LOCUS       NM_011866               7717 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus phosphodiesterase 10A (Pde10a), transcript variant 2,
            mRNA.
ACCESSION   NM_011866
VERSION     NM_011866.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7717)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7717)
  AUTHORS   Kono,A., Shikano,Y., Tanaka,K.F., Yamaura,K. and Tsutsui-Kimura,I.
  TITLE     Inhibition of the dorsomedial striatal direct pathway is essential
            for the execution of action sequences
  JOURNAL   Neuropsychopharmacol Rep 43 (3), 414-424 (2023)
   PUBMED   37553985
REFERENCE   3  (bases 1 to 7717)
  AUTHORS   Beker,M.C., Pence,M.E., Yagmur,S., Caglayan,B., Caglayan,A.,
            Kilic,U., Yelkenci,H.E., Altintas,M.O., Caglayan,A.B.,
            Doeppner,T.R., Hermann,D.M. and Kilic,E.
  TITLE     Phosphodiesterase 10A deactivation induces long-term neurological
            recovery, Peri-infarct remodeling and pyramidal tract plasticity
            after transient focal cerebral ischemia in mice
  JOURNAL   Exp Neurol 358, 114221 (2022)
   PUBMED   36075453
  REMARK    GeneRIF: Phosphodiesterase 10A deactivation induces long-term
            neurological recovery, Peri-infarct remodeling and pyramidal tract
            plasticity after transient focal cerebral ischemia in mice.
REFERENCE   4  (bases 1 to 7717)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   5  (bases 1 to 7717)
  AUTHORS   Luo,L., Cai,Y., Zhang,Y., Hsu,C.G., Korshunov,V.A., Long,X.,
            Knight,P.A., Berk,B.C. and Yan,C.
  TITLE     Role of PDE10A in vascular smooth muscle cell hyperplasia and
            pathological vascular remodelling
  JOURNAL   Cardiovasc Res 118 (12), 2703-2717 (2022)
   PUBMED   34550322
  REMARK    GeneRIF: Role of PDE10A in vascular smooth muscle cell hyperplasia
            and pathological vascular remodelling.
            Erratum:[Cardiovasc Res. 2023 May 2;119(3):879. doi:
            10.1093/cvr/cvac011.. PMID: 35137003]
REFERENCE   6  (bases 1 to 7717)
  AUTHORS   Siuciak,J.A., McCarthy,S.A., Chapin,D.S., Fujiwara,R.A.,
            James,L.C., Williams,R.D., Stock,J.L., McNeish,J.D., Strick,C.A.,
            Menniti,F.S. and Schmidt,C.J.
  TITLE     Genetic deletion of the striatum-enriched phosphodiesterase PDE10A:
            evidence for altered striatal function
  JOURNAL   Neuropharmacology 51 (2), 374-385 (2006)
   PUBMED   16769090
  REMARK    GeneRIF: findings suggest that PDE10A is involved in regulating
            striatal output, possibly by reducing the sensitivity of medium
            spiny neurons to glutamatergic excitation
REFERENCE   7  (bases 1 to 7717)
  AUTHORS   Hu,H., McCaw,E.A., Hebb,A.L., Gomez,G.T. and Denovan-Wright,E.M.
  TITLE     Mutant huntingtin affects the rate of transcription of
            striatum-specific isoforms of phosphodiesterase 10A
  JOURNAL   Eur J Neurosci 20 (12), 3351-3363 (2004)
   PUBMED   15610167
REFERENCE   8  (bases 1 to 7717)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 7717)
  AUTHORS   Hebb,A.L., Robertson,H.A. and Denovan-Wright,E.M.
  TITLE     Striatal phosphodiesterase mRNA and protein levels are reduced in
            Huntington's disease transgenic mice prior to the onset of motor
            symptoms
  JOURNAL   Neuroscience 123 (4), 967-981 (2004)
   PUBMED   14751289
  REMARK    GeneRIF: Striatal phosphodiesterase mRNA and protein levels are
            reduced in Huntington's disease transgenic mice prior to the onset
            of motor symptoms.
REFERENCE   10 (bases 1 to 7717)
  AUTHORS   Soderling,S.H., Bayuga,S.J. and Beavo,J.A.
