LOCUS       NM_011055               5314 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus phosphodiesterase 3B, cGMP-inhibited (Pde3b), mRNA.
ACCESSION   NM_011055 XM_355928
VERSION     NM_011055.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5314)
  AUTHORS   Krause,P.N., McGeorge,G., McPeek,J.L., Khalid,S., Nelin,L.D.,
            Liu,Y. and Chen,B.
  TITLE     Pde3a and Pde3b regulation of murine pulmonary artery smooth muscle
            cell growth and metabolism
  JOURNAL   Physiol Rep 12 (20), e70089 (2024)
   PUBMED   39435735
  REMARK    GeneRIF: Pde3a and Pde3b regulation of murine pulmonary artery
            smooth muscle cell growth and metabolism.
REFERENCE   2  (bases 1 to 5314)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5314)
  AUTHORS   Yook,C., Kim,K., Kim,D., Kang,H., Kim,S.G., Kim,E. and Kim,S.Y.
  TITLE     A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical
            Distribution of Interneurons, Increased Inhibitory Synaptic
            Transmission, and Autistic-Like Behavioral Deficits in Mice
  JOURNAL   Front Mol Neurosci 12, 241 (2019)
   PUBMED   31680851
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5314)
  AUTHORS   MacKeil,J.L., Brzezinska,P., Burke-Kleinman,J., Theilmann,A.L.,
            Nicol,C.J.B., Ormiston,M.L. and Maurice,D.H.
  TITLE     Phosphodiesterase 3B (PDE3B) antagonizes the anti-angiogenic
            actions of PKA in human and murine endothelial cells
  JOURNAL   Cell Signal 62, 109342 (2019)
   PUBMED   31176020
  REMARK    GeneRIF: Phosphodiesterase 3B (PDE3B) antagonizes the
            anti-angiogenic actions of PKA in human and murine endothelial
            cells.
REFERENCE   5  (bases 1 to 5314)
  AUTHORS   Polidovitch,N., Yang,S., Sun,H., Lakin,R., Ahmad,F., Gao,X.,
            Turnbull,P.C., Chiarello,C., Perry,C.G.R., Manganiello,V., Yang,P.
            and Backx,P.H.
  TITLE     Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B),
            contributes to the adverse cardiac remodeling induced by pressure
            overload
  JOURNAL   J Mol Cell Cardiol 132, 60-70 (2019)
   PUBMED   31051182
  REMARK    GeneRIF: whole-body ablation of PDE3A, but not PDE3B, provided
            similar protection against TAC-induced adverse ventricular
            remodeling
REFERENCE   6  (bases 1 to 5314)
  AUTHORS   Hasegawa,M., Tang,Y., Osawa,H., Onuma,H., Nishimiya,T., Ochi,M.,
            Terauchi,Y., Kadowaki,T. and Makino,H.
  TITLE     Differential regulation of gene expression and insulin-induced
            activation of phosphodiesterase 3B in adipocytes of lean
            insulin-resistant IRS-1 (-/-) mice
  JOURNAL   Diabetes Res Clin Pract 58 (2), 79-85 (2002)
   PUBMED   12213348
  REMARK    GeneRIF: Differential regulation of gene expression and
            insulin-induced activation of this enzyme in adipocytes of lean
            insulin-resistant IRS-1 (-/-) mice.
REFERENCE   7  (bases 1 to 5314)
  AUTHORS   Shakur,Y., Takeda,K., Kenan,Y., Yu,Z.X., Rena,G., Brandt,D.,
            Houslay,M.D., Degerman,E., Ferrans,V.J. and Manganiello,V.C.
  TITLE     Membrane localization of cyclic nucleotide phosphodiesterase 3
            (PDE3). Two N-terminal domains are required for the efficient
            targeting to, and association of, PDE3 with endoplasmic reticulum
  JOURNAL   J Biol Chem 275 (49), 38749-38761 (2000)
   PUBMED   10952971
REFERENCE   8  (bases 1 to 5314)
  AUTHORS   Hopitzan,A., Himmelbauer,H., Spevak,W. and Castanon,M.J.
