LOCUS       NM_023508               1192 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus phosducin-like 2 (Pdcl2), transcript variant 1, mRNA.
ACCESSION   NM_023508
VERSION     NM_023508.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1192)
  AUTHORS   Fujihara,Y., Kobayashi,K., Abbasi,F., Endo,T., Yu,Z., Ikawa,M. and
            Matzuk,M.M.
  TITLE     PDCL2 is essential for sperm acrosome formation and male fertility
            in mice
  JOURNAL   Andrology 11 (5), 789-798 (2023)
   PUBMED   36278277
  REMARK    GeneRIF: PDCL2 is essential for sperm acrosome formation and male
            fertility in mice.
REFERENCE   2  (bases 1 to 1192)
  AUTHORS   Li,M., Chen,Y., Ou,J., Huang,J. and Zhang,X.
  TITLE     PDCL2 is essential for spermiogenesis and male fertility in mice
  JOURNAL   Cell Death Discov 8 (1), 419 (2022)
   PUBMED   36253364
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1192)
  AUTHORS   Mizuno,S., Takami,K., Daitoku,Y., Tanimoto,Y., Dinh,T.T.,
            Mizuno-Iijima,S., Hasegawa,Y., Takahashi,S., Sugiyama,F. and
            Yagami,K.
  TITLE     Peri-implantation lethality in mice carrying megabase-scale
            deletion on 5qc3.3 is caused by Exoc1 null mutation
  JOURNAL   Sci Rep 5, 13632 (2015)
   PUBMED   26346620
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1192)
  AUTHORS   Wilsbacher,L.D., Sangoram,A.M., Antoch,M.P. and Takahashi,J.S.
  TITLE     The mouse Clock locus: sequence and comparative analysis of 204 kb
            from mouse chromosome 5
  JOURNAL   Genome Res 10 (12), 1928-1940 (2000)
   PUBMED   11116088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132738.1, AK005814.1 and AK133140.1.
            
            On Jul 16, 2015 this sequence version replaced NM_023508.6.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132738.1, AK005814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AK132738.1         3-57
            56-1153             AK005814.1         11-1108
            1154-1192           AK133140.1         972-1010
FEATURES             Location/Qualifiers
     source          1..1192
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 40.88 cM"
     gene            1..1192
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /note="phosducin-like 2"
                     /db_xref="GeneID:79455"
                     /db_xref="MGI:MGI:1890655"
     exon            1..144
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..861
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosducin-like protein 2; phosducin-like protein similar
                     1"
                     /codon_start=1
                     /product="phosducin-like protein 2 isoform 1"
                     /protein_id="NP_075997.1"
                     /db_xref="CCDS:CCDS39116.1"
                     /db_xref="GeneID:79455"
                     /db_xref="MGI:MGI:1890655"
                     /translation="MQDPNEDTEWNEILRNFGILPPKEEPKDEIEEMVLRLQQEAMVK
                     PYEKMTLAQLKEAEDEFDEEDIKAIEIYREKRLQEWKALKKKQKFGELREISGNQYVN
                     EVTNAEKDLWVVIHLYRSSVPMCLVVNQHLSVLARKFPETKFVKAIVNSCIEHYHDNC
                     LPTIFVYKNGQIEGKFIGIIECGGINLKLEELEWKLSEVGAIQSDLEENPKKGIADMM
                     VSSIRNISIYDSDSSGSDTEAK"
     exon            145..265
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /inference="alignment:Splign:2.1.0"
     exon            266..356
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /inference="alignment:Splign:2.1.0"
     exon            357..500
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /inference="alignment:Splign:2.1.0"
     exon            501..709
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /inference="alignment:Splign:2.1.0"
     exon            710..1192
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      870..875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /note="hexamer: AATAAA"
     polyA_site      890
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /note="major polyA site"
     polyA_site      1043
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
     regulatory      1164..1169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
                     /note="hexamer: AATAAA"
     polyA_site      1170
                     /gene="Pdcl2"
                     /gene_synonym="1700010B22Rik; 1700016K07Rik; Mgcphlp;
                     Tphlp"
ORIGIN      
        1 gcacatgcgc agaggtcctg ttcgctcttg gtctgcccct ggagcgttag agaccactag
       61 ccagagctgg ctggttccct ctgccagcct ggaggaagtt tgaggccctg atcccagtga
      121 ggggcacaag agaacatcat gcaggatcca aacgaagata cagaatggaa tgaaatttta
      181 aggaattttg gcattcttcc tccaaaagaa gaaccaaaag atgaaattga agagatggtg
      241 ttgcgcttac agcaggaggc catggttaaa ccatatgaga agatgacact ggcacaactg
      301 aaagaagcag aagatgaatt tgatgaagaa gacataaaag ctattgaaat atatagagaa
      361 aagcggttac aggaatggaa agcacttaag aagaaacaaa aatttgggga attgagagaa
      421 atttctggaa atcagtatgt gaatgaagtc acaaatgcag aaaaagacct gtgggttgta
      481 attcatctct atagatcaag tgtcccaatg tgcttggtgg ttaaccaaca tctgagtgtc
      541 ctagcaagaa agtttccaga aaccaaattt gttaaagcca tcgtgaatag ctgcattgaa
      601 cactaccatg acaactgttt accaacaatt tttgtttata aaaatggtca gatagaaggc
      661 aaattcattg gaattataga atgtggaggg ataaatctca agctagaaga acttgaatgg
      721 aaactatcag aagttggagc gatacagagt gacttggaag aaaaccccaa aaagggcatt
      781 gcagatatga tggtgtcttc aattagaaac atctccattt atgacagcga tagctctggc
      841 agtgacactg aggctaagta gaacttgtta ataaatagct ttatagtgta tccatcgaat
      901 gccttatttc ctgctgactt tagctacaaa tgaattgacc tcattttcat tcttatgtaa
      961 gaagtataac ctacatgtca attgaaaaaa tttcaggtat ttaagaatat tgtctcttgc
     1021 aaatatgaat atttactcct taatattttg tgacttattt tttctgactc ctgttggaca
     1081 aaacccaaca aatactttaa gtcctctgtg ttgcctaatc acttccaaaa agacacatgg
     1141 aaggaaataa atatggcttc ataaataaaa ttaagacatt ttgtatgtgt gc
//
