LOCUS       NM_001410255            8969 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus phosphodiesterase 1C (Pde1c), transcript variant 12,
            mRNA.
ACCESSION   NM_001410255 XM_006505733
VERSION     NM_001410255.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8969)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8969)
  AUTHORS   Zhang,C., Zhao,H., Cai,Y., Xiong,J., Mohan,A., Lou,D., Shi,H.,
            Zhang,Y., Long,X., Wang,J. and Yan,C.
  TITLE     Cyclic nucleotide phosphodiesterase 1C contributes to abdominal
            aortic aneurysm
  JOURNAL   Proc Natl Acad Sci U S A 118 (31) (2021)
   PUBMED   34312235
  REMARK    GeneRIF: Cyclic nucleotide phosphodiesterase 1C contributes to
            abdominal aortic aneurysm.
REFERENCE   3  (bases 1 to 8969)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8969)
  AUTHORS   Fleck,J.S., Sanchis-Calleja,F., He,Z., Santel,M., Boyle,M.J.,
            Camp,J.G. and Treutlein,B.
  TITLE     Resolving organoid brain region identities by mapping single-cell
            genomic data to reference atlases
  JOURNAL   Cell Stem Cell 28 (6), 1148-1159 (2021)
   PUBMED   33711282
  REMARK    Erratum:[Cell Stem Cell. 2021 Jun 3;28(6):1177-1180. doi:
            10.1016/j.stem.2021.03.015.. PMID: 34087154]
REFERENCE   5  (bases 1 to 8969)
  AUTHORS   Shete,V., Liu,N., Jia,Y., Viswakarma,N., Reddy,J.K. and
            Thimmapaya,B.
  TITLE     Mouse Cardiac Pde1C Is a Direct Transcriptional Target of Pparalpha
  JOURNAL   Int J Mol Sci 19 (12), 3704 (2018)
   PUBMED   30469494
  REMARK    GeneRIF: Cardiac Pde1C is a direct transcriptional target of
            PPARalpha.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8969)
  AUTHORS   Omori,K. and Kotera,J.
  TITLE     Overview of PDEs and their regulation
  JOURNAL   Circ Res 100 (3), 309-327 (2007)
   PUBMED   17307970
  REMARK    Review article
REFERENCE   7  (bases 1 to 8969)
  AUTHORS   Gong,S., Zheng,C., Doughty,M.L., Losos,K., Didkovsky,N.,
            Schambra,U.B., Nowak,N.J., Joyner,A., Leblanc,G., Hatten,M.E. and
            Heintz,N.
  TITLE     A gene expression atlas of the central nervous system based on
            bacterial artificial chromosomes
  JOURNAL   Nature 425 (6961), 917-925 (2003)
   PUBMED   14586460
REFERENCE   8  (bases 1 to 8969)
  AUTHORS   Spence,S., Rena,G., Sullivan,M., Erdogan,S. and Houslay,M.D.
  TITLE     Receptor-mediated stimulation of lipid signalling pathways in CHO
            cells elicits the rapid transient induction of the PDE1B isoform of
            Ca2+/calmodulin-stimulated cAMP phosphodiesterase
  JOURNAL   Biochem J 321 (Pt 1) (Pt 1), 157-163 (1997)
   PUBMED   9003415
REFERENCE   9  (bases 1 to 8969)
  AUTHORS   Yan,C., Zhao,A.Z., Bentley,J.K. and Beavo,J.A.
  TITLE     The calmodulin-dependent phosphodiesterase gene PDE1C encodes
            several functionally different splice variants in a tissue-specific
            manner
  JOURNAL   J Biol Chem 271 (41), 25699-25706 (1996)
   PUBMED   8810348
REFERENCE   10 (bases 1 to 8969)
  AUTHORS   Yan,C., Zhao,A.Z., Bentley,J.K., Loughney,K., Ferguson,K. and
            Beavo,J.A.
  TITLE     Molecular cloning and characterization of a calmodulin-dependent
            phosphodiesterase enriched in olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9677-9681 (1995)
   PUBMED   7568196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122847.4, AC044804.4 and AC079956.4.
