LOCUS       NM_008800               3262 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus phosphodiesterase 1B, Ca2+-calmodulin dependent
            (Pde1b), transcript variant 1, mRNA.
ACCESSION   NM_008800
VERSION     NM_008800.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3262)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3262)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   3  (bases 1 to 3262)
  AUTHORS   Manuel,M., Tan,K.B., Kozic,Z., Molinek,M., Marcos,T.S.,
            Razak,M.F.A., Dobolyi,D., Dobie,R., Henderson,B.E.P.,
            Henderson,N.C., Chan,W.K., Daw,M.I., Mason,J.O. and Price,D.J.
  TITLE     Pax6 limits the competence of developing cerebral cortical cells to
            respond to inductive intercellular signals
  JOURNAL   PLoS Biol 20 (9), e3001563 (2022)
   PUBMED   36067211
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3262)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3262)
  AUTHORS   Mathieu,M., Drelon,C., Rodriguez,S., Tabbal,H., Septier,A.,
            Damon-Soubeyrand,C., Dumontet,T., Berthon,A., Sahut-Barnola,I.,
            Djari,C., Batisse-Lignier,M., Pointud,J.C., Richard,D.,
            Kerdivel,G., Calmejane,M.A., Boeva,V., Tauveron,I.,
            Lefrancois-Martinez,A.M., Martinez,A. and Val,P.
  TITLE     Steroidogenic differentiation and PKA signaling are programmed by
            histone methyltransferase EZH2 in the adrenal cortex
  JOURNAL   Proc Natl Acad Sci U S A 115 (52), E12265-E12274 (2018)
   PUBMED   30541888
REFERENCE   6  (bases 1 to 3262)
  AUTHORS   Reed,T.M., Browning,J.E., Blough,R.I., Vorhees,C.V. and
            Repaske,D.R.
  TITLE     Genomic structure and chromosome location of the murine PDE1B
            phosphodiesterase gene
  JOURNAL   Mamm Genome 9 (7), 571-576 (1998)
   PUBMED   9657856
REFERENCE   7  (bases 1 to 3262)
  AUTHORS   Spence,S., Rena,G., Sullivan,M., Erdogan,S. and Houslay,M.D.
  TITLE     Receptor-mediated stimulation of lipid signalling pathways in CHO
            cells elicits the rapid transient induction of the PDE1B isoform of
            Ca2+/calmodulin-stimulated cAMP phosphodiesterase
  JOURNAL   Biochem J 321 (Pt 1) (Pt 1), 157-163 (1997)
   PUBMED   9003415
REFERENCE   8  (bases 1 to 3262)
  AUTHORS   Yan,C., Zhao,A.Z., Bentley,J.K., Loughney,K., Ferguson,K. and
            Beavo,J.A.
  TITLE     Molecular cloning and characterization of a calmodulin-dependent
            phosphodiesterase enriched in olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9677-9681 (1995)
   PUBMED   7568196
REFERENCE   9  (bases 1 to 3262)
  AUTHORS   Polli,J.W. and Kincaid,R.L.
  TITLE     Molecular cloning of DNA encoding a calmodulin-dependent
            phosphodiesterase enriched in striatum
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 11079-11083 (1992)
   PUBMED   1332068
REFERENCE   10 (bases 1 to 3262)
  AUTHORS   Repaske,D.R., Swinnen,J.V., Jin,S.L., Van Wyk,J.J. and Conti,M.
  TITLE     A polymerase chain reaction strategy to identify and clone cyclic
            nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA
            encoding the 63-kDa calmodulin-dependent phosphodiesterase
  JOURNAL   J Biol Chem 267 (26), 18683-18688 (1992)
   PUBMED   1326532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC058531.1, AC131721.4 and DN173601.1.
            
            On Oct 25, 2013 this sequence version replaced NM_008800.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927934.154389.1,
                                           SRR1660811.237885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               BC058531.1         1-264
            265-339             AC131721.4         186511-186585
            340-462             AC131721.4         186674-186796
            463-576             AC131721.4         203162-203275
            577-759             AC131721.4         204519-204701
            760-826             AC131721.4         204866-204932
            827-943             AC131721.4         205258-205374
            944-1084            AC131721.4         207521-207661
            1085-1185           AC131721.4         208011-208111
            1186-1311           AC131721.4         208203-208328
            1312-1413           AC131721.4         208449-208550
            1414-1534           AC131721.4         209476-209596
            1535-1616           AC131721.4         209820-209901
            1617-1725           AC131721.4         210197-210305
            1726-1856           AC131721.4         210758-210888
            1857-1979           AC131721.4         211435-211557
            1980-3218           AC131721.4         212027-213265
            3219-3262           DN173601.1         510-553
FEATURES             Location/Qualifiers
     source          1..3262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.99 cM"
     gene            1..3262
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /note="phosphodiesterase 1B, Ca2+-calmodulin dependent"
                     /db_xref="GeneID:18574"
                     /db_xref="MGI:MGI:97523"
     exon            1..339
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..462
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..576
