LOCUS       NM_026176               2859 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus phosducin-like (Pdcl), mRNA.
ACCESSION   NM_026176
VERSION     NM_026176.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2859)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2859)
  AUTHORS   Pusapati,G.V., Kong,J.H., Patel,B.B., Krishnan,A., Sagner,A.,
            Kinnebrew,M., Briscoe,J., Aravind,L. and Rohatgi,R.
  TITLE     CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity
            to the Morphogen Sonic Hedgehog
  JOURNAL   Dev Cell 44 (1), 113-129 (2018)
   PUBMED   29290584
  REMARK    GeneRIF: Pdcl has been implicated as a positive regulator of
            Hedgehog signaling that may control the trafficking of signaling
            receptors to primary cilia.
            Erratum:[Dev Cell. 2018 Jan 22;44(2):271. doi:
            10.1016/j.devcel.2018.01.002. PMID: 29401421]
REFERENCE   3  (bases 1 to 2859)
  AUTHORS   Xie,K., Masuho,I., Shih,C.C., Cao,Y., Sasaki,K., Lai,C.W.,
            Han,P.L., Ueda,H., Dessauer,C.W., Ehrlich,M.E., Xu,B.,
            Willardson,B.M. and Martemyanov,K.A.
  TITLE     Stable G protein-effector complexes in striatal neurons: mechanism
            of assembly and role in neurotransmitter signaling
  JOURNAL   Elife 4, e10451 (2015)
   PUBMED   26613416
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2859)
  AUTHORS   Tracy,C.M., Kolesnikov,A.V., Blake,D.R., Chen,C.K., Baehr,W.,
            Kefalov,V.J. and Willardson,B.M.
  TITLE     Retinal cone photoreceptors require phosducin-like protein 1 for G
            protein complex assembly and signaling
  JOURNAL   PLoS One 10 (2), e0117129 (2015)
   PUBMED   25659125
  REMARK    GeneRIF: findings reveal a common mechanism of Gbetagamma and
            RGS9-Gbeta5 assembly in rods and cones, highlighting the importance
            of PhLP1 and CCT-mediated Gbeta complex formation in G protein
            signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2859)
  AUTHORS   Gao,X., Sinha,S., Belcastro,M., Woodard,C., Ramamurthy,V.,
            Stoilov,P. and Sokolov,M.
  TITLE     Splice isoforms of phosducin-like protein control the expression of
            heterotrimeric G proteins
  JOURNAL   J Biol Chem 288 (36), 25760-25768 (2013)
   PUBMED   23888055
  REMARK    GeneRIF: evidence of a generic mechanism, whereby the splicing of
            the PhLP gene could potentially and efficiently regulate the
            cellular levels of heterotrimeric G proteins.
REFERENCE   6  (bases 1 to 2859)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   7  (bases 1 to 2859)
  AUTHORS   Lukov,G.L., Hu,T., McLaughlin,J.N., Hamm,H.E. and Willardson,B.M.
  TITLE     Phosducin-like protein acts as a molecular chaperone for G protein
            betagamma dimer assembly
  JOURNAL   EMBO J 24 (11), 1965-1975 (2005)
   PUBMED   15889144
  REMARK    GeneRIF: These results suggest a mechanism for Gbetagamma assembly
            in which PhLP stabilizes the nascent Gbeta polypeptide until Ggamma
            can associate, resulting in membrane binding of Gbetagamma and
            release of PhLP to catalyze another round of assembly.
REFERENCE   8  (bases 1 to 2859)
  AUTHORS   Humrich,J., Bermel,C., Grubel,T., Quitterer,U. and Lohse,M.J.
  TITLE     Regulation of phosducin-like protein by casein kinase 2 and
            N-terminal splicing
  JOURNAL   J Biol Chem 278 (7), 4474-4481 (2003)
   PUBMED   12466282
  REMARK    GeneRIF: physiological control of G-protein regulation by PhLP
            seems to involve phosphorylation by CK2 and alternative splicing of
            the regulator
REFERENCE   9  (bases 1 to 2859)
  AUTHORS   Garzon,J., Rodriguez-Diaz,M., Lopez-Fando,A., Garcia-Espana,A. and
            Sanchez-Blazquez,P.