            
            On Aug 1, 2022 this sequence version replaced XM_006505733.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.907604.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               AC122847.4         43623-44115
            494-571             AC044804.4         240009-240086       c
            572-622             AC044804.4         137953-138003       c
            623-794             AC044804.4         100801-100972       c
            795-908             AC079956.4         113078-113191       c
            909-1091            AC079956.4         111463-111645       c
            1092-1158           AC079956.4         110487-110553       c
            1159-1275           AC079956.4         106302-106418       c
            1276-1416           AC079956.4         104997-105137       c
            1417-1517           AC079956.4         90321-90421         c
            1518-1646           AC079956.4         88417-88545         c
            1647-1748           AC079956.4         82686-82787         c
            1749-1869           AC079956.4         81990-82110         c
            1870-1951           AC079956.4         73488-73569         c
            1952-2072           AC079956.4         70785-70905         c
            2073-2248           AC079956.4         68739-68914         c
            2249-2470           AC079956.4         58253-58474         c
            2471-2548           AC079956.4         54386-54463         c
            2549-8969           AC079956.4         31837-38257         c
FEATURES             Location/Qualifiers
     source          1..8969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.65 cM"
     gene            1..8969
                     /gene="Pde1c"
                     /note="phosphodiesterase 1C"
                     /db_xref="GeneID:18575"
                     /db_xref="MGI:MGI:108413"
     exon            1..493
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2562
                     /gene="Pde1c"
                     /EC_number="3.1.4.17"
                     /note="isoform g is encoded by transcript variant 12;
                     calcium/calmodulin-dependent 3',5'-cyclic nucleotide
                     phosphodiesterase 1C; cam-PDE 1C; 3',5'-cyclic-AMP
                     phosphodiesterase; 3',5'-cyclic-GMP phosphodiesterase;
                     dual specificity Calcium/calmodulin-dependent 3',5'-cyclic
                     nucleotide phosphodiesterase 1C"
                     /codon_start=1
                     /product="dual specificity calcium/calmodulin-dependent
                     3',5'-cyclic nucleotide phosphodiesterase 1C isoform g"
                     /protein_id="NP_001397184.1"
                     /db_xref="GeneID:18575"
                     /db_xref="MGI:MGI:108413"
                     /translation="MGSVSSVLARSRNTVVQPGSSPPHQEVPLAAPASLKDSRTQRRV
                     LGHQGSFRPSPAWEPPPAKHSQQELPKLESAELSPVRRRLPAMSQSSPSDSPGETGTG
                     KTEELNTQTDATEKQPAAGEQVANEAGDKNARPLARFSRSKSQNCLWNSLIDGLTGNI
                     KEKPRPTIVQDTRPPEEILADELPQLDSPEALVKTSFRLRSLVKQLERGEASVVDLKK
                     NLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRS
                     DEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEA
                     SGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVT