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..759
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..826
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..943
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1084
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1185
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1311
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1413
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1534
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1616
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1725
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1856
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1979
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..3222
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3199..3204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /note="hexamer: AATAAA"
     polyA_site      3218
                     /gene="Pde1b"
                     /gene_synonym="Pde1b1"
                     /note="major polyA site"
ORIGIN      
        1 gcacccctag gctctcttgc gctcctaggc gagggggagg agtggctaca ctgcgcggta
       61 gaccggcggg cgggcgggtc gaggagcagg gaggggagcg aagggagggg gccctggccg
      121 ggggaggagg agggaggcga ggaggcggct gtggcagcgc acggcggcgg tggcggaggt
      181 agcggcggcg gcggtggcgg cggcagcggc gcggagagct ggaagctgga gcccagagct
      241 cagccgggta gcgtgagaga agcagccgca ggaactgcag ccctgctagc ttgggccgag
      301 cagaaacaca ccggcctggc tggtccacgc cagccgcaga cagtggctga gcatggagct
      361 gtccccccgc agtcctccag agatgctgga gtcggattgc ccgtcacccc tggagctgaa
      421 gtcagccccc agcaagaaaa tgtggattaa gctacggtct ctgctgcgct acatggtgaa
      481 gcagttggag aatggggagg ttaacatcga ggagctgaag aaaaacctgg aatacacagc
      541 ttccctgctg gaagctgtct acattgatga gacaaggcaa atcctagaca ctgaagatga
      601 gcttcgggaa cttcggtcag atgctgtgcc ttcagaggtg cgggactggt tggcctccac
      661 cttcacccag cagacccgag ccaaaggtcg cagggcagaa gagaaaccca agttccgaag
      721 catcgtgcat gctgtgcagg ctgggatctt cgtggagcgg atgttccgga gaacgtatac
      781 ctctgtgggc cccacatact ctactgcagt ccacaactgt ctcaagaacc tggacctctg
      841 gtgctttgat gtcttttcct tgaaccgggc agccgatgac cacgctctga ggaccattgt
      901 ttttgagttg ctgactcggc atagcctcat cagccgcttt aagattccca cagtgtttct
      961 gatgagtttt ctggaggcct tggagacagg ctatgggaaa tataagaatc cttaccacaa
     1021 ccagatccac gcagccgacg tgacccagac tgtccattgc ttccttctcc gcacaggcat
     1081 ggtgcactgc ctgtcagaga ttgaggtctt ggccatcatc tttgctgcag ccatccatga
     1141 ctatgagcac acaggcacaa ccaacagctt ccacattcag accaagtcag aatgtgccat
     1201 cctgtacaat gatcgatcgg tgctggagaa tcaccacatc agctctgtct ttcgaatgat
     1261 gcaggatgat gagatgaaca tttttatcaa tctcaccaag gatgaatttg cagagctgcg
     1321 ggccctggtt atcgagatgg tgttggccac agacatgtcc tgccatttcc agcaagtgaa
     1381 gactatgaag acagcactgc agcagttgga aaggattgac aagtccaagg ccctatctct
     1441 tctgcttcat gctgctgaca tcagccaccc aactaagcag tggtcagtcc acagccgctg
     1501 gaccaaggcc ctaatggaag agttcttccg ccagggtgac aaggaggcag agctgggcct
     1561 gcccttctct ccactctgtg atcgcacttc cacattggtg gcccagtccc agataggttt
     1621 cattgacttc attgtggagc caaccttctc tgtgctgact gatgtggcag aaaagagtgt
     1681 ccagcccttg gcagatgatg attccaagcc taaaagtcag cccagcttcc agtggcgcca
     1741 gccttcttta gatgtggacg taggagaccc caaccctgat gtggtcagtt tccgtgccac
     1801 ctggaccaag tacattcaag agaacaaaca gaagtggaag gaacgggcag caagtggcat
     1861 caccaaccag atgtccattg atgaactgtc cccctgtgag gaagaagccc catcctcccc
     1921 tgcagaagat gagcacaacc agaatgggaa tctggattag ggaactgggg gctgaccagg
     1981 tcctcactga gtccaaagtc ttcgatgtca ttagcactat ccatcaggac tggttccccc
     2041 atctgctcca agggagtgtg ttggttgtgg gagagacagc tcacctgaga gccaaatgtt
     2101 ggagcgggtg gggtgtggga agggcccctc cccacccaca ggccctcagt ggtcactgtg
     2161 cccatccctt gcctctggac tcctcctttg gccacttggg aggagtaagc tccctgcagg
     2221 cttcctacag tttggagggg agggtcagag atgccagccc cctgggccct ccccatcctt
     2281 cttgcctcca agtttctaag caatacattt tgggggttcc ctcagtcccc caccccagat
     2341 cttagctggc aggtctgggt ttcccttctc ttccctgaga aagggccaga ataggatagg
     2401 aagctggcag ttttcaaagc cctgcatggg aagggcaggt gtcccttcag gttccttcct
     2461 aagatgaggt gggggacatc ctcttgatcc catacttgca cttcttcagc cccattccct
     2521 tgcaaattct ctctctcctg tgcccagaca gtggctggga gaggagagga gccattggga
     2581 ttctgtctga gggaagtctt tcctggagtc ctcaaatact tggggatggt ctgggcttga
     2641 ggggcttgta ccctgatcta gatgggtttt tgaccctttg cctccttcct gtccccggga
     2701 actaggaagc cctcatccga ccaatgtctg taaacgctct gaggtcttcc ttcaggatgt
     2761 atcttatgag caaaggaagg agagagcagc tagccccagt acaagcaggg ggaagtatta
     2821 cccagtaatg ttgacacaga gcaggtcctt cctgcctccc ttctccccga actggcccac
     2881 taagagattt ccccctcccg gggcccctgg tgggtggaag gcagatgggg aggggctcag
     2941 ggcggtagca acttggagca cccagagcga gtgcagccag gtaaagcctc ttcctgtcct
     3001 caggctcctt gccccacgtc accccattta aggccaagtc caggtgactg cctcctcctc
     3061 tcttgtaaat acatgcattt gtacagtggg ccctgttctt gtgaagtcca tctccatggt
     3121 cattagacct gccactctga accgcatgtg actcccccat gctcttggtc tcccaggccc
     3181 ctgctatagc cagagatcaa taaagaaggg agaccggctg gaaaaaaaaa aaaaaaaaaa
     3241 aaaaaaaaaa aaaaaaaaaa aa
//