  TITLE     The mouse Psma1 gene coding for the alpha-type C2 proteasome
            subunit: structural and functional analysis, mapping, and
            colocalization with Pde3b on mouse chromosome 7
  JOURNAL   Genomics 66 (3), 313-323 (2000)
   PUBMED   10873386
REFERENCE   9  (bases 1 to 5314)
  AUTHORS   Kitamura,T., Kitamura,Y., Kuroda,S., Hino,Y., Ando,M., Kotani,K.,
            Konishi,H., Matsuzaki,H., Kikkawa,U., Ogawa,W. and Kasuga,M.
  TITLE     Insulin-induced phosphorylation and activation of cyclic nucleotide
            phosphodiesterase 3B by the serine-threonine kinase Akt
  JOURNAL   Mol Cell Biol 19 (9), 6286-6296 (1999)
   PUBMED   10454575
REFERENCE   10 (bases 1 to 5314)
  AUTHORS   Lobbert,R.W., Winterpacht,A., Seipel,B. and Zabel,B.U.
  TITLE     Molecular cloning and chromosomal assignment of the human homologue
            of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A)--a gene
            involved in fat metabolism located at 11p 15.1
  JOURNAL   Genomics 37 (2), 211-218 (1996)
   PUBMED   8921398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB627812.1, AJ132271.1, CJ058099.1, BY745829.1, BU613166.1,
            BB663310.1, AK142889.1, AV270888.2 and CJ299201.1.
            
            On Aug 23, 2006 this sequence version replaced NM_011055.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF547435.1, AJ132271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               BB627812.1         2-484
            484-887             AJ132271.1         187-590
            888-1080            CJ058099.1         167-359
            1081-1611           AJ132271.1         784-1314
            1612-1627           BY745829.1         515-530
            1628-1689           AJ132271.1         1331-1392
            1690-1692           BY745829.1         593-595
            1693-2562           AJ132271.1         1396-2265
            2563-2563           BU613166.1         272-272
            2564-3325           AJ132271.1         2267-3028
            3326-3701           BB663310.1         212-587
            3702-4528           AK142889.1         588-1414
            4529-4912           AV270888.2         227-610
            4913-5314           CJ299201.1         90-491
FEATURES             Location/Qualifiers
     source          1..5314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.46 cM"
     gene            1..5314
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /note="phosphodiesterase 3B, cGMP-inhibited"
                     /db_xref="GeneID:18576"
                     /db_xref="MGI:MGI:1333863"
     exon            1..1209
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..3597
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /EC_number="3.1.4.17"
                     /note="cGMP-inhibited 3',5'-cyclic phosphodiesterase B;
                     CGIPDE1; CGI-PDE B; cyclic GMP-inhibited phosphodiesterase
                     B"
                     /codon_start=1
                     /product="cGMP-inhibited 3',5'-cyclic phosphodiesterase
                     3B"
                     /protein_id="NP_035185.2"
                     /db_xref="CCDS:CCDS21760.1"
