LOCUS       NM_011052               5961 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus programmed cell death 6 interacting protein (Pdcd6ip),
            transcript variant 3, mRNA.
ACCESSION   NM_011052
VERSION     NM_011052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5961)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5961)
  AUTHORS   Wang,Y.Z., Castillon,C.C.M., Gebis,K.K., Bartom,E.T., d'Azzo,A.,
            Contractor,A. and Savas,J.N.
  TITLE     Notch receptor-ligand binding facilitates extracellular
            vesicle-mediated neuron-to-neuron communication
  JOURNAL   Cell Rep 43 (2), 113680 (2024)
   PUBMED   38241148
REFERENCE   3  (bases 1 to 5961)
  AUTHORS   Hermosilla Aguayo,V., Martin,P., Tian,N., Zheng,J., Aho,R., Losa,M.
            and Selleri,L.
  TITLE     ESCRT-dependent control of craniofacial morphogenesis with
            concomitant perturbation of NOTCH signaling
  JOURNAL   Dev Biol 503, 25-42 (2023)
   PUBMED   37573008
REFERENCE   4  (bases 1 to 5961)
  AUTHORS   Laporte,M.H., Chi,K.I., Caudal,L.C., Zhao,N., Schwarz,Y.,
            Rolland,M., Martinez-Hernandez,J., Martineau,M., Chatellard,C.,
            Denarier,E., Mercier,V., Lemaitre,F., Blot,B., Moutaux,E.,
            Cazorla,M., Perrais,D., Lante,F., Bruns,D., Fraboulet,S.,
            Hemming,F.J., Kirchhoff,F. and Sadoul,R.
  TITLE     Alix is required for activity-dependent bulk endocytosis at brain
            synapses
  JOURNAL   PLoS Biol 20 (6), e3001659 (2022)
   PUBMED   35658004
  REMARK    GeneRIF: Alix is required for activity-dependent bulk endocytosis
            at brain synapses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5961)
  AUTHORS   Jin,Z.L., Yao,X.R., Wen,L., Hao,G., Kwon,J.W., Hao,J. and Kim,N.H.
  TITLE     AIP1 and Cofilin control the actin dynamics to modulate the
            asymmetric division and cytokinesis in mouse oocytes
  JOURNAL   FASEB J 34 (8), 11292-11306 (2020)
   PUBMED   32602619
  REMARK    GeneRIF: AIP1 and Cofilin control the actin dynamics to modulate
            the asymmetric division and cytokinesis in mouse oocytes.
REFERENCE   6  (bases 1 to 5961)
  AUTHORS   Chatellard-Causse,C., Blot,B., Cristina,N., Torch,S., Missotten,M.
            and Sadoul,R.
  TITLE     Alix (ALG-2-interacting protein X), a protein involved in
            apoptosis, binds to endophilins and induces cytoplasmic
            vacuolization
  JOURNAL   J Biol Chem 277 (32), 29108-29115 (2002)
   PUBMED   12034747
  REMARK    GeneRIF: overexpression of Alix-CT leads to cytoplasmic
            vacuolization into tubulo-vesicular structures
REFERENCE   7  (bases 1 to 5961)
  AUTHORS   Aubry,L., Mattei,S., Blot,B., Sadoul,R., Satre,M. and Klein,G.
  TITLE     Biochemical characterization of two analogues of the
            apoptosis-linked gene 2 protein in Dictyostelium discoideum and
            interaction with a physiological partner in mammals, murine Alix
  JOURNAL   J Biol Chem 277 (24), 21947-21954 (2002)
   PUBMED   11927596
  REMARK    GeneRIF: Biochemical characterization of two analogues of the
            apoptosis-linked gene 2 protein in Dictyostelium discoideum and
            interaction with murine Alix.
REFERENCE   8  (bases 1 to 5961)
  AUTHORS   Chen,B., Borinstein,S.C., Gillis,J., Sykes,V.W. and Bogler,O.
  TITLE     The glioma-associated protein SETA interacts with AIP1/Alix and
            ALG-2 and modulates apoptosis in astrocytes
  JOURNAL   J Biol Chem 275 (25), 19275-19281 (2000)
   PUBMED   10858458
REFERENCE   9  (bases 1 to 5961)
  AUTHORS   Missotten,M., Nichols,A., Rieger,K. and Sadoul,R.
