LOCUS       NM_001159582            4514 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus phosphodiesterase 1A, calmodulin-dependent (Pde1a),
            transcript variant 1, mRNA.
ACCESSION   NM_001159582
VERSION     NM_001159582.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4514)
  AUTHORS   Zhang H, Pan B, Wu P, Parajuli N, Rekhter MD, Goldberg AL and Wang
            X.
  TITLE     PDE1 inhibition facilitates proteasomal degradation of misfolded
            proteins and protects against cardiac proteinopathy
  JOURNAL   Sci Adv 5 (5), eaaw5870 (2019)
   PUBMED   31131329
  REMARK    GeneRIF: PDE1 inhibition induces PKA- and PKG-mediated promotion of
            proteasomal degradation of misfolded proteins and treats heart
            failure with preserved ejection fraction caused by CryAB(R120G) in
            a mouse model of cardiac proteinopathy
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4514)
  AUTHORS   Aydogdu N, Rudat C, Trowe MO, Kaiser M, Ludtke TH, Taketo MM,
            Christoffels VM, Moon A and Kispert A.
  TITLE     TBX2 and TBX3 act downstream of canonical WNT signaling in
            patterning and differentiation of the mouse ureteric mesenchyme
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30478225
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4514)
  AUTHORS   Paul A, Crow M, Raudales R, He M, Gillis J and Huang ZJ.
  TITLE     Transcriptional Architecture of Synaptic Communication Delineates
            GABAergic Neuron Identity
  JOURNAL   Cell 171 (3), 522-539 (2017)
   PUBMED   28942923
REFERENCE   4  (bases 1 to 4514)
  AUTHORS   Wang X, Yamada S, LaRiviere WB, Ye H, Bakeberg JL, Irazabal MV,
            Chebib FT, van Deursen J, Harris PC, Sussman CR, Behfar A, Ward CJ
            and Torres VE.
  TITLE     Generation and phenotypic characterization of Pde1a mutant mice
  JOURNAL   PLoS One 12 (7), e0181087 (2017)
   PUBMED   28750036
  REMARK    GeneRIF: These results support an important role of PDE1A in the
            renal pathogenesis of autosomal dominant polycystic kidney disease
            and in the regulation of blood pressure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4514)
  AUTHORS   Isidori AM, Cornacchione M, Barbagallo F, Di Grazia A, Barrios F,
            Fassina L, Monaco L, Giannetta E, Gianfrilli D, Garofalo S, Zhang
            X, Chen X, Xiang YK, Lenzi A, Pellegrini M and Naro F.
  TITLE     Inhibition of type 5 phosphodiesterase counteracts beta2-adrenergic
            signalling in beating cardiomyocytes
  JOURNAL   Cardiovasc Res 106 (3), 408-420 (2015)
   PUBMED   25852085
REFERENCE   6  (bases 1 to 4514)
  AUTHORS   Vasta V, Sonnenburg WK, Yan C, Soderling SH, Shimizu-Albergine M
            and Beavo JA.
  TITLE     Identification of a new variant of PDE1A calmodulin-stimulated
            cyclic nucleotide phosphodiesterase expressed in mouse sperm
  JOURNAL   Biol Reprod 73 (4), 598-609 (2005)
   PUBMED   15901640
  REMARK    GeneRIF: new variant PDE1A_v7 is the major form of cyclic
            nucleotide phosphodiesterase 1A expressed in mature sperm and is
            therefore likely to play an important role in cyclic nucleotide
            regulation of mature sperm function.
REFERENCE   7  (bases 1 to 4514)
  AUTHORS   Lefievre L, de Lamirande E and Gagnon C.
  TITLE     Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as
            a stable complex with calmodulin, and PDE3A in human spermatozoa
  JOURNAL   Biol Reprod 67 (2), 423-430 (2002)
   PUBMED   12135876
REFERENCE   8  (bases 1 to 4514)
  AUTHORS   Fu X and Kamps MP.