                     /db_xref="GeneID:18576"
                     /db_xref="MGI:MGI:1333863"
                     /translation="MRKDERERDAPAMRSPPPPPASAASPPESLRNGYVKSCVSPLRQ
                     DPPRSFFFHLCRFCNVEPPAASLRAGARLSLGVLAAFVLAALLGARPERWAAAAAGLR
                     TLLSACSLSLSPLFSIACAFFFLTCFLTRAQRGPGRGAGSWWLLALPACCYLGDFAAW
                     QWWSWLRGEPAAAGRLCLVLSCVGLLTLAPRVRLRHGVLVLLFAGLVWWVSFSGLGAL
                     PPALRPLLSCLVGGAGCLLALGLDHFFHVRGASPPPRSASTAEEKVPVIRPRRRSSCV
                     SLGESAAGYYGSGKMFRRPSLPCISREQMILWDWDLKQWCKPHYQNSGGGNGVDLSVL
                     NEARNMVSDLLIDPSLPPQVISSLRSISSLMGAFSGSCRPKINSFTPFPGFYPCSEVE
                     DPVEKGDRKLHKGLSGRTSFPTPQLRRSSGASSLLTNEHCSRWDRSSGKRSYQELSVS
                     SHGCHLNGPFSSNLFTIPKQRSSSVSLTHHAGLRRAGALPSHSLLNSSSHVPVSAGSL
                     TNRSPIGFPDTTDFLTKPNIILHRSLGSVSSAADFHQYLRNSDSNLCSSCGHQILKYV
                     STCEPDGTDHPSEKSGEEDSSVFSKEPLNIVETQEEETMKKACRELFLEGDSHLMEEA
                     QQPNIDQEVSLDPMLVEDYDSLIEKMNNWNFQIFELVEKMGEKSGRILSQVMYTLFQD
                     TGLLETFKIPTQEFMNYFRALENGYRDIPYHNRVHATDVLHAVWYLTTRPIPGLPQIH
                     NNHETETKADSDGRLGSGQIAYISSKSCCIPDMSYGCLSSNIPALELMALYVAAAMHD
                     YDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHMEFK
                     RFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSSENDRLLVCQVCIKLADI
                     NGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRSSPQLAKLQESFITHIV
                     GPLCNSYDAAGLLPGQWIETEEGDDTESDDDDDDDDGGGEELDSDDEETEDNLNPKPQ
                     RRKGRRRIFCQLMHHLTENHKIWKEIIEEEEEKCKAEGNKLQVDNASLPQADEIQVIE
                     EADEEEEQMFE"
     exon            1210..1260
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1509
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1649
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1756
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1967
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2041
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2181
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2319
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2431
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2545
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2745
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2949
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3111
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3379
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3380..5286
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5263..5268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5286
                     /gene="Pde3b"
                     /gene_synonym="9830102A01Rik"
                     /note="major polyA site"
ORIGIN      
        1 aactgttgca gcgcgcggga gctgggaggc gacgccgccg tctcccgtcc cgagccgcgc
       61 ttgagggaaa agggaagagg cgtccgcggc ggtcccggga caccaagaag cccttctcgc
      121 cgctctcagt ggccggcatg aggcggacgc cgccgcccct cagcccgcgc gccggggatc
      181 ccggccggtg gcggcggcgg gcgcagccgt gaccgctctg cgaagctcgg ggcgcccaga
      241 acgcggaggg cggcgcgggg tcggcaagcg ccagcggccc cccggcggcc cggggccatg
