LOCUS       NM_178668               7510 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus phosphodiesterase 12 (Pde12), mRNA.
ACCESSION   NM_178668
VERSION     NM_178668.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7510)
  AUTHORS   Wei,Q., Chen,L., Luo,W., Chen,C., Shi,Y., Xie,J., Xie,X. and
            Luo,H.B.
  TITLE     PDE12 disrupts mitochondrial oxidative phosphorylation and mediates
            mitochondrial dysfunction to induce oral mucosal epithelial barrier
            damage in oral submucous fibrosis
  JOURNAL   Eur J Pharmacol 967, 176353 (2024)
   PUBMED   38325798
  REMARK    GeneRIF: PDE12 disrupts mitochondrial oxidative phosphorylation and
            mediates mitochondrial dysfunction to induce oral mucosal
            epithelial barrier damage in oral submucous fibrosis.
REFERENCE   2  (bases 1 to 7510)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 7510)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 7510)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 7510)
  AUTHORS   Omori,K. and Kotera,J.
  TITLE     Overview of PDEs and their regulation
  JOURNAL   Circ Res 100 (3), 309-327 (2007)
   PUBMED   17307970
  REMARK    Review article
REFERENCE   6  (bases 1 to 7510)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121919.3.
            
            On Aug 31, 2022 this sequence version replaced NM_178668.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143567.1, AK051991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1421              AC121919.3         74103-75523
            1422-1500           AC121919.3         77315-77393
            1501-7510           AC121919.3         77804-83813
FEATURES             Location/Qualifiers
     source          1..7510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.09 cM"
     gene            1..7510
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /note="phosphodiesterase 12"
                     /db_xref="GeneID:211948"
                     /db_xref="MGI:MGI:2443226"
     exon            1..1421
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1943
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /EC_number="3.1.13.4"
                     /note="2'-phosphodiesterase; mitochondrial deadenylase"
                     /codon_start=1
                     /product="2',5'-phosphodiesterase 12"
                     /protein_id="NP_848783.3"
                     /db_xref="CCDS:CCDS26882.1"
                     /db_xref="GeneID:211948"
                     /db_xref="MGI:MGI:2443226"
                     /translation="MWRLPGRSALRGVRSVVERRSRAEAGTHEAVRAMERAVVRCVPS
                     EPKLSLSFALADGSHKNMQRDQSEPLGRALSRIATNALKGHAKVAAAKKSRKNRAHSS
                     GGAACEATGPEPVATCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNP
                     PTFTELQLPRYIMAGFPVCPKLGVEFGDPASSVFRWYKEVKPGAAEPGDSGPASSSHS
                     SQPSAWIETGVDERVYTPCNADIGLRLRLHCTPGNGQRFGPSRELESLCPVEAGPGTC
                     TFDHRHLYTKKVTEDSFIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLI
                     QKELTGYNADLICLQEVDRAVFSDSLVPALEAFGLEGVFRIKQHEGLATFYRKSKFRL
                     LSQHDISFQEALKSDPLHKELLEKLALNPLAQEKVLQRSSVLQISVLQSTTDSSKKIC
                     VANTHLYWHPKGGYIRLIQMEVALVHIRHVSRDLYPGIPVIFCGDFNSTPSTGMYHFV
                     ISGSIAEDHEDWASNGEEERCSMPLSHCFKLKSACGEPAYTNYVGGFHGCLDYIFIDL
                     NTLEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKWK"