  TITLE     Alix, a novel mouse protein undergoing calcium-dependent
            interaction with the apoptosis-linked-gene 2 (ALG-2) protein
  JOURNAL   Cell Death Differ 6 (2), 124-129 (1999)
   PUBMED   10200558
REFERENCE   10 (bases 1 to 5961)
  AUTHORS   Vito,P., Pellegrini,L., Guiet,C. and D'Adamio,L.
  TITLE     Cloning of AIP1, a novel protein that associates with the
            apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction
  JOURNAL   J Biol Chem 274 (3), 1533-1540 (1999)
   PUBMED   9880530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167246.2, AK167574.1, BE623112.1, AK029827.1, AK157704.1 and
            BM899382.1.
            
            On Sep 15, 2009 this sequence version replaced NM_011052.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. This
            results in a shorter protein (isoform 3), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169704.1, AK129340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC167246.2         97413-97455         c
            44-3223             AK167574.1         2-3181
            3224-3603           BE623112.1         134-513
            3604-4440           AK029827.1         3570-4406
            4441-5950           AK157704.1         637-2146
            5951-5961           BM899382.1         8-18                c
FEATURES             Location/Qualifiers
     source          1..5961
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 64.03 cM"
     gene            1..5961
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /note="programmed cell death 6 interacting protein"
                     /db_xref="GeneID:18571"
                     /db_xref="MGI:MGI:1333753"
     exon            1..361
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            362..416
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            417..486
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            487..614
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            615..768
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            769..869
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            870..986
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1209
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1333
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1511
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1623
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1793
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..2042
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2177
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2272
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2396
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2587
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..5951
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3202..3207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /note="hexamer: AATAAA"
     polyA_site      3223
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /note="major polyA site"
     regulatory      3486..3491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /note="hexamer: AATATA"
     polyA_site      3505
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
     regulatory      5930..5935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /note="hexamer: AATAAA"
     polyA_site      5951
                     /gene="Pdcd6ip"
                     /gene_synonym="Aip1; Alix; Eig2; mKIAA1375"
                     /note="major polyA site"
ORIGIN      
        1 gcgggggctc ccggaagtgg ccagctcgaa gcgctggcgg cccagtccgt cggcccgtcg
       61 gtccgctcct ccgctgccgg tgccgagcgc gcctaggccg tggtcgctgt ccctccgtct