      301 aggaaagacg agcgcgagcg ggacgcgcca gccatgaggt ccccgccgcc gccgccagcc
      361 tcggccgcct cgccccccga gagcctgcgc aacggctacg tgaagagctg cgtgagcccg
      421 ctgcggcagg accctccgcg cagcttcttc ttccacctct gccgcttctg caacgtggag
      481 ccgccggcgg cctcgctccg cgccggggca cgcctctcgc tcggcgtcct ggccgccttt
      541 gtcctggccg cgctgctggg cgcgaggccc gagcgctggg cggccgcggc agccgggctc
      601 cggacgctgc tgagcgcctg ctcgctcagc ctcagcccgc tcttcagcat cgcctgtgcc
      661 ttcttcttcc tcacctgttt cctgacgcgc gcgcagcgcg gcccgggccg cggcgccggc
      721 tcctggtggc tgctggcgct gcccgcctgc tgctacctgg gcgacttcgc ggcgtggcag
      781 tggtggtcgt ggctgcgtgg ggagccggcg gcggcgggcc ggctctgcct ggtgctgagc
      841 tgcgtggggc tgctgacgct cgcgccccgc gtgaggctgc ggcacggcgt cctggtgctg
      901 ctcttcgccg gcctggtgtg gtgggtgtcc ttctccggcc tcggggctct gccgcccgcg
      961 ctcaggcctc tgctgtcgtg cctggtcggg ggcgcgggat gcctgctagc cctgggcttg
     1021 gaccacttct ttcacgtccg gggagcctcc cctccgccgc gctcggcgag taccgcggag
     1081 gaaaaagtgc ctgtgatcag accccggagg aggtccagct gcgtgtcgct gggagaaagc
     1141 gcagccggtt actatggcag tggcaagatg ttcaggagac cgtcgttgcc ttgtatttcc
     1201 cgagaacaga tgatcctctg ggactgggac ttgaagcagt ggtgtaaacc tcattaccag
     1261 aattctggag gtggaaatgg agttgatctt tcagtgctaa atgaagctcg caatatggtg
     1321 tcagacctgc tgattgaccc aagccttccc ccacaagtca tttcttctct gcggagtatc
     1381 agtagcttga tgggtgcttt ctcaggttcc tgtaggccaa agattaattc ttttacacca
     1441 tttcctggat tttatccctg ctctgaagta gaagatccag ttgagaaagg agatcgaaaa
     1501 cttcacaagg gattgagtgg cagaaccagt ttcccaactc cacagctgag gaggagctct
     1561 ggagcctcat cgttgctgac taatgagcac tgttcaaggt gggatcgcag cagtggtaag
     1621 aggtcttacc aagaactcag tgtttcaagt catggatgcc acctaaatgg gccttttagt
     1681 tcaaatcttt ttacaattcc aaagcagagg tcatcgtctg tgtcactgac gcaccatgca
     1741 ggtctgagaa gagctggtgc tttgcccagc cacagtcttc tgaattcttc aagccatgta
     1801 ccagtgtctg ctggctctct aactaatcga tcacccatag gatttcctga taccactgat
     1861 tttcttacta agccaaatat tattttacat agatcactgg gcagtgtatc aagtgcagca
     1921 gatttccatc agtaccttag gaactctgac agcaatctgt gtagcagctg tggacaccaa
     1981 atactcaaat atgtttcaac atgtgaaccc gatggtacag accaccccag tgaaaaatca
     2041 ggtgaagaag acagcagtgt tttctcaaaa gaaccattga acattgtgga aacccaagaa
     2101 gaagagacca tgaagaaagc ctgcagggag ttatttttgg aaggtgatag tcacctgatg
     2161 gaagaggcac agcaaccaaa tatcgatcag gaagtgtcac tggatccaat gttagtagaa
     2221 gattatgatt cattaataga aaagatgaac aactggaatt ttcagatttt tgagcttgta
     2281 gaaaagatgg gagaaaaatc aggaaggatt ctcagtcagg ttatgtatac tttatttcaa
     2341 gatactggtt tattggaaac atttaaaatt cccactcaag aatttatgaa ttattttcgt
     2401 gccttagaaa atggctaccg ggacattcca tatcacaatc gtgtgcatgc cacagatgtc
     2461 ctacatgctg tttggtattt gacaacccga ccaattcctg gcttacctca gatccataat
     2521 aaccatgaaa cggaaaccaa agcagattca gatggtagac ttggttctgg acagattgct
     2581 tacatttctt cgaagagttg ctgtattcca gatatgagtt atggctgcct atcttcaaac
     2641 atccctgcat tagaattgat ggctttgtat gtggcagctg ccatgcacga ttacgatcac
     2701 ccaggaagaa caaatgcgtt tctagtggct acaaatgcac ctcaggcagt tttatacaat
     2761 gacagatctg ttctagagaa tcatcatgct gcatcagctt ggaatctgta tctttctcgc
