LOCUS       NM_001168491            2330 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus programmed cell death 4 (Pdcd4), transcript variant 2,
            mRNA.
ACCESSION   NM_001168491
VERSION     NM_001168491.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2330)
  AUTHORS   Cheng,J., Yuan,L., Yu,S., Gu,B., Luo,Q., Wang,X., Zhao,Y., Gai,C.,
            Li,T., Liu,W., Wang,Z., Liu,D., Ho,R.C.M. and Ho,C.S.H.
  TITLE     Programmed cell death factor 4-mediated hippocampal synaptic
            plasticity is involved in early life stress and susceptibility to
            depression
  JOURNAL   Behav Brain Res 468, 115028 (2024)
   PUBMED   38723677
  REMARK    GeneRIF: Programmed cell death factor 4-mediated hippocampal
            synaptic plasticity is involved in early life stress and
            susceptibility to depression.
REFERENCE   2  (bases 1 to 2330)
  AUTHORS   Li,Y., Zhan,B., Zhuang,X., Zhao,M., Chen,X., Wang,Q., Liu,Q. and
            Zhang,L.
  TITLE     Microglial Pdcd4 deficiency mitigates neuroinflammation-associated
            depression via facilitating Daxx mediated PPARgamma/IL-10 signaling
  JOURNAL   J Neuroinflammation 21 (1), 143 (2024)
   PUBMED   38822367
  REMARK    GeneRIF: Microglial Pdcd4 deficiency mitigates
            neuroinflammation-associated depression via facilitating Daxx
            mediated PPARgamma/IL-10 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2330)
  AUTHORS   Zhang,J., Qin,M., Kao,C., Shi,Y., Yang,Z., Chen,T., Liu,M.,
            Fang,L., Gao,F., Qin,Y. and Ding,L.
  TITLE     PDCD4 deficiency improved 4-vinylcyclohexene dioxide-induced mouse
            premature ovarian insufficiency
  JOURNAL   Reprod Biomed Online 48 (4), 103685 (2024)
   PUBMED   38324980
  REMARK    GeneRIF: PDCD4 deficiency improved 4-vinylcyclohexene
            dioxide-induced mouse premature ovarian insufficiency.
REFERENCE   4  (bases 1 to 2330)
  AUTHORS   Zhu,J., Wang,Q., Zheng,Z., Ma,L., Guo,J., Shi,H., Ying,R., Gao,B.,
            Chen,S., Yu,S., Yuan,B., Peng,X. and Ge,J.
  TITLE     MiR-181a protects the heart against myocardial infarction by
            regulating mitochondrial fission via targeting programmed cell
            death protein 4
  JOURNAL   Sci Rep 14 (1), 6638 (2024)
   PUBMED   38503934
  REMARK    GeneRIF: MiR-181a protects the heart against myocardial infarction
            by regulating mitochondrial fission via targeting programmed cell
            death protein 4.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2330)
  AUTHORS   Yu,J., Li,R., Xia,T., Wang,J., Jin,J., Yuan,M. and Li,M.
  TITLE     [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial
            cell damage by improving mitochondrial dynamics]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 44 (1), 25-35 (2024)
   PUBMED   38293973
  REMARK    GeneRIF: [PDCD4 knockdown ameliorates lipopolysaccharide-induced
            endothelial cell damage by improving mitochondrial dynamics].
REFERENCE   6  (bases 1 to 2330)
  AUTHORS   Onishi,Y. and Kizaki,H.
  TITLE     Molecular cloning of the genes suppressed in RVC lymphoma cells by
            topoisomerase inhibitors
  JOURNAL   Biochem Biophys Res Commun 228 (1), 7-13 (1996)
   PUBMED   8912629
REFERENCE   7  (bases 1 to 2330)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   8  (bases 1 to 2330)
  AUTHORS   Roghani,A., Welch,C., Xia,Y., Liu,Y., Peter,D., Finn,J.P.,
            Edwards,R.H. and Lusis,A.J.
  TITLE     Assignment of the mouse vesicular monoamine transporter genes,
            Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis
  JOURNAL   Mamm Genome 7 (5), 393-394 (1996)
   PUBMED   8661734
REFERENCE   9  (bases 1 to 2330)
  AUTHORS   Shibahara,K., Asano,M., Ishida,Y., Aoki,T., Koike,T. and Honjo,T.