                     QTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRS
                     VLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMK
                     TALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLP
                     FSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSS
                     LNSINSSDAKRSGVKSSGSDGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPK
                     EEKAKKEAEEKARLAAEEKQKEMEAKSQAEQGTTSKGEKKTSGEAKSQVNGTRKGDNP
                     RGKNSKGEKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKTDDPEE"
     exon            494..571
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            572..622
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            623..794
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            795..908
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1091
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1158
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1275
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1416
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1517
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1646
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1748
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1869
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1951
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2072
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2248
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2470
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2548
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..8969
                     /gene="Pde1c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5383..5388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde1c"
                     /note="hexamer: ATTAAA"
     polyA_site      5401
                     /gene="Pde1c"
     regulatory      8931..8936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde1c"
                     /note="hexamer: AATAAA"
     polyA_site      8969
                     /gene="Pde1c"
                     /note="major polyA site"
ORIGIN      
        1 tggacagcca gacaggcaga caccaaccag attactttca gtccacctcc ggtgggagca
       61 tttaattctc cctgcaccct gctcagctgc cttcgtgtca gaggaggcgc agtccaccag
      121 gggcgcccgg ggtgggaagg gagccagcct ttggctgcca aggggtgcgg atccccgagg
      181 atctcgacct ggcccgctgg gatgggttct gtctcctccg tgctggcgcg gtcccgcaac
      241 accgtcgtgc agccgggatc gtcgccgccg catcaagaag tgccgctcgc tgctcccgcg
      301 tctctcaaag actctagaac ccagcgtcgg gtactcgggc atcaaggctc tttcagacct
      361 tccccagcct gggaaccgcc gccggccaag cacagccagc aggagcttcc aaagttggag
      421 agcgcggagc tgtcccccgt gcggaggcgt ttgccagcta tgtcccagtc ctcccccagc
      481 gacagcccag gagagactgg cactgggaag acagaagagt tgaacaccca gacagacgcc
      541 acagaaaaac agccagctgc aggagaacaa gttgcaaatg aagcaggaga caagaatgcc
      601 agaccacttg ctcgcttctc ccggtctaag tcacagaact gcctgtggaa ctccctcatt
      661 gatgggctca ctgggaatat taaggagaaa ccacggccaa caattgtcca ggacacgcga
      721 cccccagaag aaattctggc agatgagttg ccacagctgg atagcccaga agctttggtg
      781 aagacatctt tcaggttacg gtctttggtc aagcaattag aacgaggaga ggcctctgtg
      841 gtagacctta agaagaatct ggaatatgca gccacagtgc ttgaatctgt atatattgat
      901 gaaacaaggc gactgctgga tacagaggat gagcttagtg acattcaatc agatgctgtg