  TITLE     E2a-Pbx1 induces aberrant expression of tissue-specific and
            developmentally regulated genes when expressed in NIH 3T3
            fibroblasts
  JOURNAL   Mol Cell Biol 17 (3), 1503-1512 (1997)
   PUBMED   9032278
REFERENCE   9  (bases 1 to 4514)
  AUTHORS   Spence S, Rena G, Sullivan M, Erdogan S and Houslay MD.
  TITLE     Receptor-mediated stimulation of lipid signalling pathways in CHO
            cells elicits the rapid transient induction of the PDE1B isoform of
            Ca2+/calmodulin-stimulated cAMP phosphodiesterase
  JOURNAL   Biochem J 321 (Pt 1) (Pt 1), 157-163 (1997)
   PUBMED   9003415
REFERENCE   10 (bases 1 to 4514)
  AUTHORS   Yan C, Zhao AZ, Bentley JK, Loughney K, Ferguson K and Beavo JA.
  TITLE     Molecular cloning and characterization of a calmodulin-dependent
            phosphodiesterase enriched in olfactory sensory neurons
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9677-9681 (1995)
   PUBMED   7568196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF741268.1, AK043647.1, AK134679.1 and BC090628.1.
            
            [WARNING] On May 3, 2023 this sequence was replaced by
            NM_001159582.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (2). Variants 1, 2, 10,
            and 11 all encode isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050004.1, ERR3363658.2797533.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-639               CF741268.1         1-639
            640-2883            AK043647.1         436-2679
            2884-4492           AK134679.1         160-1768
            4493-4514           BC090628.1         4234-4255
FEATURES             Location/Qualifiers
     source          1..4514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..4514
                     /gene="Pde1a"
                     /note="phosphodiesterase 1A, calmodulin-dependent"
                     /db_xref="GeneID:18573"
                     /db_xref="MGI:MGI:1201792"
     exon            1..332
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            333..443
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1980
                     /gene="Pde1a"
                     /EC_number="3.1.4.17"
                     /note="isoform 2 is encoded by transcript variant 1;
                     calcium/calmodulin-dependent 3',5'-cyclic nucleotide
                     phosphodiesterase 1A; cam-PDE 1A; 61 kDa Cam-PDE; dual
                     specificity calcium/calmodulin-dependent 3',5'-cyclic
                     nucleotide phosphodiesterase 1A"
                     /codon_start=1
                     /product="dual specificity calcium/calmodulin-dependent
                     3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2"
                     /protein_id="NP_001153054.1"
                     /db_xref="CCDS:CCDS16172.1"
                     /db_xref="GeneID:18573"
                     /db_xref="MGI:MGI:1201792"
                     /translation="MGSTDTDIEELENATYKYLIGEQTEKMWQRLKGILRCLVKQLEK
                     GDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFT
                     RKMGMMKKKPEEKPKFRSIVHAVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKW
                     SFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPY
                     HNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRS
                     DVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSG
                     HFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQG
                     DKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKS
                     QSSNYGASSSSTMIGFHVADSLRRSNTKGSVCDGSYAPDYSLSAVDLKSFKNNLVDII
                     QQNKERWKELAAQGELDLHKNSEELGNTEEKHADTRP"
     exon            444..557
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            558..740
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            741..807
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            808..924
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1065
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1166
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1292
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1394
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1515
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1597
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1718
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1906
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2023
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..4495
                     /gene="Pde1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttttaagt gccgcttcca gatcaattaa gagacaaaag ccttggtatt taaacaggca
       61 ctttcttccc agggtggtgc tgctggtact gcttcctacc atctggtttc ttattacatc
      121 ctgccctgct tcagctgcta gagaggaatt cagcttcttg tagagcgcga aagtcattca
      181 cgtttctttc gtgcataatt gagctcgtaa actgtagaaa ttctgatgtg cttctgtgca
      241 cggaacagtt gcagatgagc tgcttggcaa atagcctgag cagtcggtca gtagtacagt
      301 agcagctcac atgtgtggat tgctcccgtg aggaacatca tcatggggtc tactgatacg
      361 gacatcgaag aattggaaaa cgccacttac aagtatctca ttggagaaca gaccgagaag
      421 atgtggcagc gcctgaaggg aatactaaga tgcttagtga agcagctgga gaaaggtgat
      481 gtcaacgttg ttgacctaaa gaagaatatc gaatatgcag catcagtact ggaagctgtt
      541 tacatcgatg agacaagaag actgctggac acagaggatg aactcagcga catccagact
      601 gactccgtcc catcggaagt ccgggattgg ttggcttcaa ctttcacacg caaaatgggg
      661 atgatgaaaa agaagcctga agaaaaacca aagtttcgca gcattgtcca tgctgtccag
      721 gctgggattt ttgtggaaag gatgtacagg aagaactatc acatggttgg tttgacatat
      781 cctgcagctg tcatagtgac actcaaggaa gttgataaat ggtcttttga tgtatttgcc
      841 ttaaatgaag caagcgggga gcatagcctg aagtttatga tttatgaact ctttaccaga
      901 tatgatctta tcaaccgctt caagattcct gtttcttgcc taattgcctt tgcagaagcc
      961 ttagaagttg gttacagcaa gcacaaaaat ccatatcata atttggtcca tgcagctgac
     1021 gtcactcaaa ctgtgcatta tataatgctt catacaggta tcatgcactg gctcactgaa
     1081 ctggaaattt tagccatggt ctttgcagct gccattcatg attatgagca cacaggaaca
     1141 acaaacaact tccatattca gacgaggtcg gacgttgcta ttctgtacaa cgaccgctca
     1201 gtgcttgaga atcaccacgt cagcgcagcc tacagactta tgcaagagga ggaaatgaat
     1261 attttggtaa atttgtctaa agatgactgg agggatcttc ggaacttagt gattgaaatg
     1321 gtcttagcga cagacatgtc agggcatttt cagcaaatta aaaacataag aaacagcttg
     1381 cagcagccgg aagggattga cagagccaaa actatgtccc tgatactcca tgcagctgac
     1441 atcagccacc cagccaaaac ttggaagttg cactacagat ggaccatggc cctaatggag
     1501 gagtttttcc tgcagggaga caaagaagct gaattagggc ttccattttc tccactttgt
     1561 gatcggaagt caacaatggt tgcccagtcg caaataggtt tcattgattt catagtggag
     1621 ccaacgtttt ctctcctgac ggactcaaca gagaaaattg tcattcctct tatagaggaa
     1681 gcttcaaagt cacagtcttc aaactacggg gcaagcagct cgtccaccat gattgggttc
     1741 catgttgctg actctctgag gcggtcaaat acaaaaggct ccgtgtgtga tgggagctat