     exon            1422..1500
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..7510
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2429..2434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2449
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /note="major polyA site"
     regulatory      3329..3334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3348
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
     regulatory      7307..7312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /note="hexamer: AATAAG"
     polyA_site      7326
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
     regulatory      7485..7490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
                     /note="hexamer: AATAAT"
     polyA_site      7510
                     /gene="Pde12"
                     /gene_synonym="2'-PDE; 2-PDE; E430028B21Rik"
ORIGIN      
        1 gccgccgacc ggaagtccac ggtctgaatg ggtcttgtac ccggccacgg ccgctcctcc
       61 cggtggactt gacagcgggc gactctggat ctctgatctc gtcggctgcc aggttcatgt
      121 ggaggctccc gggccgcagc gcgcttcgtg gggtccggtc ggtggtggag cggcgcagcc
      181 gggccgaggc agggactcac gaggcggtgc gcgccatgga gcgcgcggtg gtgcgctgtg
      241 tgccctcgga gcccaagctc agcctgtctt tcgcgttggc cgacggcagc cacaaaaaca
      301 tgcagaggga ccagagcgag cctctgggcc gggccctcag ccggatcgct accaacgccc
      361 tcaagggaca cgcaaaggta gcggccgcca agaagagcag gaagaaccga gcccactcga
      421 gcggtggcgc ggcctgtgag gctacagggc ctgagccggt tgcgacctgc gagccggtgg
      481 tgaagctgta ctaccgggag gaggcggtgg ccgaggatgt gctcaatgtg gacgcctggc
      541 aggacggagc ggtgctgcag atcggcgacg tcaagtacaa ggtggagcgc aacccgccca
      601 ccttcacgga gctgcagttg ccgcgctaca tcatggctgg cttccctgtg tgccccaaac
      661 tcggcgtgga atttggggat cccgccagct ccgtgttccg ctggtacaag gaagtcaaac
      721 ccggggcggc agaacctggg gacagcggcc ccgcgtcctc gtctcactct tcgcagcctt
      781 cagcttggat cgagaccggt gtggacgagc gcgtctacac cccgtgcaat gcagacatcg
      841 ggctccggct ccggcttcac tgtacaccgg gcaatgggca gcgcttcggg ccaagccggg
      901 agctagaaag cctgtgcccg gtggaggccg ggcctggcac ctgcactttt gaccatcgac
      961 atctgtacac caagaaggtg acggaggact ctttcatccg cactgtctcc tacaacatcc
     1021 tggcagacac gtacgcccag actgagttct ctcggacggt cttgtacccg tactgtgccc
     1081 cctacgccct ggagcttgac taccgccaga atctcataca gaaggagctc acaggctaca
     1141 acgcagacct catctgtttg caggaggtgg accgcgcggt gttctccgac agcttggtac
     1201 cggccctgga ggccttcggg ctggagggcg tgttccgaat caagcagcac gaaggcctgg
     1261 ccactttcta ccggaagtcc aagttcaggc tccttagtca acatgacatc tcttttcaag
     1321 aagccctcaa gtcggaccca ctgcacaaag aattactaga gaagctggct ttgaacccat
     1381 tagcacagga gaaggtcctc cagaggtcat ctgtccttca gatttcagtt cttcagtcta
     1441 caacagactc ttccaaaaag atatgtgttg ctaataccca tctctactgg cacccaaaag
     1501 gtggatacat tcgtctcatt caaatggaag tagccttggt tcatattaga catgtctcac
     1561 gtgatctcta tcctggcata ccagttatat tttgtggaga ctttaatagt acaccatcaa
     1621 caggcatgta tcattttgtc atcagtggca gcattgcaga ggatcatgaa gactgggctt
     1681 ccaatgggga agaggagaga tgcagcatgc ctctctcaca ctgtttcaaa ctgaagagtg
     1741 cttgtggtga acctgcctac acaaattatg tcggtggctt tcacggatgt ctagattaca
     1801 ttttcattga cttaaatact ttagaggttg aacaggtgat tccattacct agtcatgaag
     1861 aagttaccac ccaccaggcc ttacctagtg tttctcatcc ttctgatcac atagcacttg
     1921 tatgtgactt aaaatggaaa tagattttac ttcactaact ctgaaaggaa gctaggaact
     1981 gtccaaaaaa atgtaatatg aaacaaagcc catatatcaa ccttcagtga ggcaacacca