      961 ccttcagaag ttcgggattg gctggcctcc accttcacac ggcagatggg gatgatgctt
     1021 aggagaagtg atgagaagcc caggttcaag agcatcgtcc atgcggtgca agctgggata
     1081 tttgtggaaa gaatgtacag acggacatca aacatggttg ggctgagcta tccaccggct
     1141 gtaatcgatg cattgaagga tgtggatacg tggtccttcg atgtcttttc cctcaatgag
     1201 gccagtggag atcatgcact gaagttcatt ttctatgaat tactcacacg ttatgacctg
     1261 atcagccgtt ttaagatacc gatttctgca cttgtctcat ttgtggaggc cctcgaagtg
     1321 ggttacagca agcacaaaaa tccttaccat aacctgatgc atgcagctga cgtcacacag
     1381 actgtgcatt acctccttta taagacagga gtagcaaact ggctgacaga gctggagatc
     1441 tttgcaataa tcttttcggc tgccatccat gactatgaac atactggaac tacaaacaat
     1501 ttccacattc agactcggtc agatccagct atcctgtaca atgacagatc tgtcctggag
     1561 aaccaccacc tgagtgcagc ctaccgcctt ctgcaggaag acgaagagat gaatattctg
     1621 gttaacctct caaaggatga ctggagggag tttcgaactt tggttattga gatggtaatg
     1681 gccacagata tgtcctgtca tttccagcaa atcaaagcca tgaagacagc cctgcagcaa
     1741 ccagaagcaa ttgagaagcc gaaagcctta tccctcatgt tacacacagc agacatcagt
     1801 catcctgcga aagcatggga cctgcaccac cgctggacca tgtctctcct ggaggagttc
     1861 tttagacagg gtgacagaga agcagagctg gggctgccat tttctcctct ttgtgacaga
     1921 aagtcaacca tggttgctca gtcacaagtg ggttttattg acttcattgt ggagcccacc
     1981 ttcactgtgc tcacggacat gaccgagaag attgtgagtc cattaattga cgaaagctcc
     2041 cagactggtg ggacagggca gaggagatca agtttgaaca gcatcaactc atcagatgca
     2101 aagcgatccg gtgtcaagag ttctgggtca gatggaagtg ctcccatcaa caattctgtc
     2161 attcctgttg actataagag ttttaaagcc acttggactg aggtggtgca gatcaatcgg
     2221 gagcggtggc gagccaaggt acccaaagaa gaaaaagcca agaaggaagc tgaagagaag
     2281 gctcgcctgg ctgctgagga aaagcaaaag gaaatggaag ccaaaagcca agctgaacaa
     2341 ggcacaacca gcaaaggcga gaaaaagaca tcaggagaag ccaaaagtca agtcaatgga
     2401 acacgcaagg gtgataaccc tcgtgggaag aactccaaag gagaaaaggc aggcgaaaag
     2461 cagcagaacg gtgacttgaa agacggtaaa aataaggcag acaagaagga tcactccaac
     2521 accggaaatg agtcaaagaa aacagatgat ccagaggagt agaaaagacc tcacatagac
     2581 tgaggctgcc agtgtctccc gccattttag ctgagcttct ccattctcct tcttccacaa
     2641 agactcatag ctggggaagg tgtacagctt tcaaagccaa gtcccacatt tggccttctc
     2701 tctccctccc aggggcctct gggggttggc ttgaggtctt agaattctgg gggatttctt
     2761 tccctgaaca cacaaaaccc atgtgtggtt ccttatgttc tttttatttt cattttggtt
     2821 tcccccccat ccccagccca gcagaaatca aacatgaaag gccactttat aatccattac
     2881 tagtaatctg gctttctgga cctggtgaaa gactgccatt ccggatgcgc tgagtgagac
     2941 ctggagactg ccgttttgtt tttgttaatg ctgttatctt agattgttgc ctttcacccc
     3001 ggctcctgat ggtgaatata gccagactgg ccttcattac gactacagtg aaatgccaat
     3061 ctctggttct tttatttttc atcagtcaac aactttcatt tttttttcag tttactttat
     3121 gacttaaaat taagaacaat tttttcccat ttgtgtaata caaaactgtt ttttaaagag
     3181 gagcttatcc tgtaggtctc tgtatttgat gcttaattta ttatctgtaa attcataaat
     3241 atatacttga atgtgttagc tgatgaccat attgccaggc gggttcccca gtgctgtgac
     3301 tgggaagtac caatcactac aatgtcgctc aaatgttgac cactgtctgt tcattttctt
     3361 ttgaatatct ataaattggc ctcattaatt taaaaatgct ttagaaaggg aagtgataag
     3421 ggacccagaa ccagagagat gagattcatt taaatgagat ttttaacact ataaaggagt
     3481 ttattaatag cacaaataga aaataaagat aagatatttg gtaggaaaag ggaataaaag
     3541 tagatttttc tgaagccaaa cagaaagtgg gatccagtga aatgcaagga aggtgtgatt
     3601 tttttccccc catcatttga tttggatgta tttttatttt atagttttag gtcctttttg