     1801 gccccagact actcgctctc agctgtggat ctgaagagtt tcaaaaacaa cctggtggac
     1861 atcattcagc agaacaaaga gaggtggaaa gagttggctg cccaaggtga acttgatctt
     1921 cataagaact cagaagagtt aggaaatact gaagaaaagc atgctgacac acgtccatag
     1981 gtgtgaacaa actttaagag ttcagttgtt ttaaacacaa caggaaaatg aaagcagcat
     2041 gaaaaacaca caaagacctt gattttctaa aaaaataaaa taaaatgttt ggctcagtcc
     2101 attttagtgg actcctctgt aaggaagaaa agcataaatt tcagtctagt aactgagcca
     2161 caaagttccc acgagttatc attaggatcc tggccactgt ttttgccatg gttttccttc
     2221 catgatttgg tcatcttagc cagagaaatc ttttaaggct gaaagctgga tgctttcaag
     2281 ttttcatcat ttttaacttg tatagaagat ggaatggatt tcaatataca acttgcactg
     2341 tgttactcca gagtgacgca acaacacaat tgtcaacaag caaggacaac aagaagaaaa
     2401 acaaacaaac aaacaaaaaa agagtaaaag aaaggcaaaa caaaatgatg aaaaccctgt
     2461 tttcttgcaa tgctgatctg gtaagactgt cttgttttaa atgcatggga acagaatgag
     2521 aatcagatct gtcttcagaa gcgccagcaa cagctgaccg taagacctgc cgcacagtga
     2581 ttggatgaac gcctctatgg gcctccagct gggaaactac agtgccatct tctcctgaag
     2641 tcatcgacca tcctgcagcc atccactgag ttttaaggca ctagtgtatc acccatgtgt
     2701 gtgtggttat attataggtc gcagtttgct gtagggccaa tgtaacaagg aacatcagcc
     2761 attgcaggag aagggcactc aaagagaaga cagaattttc cttctgggat gttgttacca
     2821 ctagaatata aagatatatt acaggctgag gcataagatg tgtgtgtgtg tgtgtgtgtg
     2881 tgtgtgtgtg tgtgtgtgtg tttgtgtctg tgtgtctgtg tgtctgtgtg tgtgtatgtt
     2941 gtagatgtgt gcactcgtgc tcagaggtgt atatggaaac acatactttt ctgtacagct
     3001 aaaactgtta tgtgatgtga ctttttaatt ttactgaaga gaaatgaact gcaaccctca
     3061 gaggccctgc ttcttggtca tgttttgcct gagcatgtgt gaagtagcta acaggaatgg
     3121 tcaagcccaa ttagatgttg tagtattttc actgtacata cagttcaggg attgcgaact
     3181 tcgtgaaagg tgacaattag atggaatgaa cagttactgt caattaggtg atgtgcagaa
     3241 aggttcaccc atcctaatga gttgcttctc gcacctgtgt ttccccccag gttcctcaag
     3301 gctaagcaat atttcagaga gggacatgac aagaagcttt taagcctaag ttgtgaggtc
     3361 tttataactc acaatttaga tctactttaa tgtgtaagcc atattctcta tgcatattta
     3421 gtatgcattt attgtattta agatatattg tgagtagact gtataaaatg cttttaaatg
     3481 ttctatgaat tagattacta gtgttattat tgtctagatc ttgttaaata attgaattgt
     3541 attatagcca ttataatgtg atggatattt taaatatcaa cagtaaagat tgatctataa
     3601 taatgtgttg agattaatag aaatgtgtat gttagtagcc tttgtccttt aaaatggaca
     3661 ttttatttct atttatggag aaactgtaac tactgctttt caaatcttct ttttaaaaat
     3721 gagatattta ctatctagaa aacattctgc tttcaaagta aaatctgaga gtctaagaag
     3781 tctaattact attgttccta attgagccag ttgtctttca gtaaagctag aatctaagga
     3841 gagaagaata aaatgaagct ctgctcctct catggcgtag acaatacatc tattttgttc
     3901 ctttgatctc tatgcttggt taatgtaaat taaagaatat gcacattgat cagtgtatgt
     3961 ctgctagcct aattgtccag gctatgtgac ttacagagca ctgtgaccaa ccgacttgca
     4021 ggggtagctg gggaggcaca ctgcttcaga gccatcacac tgcctggacc atgcacgcta
     4081 ctcctcacct ccctcccttt tcttcctgtc tccacgatgc ccaatgtgtc tgatattttg
     4141 cctttggcct tccacactcc ttccttcctc tctccacagg acagctccta ctggaagata
     4201 ataagtaggg gtcacactgg agatcacatg agcctccaaa tatacagata atggtgtgaa
     4261 aggccacacc atgaggcggg actatctctc tccaaaggct gctgcacatg ctttgcattt
     4321 gtactcacag tgacccacca tatacttgcg agttcatctg ccttttcatt tagccagaac
     4381 tttacttttt aacatgacaa cctatgattc ttgtgttttt attatgctgc gactctctgt
     4441 atttcctact atatatgatt gctgaataaa tcatattcga tggaaattat cctgaaaaaa
     4501 aaaaaaaaaa aaaa
//