     2041 gactcaatgg tcattcccta ctggttatgt tccagacggc tttgttacag aactaattca
     2101 tctttgcatc atataatatc gttatcctcc tttttaaaat tccctacatt tagaggaaaa
     2161 catatttatg actagcaaga agaaaattga attattgtgt acattttata agttttttta
     2221 agctggtaat tacgactttt aagtactatt tgaataatct caatttttct ttcacagcac
     2281 attttacatt gaattatgtt aatataattg gggaaggagg ggacatgtag gtaaaacgtg
     2341 agagacttca gagacacatg gaatacatta gtctgtcact acctcaattt ggttagaatt
     2401 tattataatt ttggagcttt aacaaaagat taaaatgtac cattaccaat tcttatagct
     2461 tcttcgtttt tcagttagca aggtattttc cttcctgcgt tgttttcagt gtacaaacga
     2521 cggttcaaac gcgtctactt tgtcttctta cttgcacttg agctcatttt aatagtagga
     2581 tacaagcaca aaagagtatt caaagggacg gggacttgac ttgatccctt gcctttgctc
     2641 ttactcataa aatataagca cacagggaaa aggggaagca ggcatggtgc tttatagctg
     2701 taatcctagt gctcaggtac gtgaggcagg actgcgtcga ggtcagttct ggtctgggtt
     2761 acacagttca aggccagctt gggctacata cataggaaaa aaggggacaa tgggtttttg
     2821 tcaatatctg aaataaactt tttatagatg taagcattat agcttgagga acagaatagt
     2881 gccacataat ttatataaaa aatttgaaga tgaagccaac atttgaagat gagaaattcc
     2941 aagctgtgtt gattagtatc tagtttagat gcttttactg catttgttct caccatgtct
     3001 gcttggtgat gctttagcgg ttgctttgtc atgtccaggt ttaactgtag cataagcata
     3061 gctttctgca cttaatttct agcatagata ataaaggcct cttacctcaa aaagaggtct
     3121 tattttccaa gtcttcaaat tatttaatct gtaaatccat tttttcccca tattctctaa
     3181 tgtgatctgt gttttccata ttctgttatc agatactctt aggttagtaa gtctgaaaaa
     3241 tataagcatt tcatttgcac ttcacattga acctttattc atattattta aagggaaata
     3301 taaaatgaca gtttcttggg atgcttaaaa taaaaaagct gatgaaaagt tgatgttacc
     3361 aaattgtgcc ttcataaata tggtagtttc tcttcccacg ggtcaaattc agggcactca
     3421 gttatattcc cagccgtgta catgccactt ttgagagcat tttagtggca gtttatatag
     3481 tcagaactag ttcttttaca aaatattatt tcagtattat tttatttctg tgttgctggg
     3541 gattgaaccc agaatcctga gcatgctagc catgtttagt actccaagct acatcagagc
     3601 tacaaccctt ttcaaaatta gttttgtttt gccttcagat aaccatgttg acaaacttac
     3661 ttgaacactt caggaattaa cagtaattta ctcagcaaga agtgagcatt ttgaaagaaa
     3721 aatgtttgta attcataccc atgcattgac atcctgtatt aactccgtgg cgaagtagaa
     3781 ctgtgattta ccaagcatcc catgtcctaa atccttaaat ttgatatttg tggattaaat
     3841 ggtatagtca gattatatac aggtatttca ggatattctg ataatgaagt gtaaagaact
     3901 gactccagct tacaatgtgc aaaggtaggg agcactccac aaattctatg aagattatac
     3961 caaacttatt tgtacttagg acaaggtgtt aatcgttaat cagaagtgtt taaagttatc
     4021 ttcgtgattg aatttttcta ttagttttga aatttttagt atttaatttt aatgattctg
     4081 agaactctag caacgttgtg gcaaaccaca tttatgtcac aagttcttag taaaggaaat
     4141 gtgaatattt taaagtatgt tattctgcta aaatcactct taaagttgtc ccagtaacac
     4201 taacagtttg caattcatta gcaaaaatat catttctggc tacagtatct tttctttaaa
     4261 gttctaaaat gtaaaatctc tatattgtaa gggaagataa aatttgtagt tttcatcata
     4321 aaactcagta gggaagtctt ctaaaataca gccaacacca attttctaaa cactatttaa
     4381 aaatgtgttt gaaaaccttt tgctcagcct acttgcaaga agtattatct tggtttcatt
     4441 tgtagagagg ataagagctt tcacttataa agtgagttct atggtcctaa tttctaagaa
     4501 atatgccatt tctaataagt ggtgatgagt tattacctgg gtgaattttt agcattacaa
     4561 tataacaata ttgcattctg gttacaatac caaagcactg aggtaaaact aatcatttaa
     4621 atacataaaa cctacttgta tttaatacat tcactgttgt gtagccgact ctaaggcatt
     4681 ttcatcactt cacaagggaa gcctaaagta tatcctcatt ctctaccagt agacacatca
     4741 tctgccagtt ctgatatctg tccgatttga ctggtgtttt tcaagcttat ctgtgtaaca