  TITLE     Glycosylated phosducin-like protein long regulates opioid receptor
            function in mouse brain
  JOURNAL   Neuropharmacology 42 (6), 813-828 (2002)
   PUBMED   12015208
  REMARK    GeneRIF: N-glycosylated phosducin-like protein long (PhLP(L)) is
            expressed in all structures of the central nervous system and
            regulates opioid receptor function in the brain.
REFERENCE   10 (bases 1 to 2859)
  AUTHORS   Thibault,C., Sganga,M.W. and Miles,M.F.
  TITLE     Interaction of phosducin-like protein with G protein betagamma
            subunits
  JOURNAL   J Biol Chem 272 (19), 12253-12256 (1997)
   PUBMED   9139665
  REMARK    GeneRIF: These data are consistent with the hypothesis that PhLP is
            a widely expressed modulator of Gbetagamma function.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY024444.1, AK028668.1 and AV286628.1.
            
            On Jan 18, 2008 this sequence version replaced NM_026176.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006578.1, AK133747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               BY024444.1         1-111
            112-2762            AK028668.1         2-2652
            2763-2859           AV286628.1         155-251
FEATURES             Location/Qualifiers
     source          1..2859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.19 cM"
     gene            1..2859
                     /gene="Pdcl"
                     /gene_synonym="1200011E13Rik; PhLP1"
                     /note="phosducin-like"
                     /db_xref="GeneID:67466"
                     /db_xref="MGI:MGI:1914716"
     exon            1..190
                     /gene="Pdcl"
                     /gene_synonym="1200011E13Rik; PhLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..367
                     /gene="Pdcl"
                     /gene_synonym="1200011E13Rik; PhLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..549
                     /gene="Pdcl"
                     /gene_synonym="1200011E13Rik; PhLP1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..2858
                     /gene="Pdcl"
                     /gene_synonym="1200011E13Rik; PhLP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2834..2839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcl"
                     /gene_synonym="1200011E13Rik; PhLP1"
                     /note="hexamer: AATAAA"
     polyA_site      2857
                     /gene="Pdcl"
                     /gene_synonym="1200011E13Rik; PhLP1"
                     /note="major polyA site"
ORIGIN      
        1 gataagcttc ttgtgattgg gtagcgtgcg tccgccgcga cgccggaagg ccgtgtgatt
       61 ggtccgcaga gtccacggca gctttttctc tgtcgctcaa ggctttcggc cacttctctt
      121 tctctaggcg agcgtccttt gttggtgaca ggagctgcta gtctagaagg agcagactga
      181 gcgaggcgag gcaccatgac aaccctggat gataagttac tgggggagaa attacagtac
      241 tactacagca ccagcgagga tgaggacagt gaccatgaag acaaagacag aggcagggga
      301 gcaccagcca ttagttccac acctgcagag gctgagctgg caggcgaagg catctccatc
      361 aatacaggtc caaaaggtgt gatcaatgac tggcgccgct tcaagcagtt ggagacagag
