LOCUS       NM_001310465            3305 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus phosphodiesterase 4C, cAMP specific (Pde4c),
            transcript variant 1, mRNA.
ACCESSION   NM_001310465 XM_011242253
VERSION     NM_001310465.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3305)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3305)
  AUTHORS   Boyd,A., Aragon,I.V., Rich,J., McDonough,W., Oditt,M., Irelan,D.,
            Fiedler,E., Abou Saleh,L. and Richter,W.
  TITLE     Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of
            Nausea in Mice
  JOURNAL   Biology (Basel) 10 (12), 1355 (2021)
   PUBMED   34943270
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3305)
  AUTHORS   Boyd,A., Aragon,I.V., Abou Saleh,L., Southers,D. and Richter,W.
  TITLE     The cAMP-phosphodiesterase 4 (PDE4) controls beta-adrenoceptor- and
            CFTR-dependent saliva secretion in mice
  JOURNAL   Biochem J 478 (10), 1891-1906 (2021)
   PUBMED   33944911
REFERENCE   4  (bases 1 to 3305)
  AUTHORS   Aragon,I.V., Boyd,A., Abou Saleh,L., Rich,J., McDonough,W.,
            Koloteva,A. and Richter,W.
  TITLE     Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the
            anesthetic effects of Isoflurane in mice
  JOURNAL   Biochem Pharmacol 186, 114477 (2021)
   PUBMED   33609559
REFERENCE   5  (bases 1 to 3305)
  AUTHORS   McDonough,W., Aragon,I.V., Rich,J., Murphy,J.M., Abou Saleh,L.,
            Boyd,A., Koloteva,A. and Richter,W.
  TITLE     PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces
            gastroparesis in mice
  JOURNAL   FASEB J 34 (9), 12533-12548 (2020)
   PUBMED   32738081
REFERENCE   6  (bases 1 to 3305)
  AUTHORS   Koza,R.A., Hohmann,S.M., Guerra,C., Rossmeisl,M. and Kozak,L.P.
  TITLE     Synergistic gene interactions control the induction of the
            mitochondrial uncoupling protein (Ucp1) gene in white fat tissue
  JOURNAL   J Biol Chem 275 (44), 34486-34492 (2000)
   PUBMED   10931824
REFERENCE   7  (bases 1 to 3305)
  AUTHORS   Seymour,A.B., Yanak,B.L., O'Brien,E.P., Rusiniak,M.E., Novak,E.K.,
            Pinto,L.H., Swank,R.T. and Gorin,M.B.
  TITLE     An integrated genetic map of the pearl locus of mouse chromosome 13
  JOURNAL   Genome Res 6 (6), 538-544 (1996)
   PUBMED   8828042
REFERENCE   8  (bases 1 to 3305)
  AUTHORS   Cherry,J.A. and Davis,R.L.
  TITLE     A mouse homolog of dunce, a gene important for learning and memory
            in Drosophila, is preferentially expressed in olfactory receptor
            neurons
  JOURNAL   J Neurobiol 28 (1), 102-113 (1995)
   PUBMED   8586960
REFERENCE   9  (bases 1 to 3305)
  AUTHORS   Ramamoorthy,S., Leibach,F.H., Mahesh,V.B., Han,H., Yang-Feng,T.,
            Blakely,R.D. and Ganapathy,V.
  TITLE     Functional characterization and chromosomal localization of a
            cloned taurine transporter from human placenta
  JOURNAL   Biochem J 300 (Pt 3) (Pt 3), 893-900 (1994)
   PUBMED   8010975
REFERENCE   10 (bases 1 to 3305)
  AUTHORS   Milatovich,A., Bolger,G., Michaeli,T. and Francke,U.
  TITLE     Chromosome localizations of genes for five cAMP-specific
            phosphodiesterases in man and mouse
  JOURNAL   Somat Cell Mol Genet 20 (2), 75-86 (1994)
   PUBMED   8009369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162446.2 and AK149514.1.
