LOCUS       NM_026850               1706 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus phosducin-like 3 (Pdcl3), mRNA.
ACCESSION   NM_026850
VERSION     NM_026850.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Krzemien-Ojak,L., Goral,A., Joachimiak,E., Filipek,A. and
            Fabczak,H.
  TITLE     Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein
            Hsp90
  JOURNAL   J Cell Biochem 118 (2), 420-429 (2017)
   PUBMED   27496612
  REMARK    GeneRIF: results have shown that PhLP2A interacts with Hsp90 and
            exhibits molecular chaperone activity toward denatured proteins.
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Srinivasan,S., Chitalia,V., Meyer,R.D., Hartsough,E., Mehta,M.,
            Harrold,I., Anderson,N., Feng,H., Smith,L.E., Jiang,Y.,
            Costello,C.E. and Rahimi,N.
  TITLE     Hypoxia-induced expression of phosducin-like 3 regulates expression
            of VEGFR-2 and promotes angiogenesis
  JOURNAL   Angiogenesis 18 (4), 449-462 (2015)
   PUBMED   26059764
  REMARK    GeneRIF: The data provide new insights for the chaperone function
            of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal
            methionine acetylation in PDCL3 expression and its effect on
            VEGFR-2.
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Srinivasan,S., Meyer,R.D., Lugo,R. and Rahimi,N.
  TITLE     Identification of PDCL3 as a novel chaperone protein involved in
            the generation of functional VEGF receptor 2
  JOURNAL   J Biol Chem 288 (32), 23171-23181 (2013)
   PUBMED   23792958
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Wilkinson,J.C., Richter,B.W., Wilkinson,A.S., Burstein,E.,
            Rumble,J.M., Balliu,B. and Duckett,C.S.
  TITLE     VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor
            that modulates caspase activation
  JOURNAL   J Biol Chem 279 (49), 51091-51099 (2004)
   PUBMED   15371430
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC140367.3.
            
            On Apr 30, 2007 this sequence version replaced NM_026850.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078372.1, BY719264.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC140367.3         29908-29943
            37-166              AC140367.3         33340-33469
            167-257             AC140367.3         37009-37099
            258-401             AC140367.3         37339-37482
            402-610             AC140367.3         37829-38037
            611-1706            AC140367.3         38235-39330
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 17.36 cM"
     gene            1..1706
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /note="phosducin-like 3"
                     /db_xref="GeneID:68833"
                     /db_xref="MGI:MGI:1916083"
     exon            1..36
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..753
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /note="IAP-associated factor VIAF1; VIAF-1; viral
                     IAP-associated factor 1"
                     /codon_start=1
                     /product="phosducin-like protein 3"
                     /protein_id="NP_081126.2"
                     /db_xref="CCDS:CCDS14903.1"
                     /db_xref="GeneID:68833"
                     /db_xref="MGI:MGI:1916083"
                     /translation="MQDPNADTEWNDILRKKGILPPKESLKELEEEEAEKEEQLLQQS
                     VVKTYEDMTLEELEENEDEFSEEDERAIEMYRQQRLAEWKATQLKNKFGEVLEISGKD
                     YVQEVTKAGEGLWVILHLYKQGIPLCSLINHHLSGLARKFPDVKFIKAISTTCIPNYP
                     DRNLPTVFVYREGDIKAQFIGPLVFGGMNLTIDELEWKLSESGAIKTALEENPKKPIQ
                     DLLLSSVRGPVPMRRDSDSEDD"
     exon            37..166
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..257
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..401
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..610
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..1706
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1086..1091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /note="hexamer: AATAAA"
     regulatory      1108..1113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /note="hexamer: TATAAA"
     polyA_site      1116
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
                     /note="major polyA site"
     polyA_site      1131
                     /gene="Pdcl3"
                     /gene_synonym="1110061A19Rik; Viaf1"
ORIGIN      
        1 agagggctgg tttgagtgac tgaaggcaag atgcaggacc ccaatgcaga caccgagtgg
       61 aatgacatcc tacgtaaaaa gggcatcctt cccccgaagg agagcctgaa ggagctggag
      121 gaggaggagg cggagaagga ggagcagctc ctccagcagt cagtggtgaa aacatacgag
      181 gacatgactc tggaagagct ggaggagaac gaggatgagt tcagtgagga ggatgaacga
      241 gctatcgaga tgtaccggca acagaggttg gctgagtgga aagcaactca gctgaagaac
      301 aaatttggag aagttttaga gatctcagga aaggactatg ttcaagaagt tacgaaagcc
      361 ggcgagggcc tgtgggtgat cttacacctg tacaaacaag ggattcccct ctgttccttg
      421 ataaaccatc acttgagtgg actcgccagg aagtttcccg atgtgaaatt tatcaaagcc
      481 atttcaacga cctgcatacc caactacccc gacaggaatc tccccacggt gttcgtctac
      541 cgggaagggg atatcaaggc acagttcatt ggtcctctgg tgttcggtgg catgaacctg
      601 accatagacg agttggagtg gaaactgtct gagtcaggag cgatcaagac agccctggag
      661 gagaacccca agaagcccat ccaggacctg ctgctgtcct cagtccgggg ccctgtcccc
      721 atgaggaggg acagtgattc tgaggacgac taagatggca gtgatggaac ctttgaacct
      781 tcttgatatg acgcattgtc tgggtttttt ataaggaggg aaaagcaaaa tgtatcattt
      841 tggtttttaa cctttttata attatttaaa ttttatacat ttcggatata atcattgctg
      901 aactttttta agaaatttgt tggaactctt taattaatca tgtttcttta agagaaattt
      961 aagcaagctt gttatgtcac atatctatgt tttcctatgt gtatttcagg aaaccatgaa
     1021 actgttcagt attttttgac atgtaactct atagaaagga atgtggactt aaaaaatata
     1081 atgcgaataa atttaagtta aaatctctat aaaaaataac agtgcaaaaa atgagaactc
     1141 agctttctag ttagatcgtt cgttttcctt ttgtaaagct agcaaaagga gtatcagcta
     1201 aaagaaatgg ctgataattt tgagacagat actgatttat caaattagct gacagatttc
     1261 agctcactgc catgtctgtt tgctttcagc ccagtcttcc aggtaaacta atgttctcta
     1321 tggctgttaa gacaccagct attctttgta gtggcacatg cctttaatct cagcactggg
     1381 agacaggggc aggcaggtca tgtgagatca aggccagtct ggtttgcata gttaccagct
     1441 agccagggct gcgttaccaa gaccctgtct ccaaaccaag cagctcttct tggctgtaag
     1501 gtcctgttag agttggtttg ggggaataag gtttaagcag atacatatat aagctctatc
     1561 ccagtcgatt tgtaaaaata tttcaggata tcctgtaaag tgacaatgaa agccgaaaaa
     1621 tatctataat atttttgttg aatgctatac cctgtatagc tgattggaat cttagagata
     1681 agagtctaag aatacagggt ttactc
//