  TITLE     Isolation and characterization of a dual-substrate
            phosphodiesterase gene family: PDE10A
  JOURNAL   Proc Natl Acad Sci U S A 96 (12), 7071-7076 (1999)
   PUBMED   10359840
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014090.1, AK039249.1 and AC104323.27.
            
            On Jul 16, 2005 this sequence version replaced NM_011866.1.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 5' UTR, lacks a portion of the 5' coding region, and initiates
            translation at an alternate start codon compared to variant 1. The
            resulting protein (isoform 2) has a shorter N-terminus compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY360383.1, SRR7652917.24771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               AK014090.1         54-583
            531-2672            AK039249.1         577-2718
            2673-7717           AC104323.27        113903-118947
FEATURES             Location/Qualifiers
     source          1..7717
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.96 cM"
     gene            1..7717
                     /gene="Pde10a"
                     /note="phosphodiesterase 10A"
                     /db_xref="GeneID:23984"
                     /db_xref="MGI:MGI:1345143"
     exon            1..401
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..2725
                     /gene="Pde10a"
                     /EC_number="3.1.4.17"
                     /note="isoform 2 is encoded by transcript variant 2; cAMP
                     and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase
                     10A; dual-substrate cAMP and cGMP, cyclic nucleotide
                     phosphodiesterase"
                     /codon_start=1
                     /product="cAMP and cAMP-inhibited cGMP 3',5'-cyclic
                     phosphodiesterase 10A isoform 2"
                     /protein_id="NP_035996.2"
                     /db_xref="CCDS:CCDS28384.1"
                     /db_xref="GeneID:23984"
                     /db_xref="MGI:MGI:1345143"
                     /translation="MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFV
                     SESVSAETVEKWLKRKTNKAKDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDN
                     HLLLYELSSIIRIATKADGFALYFLGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTT
                     ISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYR
                     HWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVA
                     IDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPIFKKTKEIRF
                     SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVV
                     QMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSI
                     CTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKL
                     CRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLD
                     HRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLE
                     IIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLW
                     PVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTT
                     LTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKSTPEKLNVKVED"
     exon            402..530
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            531..559
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            560..680
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            681..730
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            731..871
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1027