     2821 ccagagtaca acttcctcct taaccttgat cacatggaat tcaagcggtt tcgattttta
     2881 gttatagaag caatccttgc tacagatctc aaaaaacatt ttgatttcct tgcagaattc
     2941 aatgccaagg ccaatgatgt aaatagtaac ggtatagaat ggagcagtga aaacgatcgc
     3001 ctcttggtct gccaggtgtg catcaaatta gcagatatca atggcccagc aaaagatcgg
     3061 gacctacatt tgagatggac agaaggcatt gtgaatgaat tttatgagca gggagatgaa
     3121 gaagcaaccc tgggtctacc tattagtccc ttcatggatc gttcttctcc tcaactagca
     3181 aaactccaag aatcttttat cacccacatt gtgggccccc tgtgcaactc ctatgatgct
     3241 gctggcttgc tgccgggtca gtggatagaa acagaagagg gtgatgatac agaaagtgat
     3301 gatgatgatg atgatgatga tggtggtggt gaagaattag attcagatga tgaagaaaca
     3361 gaagacaatc taaatcctaa accacaaaga aggaaaggca ggcggcgaat attttgccaa
     3421 ctaatgcacc acctcactga aaaccacaag atatggaagg aaatcataga agaagaagaa
     3481 gaaaaatgta aagctgaggg gaacaaactg caggtggata atgcctcctt acctcaggca
     3541 gatgagattc aggttattga agaagcagat gaagaggaag aacaaatgtt tgaatgagaa
     3601 gagaactcat gctgaaggag cctggggtgc tgttcccagg gtcattacct aatgctcact
     3661 gtactgattc tcaactgacc attcccatgt gggcacgcct taatactgtg agaggatcct
     3721 ggctaccctg gcagttctca ctcctaagca ctttcattac aaacaagaaa ctgattctta
     3781 gagcttgctg cagttgactc atgctgcaaa gccttcctca aagccttcac tggtgtgtaa
     3841 atagtgtgtc ataatgctgc tttgctgggt agtgagctct tatttctcat gatgagggag
     3901 ggaaggctaa aactgaaaag tcaagtgact tcggtttttg aagtaaccat atttctttta
     3961 tgaaaacagg attcatcttg tatttccaaa tatatctttt atgtctttgt ttgggggtgg
     4021 ggtggtgcaa gaaacagacc tctatgctta atacaaaaat gaattcatgg tggcctttct
     4081 gagtgatttc tgctcgtggc agcacactgt tcagtgtggt tctcctggct tcatcgagga
     4141 aggactgagg acctttgtta tacttagcaa aacccagatg catcaatttc tgatgctttt
     4201 tattgttgtg tataatctat ttacttgttt tatttctgcc taaagtattc aggtttgctg
     4261 tggacatcag aggtctgaat tctgttctta ctgattttgt tccatggttg aatttaaaag
     4321 tatataataa tgaaggagct ttattcttta ttcaaatctg ttcttattct tattctttct
     4381 caggataagt aattttaaac aattattata aatattgcat agatttgcca gagaaaaaaa
     4441 cattgtcctg atattgatgt tatcttttat gaaatgagca ccattttatt ttaattagag
     4501 tcaagaaaaa ggagctggcc atcttttgcc ttaatggaaa atcaatgaaa ccaatcccat
     4561 cgaagatatt gcctaaatat ttagttatct ttagatatat gtcttaggtg tctagtaaaa
     4621 ttgacatttt ttattgttaa tatctttctg cttcaagagt acatggcaga gatgacacat
     4681 cactatttag taatattaca gccccacaga cagaattttg aagtaaagta cataatggga
     4741 atgcatatta atttttaata aagtgctata aaataaatat gctatgaata gttcaataaa
     4801 taattccata aatgcttata aataaataat ttactaagaa aacaggacac atttatgttt
     4861 atataatctc attagagtgt ggctatgtgc cccagttgtg aaaaattatt gaagttatac
     4921 aaagcaacca aaataatacc aaaatggtaa actggtttct tcttatcctt tatacattat
     4981 tttgaagcca ttgaactttg tgcacagtta actgtcagtt tccacagtat ttcctatata
     5041 gtgtgatgct ggaatttctt acctacctaa gatatttggg ttgtctacaa ggccacagtt
     5101 aaagattgat tggagtactg gtatttttga tcctgtaggt accatattta atgaatcact
     5161 acactttatt tattaaacat gttgagtgct gagttccttc ctgtcacttt tgctaccaca
     5221 actacatcat ttgtaaactg gtcccaccat atattactaa gtaataaaat tttaactgat
     5281 aatctaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