      121 gtgcggcccg acgcggcggc cgggcgctca ccatggcgtc gttcatctgg gtgcagctga
      181 agaagacctc ggaggtggac ctggccaagc cgctggtgaa gttcatccag cagacgtacc
      241 cgagcggcgg cgaggagcag gcccagtact gccgtgcggc cgaggagctc agcaaactgc
      301 ggcgctcggc gctcggtcgc ccgctggaca agcatgaggg cgccctggag acgttgctga
      361 ggtattatga tcagatttgt tccattgaac ccaagttccc attttctgaa aatcagatct
      421 gcttgacgtt cacgtggaag gatgcttttg ataaaggttc cctttttgga gggtctgtaa
      481 aattggctct tgcaagctta ggatatgaaa agagctgtgt gttgttcaat tgtgctgcct
      541 tagctagcca gattgcagca gagcagaacc tggataatga tgaaggattg aaaaccgctg
      601 ctaagcagta ccagtttgct agtggtgcct ttttacatat taaagacaca gtgttatctg
      661 ccttaagtcg agagcctact gtggacatat ctccagatac tgttggaact ctcagtctta
      721 ttatgctggc tcaagctcaa gaagtatttt tcttaaaagc cacaagagat aagatgaaag
      781 atgccatcat agctaagctg gcaaatcagg ctgcggatta ctttggcgat gctttcaagc
      841 agtgtcagta caaggacacg ctccccaagg aggtattccc caccctggct gcaaagcagt
      901 gcatcatgca ggccaatgct gagtaccacc agtccatcct ggccaagcag cagaagaagt
      961 ttggggaaga gatcgcaagg ttgcagcacg cagcagaact gatcaagaat gtggcctctc
     1021 gctatgatga gtatgtcaat gtgaaggatt tttctgacaa aatcaaccgt gcccttactg
     1081 cagcaaagaa ggataatgat tttatttatc atgaccgtgt tccggacctt aaggatctgg
     1141 atcctatcgg caaagccaca cttgtgaagc ccaccccagt caatgtacct gtcagccaga
     1201 agttcacgga tttgtttgag aagatggtcc ctgtgtctgt gcagcagtcc ctggctgtgt
     1261 ttagtcagag gaaagctgac ttggtcaaca gatcaatcgc tcagatgaga gaagctacga
     1321 ctttggcaaa tggagtattg gcttccctta accttccagc agcaattgaa gatgtgtctg
     1381 gagacactgt acctcagtct atacttacca agtctacatc tgtagttgaa cagggaggca
     1441 tccagactgt cgaccagctg ataaaagagc tacctgagct gctgcaaaga aatagagaaa
     1501 tattagagga gtcgctaaga ttgttggatg aagaagaagc aactgacaat gatttaagag
     1561 caaaattcaa ggaccgctgg caaaggactc catccaatga cctgtacaag cctttacgag
     1621 cagagggagc caaattcaga gccgttttag ataaagctgt gcaagcggat ggacaggtga
     1681 aggagcgcta ccagtcccat cgagacacca tcgcacttct gtgtaagccg gagccagagc
     1741 tgaatgctgc catcccctct gctaacccag caaagaccat gcagggcagc gaggttgtaa
     1801 gtgtcttaaa gtccttatta tcaaatcttg atgaaatcaa gaaggaaaga gagagtcttg
     1861 agaatgacct gaagtcagtg aattttgaca tgacaagcaa gtttttgaca gctctggccc
     1921 aagatggcgt gataaatgag gaggctctct ctgtcactga gctggatcgg atctatggcg
     1981 gtctaacaag taaagttcaa gagtctctga agaaacaaga gggacttcta aaaaatatac
     2041 aggtctcaca ccaagaattc tccaaaatga agcaatctaa caacgaggct aacttgagag
     2101 aagaagttct gaagaaccta gcaactgcgt atgacaactt tgttgagctt gtagctaact
     2161 tgaaggaggg cacaaagttt tacaatgagc tgactgagat cctggtcagg ttccagaaca
     2221 aatgcagtga catagtgttt gcacggaaga cagaaagaga cgagctcttg aaggatctgc
     2281 agcagagcat tgccagagag cccagcgctc cttcaatccc tcctccagcc tatcagtcct
     2341 ccccagcagc ggggcatgca gcagcgcctc caactccagc cccaagaacc atgccgcctg
     2401 ctaagcccca gcctccagcc cggcctccac ctcctgtgct tcctgcaaac cgagttcctc
     2461 ctgcttctgc tgctgctgcc cctgcaggcg tggggacggc ttcagcagcg ccgccacaga
     2521 cccctggctc tgctcccccg ccacaggctc agggaccacc ataccctacc tatccaggat
     2581 atcccgggta ttgccaaatg cccatgccca tgggctacaa cccctacgca tatggccagt
     2641 acaatatgcc gtacccaccg gtgtatcacc agagccccgg acaggctcca tacccaggac
     2701 cccagcagcc tacctacccc ttccctcagc ccccgcagca gtcctactat ccacagcagt
     2761 aacgctgcca cgtgctgctg gttcagatca gagcgacagg acagcagctg ccaccagctc
     2821 taagccacgc tctggccact cgagagtatc ttgctctatt gattgctgtg gatgatttct
     2881 gtctgtggct aaagccgaag gctgggcccc acctccacat ttgatcgcac tcgtgagatt
     2941 ctgctgctgt tgcagtataa acgctagcta taatagcatt tgaaaaaaat tacagttcca
     3001 taaaatgctg aaaatgagaa attaaacctg caagtgaaac atttgaaatt agcatacttt