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1078
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1137
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1189
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1332
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1425
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1612
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1755
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1839
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1990
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2146
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2319
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2431
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2512
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2601
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..7717
                     /gene="Pde10a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7695..7700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pde10a"
                     /note="hexamer: AATACA"
     polyA_site      7714
                     /gene="Pde10a"
                     /note="major polyA site"
ORIGIN      
        1 acaagaggca gctcccttga gcgtcccccc aggcagtagt caccgcagca gcggtggcag
       61 cagcggtggc agcggcgggc ggcggcggct cttcctctcg cctgcgattc aaggcttgct
      121 gctccctgcc cgcgccgggc cccggccatc tccgccgccg cggcttcccc tacacccggg
      181 tgcacgccgc gcggactcct cggattttcc gggcgccggc gggggctgcc ctggcctcgg
      241 ccccggctct gccgccggtg gccgaactct ttggcggccc cgaggcgccg ccttccccct
      301 tgccaccgtt tggccgctgc ccttcggctc cgacatggaa gatggaccct ctaacaatgc
      361 gagttgcttc cgaaggctga ccgagtgttt cctcagcccc agtttgacgg atgaaaaggt
      421 gaaggcctat ctttctctcc atccccaggt attagatgaa tttgtttctg aaagtgttag
      481 tgcagagact gtggaaaagt ggctgaagag gaaaaccaac aaagcaaaag atgaaccatc
      541 tcccaaggaa gtcagcaggt accaggatac gaatatgcag ggagtcgtgt acgagctgaa
      601 cagctacata gagcagcgcc tggacacggg cggggacaac cacctgctcc tctatgagct
      661 cagcagcatc atcaggatag ccacaaaagc cgacggattt gcactgtact tccttggaga
      721 gtgcaataat agcctgtgtg tgttcatacc acccgggatg aaggaaggcc aaccccggct
      781 catccctgca gggcccatca cccagggtac caccatctct gcctacgtgg ccaagtctag
      841 gaagacgttg ttggtagagg atatccttgg ggatgagcga tttcctcgag gtactggcct
      901 ggaatcagga acccgcatcc agtctgttct ttgcttgccc attgtcactg ccattggaga
      961 cttgattggc atccttgaac tgtacaggca ctggggcaaa gaggccttct gcctcagcca
     1021 tcaggaggtt gcaacagcca atcttgcttg ggcttccgta gcaatacacc aggtgcaggt
     1081 gtgtagaggt ctcgccaaac agaccgaact gaatgacttc ctactcgacg tatcaaagac
     1141 atactttgat aacatagttg ccatagactc tctacttgaa cacatcatga tatatgcaaa
     1201 aaatctagtg aacgccgacc gctgcgcgct cttccaggtg gaccacaaga acaaggagct
     1261 gtactcggac ctgtttgaca ttggggagga gaaggagggg aagcccatct tcaagaagac
     1321 caaggagatc agattttcca ttgagaaagg gattgctggt caagtggcaa gaacaggcga
     1381 agtcttgaac attcccgatg cctacgcgga ccctcgcttt aacagggagg tggacctgta
     1441 cacaggctac accacgagga acattctgtg tatgcccata gtgagccgag gcagcgtgat
     1501 tggcgtggtg cagatggtga acaagatcag cggtagcgcc ttctccaaga cagacgagaa
     1561 caacttcaag atgtttgctg tcttctgcgc actggccttg cactgtgcta acatgtacca
     1621 caggatccgc cactcagaat gcatctacag ggttaccatg gagaagcttt cctaccacag
     1681 catctgcacc tccgaggagt ggcaaggcct catgcgcttc aacctaccag cacgcatctg
     1741 ccgggacatc gagctattcc actttgacat tggtcctttc gagaacatgt ggcctgggat
     1801 ctttgtctac atgatccatc ggtcttgtgg gacatcctgt tttgaacttg aaaaattgtg
     1861 ccgttttatc atgtctgtga agaagaacta tcggcgggtt ccttaccaca actggaagca
     1921 tgcagtcacg gtggcacact gcatgtatgc catacttcaa aacaacaatg gcctcttcac
