LOCUS       NM_019746                642 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus programmed cell death 5 (Pdcd5), mRNA.
ACCESSION   NM_019746
VERSION     NM_019746.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 642)
  AUTHORS   Li,B., Ye,J., Liu,R., Weng,L., Cao,Y., Jia,S., Xu,C., Liu,Y.,
            Yan,S. and Zheng,M.
  TITLE     Programmed cell death 5 improves skeletal muscle insulin resistance
            by inhibiting IRS-1 ubiquitination through stabilization of MDM2
  JOURNAL   Life Sci 285, 119918 (2021)
   PUBMED   34480939
  REMARK    GeneRIF: Programmed cell death 5 improves skeletal muscle insulin
            resistance by inhibiting IRS-1 ubiquitination through stabilization
            of MDM2.
REFERENCE   2  (bases 1 to 642)
  AUTHORS   Park,S.Y., Hong,J.Y., Lee,S.Y., Lee,S.H., Kim,M.J., Kim,S.Y.,
            Kim,K.W., Shim,H.S., Park,M.S., Lee,C.G., Elias,J.A., Sohn,M.H. and
            Yoon,H.G.
  TITLE     Club cell-specific role of programmed cell death 5 in pulmonary
            fibrosis
  JOURNAL   Nat Commun 12 (1), 2923 (2021)
   PUBMED   34011956
  REMARK    GeneRIF: Club cell-specific role of programmed cell death 5 in
            pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 642)
  AUTHORS   Wang,K., Zhang,X., Wang,Y., Jin,G., Li,M., Zhang,S., Hao,J.,
            Jin,R., Huang,X., Wu,H., Zhang,J., Chen,Y. and Ge,Q.
  TITLE     PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate
            decision
  JOURNAL   Cell Mol Immunol 16 (9), 746-756 (2019)
   PUBMED   29921968
  REMARK    GeneRIF: PDCD5 regulates iNKT cell terminal maturation and iNKT1
            fate decision.
REFERENCE   4  (bases 1 to 642)
  AUTHORS   Lee,S.H., Seo,J., Park,S.Y., Jeong,M.H., Choi,H.K., Lee,C.J.,
            Kim,M.J., Guk,G., Lee,S., Park,H., Jeong,J.W., Ha,C.H., Park,S. and
            Yoon,H.G.
  TITLE     Programmed cell death 5 suppresses AKT-mediated cytoprotection of
            endothelium
  JOURNAL   Proc Natl Acad Sci U S A 115 (18), 4672-4677 (2018)
   PUBMED   29588416
  REMARK    GeneRIF: serum PDCD5 levels reflect endothelial NO production and
            are correlated with diabetes mellitus, high-density lipoprotein
            cholesterol, and coronary calcium
REFERENCE   5  (bases 1 to 642)
  AUTHORS   Li,G., Xu,C., Lin,X., Qu,L., Xia,D., Hongdu,B., Xia,Y., Wang,X.,
            Lou,Y., He,Q., Ma,D. and Chen,Y.
  TITLE     Deletion of Pdcd5 in mice led to the deficiency of placenta
            development and embryonic lethality
  JOURNAL   Cell Death Dis 8 (5), e2811 (2017)
   PUBMED   28542142
  REMARK    GeneRIF: Pdcd5 knockout in mouse embryos results in placental
            defects and embryonic lethality.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 642)
  AUTHORS   Wang,Y., Chu,H., Zhou,L., Gao,H., Xiong,H., Chen,Q., Chen,J.,
            Huang,X. and Cui,Y.
  TITLE     Correlation of PDCD5 and apoptosis in hair cells and spiral
            ganglion neurons of different age of C57BL/6J mice
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 32 (1), 113-118 (2012)
   PUBMED   22282256
  REMARK    GeneRIF: It is implied that overexpression of PDCD5 causes the
            increase in caspase-3 activity and the subsequent increase of
            apoptosis in cochlear hair cells and SGNs, and thereby plays a role
            in the pathogenesis of presbycusis.
REFERENCE   7  (bases 1 to 642)
  AUTHORS   Wang,Y., Chu,H.Q., Zhou,L.Q., Chen,J., Li,Z.Y., Liu,Y., Zhang,P.,
            Huang,X.W. and Cui,Y.H.
  TITLE     [Expression of PDCD5 and caspase 3 in the cochlea of different age
            of C57BL/6J mice]
  JOURNAL   Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 46 (9), 747-751
            (2011)
   PUBMED   22177044
  REMARK    GeneRIF: The expression levels of PDCD5 and caspase 3 in the
            cochlea of C57 mice increase with age.
REFERENCE   8  (bases 1 to 642)
  AUTHORS   Gu,L., Tang,Z., He,D., Ka,W., Sun,D. and Wen,Z.
