LOCUS       NM_011051               1524 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus programmed cell death 6 (Pdcd6), transcript variant 1,
            mRNA.
ACCESSION   NM_011051
VERSION     NM_011051.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1524)
  AUTHORS   Sun,L., Wu,S., Wang,H., Zhang,T., Zhang,M., Bai,X., Zhang,X.,
            Li,B., Zhang,C., Li,Y., Zhou,J. and Li,T.
  TITLE     PDCD6 regulates lactate metabolism to modulate LC3-associated
            phagocytosis and antibacterial defense
  JOURNAL   Nat Commun 15 (1), 10157 (2024)
   PUBMED   39578445
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1524)
  AUTHORS   Sargeant,J., Seiler,D.K., Costain,T., Madreiter-Sokolowski,C.T.,
            Gordon,D.E., Peden,A.A., Malli,R., Graier,W.F. and Hay,J.C.
  TITLE     ALG-2 and peflin regulate COPII targeting and secretion in response
            to calcium signaling
  JOURNAL   J Biol Chem 297 (6), 101393 (2021)
   PUBMED   34762908
  REMARK    GeneRIF: ALG-2 and peflin regulate COPII targeting and secretion in
            response to calcium signaling.
REFERENCE   3  (bases 1 to 1524)
  AUTHORS   Mikasa,T., Kugo,M., Nishimura,S., Taketani,S., Ishijima,S. and
            Sagami,I.
  TITLE     Thermodynamic Characterization of the Ca2+-Dependent Interaction
            Between SOUL and ALG-2
  JOURNAL   Int J Mol Sci 19 (12), 3802 (2018)
   PUBMED   30501057
  REMARK    GeneRIF: Results provide a better understanding of the target
            recognition mechanism and conformational change of SOUL in the
            interaction with ALG-2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1524)
  AUTHORS   Zhang,D., Wang,F., Pang,Y., Zhao,E., Zhu,S., Chen,F. and Cui,H.
  TITLE     ALG2 regulates glioblastoma cell proliferation, migration and
            tumorigenicity
  JOURNAL   Biochem Biophys Res Commun 486 (2), 300-306 (2017)
   PUBMED   28300556
  REMARK    GeneRIF: ALG2 regulates glioblastoma cell proliferation, migration
            and tumorigenicity.
REFERENCE   5  (bases 1 to 1524)
  AUTHORS   Tanner,J.J., Frey,B.B., Pemberton,T. and Henzl,M.T.
  TITLE     EF5 Is the High-Affinity Mg(2+) Site in ALG-2
  JOURNAL   Biochemistry 55 (36), 5128-5141 (2016)
   PUBMED   27541325
REFERENCE   6  (bases 1 to 1524)
  AUTHORS   Missotten,M., Nichols,A., Rieger,K. and Sadoul,R.
  TITLE     Alix, a novel mouse protein undergoing calcium-dependent
            interaction with the apoptosis-linked-gene 2 (ALG-2) protein
  JOURNAL   Cell Death Differ 6 (2), 124-129 (1999)
   PUBMED   10200558
REFERENCE   7  (bases 1 to 1524)
  AUTHORS   Shen,J., Bronson,R.T., Chen,D.F., Xia,W., Selkoe,D.J. and
            Tonegawa,S.
  TITLE     Skeletal and CNS defects in Presenilin-1-deficient mice
  JOURNAL   Cell 89 (4), 629-639 (1997)
   PUBMED   9160754
REFERENCE   8  (bases 1 to 1524)
  AUTHORS   Vito,P., Lacana,E. and D'Adamio,L.
  TITLE     Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and
            Alzheimer's disease gene ALG-3
  JOURNAL   Science 271 (5248), 521-525 (1996)
   PUBMED   8560270
REFERENCE   9  (bases 1 to 1524)
  AUTHORS   Hirota,M., Miyashita,S., Hayashi,H., Furukawa,Y. and Hayashi,K.
  TITLE     pS2 gene especially expressed in the late G1/S phase of mouse
            astrocytes
  JOURNAL   Neurosci Lett 171 (1-2), 49-51 (1994)
   PUBMED   8084497
REFERENCE   10 (bases 1 to 1524)
  AUTHORS   Kageyama,H., Shimizu,M., Tokunaga,K., Hiwasa,T. and Sakiyama,S.
  TITLE     A partial cDNA for a novel protein which has a typical E-F hand
            structure
  JOURNAL   Biochim Biophys Acta 1008 (2), 255-257 (1989)
   PUBMED   2736249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU604816.1, AK028223.1, AK008610.1 and AV299538.1.