     3661 aacataatgc atgtcttata ggattaatgt tagggaaaaa aaaatgaact aggtaataaa
     3721 cttagatgag ctccacagat ttaatttcta tattaaaagc atacagtcag atattttaaa
     3781 gtatctgtat tgctgaaata agttattagt gtttcttgag aggttaaaga agactgtgta
     3841 gggtccttac gacctcttgg ctcacagaaa caggctacag caggaagtcg ggaagaaagt
     3901 tgttgcctgg agcacacaga accgatgttt actgactttt ctctgttggt tgtatatttg
     3961 gcctcatcac aacactgaca cttcttcatt gctctatctg ctttcctaac taaactatga
     4021 gctttcagat ttaaataact ttgggagcat agatggaagg gccaaatgtc atgattagaa
     4081 caagccatgt aatatctaag tattggaata caaggcagtt tgatgggctg tgatatcaag
     4141 gagacagtaa gaaagagtaa gaatgttggg gtcctggaga ggcatggctg tgagagaaga
     4201 gtgaggatgc tcaggaattg atgaggctgg gtgttagtga agagtaagga tggggaggaa
     4261 ctgctgaagg agatgctgtg gtaagaaagc agcagcccag tatcatgggc tatatctgtg
     4321 ctgtgtagga acaggggtcc tacgtacaca gtattttgtg taaatctcct acaaagtttt
     4381 atacattggc ttcgaattca gatgcttacg ctgcactagt gcaagaaaat gtgcttatga
     4441 gctgcatgcc acccagggat caccggatta caaactgtgt tcttaaaggt agactgattc
     4501 cgtgtgtcaa ttcaatgctt gagtgtatgc agtctatgcc tttggaacat gggcctttta
     4561 cctcacatct actctatatt tttgtatgtg aagcacttgg gcagttgata cagaatgcct
     4621 actgcttcat tttataatct agcaaataat actacacaat atttaaaaag aaataggaat
     4681 atagccattt ctctagaatc agtgaagatg taaatgattt aaatttgctg ttagccacta
     4741 atctgctgaa aaagaatggg aaaagaagga acaaaagctc tgctaactca gtcccagcat
     4801 tctacttctc aagtgtcaaa gcacattgac tacacatgca aagccatttg tttagcagca
     4861 cactactctg ctctaaactc atcctagatc tgataccaca ttagaataat tattccaggt
     4921 cagtattcac aagaagaaac aatatttcca aagctctagc attttttaac gtgggttttg
     4981 cttttcttga aacagcttct tccaagtttt gctttgatat ccaaccggca tcatcccata
     5041 ccccagttat catcttgctc tggttcatgt gcatagtgca gccttgcaca ccagagttac
     5101 tataagaaac cgtgggcaca tcagtggcct catactcatt agtattacaa taaatacttt
     5161 tcatgtttct gagtatagct tgataactgg aatcacttct tgagttgtac cttcatatca
     5221 cccaacaagt ctatatccaa gttatgtcac tatggtctca tctcaggaca gagggactga
     5281 tccttacgga gttgtggttt ttatttctta tttgtagctg cctttcctag tctgtgtgtc
     5341 ccagtagctt atggcatcaa ttaaaagata catttctaaa tcattaaagc acttttttcc
     5401 actggccgtt ttgttcttgg aacttttaag aaactattga agacatctga caggattctg
     5461 cgcacatcta cctttataga catcatgata agcactaaag gcaaaggcaa gctagtgttg
     5521 cagatttatc tcctttgtag aatctcagac atcatatttt ctaactccag ccatgacatt
     5581 agaaagcata aaaatgaaaa gggaagggta atgttatcat acagtgtgag gggagggggc
     5641 tattttgtgc tccacattct ggcacttggg aacctgaact ctcttctctc atgagtaagt
     5701 tttctttaca cagactttat gagtcaatgg gaggagagat ggggggacaa ataaggtata
     5761 tcttcctctg gtgtttgtta atgtgtgagt agacatttta taacgagaaa cattttataa
     5821 tgttctccca atgagtgtgg ggaaaaaaat aataaaaagt agaaaatcct tttcatgatg
     5881 agacagagaa gattccagga ttgcaagtct gagtgtagca taattttcca aataaaagag
     5941 attgggggag tacctttatt cccagtcaga ctcttcattc taacactgag atgcccagcc
     6001 acactgcagg aattagaggt ctggtctgtc acagtgcctg tcacccagcc aacattcagg
     6061 acacatggga gcactgtcag atggaatcat actgtcccct tccaattcaa acaaagttca
     6121 aatttccttt acaacatatt ccaaaccttc tccttccatg tggctgtatt catgagactt
     6181 gcattctggg taaatgcaga catacttgaa tcacaagggg aaacagcagg ctatttgggg
     6241 aaattgtcag agctaacaag tgcatgaaag tcgattaata tattttctgt ggcctttaat