     4801 gtatgtacca atacttcatc tcttttacac atttcctact gcatggataa tacatcttgc
     4861 ttatgtgagc atttggattg gttagtttcc tgttgtgact agtatgtgga gatctatgct
     4921 caagtttttg atggaacatc ctctttttaa tttgttagta ctagggaatc aaaccctggg
     4981 ctggtgtatg gactgctctg agctgcacac ccagtccaaa catctgtttt cagttcttct
     5041 agagaatata acttagtgaa gtgctgtagc tttctgcagc aatgccatcc tttcccacag
     5101 tggctacact accctaaacc tccctcactg ccatatacag gttcaggttc cctccatcct
     5161 cacaaattat atccattttt taaacagcca tcctgttcac acttcagtga cacgctttga
     5221 actttggaat tgcagttgtt gcagtcacaa gcaagcttat cttaaacagc ttagcaaacc
     5281 tcttcccaga gccactttca gcagctgctg cttagtttta tgatttctgc gtcaagtagg
     5341 aaaggtttta ttgcttcctt taaagaaaac tgaatatcaa agttaaaaat acaaccgtga
     5401 ctataaagaa ttttggtaaa ggcctaagac ctgcacagca aaaggccata tttcaccctt
     5461 cagcaactgc agagaactta cttttaaatt ggtccacttt aaaatctaaa aggtacagat
     5521 tagcagatgg caagaatgtc taagttttga gaaaactaga tggatataat tgagtataat
     5581 ttataatata aattatgtat aatcattgaa agttcaagct attctagatt ttttaaaaaa
     5641 aatctctaaa ttcaagttaa tgtaaacttt aagccaataa acttaagctg gcatttaccc
     5701 tgttaaataa gaggtaggga aaatattact tgaccactta aggtagtgtc ttaataatac
     5761 agatgctaaa atttaattta catagaagct aattttaaac attaagctca tcagttgaac
     5821 tggttgatac catccactat agaactatta ataagtttta attaaaacat taaacctgag
     5881 cctgaaaaga ccacttgttc ttccaaagga cccggagttc atttcccaag acccacatga
     5941 tggctcacaa ccttttgtaa ctccagggcc agggagccca cagccttaac tggcatctct
     6001 ggactccagg catgcaggca aaacacaccc atacctgtaa acttaaaaat caccaagaag
     6061 aaaataaaca aaaactagat aaaacaaccg ttgaagcagt cggttcaact tttcagcttc
     6121 caatctgatt attctgatgg gaatctcttg ttgatttgtc aaaacccaag ctctgcaatg
     6181 ttttgtgggt ttttcctgag ggtttctcta tgtagacaag gctagcctcg aactggagat
     6241 ttgcctccta agtgtgagga ttaagggtgt gtactaccac cacttggctc tgtaatactt
     6301 atttttttaa attgttcatt tttaaactca ttggaagttg ggtatgatgg tgcatgcctt
     6361 tggtctcgaa ggcagagagg caggtagatc tctgagttca agaccagcct ggtcagaatt
     6421 acaggatgac caggcctgtt accatgtttt gaaaaacaaa aacaatttct ttcggacact
     6481 aaaaaactat ctccatcata tatccatttt gtggtgaatt taagcctatt tcatctggca
     6541 attctctctc ataccctgga gagctaccat tgcacgtttc cttaggatac tgaaatagct
     6601 gtaggttgca tttttgctag tttgtatgtg catcctacaa ctattgggat tgattctgta
     6661 gggaatttga cagtttagtt gactttctta tattgaaaag gcactttaaa gagaatttat
     6721 cgccgggcgg tggtggcaca tgcctttaat cccagcactt gggaggcaga ggcaagcgga
     6781 tttctgagtt caaggccagc ctggtctaca gagtgagttc caggacagcc agggctacac
     6841 agagaaaccc tgtctcaaaa aacaaagaaa aaaaaaagaa tttatcatac ataaagcatt
     6901 attgctaacc atacatccag acaaagtgac atggaaaaca ctctattttg acagctgtta
     6961 aaggtggcac atagcaggaa tcctagcact tgggaggtgg aaacagatga atccactcag
     7021 tgtcatccgc agctgttcag taagttggag gccagcctga attatgagac tgacagttaa
     7081 aataaaactg ggttaatggt agtattacag attatctaaa acaagttaca taaccctttc
     7141 atatttccca ccatcctagt ctttccctat tcttaaactg gtggtggtaa ctttaagagg
     7201 ttttggtatt tgaatgtcag agaaatccta cttaaagata gttactcggt ttgctcgggc
     7261 aaccccctta cctgtctcca tgaaatgtct attttggact ttcataaata agtacttcaa
     7321 aaaccatgta ttttgtgact ggcttctttt cacttagact gtttaggtat ttccatgttg
     7381 tagcatcagt actgggattt ttaatgatga atattccatt gttaggctgt actaaatttc
     7441 atcaatctac ttgtaggtta atggacattc atactgcttc cacaaataat ttttctgtct
     7501 ttgtgtacaa
//