     3061 ataagatgca gttgggacaa agatggctta agtactgata tttaaggaaa aagttttctt
     3121 tctcttttgg tttattgatt tagtttaatt tctattatga tattttgcat aatcaaggca
     3181 ttgtaaatct tataatttaa aaataaatta cttacgaaca gttgtcattg ttatgttttg
     3241 tcattgattc tcattgctgt ctagttcctt tctggtatta gcctctcctt ctgtatgttc
     3301 acaggctcca ttactgtgtt gaattgcgtg agcgtcaggt gagcagtcag ggagggctgc
     3361 tctgcggagc ccaagcgcag caccagcttg tctcaggctc agcagtcagc tcatctggac
     3421 atttctattt aaaagtcctt taatgtggaa gatacacaca attgttacca aagattcttc
     3481 aaataaatat aacatttaaa aagtatgtat taatgtttta ttgttagatt ttccaaaaaa
     3541 atgatgcaaa ttctggtaat attcatttcc ctcacccata atttggttaa aatgagtagt
     3601 tttagccata cagtctcatc tgctgtggag gaacctggag aaagtcccct gtgcctttct
     3661 agcccttggt tctattctta tcctgcaatg tctactgcac agtgtgtttg agcagatcct
     3721 aaccctcctt ttacagtttc ttcttcttac ttctttattc ttttgtggct cctgaaatct
     3781 gaggttattt tgtaattcag gagcatgcag gacaattgtt gggacatgtg cctagtccgg
     3841 aatacagccc aggacagcaa ggagatgcgt cctgcaccag gaagccgtgc aggcaggagc
     3901 tgtccaaggt cccggcggct ctgcctgtgt gaggcaggag aatgagcaga ttcctaatct
     3961 atgttctcga agtttaatgc tgatgttgtc ttgccttatc tcatttaact gatactgtca
     4021 cccagtccac ctttgctctc attgcaaagt cagactgtaa tttcaaatgt aagactgaag
     4081 atacgattgt aaaagggagt aaactggttt aaacgtgtta ttctaaagca ccttactttg
     4141 ttgttgtatg cagaaaacac agatgcgcta attcagtata aatgactgat tgcctggaat
     4201 atggacgttg gcttaaagtc cgatagctaa accttggcaa aacataacaa acatttcatt
     4261 gctcagcctc agtgctctgg agtattcagt gtatgagaca ggtttatttg agtcctctgt
     4321 aaatggcatt tgaattttat attctcccct cccgagtatc ttataagaca tcccctgagt
     4381 tagggagttc ccagactgct actctattcc ttatgaatgc aaaacaacca ccaatagaac
     4441 aaagaaaaag aaaaaaatgg cctgaatatt ctcttgggaa agggggttgg aggtctataa
     4501 agggaagggt aagtgtatca gaaatccaaa gggaggaggg gtcaggccag cagccatttc
     4561 ctcatgctct gtgttatgcc tgcagggtca cagaggacag gcagcgtggt ggtggggggc
     4621 agctccttcc agtccccctg ccccagctca gctcctgagg gacacctctt gccaactctc
     4681 tcatccttta agttgctcag gatgttcttc gggtctcagg ctaggtgcca ttaagctgca
     4741 gtgcttgctt tgccttctta agcctgtcct gtttgactgg tggaaagccg actcacgtgc
     4801 ctacctactg tgcttcctag gaaactagat ggcggccctc acctgggcgg gcttgtcagc
     4861 acaccctaac ctctgctcgg tttgctgtgc tcttgagaac gcactgcaga agttactgtg
     4921 ctcgatggca ggtcgagggt tccactctgg ctcgagtatg ttatcccgtt tataattaga
     4981 ctttctgcta ccttcttaaa tgaaggcacc tcccccgacc cccacacaca ccccggccat
     5041 ttatgttggc tctctaagcc tcttatgaaa tggattgatt acctgccagc tactgaagct
     5101 ttgccgagac accagtcaga agaggggaaa gccatccaac ttggatttcc tgtccccaga
     5161 gatggatggc ttgactactc agcatggtgt cagtctctga gctggagaac tatttctctg
     5221 ttccttggtc cctttcttga ttgagaaaag tgctcgtgtc acactgcaca gcagccagtc
     5281 tctgagacgc cgggtctaca ctctggcacc cttgcattta tgtccccagt atcagtgagg
     5341 atgtggcagt tgtatcccca cctctgtccc agccagctac ctttttagtc aagacagatt
     5401 agtggttttt gttttttttg ttttccagtt gtgatttaca gtttgtaagc attcctttgt
     5461 atacatttcc taatttcatg aacaggataa aatagtaagc aggccttggt tggctagtgg
     5521 gagtttttaa accaatgacg agtatgtctt gaagccttgc tacagccctg tggcctatga
     5581 tttctaagac ttgtgcagct agttgactca cagtgtagaa ccgggcacaa gctggacaaa
     5641 acctttgcaa gaagagttaa aattattggt ttaagtacag actttagaac taaatggaag
     5701 agcatagaag gaaaattata tttttaacaa aagagaatat tcaggcttta tttctggtat
     5761 gaaatttata ttttttagaa aatatatcct atattatcac accggagatt ttagattcct
     5821 ttctggttac aaacattgct ggtagttgga ttatattttt attgtattca tttctcttag
     5881 ggggaaaatt gtaaagaaac aaaaagattc cggatgaatg tatcctagaa ataaaagttg
     5941 aaagattctt aaaaaaaaaa a
//