      421 cagagggagg agcagtgccg ggagatggag cggctgatca aaaagctgtc tatgagctgc
      481 aggtcccatc tggatgaaga ggaggagcaa cagaaacaga aggacctcca ggagaaaatc
      541 agtgggaaga tgactctaaa ggagtttggt acaaaggaca agaacttgga tgatgaagag
      601 tttttgcagc agtatcggaa gcagaggatg gaagagatgc ggcagcagtt tcataaaggg
      661 ccccaattca agcaagtttt tgaaatcccc agtggagaag ggtttttaga tatgattgat
      721 aaagaacaaa aaagcacact tatcatggtt catatttatg aagatggcgt cccagggact
      781 gaagccatga atggctgcat gatctgcctt gccacagagt accccgccgt caaattctgt
      841 cgggtgagga gctcagttat tggggccagt agtcgtttta cccggaatgc ccttcctgct
      901 ctgctcatct acaaggcggg tgaattgatt ggcaattttg ttcgagtcac tgaccagctg
      961 ggggaagatt tctttgctgt agaccttgaa gctttcctgc aggaatttgg attgctccca
     1021 gaaaaggaag tcttggtgct gacatctgtg cgaaactctg ccacctgtca cagtgaagac
     1081 agcgatctgg aaatagattg aactgataat ctagttccgt agctatctca ttgtttgggc
     1141 tggaggacac atgtctgtat ttatttctgt ccttcctgtg tcttctggct ttacagctgt
     1201 tctttgtagt ctcatttagt atgtgaaaag tcaagaaatt cttagattaa atcagaatgc
     1261 tgactcactt tgtagctagc agtaaagtga cttcaaatta tataagcagg aaactaggtt
     1321 cttgagctgt ttacttctct agcgtgacat ctctgatact gtttccagtc aatattgaca
     1381 tggcaccctt gcaggcaatg tcttgaaaat tgtcttctga tgacctcaga attctaccag
     1441 ttctgagagt agaattccct agtgagtgtg ttctgtgcaa tgtaaacagt gcatttccat
     1501 aatcacttga ttgcaaatca tgtttacttg caatcagatg catagctgta ctttttttct
     1561 ctagatctgt ctctaccagg gtccatacaa ggttgggaat gtagctcggt ggtgaactct
     1621 tactatgcac atggccccaa gatacctgat tcctagcact gtcaagacta aaggttccag
     1681 atggtgcctg gtgctgtagt tagcagtggc ctctgctgtg gcggtcagtg gtccagtcca
     1741 gcataatgaa caggaaagga tggtttttgc tgactgctgt catgttggga ggcaagcatc
     1801 ttattgactg acattggtgt gtgtggagct tgaaaacctc agtgggagga tctttctgta
     1861 ctcctgctca tcagtatctc ttcctgttat taacaaggcg acttcttgtt taacctcagc
     1921 tttttttaaa tgcttttttg cctattagga aaaaaaaatc atatttagta gaggaaaatt
     1981 ggccaaaata aagatgtaaa aatggtttaa aaatgtaatt ctgccaccta aatactatat
     2041 gttttggtat agttcatata taggtttttt ttttttaatg tattcattgg cttttgtttg
     2101 tctttaaatg acactgggat aattctgagc atagtgtctg atattatggt cagctactaa
     2161 catcagatgt ttttcatgtt attaaatact cttctgtaac attttaatag ctgttgatat
     2221 ttccactgat agatatactg taatatgctt ggtggttggt ttttagaaag atggcaaact
     2281 tttttattat gaacctttta ttatgaaatg tgtccctcat agaacataca ataaaaatta
     2341 agctaaaaag atatttaaaa gccatacagt tttactactg ataattatgt caccattttt
     2401 atagatctct ttatagcttt atgtgtatgt gtatatttat aaaattcatt gtcattcaag
     2461 tttttttcct tttagttatt ctttatatgt tcttgtgtca gtggagaaga aatgtagtct
     2521 ggaagtaaat attagcttta gtatgcacac ttgagttttt tggttgctca gaaactaact
     2581 gtaaatgagt cttgaaagtg tctgttggat ttaatcaaca aaaacagttg tcattttctg
     2641 actaaggagc ttattgtaga agtgaagaaa atcattagga acagagaaag ctgatgtaag
     2701 tattctagtt tttttctttc caatccttct gtccccattc ttaataacat tgatagttac
     2761 tgaattctgt gtcctacttt atgtaatagt acatactaaa atactttgct atattgtaaa
     2821 agttcaccat ttaaataaat cataccatat tgactcaga
//