  TITLE     Effects of TFAR19 gene on the in vivo biorheological properties and
            pathogenicity of mouse erythroleukemia cell line MEL
  JOURNAL   Sci China C Life Sci 50 (1), 111-119 (2007)
   PUBMED   17393091
  REMARK    GeneRIF: Suppresses the pathogenicity of transplanted mouse
            erythroleukemia (MEL) cells in mice.
REFERENCE   9  (bases 1 to 642)
  AUTHORS   Chen,Y., Sun,R., Han,W., Zhang,Y., Song,Q., Di,C. and Ma,D.
  TITLE     Nuclear translocation of PDCD5 (TFAR19): an early signal for
            apoptosis?
  JOURNAL   FEBS Lett 509 (2), 191-196 (2001)
   PUBMED   11741587
REFERENCE   10 (bases 1 to 642)
  AUTHORS   Liu,H., Wang,Y., Zhang,Y., Song,Q., Di,C., Chen,G., Tang,J. and
            Ma,D.
  TITLE     TFAR19, a novel apoptosis-related gene cloned from human leukemia
            cell line TF-1, could enhance apoptosis of some tumor cells induced
            by growth factor withdrawal
  JOURNAL   Biochem Biophys Res Commun 254 (1), 203-210 (1999)
   PUBMED   9920759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC151531.3.
            
            [WARNING] On Feb 6, 2025 this sequence was replaced by NM_019746.5.
            
            On Nov 17, 2006 this sequence version replaced NM_019746.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092092.1, BY708516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC151531.3         103-279
            178-215             AC151531.3         1404-1441
            216-277             AC151531.3         3173-3234
            278-369             AC151531.3         3870-3961
            370-441             AC151531.3         4899-4970
            442-642             AC151531.3         5400-5600
FEATURES             Location/Qualifiers
     source          1..642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.37 cM"
     gene            1..642
                     /gene="Pdcd5"
                     /gene_synonym="2200003D22Rik; Tfar19"
                     /note="programmed cell death 5"
                     /db_xref="GeneID:56330"
                     /db_xref="MGI:MGI:1913538"
     exon            1..177
                     /gene="Pdcd5"
                     /gene_synonym="2200003D22Rik; Tfar19"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..492
                     /gene="Pdcd5"
                     /gene_synonym="2200003D22Rik; Tfar19"
                     /note="TF-1 cell apoptosis-related protein 19"
                     /codon_start=1
                     /product="programmed cell death protein 5"
                     /protein_id="NP_062720.1"
                     /db_xref="CCDS:CCDS52203.1"
                     /db_xref="GeneID:56330"
                     /db_xref="MGI:MGI:1913538"
                     /translation="MADEELEALRKQRLAELQAKHGDPGDAAQQEAKQREAEMRNSIL
                     AQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSGKVSEQGLIEILEKVSQQ
                     TEKKTTVKFNRRKVMDSDEDDADY"
     exon            178..215
                     /gene="Pdcd5"
                     /gene_synonym="2200003D22Rik; Tfar19"
                     /inference="alignment:Splign:2.1.0"
     exon            216..277
                     /gene="Pdcd5"
                     /gene_synonym="2200003D22Rik; Tfar19"
                     /inference="alignment:Splign:2.1.0"
     exon            278..369
                     /gene="Pdcd5"
                     /gene_synonym="2200003D22Rik; Tfar19"
                     /inference="alignment:Splign:2.1.0"
     exon            370..441
                     /gene="Pdcd5"
                     /gene_synonym="2200003D22Rik; Tfar19"
                     /inference="alignment:Splign:2.1.0"
     exon            442..642
                     /gene="Pdcd5"
                     /gene_synonym="2200003D22Rik; Tfar19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggctcga gtctccggcc gaagcgattc caaccgagtg taccggaggg cggctgcggc
       61 tgcgcgaccc ccgacggccg ctgcgcctgc gcgacgtggg acagccgcgc catggcggac
      121 gaagaacttg aggcgctgag gaagcagagg ctggccgagt tgcaggccaa gcatggagat
      181 cctggtgatg cagcccaaca ggaagcaaag caaagggaag cagaaatgag aaacagtatc
      241 ttagcccaag ttctggatca gtcagcccgg gccagattaa gtaacttagc acttgtaaag
      301 cctgaaaaaa ctaaagcagt ggagaactac cttatacaga tggcgcggta tggacagcta
      361 agtgggaagg tgtcagaaca aggtttgata gaaatacttg agaaagtcag ccaacagaca
      421 gaaaagaaaa caacagtgaa attcaacaga agaaaagtaa tggactccga tgaagacgac
      481 gccgattact aagaggacgc acttagacag acttccggag cagtgtctag gacagtcacc
      541 accttgtaaa tgtttacttt gttccctgtc tatatatgcc ttttgaaaaa taaacttgta
      601 cctcaaactc aaacagtttg ggtgtttcag aatcacaggc aa
//