     1981 agacctcgag cgcaaaggcc tgctaattgc gtgtctgtgc catgacctgg accacagggg
     2041 cttcagtaac agctacctgc agaagttcga ccaccccctg gcggcgctgt actccacctc
     2101 caccatggag caacaccact tctcccagac ggtgtccatc cttcagctgg aagggcacaa
     2161 tatcttctcc accctgagct ccagcgagta cgagcaggtg ctggagatca tccgcaaagc
     2221 catcatcgcc accgacctcg ccctatactt tgggaacagg aagcagttgg aggagatgta
     2281 ccagacaggg tcgctgaacc tccacaacca gtcccatcga gaccgtgtca tcggcttgat
     2341 gatgactgcc tgtgatcttt gctctgtgac caaactatgg ccagttacaa aattgacagc
     2401 gaatgatata tatgcagaat tctgggctga gggtgatgag atgaagaagc tgggcataca
     2461 gcccattcct atgatggaca gagacaagcg agatgaagtc cctcaagggc agctcggatt
     2521 ctacaatgct gtggccattc cctgctatac caccttgacg cagatcctcc cacccacaga
     2581 gcctctgctg aaggcctgca gggataacct caatcagtgg gagaaggtaa ttcgcgggga
     2641 agagacagca atgtggattt caggcccagg cccggcgcct agcaagagca cacctgagaa
     2701 gctgaacgtg aaggttgaag actgatcctg aagtgacgtc ctgatgtctg cccagcaacc
     2761 gactcaacct gcttctgtga cttcgttctt tttgttttca aggggtgaaa accccctgtc
     2821 agaaggtacc gtcgcatatc catgtgaagc agacgactcc ctgcttgccg cacacacctc
     2881 ggacagtgag caacccaggc tctgccgtgt tcagacgtcg gctactccgt ggctccacct
     2941 gacctccgaa tgctatttgc tcccaggcca gcactgcact gtctggaggg ggcagagacc
     3001 acaggagagg ttcttgcctg catcctccca tgagggtgtg gccagttccc tggttctgtg
     3061 ccatgctgct gcttggtggc attggttagg aatgggacac acgccccttg ttgtgaagtt
     3121 tacatgtgac cttcttatag gttaactgag tttgtggcct gggacacatg taatgaaggt
     3181 cacagtccac aggtgacaga gaaatccaaa ctgttgatta caggtgcact acaggtatgc
     3241 tctttcagtc tatctggggg cacataggtg agtctgctcc actcagaagg aagcatacct
     3301 ctgccctcat ccaggggaca cagggtacat cccaggcatc ggggaactga agctctcact
     3361 tcaaaccatg tcaaagaatt aaaacacctc ccctccccct cactgtagcc ttcggcaact
     3421 gcgccaatcc ctttatacaa agaaaataaa agtaaggcat ataaatttcc tccagcaagc
     3481 aaatcttgtg ggtaaaaaaa aaaatgtgaa ttttaacaac ctctatattt tcactgtatg
     3541 ttatggcaga attttagtca cgtccaaaac aaaagattat tccagaagat acctcatcct
     3601 atgcctgaaa ggctccacag catggcgtcc gtctcccagg gttctgatcc gtctcctcac
     3661 ggtgcaatca ggcaggacag gaggaggtgc agggctacca cattgaccca gatggtatct
     3721 cctctcacca ttcagacatc cataaggaat gccaaatgct gtattgaata gttctcctgt
     3781 gtgactttct agagaagcca ggacacccct gagcctttcc tgggaactcc taaggaagtc
     3841 acaggttcac accgtgggga ttttcaggat agcatggaga ccagagaatc ccggttcggt
     3901 tgttctcact cggtgagcct tgagaaggaa gagactgacc agaaacactc actcagcact
     3961 ctggcaggag caggagaaga tactttaaga tgaatctttg ggatagattt tgatacaccc
     4021 aataccatac acacaggagc ttggcatttg caaagtctat tcagtttcct tccacactct
     4081 gacccacggt tgtagcggag tgggctgaac actgtaacac tgtacatgcg atttccccat
     4141 gggcttctaa aatgtcacca tctcctcccc tgctgtgtcc tactccattt actggttaca
     4201 aggtgatgtc aacaagagaa gctatcacaa caccagggct gtgcacacgt gcacacacat
     4261 gtatgcacaa gcacacagat gtatgtacag cacacacaca cacacacacc ccaaaaggag
     4321 agaaaaggaa gaaaacattt ataaaaagcg acagctaccc ccatattcaa aaatagttct
     4381 tttccctgta gggaaacagg tagctctcca taaggaaatt atcatgagtg tgttctccca
     4441 tcagtgcact tctcccaggg gtgctcactg aagctggtcc acgtctataa acaggtgaca
     4501 ctggctgcag caaaaagcca ttcgatccac acaaattgat cttctatcat cttggaatct
     4561 gaattgcagg gaggagcagc atgtaagacg accgtttaat tcaggcattc cgaaggcatg
     4621 agcgcatgga ttctgtcacc aagcgtataa aaggaccctg gcattgggaa acctatgacg
     4681 gactgttttt gctgtagaag tagggatttt acagaagtct ccttgaattt gccctgcctg
     4741 gggcagtttt gcagaggaac ctgccagaga tttattggct ggtcagtctc ttgtgaaata
     4801 gtatcatgtg agaaacagtt tgtagaaaaa aactatacct gggaagacct ttgcaacatt
