcgcacaaac cttgtttcaa gttcttgaat ccaaacgatg
     5101 cttagagcct ttggtacaga agtgtttctg atctgtggca tagggcggga taaaaatcaa
     5161 ataagtgatc attggcgggc tagccacctt tccttgtgaa gagtgcatgg tgcacagtca
     5221 gcctttgtgt gaccagagat ttcacaaaac ctggggcacc tgtttctctt ttcatttcac
     5281 ggatccctga aggaggtcta gaagaaaagg cgatgagtct agagtttatc cccctttcga
     5341 aatcattctc gctttccttc ctccctacgt gtggcatttc ccccaccccc ccacccccta
     5401 cagggtgcct gtagtcttca taatagagta agtaagtaag taagtaaata agcaatatgt
     5461 cataaacaga tccatactgc aggtgtttac agctacagta gtggagcatt tgttgtgtag
     5521 tgtgttggtt ttgaatggca ttgtgctgtc gaggtatcca ctgatggaca atcaagctgt
     5581 agaggacaca caatagccaa gagttaggga ctagtacacc agacctactc agccatctgc
     5641 ttaccacccc aactccttga ccatgccccg ccccggctca ctcttgtcaa agtgtgcttc
     5701 acgcattaac aagaacatct ttatacaagt ggcttcacat cccctaaaac gccataagaa
     5761 aaaaaaatgc aatatctggg tactgtatgg ggggaaagaa gtctaagatt tgcataaaac
     5821 cagtacattt cagcttgcaa gttacggaac gtgataacgc tgtttccatt acgttttcat
     5881 ccacatcagt aagtcgcagt aacacagtgg agatagaaca aaccacagat aaggagagaa
     5941 aaaaaaaact tgaatgaaac agattttaca gaaagcttta tgataatttt taatgcatta
     6001 tttatttttt tgtgccatgc atttttttcc tcaccaaatg accttacctg taatacagtc
     6061 ttgtttgtct gtttacaacc gtgtatttat tgcaatgtac atactgtaat gttaattgta
     6121 aattatcggt tcttattaaa acatcatccc gcgctgggat ggtgttgaca tatttggaaa
     6181 ctcttggtga gagaatgaat ggtgtgtata catgctcctt gtacattttt ctgtttcttc
     6241 tgtaatatag tctcgtcatc atagagctcg tttatggaaa aattcaagaa aaatataaaa
     6301 tacataaaga tatataaatt taaataacat agctgcaggt ctttggtccc agggctgtgc
     6361 cttaactata accaatactt tcttctgttt tgctgcaatt caaagttagg tggtagtgag
     6421 gctcgggctg ggcgttttgg agccgtgctc ctcattgatt ggattgcaaa actatagatc
     6481 acggctggag aaccttctga cccttgtgag acaaaacctc tgacatacat gttgccacgg
     6541 agcacaatgg cactggtggt gcgtatttac cagctgagtg ccgggagcta ctacacctgg
     6601 atacacagga ttggttttct tcttcccaaa ccacacacca agaaaacatt cttctctagg
     6661 gactggagaa tggccttctg gcttctggtc ctcacaggaa gatgaatttg atttgaaatg
     6721 ggagccatag ttcactgatc tcgtcagtcc tgtgttcacc ggcttcctgc catgccaaga
     6781 cattacacta ttttaaatac tctcctcgtc tccaagacta accaaattta gaaatatgta
     6841 tgatacatag tccatatgtg tcatacatat gcatacagac acgtgcacag atatgtacac
     6901 gtcagtcacc tgcgtaaaca cagttatatg atgatgccaa ttcatgtaaa ataaagaatc
     6961 catgtctctc gaaaattgtt tttgtgtgtc cacgtggaat tgttaagcat agccttgtac
     7021 agtggccagt cctgaaagcc acaagagctt ccttgtggaa aaggtggcca cctcccacca
     7081 tagcccagcc cttagaatat gtgacgtaga aaaaagaaat tctttttttt ctaggggaaa
     7141 aaaaaagagc ctcttattat ttcattttat tttttgacac aaactgtaga ttttagcagc
     7201 cctggcccaa aggaatttga ttacttttgt tttaaacagt acaaatggga cactatactg
     7261 agaaaataca tcctttgctg atttcagttt ttttatccct ttatttcttt gggtatgttt
     7321 tcagagtggt gaactgtgtg cgagcatcac agacgatgga tctgtcagtg gtttcttagc
     7381 ctctcttaca gcccatgggg atagcactgt acatcaatac cttcatatca aatttttata
     7441 tgccatgaaa ataaaagcat gggttgattc tgccta
//