            
            On Jul 14, 2015 this sequence version replaced XM_011242253.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC162446.2         76276-76326
            52-2926             AK149514.1         2-2876
            2927-2927           AC162446.2         103020-103020
            2928-3291           AK149514.1         2877-3240
            3292-3305           AC162446.2         103385-103398
FEATURES             Location/Qualifiers
     source          1..3305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..3305
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /note="phosphodiesterase 4C, cAMP specific"
                     /db_xref="GeneID:110385"
                     /db_xref="MGI:MGI:99556"
     exon            1..154
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            155..207
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..2226
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /EC_number="3.1.4.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cAMP-specific 3',5'-cyclic phosphodiesterase 4C;
                     cAMP-specific phosphodiesterase 4C; 3',5'-cyclic-AMP
                     phosphodiesterase 4C"
                     /codon_start=1
                     /product="3',5'-cyclic-AMP phosphodiesterase 4C isoform 1"
                     /protein_id="NP_001297394.1"
                     /db_xref="CCDS:CCDS80891.1"
                     /db_xref="GeneID:110385"
                     /db_xref="MGI:MGI:99556"
                     /translation="MRRSGTALSFLWTERVREPVDSGVAPVSPLGGGVILRRFSGTLL
                     LPPLSSRLGSSGEAESAAHVVFTIGTQGTQRNLGSAQSSFDLENGLPGGKGLLDAQSG
                     PSLGRALQPPVHHVQRRESFLYRSDSDHEPSPKAVSRTSSAASDLHGEDMIVTPFAQV
                     LASLRTVRNNVAALAHGPGSATRQVLLGTPPHSSQQAAPTEDSGLQLVQETLEELDWC
                     LEQLETLQTRRSVGEMASNKFKRMLNRELSYLSETSRSGNQVSEYISQTFLDQQAEVE
                     LPQPPTEDDPWPMAQITELRRSSHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLD
                     VFKVAELSGNRPLTAVIFSVFQERDLLKTFQIPADTLLAYLLTLEGHYHSDVAYHNSM
                     HAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELAL
                     MYNDSSVLENHHLAVGFKLLQGENCDIFRNLSTKQRLSLRRMVIDMVLATDMSKHMSL
                     LADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIM
                     AEFFQQGDRERESGLDISPMCDKHTASMEKSQVGFIDYIAQPLWETWADLVHPDAQEL
                     LDTLEDNREWYQSRIPCSPPHTMGSDRFKFELTLEEAEEEEEEEDEGQCTALNRESSE
                     LPST"
     exon            208..413
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            414..605
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..642
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..713
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            714..766
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            767..879
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            880..973
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1134
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1233
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1398
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1498
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1653
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1776
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1959
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..3305
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2563..2568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      2593
                     /gene="Pde4c"
                     /gene_synonym="Dpde1; dunce; E130301F19Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccctcctcca gtcccgaggg tgcctcctgg ctcgggtcta gtctggtgct cagttaaaga
       61 acccagctgg gagtgggata ggaccgtctg tcctctgctc ctgggaggtc acagagcaca
      121 ctcacagcgc aggtccccac aggagcagct ggaaaagcct gcaccatgag gcggagtggc