     6301 tttgagaaag aacaacaaaa acaaaacaaa aaaatgaata aataaaatca atgaaatgag
     6361 gttcttcaga gactgaacca ggagggataa tgccacagaa ctgcaggaag tgctcatgac
     6421 tctgcttaga atccaagctg aaacttggac gctcttgaaa caaatgggaa atactatcaa
     6481 tgcagcatga gaaatcactg cagggtttgc tctgctaccg tggtgggcac aacgcccagc
     6541 tgcagtgaag ctgagtgtta ttgaatataa tgtttcaata atgatgttat attggttctt
     6601 attcttgaac aaatggaaaa ttatacttgt aatccatcaa cagcgatccg tgattaaagg
     6661 cctcattatc actgagaaag agagcataat gagctgccag ttatgaacag caacaacgtt
     6721 cctgtgaaac caggggactc attaccctat gtccaagcag aaacactggt gggcacagag
     6781 gtggccctga agtcaggata taaccagggc cacctactga tttgactgca gtgtttagca
     6841 aatgtgagta aggttagaaa aatgtgagct tctcagtgga tctttgtatg ggggatgttc
     6901 tctccaggag atctcctgtg atgagcaaag ccagcctcat ttaagaactt gttttctcag
     6961 gaaacaatgg tgaggccagc aggagacctg atccgagaag ttcaaggtca ggctttaaag
     7021 actgaagttc tgattatctt cttatatcaa cgctgcttcc cattttcact caaaatatcg
     7081 gcacacatat tagagatgaa ttagcattca tcctgacttt tgttcaagtg gaactgggtt
     7141 aacactggca agggcaggtt tccctgatac acctgttccc aaactaaggg gccattgcag
     7201 agtcaggaac aggagaatgg tggaaccttt cagctcaacc agaacacact tacctagctt
     7261 ctctgctggg gattcatctg ccttctgtgt gactgctgac tgtaccagtc cacagtcagt
     7321 gtcagtactg agcatctttt ctggagggct caggctcacc cattgcctct gaggctccca
     7381 catggacaca ctcttcatgg gagctgaagt ctacacttgc agaagcactc acaggcaagc
     7441 tcactagagc cctggggctg aaatggcttt taaccaagtg ctcaggaggc atacctctgc
     7501 ttatatctgc tcttcttatg tgctctatac tagggagggg gctttgtata ctgctgccct
     7561 tgtcttcaaa taggtataca tgtgatatgt gtgatgatat aaaaaacaca cacattaata
     7621 cttatagctt tatagtgaaa atctacagcc atacatacca tccagtgatg gattctagaa
     7681 acagactgta gagaattcct ttctttcttt tttttttttt cttgttttga ggcgatttta
     7741 tacaatttta tatgctgtaa gattttaaaa tatttttgct attttcattt gtagatcttg
     7801 gctcgggttg tcttagctct tttgttccgc tgtacaggga cacccgcttg acttttgaag
     7861 tatcctctcc ctgcttcatg cccttccctt cgtggtttcc tttgtgtctc acattttctg
     7921 tcatttccca agtctcttca gtggcttctg tccagataag ccatgctacc tgcagtatca
     7981 tttgagcaca gagaaacaca aaatagtggg gggggggcac attttctagt gtaatccaaa
     8041 tgaggaagtg ttaagtgtct aaagcaaagt gaagaagcta tacagggaga aagggatata
     8101 ttggtaaagg gaggcaagga caaggaactc agaatgggag gaaatttttc aaagcaactt
     8161 acaggttaat acaatgtttt gtcttccttg attgtaggac attttttttt ttctgttaca
     8221 agggtttttt cctctggatg ttatgttctc atcatgagtc tgtagactca ctcattcctt
     8281 gtagggagct tctctcccct gcctatatag gaatagaagg tagaaaccct ttctaagcct
     8341 tagatgttgc tgctgttcag atccagacgg ctagatttgt gacaagtgtc taaaatgctg
     8401 tcaagaacat ttagcagaac tctgaagaaa gaaggctgcc agcctgccag acttttccca
     8461 gattaggcca catacctagt tgttgggaga gggggagtta agaaatgtat ggttgtggta
     8521 ctgcagatgc ctttccaaaa aggaagatcg gaaatggctt gtgtttactt catggcacaa
     8581 tatcatgtac ttccctgatg tgagggagtc tcaggcagac atagtgcagg tttcagcttg
     8641 catgtatcca tcacagagca agggaatggc catccattct aaggaaaagt attctgtccc
     8701 ctatggtgct gtaccgtcat gctaattgtt cacacactgt aacatcacac ctccaaatgc
     8761 aaaatcgaag cacgggattc atgtaaaaac agagagtgcc aaactgctgt taaaacattt
     8821 aaaaatatgt ttattgtaaa tctttattgc acaaaagagc ctgataatcc ttcatgtata
     8881 attcccccta acatctagta ataaataatt gtatgttcct ctaattgtca aataaagaca
     8941 ttagttaacc tctttattgg aatttgaaa
//