            
            On Dec 18, 2007 this sequence version replaced NM_011051.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008610.1, AK028223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BU604816.1         4-49
            47-1127             AK028223.1         2-1082
            1128-1517           AK008610.1         1052-1441
            1518-1524           AV299538.1         275-281
FEATURES             Location/Qualifiers
     source          1..1524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..1524
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /note="programmed cell death 6"
                     /db_xref="GeneID:18570"
                     /db_xref="MGI:MGI:109283"
     exon            1..220
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..695
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     programmed cell death protein 6; PMP41; ALG-257; probable
                     calcium-binding protein ALG-2; apoptosis-linked gene 2
                     protein"
                     /codon_start=1
                     /product="programmed cell death protein 6 isoform 1"
                     /protein_id="NP_035181.1"
                     /db_xref="CCDS:CCDS26642.1"
                     /db_xref="GeneID:18570"
                     /db_xref="MGI:MGI:109283"
                     /translation="MAAYSYRPGPGGGPGPAAGAALPDQSFLWNVFQRVDKDRSGVIS
                     DNELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTY
                     DRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQR
                     LTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV"
     exon            221..282
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..327
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /inference="alignment:Splign:2.1.0"
     exon            328..486
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..596
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /inference="alignment:Splign:2.1.0"
     exon            597..1524
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1107..1112
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /note="hexamer: AATAAA"
     polyA_site      1125
                     /gene="Pdcd6"
                     /gene_synonym="alg-2; Alg2; MA-3; PS2"
                     /note="major polyA site"
ORIGIN      
        1 gactcaaagg tgcgcgcttc cgttgttccc aggaagttgt gggctcctgg tcctgcccca
       61 taactgaggc ggaagcatag cttgtggagc tgggccgcgt tgccgctgtg catcagccca
      121 tggctgccta ctcctaccgc ccaggcccgg gtggtggccc cggccctgct gctggagctg
      181 cactgccaga ccagagcttc ctgtggaacg tcttccagcg ggttgataaa gacaggagtg
      241 gagtgatttc agacaatgag cttcagcaag cattatccaa tggtacatgg actccattta
      301 acccagtgac tgtgaggtca atcatttcta tgtttgaccg agaaaacaag gctggtgtga
      361 acttcagtga attcacgggt gtgtggaagt atatcacaga ctggcagaat gtcttccgga
      421 cctacgacag ggacaactct gggatgattg acaagaacga gctcaaacaa gcactctcag
      481 gttttggcta ccggctctct gatcagttcc atgacatcct catccgaaaa tttgacaggc
      541 aaggacgggg ccagatcgca tttgatgact tcatccaggg ctgcatcgtc ttgcagaggt
      601 tgacagacat attcagacgc tatgacacgg atcaggatgg ctggattcag gtgtcttatg
      661 agcaatatct ctccatggtc ttcagcattg tataaccagg ccttgagaac agcaagcacg
      721 gcatgcaaaa gactgaagat gccaaatccc ttacctgtga tagaacaggg cacagctgca
      781 gtgagatgcc gtccttcccg ttggctgtat cgttcatact tggggacctg gctgtacata
      841 tgtgaatatg ctggtcagtg attctgtagt gactctagct acactgttgt gatacaaacc
      901 ttgggtttgc tgactaattg tgccatgaga cctaataatg cttcaggatt ttgctctcaa
      961 actatcatgt tcttttctag atgtctctaa gtctatagtt gcaatgcttt tattagccaa
     1021 tagaatttta aaataatatg gaacttgcac agaaggcttt tcatgtgcct tactttttaa
     1081 aaaaaattgg aatatgtaac ataagcaata aagtgatgat acagactggt tgcctagttt
     1141 tggctggttt tttgctttgt tttgttttaa ccaaacaggt ggaagagctg tgccgtttgt
     1201 tacactactc tagcataaca cgtgtgctgc gtgaacctgg gagtgtgggg cctaaaaatg
     1261 aggcagacta aagtctcatg caaaagccaa ctttatttag agcatcagaa aatttatact
     1321 ctgagggtta agaggaacca caaagaagtc acacatggca aaaacatgtt ttttccataa
     1381 aggcgtatga atagcaacag ctgcagtaaa ctcactccgg tcttccatac ctgggaggag
     1441 cacaaagaca cattctggaa ccaattctgt gaattgaaga aacgggtcat gtaacgtaag
     1501 caataaagta atgatataga ctgg
//