  TITLE     Isolation of a novel mouse gene MA-3 that is induced upon
            programmed cell death
  JOURNAL   Gene 166 (2), 297-301 (1995)
   PUBMED   8543179
REFERENCE   10 (bases 1 to 2330)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117612.9.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172654.1, D86344.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC117612.9         50725-50862
            139-245             AC117612.9         54823-54929
            246-548             AC117612.9         56486-56788
            549-643             AC117612.9         58302-58396
            644-757             AC117612.9         60186-60299
            758-979             AC117612.9         66989-67210
            980-1077            AC117612.9         68592-68689
            1078-1192           AC117612.9         69391-69505
            1193-1300           AC117612.9         73580-73687
            1301-1411           AC117612.9         73909-74019
            1412-1551           AC117612.9         74568-74707
            1552-2330           AC117612.9         76457-77235
FEATURES             Location/Qualifiers
     source          1..2330
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 48.73 cM"
     gene            1..2330
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /note="programmed cell death 4"
                     /db_xref="GeneID:18569"
                     /db_xref="MGI:MGI:107490"
     exon            1..138
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            139..245
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1612
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /note="protein MA-3; topoisomerase-inhibitor suppressed
                     protein"
                     /codon_start=1
                     /product="programmed cell death protein 4"
                     /protein_id="NP_001161963.1"
                     /db_xref="CCDS:CCDS29903.1"
                     /db_xref="GeneID:18569"
                     /db_xref="MGI:MGI:107490"
                     /translation="MDIENEQTLNVNPTDPDNLSDSLFSGDEENAGTEEIKNEINGNW
                     ISASTINEARINAKAKRRLRKNSSRDSGRGDSVSDNGSEAVRSGVAVPTSPKGRLLDR
                     RSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLD
                     ETAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREM
                     TSKLLSDLCGTVMSTNDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCN
                     TYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQPVNHLVKEIDML
                     LKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIVMVLESTGESAFKMILDLLKSLWK
                     SSTITIDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSR
                     GRKRFVSEGDGGRLKPESY"
     exon            246..548
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            549..643
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            644..757
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            758..979
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1077
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1192
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1300
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1411
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1551
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..2330
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2298..2303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /note="hexamer: AATAAA"
     polyA_site      2320
                     /gene="Pdcd4"
                     /gene_synonym="D19Ucla1; Ma3; Tis"
                     /note="major polyA site"
ORIGIN      
        1 gttactgggt agaacaaaac aaaaacaaac agagcgagcg gggccagagg cgctccgagg
       61 cagcggcggc ggaggctgag gaacggggtc ggggcccggc ggaccggaga cccgggcgag
      121 cggcggcggc ccgaggggat cctcaaggaa gacttgcatt tagtaagttg tgtataatca
      181 gtgcaagcga aattaaggaa aaatggatat agaaaatgag cagacactga atgtgaaccc
      241 cactgaccct gacaatttaa gcgactctct cttttctgga gatgaagaaa atgctggcac
      301 tgaagaaata aagaatgaaa taaatggaaa ttggatttcc gcatctacta ttaatgaagc
      361 tagaatcaat gcaaaagcca aaagacgact gcggaaaaat tcatcccggg actctggccg
      421 aggagactca gtcagtgaca atggaagtga agcggttaga agtggagttg ctgtgcccac
      481 cagtccaaaa ggaaggttgc tagataggcg gtccagatct gggaaaggaa gggggctgcc
      541 aaagaaaggt ggtgcaggcg gcaagggtgt ctggggcaca cctggacagg tgtatgatgt
      601 ggaagaggtg gatgtgaaag atccaaacta tgatgacgac caggagaact gtgtttatga
      661 aactgtagtt ttgcccctgg atgagaccgc atttgagaag actctaacac caattataca
      721 ggaatacttt gagcatggag atacaaatga agttgcggag atgttaagag acttaaacct
      781 tggggagatg aagagtggcg tgccggtgtt ggcagtgtcc ttagccttgg aggggaaggc
      841 cagccaccgg gagatgacat ccaagctgct ttctgacctt tgcgggacgg tgatgagcac
      901 aaatgacgtg gaaaagtcat ttgacaagtt gctgaaggat ctccctgagc tagccttgga
      961 cactcctagg gcaccgcagt tggtgggcca gtttattgct agagctgttg gagatggaat
     1021 cttatgtaat acctatatcg atagttacaa aggaactgta gattgtgtac aggctcgagc
     1081 tgctctggat aaggctactg tgctcctgag tatgtccaaa ggcgggaagc ggaaagacag
     1141 tgtgtgggga tctggaggcg ggcaacagcc tgtcaatcac cttgttaaag agattgatat
     1201 gctgcttaaa gagtatttac tctctggaga tatatctgaa gctgaacact gccttaagga
     1261 actggaagta cctcattttc accacgagct tgtatatgaa gccattgtaa tggttttaga
     1321 gtcaactgga gaaagtgcat tcaagatgat cttagattta ttaaaatcct tgtggaagtc
     1381 ttctactatt accatagacc aaatgaaaag aggctatgag agaatttaca atgaaatccc
     1441 agacattaat ctggatgtcc cacactcata ctctgttctt gagagatttg tggaggaatg
     1501 ttttcaggct ggaataattt ccaaacaact ccgtgatctt tgtccatcaa ggggaagaaa
     1561 gcgttttgta agtgaaggag atggaggccg tcttaaacct gagagctact gagcacagca
     1621 actcttacag tcttaggtgt taccaagaac agatctcaac tgtaagagtt gtcagtacag
     1681 gttttctttt ccttttgttt ttgttattgt tttttttttt tttttttttt tttttaaaga
     1741 atttgttttg ggtacaaggc atttctaaaa ttttataaac ttaagtttaa tgggattttt
     1801 tgaaggattt tctttctttt tctttttctt tctttttttt ttttttgagg ggaaattaat
     1861 ggagggacag aagaggaacc accgaagtgt gggtgttctg ataagctact ttctaagtgc
     1921 catgtttagg acctgatcat tccaagtttc acgttcatgt atgactgccg ctcctttctt
     1981 tcaaggacag tgttttttgt agtaaaatca ctggtttatt caaagcttta gttaggggtg
     2041 agtgaagcta ctaaacccca tgttggctgc tgctgtggaa atgctgtgct ttgagagtaa
     2101 acacacacac acacacacac acactttttg ttttaaagaa tttttaaaaa aacgagttag
     2161 tcatgagact ttttcatctt tccagggaac atattgattg gtcttaaata ttagacagtt
     2221 aagtaaatgg tggctggaac atctattttt ctacaaaact ggaaaaacga acccggttct
     2281 acaagaatgt acagcaaaat aaaacatgtg aaacactgtt gattctttag
//