      181 acggccctgt ccttcctgtg gactgagcga gtccgagagc cagtggattc tggagtggcc
      241 cctgtcagcc ccctaggtgg gggtgtgatc ctgagacggt tctcagggac cctgctgctg
      301 cctccactgt ccagccgcct ggggtcctct ggggaggcgg agtctgctgc ccacgtggtc
      361 ttcacaattg gaactcaagg gacacagaga aaccttggct cagctcagag cagctttgac
      421 ctcgaaaatg ggcttccggg cggcaagggt ctcctagacg ctcagtccgg gccgagtctc
      481 ggccgcgccc tccagccccc tgtccatcat gtccagcggc gcgagtcctt cctgtaccgt
      541 tcggacagcg accatgaacc ttcacccaag gctgtgtccc ggacctcctc ggcggccagt
      601 gacctacatg gagaagacat gattgtcacg cccttcgccc aggtcctggc cagtctcagg
      661 acggtccgta acaacgtggc tgcccttgca catggcccgg gtagtgccac caggcaggtg
      721 ctcctgggaa cccctccgca cagcagtcaa caggcagccc caacagagga ctctgggctg
      781 cagctggtgc aggagaccct ggaggagctg gactggtgcc tggagcagct ggagacactg
      841 cagactcgtc gctcagtggg cgagatggcc tccaacaagt tcaagcgcat gctcaaccgt
      901 gagttgtctt acctgtcgga aaccagccgc tcagggaacc aggtgtcgga gtacatctcg
      961 cagactttcc tggaccaaca ggctgaggtt gagctgcctc agccgcccac ggaagacgac
     1021 ccatggccca tggcccagat cactgagctg cgtaggtcct cccacaccag ccttcccaca
     1081 gctgctatcc cacgctttgg ggtccagaca gatcaggagg agcagctggc taaggagctt
     1141 gaagacacca acaaatgggg acttgatgtg ttcaaagtgg ctgagctgag tgggaaccgg
     1201 cctctcacag ctgtcatatt cagcgtcttc caggaacgag acctcctcaa gacgttccag
     1261 atcccagcag acacgctgct ggcgtacttg ctgacactag aggggcacta ccactccgac
     1321 gtggcgtacc acaacagcat gcatgctgcc gatgtggtgc agtccgcaca cgtgttgctg
     1381 ggcaccccag ccctggaggc tgtgttcacg gacctagaag tcttggcagc tatctttgca
     1441 tgtgctatac acgacgtaga ccacccgggg gtctccaacc agtttctcat caacaccaac
     1501 tcagagctgg cactgatgta caatgattca tcggtgctgg agaaccatca cctcgcggta
     1561 ggcttcaagc tcctgcaggg ggaaaactgc gacatcttcc ggaacctcag taccaagcag
     1621 agactgagtc tgcgcaggat ggtcatagac atggtgctgg ccacagatat gtctaagcac
     1681 atgagccttc tggccgacct caagaccatg gtggagacga agaaagtgac cagccttggc
     1741 gtcctgctct tggacaacta ctctgaccgc atccaggttc tccagagcct ggtgcactgc
     1801 gctgacctca gcaaccccgc caagccgcta cccctctacc gccagtggac ggagcgcatc
     1861 atggccgagt tcttccagca gggtgaccgg gagcgagagt cgggtctgga catcagcccc
     1921 atgtgcgaca aacacacagc ctcgatggag aaatcccagg tgggattcat tgactacatc
     1981 gctcagccat tgtgggagac atgggctgac ctagtgcacc ccgatgctca ggagcttctg
     2041 gacaccttgg aagacaacag agagtggtat cagagtagga ttccctgcag ccctccacac
     2101 accatgggct cggacaggtt caagtttgag ctgaccctgg aggaagcaga ggaagaggag
     2161 gaagaggagg atgaagggca gtgcacagca ctgaacaggg agtcctcaga gttacccagc
     2221 acttaactcc tgtcctctaa ggccagccca gagcccaggg tctgctttgt ccaacaagag
     2281 ttgggctagc ttagtgtgga ccgtggagtc ctggtcaggc catgggcacc tatgggcact
     2341 gatgacgttc caccactcaa agaggacagc caaggtttac acagagccaa gcctgaggga
     2401 ggctgggacc agctctgccc acagactgga atggcaccag ccctgggaag cgccgactcc
     2461 tgcatctcag aagacagact tagactcagc tgcagtctgc acgtcagctt cagcacatgc
     2521 agtcggactc tgtgttatgg tttagttggt ttcttttttg gcactaaaga tggaaccaat
     2581 gttgccttca ccagtccagc tgcaagcctt tactgagtcc ctcgggggaa tccctttcgt
     2641 aaaatgcggg cggggaacac ttcccactga ggtctggtgt ctcctgacac cattggctgc
     2701 acaagactct tcttagatat caggaggccg gtgaccctcc tagaagacca ctgcaggcct
     2761 cagtcctccc atcaatgagg atccccgtct ccgacaagat tgggcttctc aaaccagtgt
     2821 gctggtgcac ctctcttcac cataggcatc ccccagactt ggctgtgtgt gtgtggagac
     2881 agctggtcca ggctgggcag cctgactaga aataaaaaga gctggaagtg ggctggaaag
     2941 atggctcagt ggttaggagc actgactgtt cttccagagg tcctgagttc aaatcccagc
     3001 aaccacgtgg tggctcacaa tcatctgtaa tgggatctgt tttttgtttt gttttgtttt
     3061 gtttgtttgt tttcgataca gggtttctct gtgtagccct ggctgtcctg gaactcactc
     3121 tgcagaccag gctggcctcg aactcagaaa tccacctgcc tctgcctccc aagtgctggg
     3181 attaaagaca tgtgccacca ccactgtgtg gcctgaaatg ggatctgatg ccctcttctt
     3241 ttgtgtctga agaaagcaat ggttactcac atataataaa taaataaatc tttaaaaaaa
     3301 aaaaa
//