     4861 gttccttcca tgggccaaga ctcagttagg aggcataaat ctgcccggaa taaactaggc
     4921 caggatacag ccatgtttag ttaataattt ggttttagaa ttcacacagg caggattggt
     4981 ttttttgtgt cttggcaagt ggagcatatt taacatacag gcatgggaat cctgcctctt
     5041 agcttttccc accctcttgt ctcaccaagt tttttctctc caaaggtttc caggaatttc
     5101 tcattaatgg ctgatgcaaa cttagtgaat aataatgaat ataaacaatg ctcacctcac
     5161 caaaattata ttatttgcag tcatttgtga taacacaaat tttatcgcaa tggttattat
     5221 ttaatttgtg gccacacact gtggttatct tttgttgtgg ttgtttctga gaaaatgttc
     5281 ttggatatgt aagtgccaat accagtgtga agtattgatc ccgggcagca aaatacagcc
     5341 taaggtttgt aaacatcaat tctatctcag ttcatcagag ggcctgagaa gctgcggggc
     5401 agtgtaaagt aaagtatgct gggctggtgg tggtcagcct tccccttgcc aagaagagag
     5461 caattgaatc ctgtccccag ctccctccag cctgaagagt gaccagtgct ggcccgacgg
     5521 atcgctgaga tattctccca taatggcaaa aaataggcag tttgatgtga cctgtttagt
     5581 gtggctctcc tcttttgagc atgtgttagc atttttattt tatactcatc cagtgaactc
     5641 tgctcttcca agtgtgttca tgtatgtgct agatatatta gcacagcctg ccttctgctg
     5701 cacaacgcct tagagacccg gcctttcaat gagcttagct tgtgctctgt ttctgctctc
     5761 ttaggtctaa actatggtgt cagttttaat agaacaaaag tatgcatctt gccttggctt
     5821 gagccttttc gttttcaatg ctgacttctc ccctttctct cctgtgctca ccttaccttt
     5881 ccagagtgta agggacaact tttaaggagg cgtgtccctg gtaggggcat ccctgttcac
     5941 caggtgcctg tcatcacccc acttgactga catctaccct ggtgactatg ggttcctctt
     6001 gtttgtaggg aacggtggct ccaggtggag gcatcaatct gttgggttct ggttcccggc
     6061 tgcctttggt tttgaaagtc tcttctctgt atattcctac cctgcatttg ctttgtgtgg
     6121 tgctgatgct gtgcgcagta ggattcttgg atgactctcc atcagtcaca gactccccct
     6181 gttgcaaagt gtcaggctga ctcgacagtc accgtaaaat ctgagtcagt cacacacagg
     6241 ctgtcagcca cggcttccac ttgcatggct attctatttt cacacgtgag tttctgttgc
     6301 tggctggctg actggcatta tctatgctaa gttgaaatca ggggtgccca gcagagccca
     6361 tcattctcac tgtctttgaa acaaagctgt acggtttgat cgatgaacgt atttaaagca
     6421 tttcatgcaa tgacaaagtg ctcagtagtg gaaggcaggc tgtgaccagt ctgcctgctc
     6481 cttactataa ttgtgaggat ttgttactgg aacagtacat ggaggcctga ccttgtgggg
     6541 gcacagggtg gaaccttagc tgaatatagt gtgtgtctca agaggaagtc agggtactag
     6601 ctcagtgctc aatctccagg tactatatat acatttgccc gttttatctc taatgtgaaa
     6661 taaatcccca aacacttgtt tatcgtgtag cgtacctaaa agactattct attatgggtg
     6721 tccccacttt cttggtttgg tcaccccgat cccccggtct tctgctgtat ctagaacagt
     6781 gactataaat gatgtatggg aatagtgttt ccatatgatc tgttgtctgg agtatatgct
     6841 acatgttcat ttactgtaca aaaacccagt gcagctgatg atgcaaagca gtctctctct
     6901 gtgtacagtg ccccacctat ttaaaaatca cgtacttgcc cagaacactg tgaaacactt
     6961 aacataagaa caaacgcagc gtctggattc tttccaagga gagcagcttt ctccacagga
     7021 acacagtaac aaaagaggtc cgccgccatc cacacccagc caagacacct cagaggccat
     7081 agggacaacc tccttgctgg ccaacacctg ctggagcagg ggcacaggtc ccagcaactg
     7141 atcctcagtg gatgggtctg cagccaaagc cttaatgggc tctcttttga aggggaaaga
     7201 aagaatttca agcttatgat atccaacatt attatagttg atgagttagt aaattccaaa
     7261 aaaaaaagat gattttatat gtatgacata aaaaaaatct ttgtaaagtg cgcaagtgca
     7321 ataatttaaa gaggtcttat ctttgcattt ataaattata aatattgtac atgtgtgtaa
     7381 tttttcatgt attcatttgc agtctttgta tttaaaaaaa ctttactgtt atgtttgtat
     7441 aatagaacat taatcattta ttataactca gacaaggtgt aaataaattc ataattcaaa
     7501 cagccagtat atatgcatat atgggtgtta cattgcaaaa atctctatct ttgttctatt
     7561 cacatgctta aagaagtaag aaatcttttg tggatatgta attatacata taaagtatat
     7621 atatatgtat gatacatgaa atatatttag aaatgttcat aattttaatg gatattcttt
     7681 ggtgtgaata attgaataca acatttttaa aatatca
//
