LOCUS       NM_008799               1113 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus programmed cell death 2 (Pdcd2), transcript variant 1,
            mRNA.
ACCESSION   NM_008799
VERSION     NM_008799.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1113)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1113)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1113)
  AUTHORS   Saita,S., Shirane,M., Ishitani,T., Shimizu,N. and Nakayama,K.I.
  TITLE     Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog
            (Shh) signaling pathway
  JOURNAL   J Biol Chem 289 (37), 25639-25654 (2014)
   PUBMED   25077969
REFERENCE   5  (bases 1 to 1113)
  AUTHORS   Granier,C.J., Wang,W., Tsang,T., Steward,R., Sabaawy,H.E.,
            Bhaumik,M. and Rabson,A.B.
  TITLE     Conditional inactivation of PDCD2 induces p53 activation and cell
            cycle arrest
  JOURNAL   Biol Open 3 (9), 821-831 (2014)
   PUBMED   25150276
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1113)
  AUTHORS   Trachtulec,Z., Vlcek,C., Mihola,O., Gregorova,S., Fotopulosova,V.
            and Forejt,J.
  TITLE     Fine haplotype structure of a chromosome 17 region in the
            laboratory and wild mouse
  JOURNAL   Genetics 178 (3), 1777-1784 (2008)
   PUBMED   18245833
REFERENCE   7  (bases 1 to 1113)
  AUTHORS   Baron,B.W., Zeleznik-Le,N., Baron,M.J., Theisler,C., Huo,D.,
            Krasowski,M.D., Thirman,M.J., Baron,R.M. and Baron,J.M.
  TITLE     Repression of the PDCD2 gene by BCL6 and the implications for the
            pathogenesis of human B and T cell lymphomas
  JOURNAL   Proc Natl Acad Sci U S A 104 (18), 7449-7454 (2007)
   PUBMED   17468402
  REMARK    GeneRIF: repression of PDCD2 by BCL6 is likely important in the
            pathogenesis of certain human lymphomas
REFERENCE   8  (bases 1 to 1113)
  AUTHORS   Mihola,O., Forejt,J. and Trachtulec,Z.
  TITLE     Conserved alternative and antisense transcripts at the programmed
            cell death 2 locus
  JOURNAL   BMC Genomics 8, 20 (2007)
   PUBMED   17233890
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1113)
  AUTHORS   Trachtulec,Z. and Forejt,J.
  TITLE     Synteny of orthologous genes conserved in mammals, snake, fly,
            nematode, and fission yeast
  JOURNAL   Mamm Genome 12 (3), 227-231 (2001)
   PUBMED   11252172
REFERENCE   10 (bases 1 to 1113)
  AUTHORS   Vaux,D.L. and Hacker,G.
  TITLE     Cloning of mouse RP-8 cDNA and its expression during apoptosis of
            lymphoid and myeloid cells
  JOURNAL   DNA Cell Biol 14 (3), 189-193 (1995)
   PUBMED   7880439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154378.2.
            
            On Oct 20, 2022 this sequence version replaced NM_008799.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045985.1, U10903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               AC154378.2         206945-207252       c
            309-548             AC154378.2         206327-206566       c
            549-680             AC154378.2         205223-205354       c
            681-784             AC154378.2         202757-202860       c
            785-898             AC154378.2         201870-201983       c
            899-1113            AC154378.2         201533-201747       c
FEATURES             Location/Qualifiers
     source          1..1113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.95 cM"
     gene            1..1113
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /note="programmed cell death 2"
                     /db_xref="GeneID:18567"
                     /db_xref="MGI:MGI:104643"
     exon            1..308
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1057
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     programmed cell death protein 2; zinc finger protein Rp-8"
                     /codon_start=1
                     /product="programmed cell death protein 2 isoform 1"
                     /protein_id="NP_032825.2"
                     /db_xref="CCDS:CCDS28413.1"
                     /db_xref="GeneID:18567"
                     /db_xref="MGI:MGI:104643"
                     /translation="MAAAAPGPVELGFAEEAPAWRLRSEQFPSKVGGRPAWLGLAELP
                     GPGALACARCGRPLAFLLQVYAPLPGRDDAFHRSLFLFCCREPPCCAGLRVFRNQLPR
                     NNAFYSYEPPSETEALGTECVCLQLKSGAHLCRVCGCLAPMTCSRCKQAHYCSKEHQT
                     LDWRLGHKQACTQSDKIDHMVPDHNFLFPEFEIVTETEDEILPEVVEMEDYSEVTGSM
                     GGIPEEELDSMAKHESKEDHIFQKFKSKIALEPEQILRYGRGIKPIWISGENIPQEKD
                     IPDCPCGAKRIFEFQVMPQLLNHLKADRLGRSIDWGVLAVFTCAESCSLGSGYTEEFV
                     WKQDVTDTP"
     exon            309..548
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            549..680
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            681..784
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            785..898
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1113
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1099..1104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /note="hexamer: AATAAA"
     polyA_site      1113
                     /gene="Pdcd2"
                     /gene_synonym="Pcd2; RP-8"
                     /note="major polyA site"
ORIGIN      
        1 ctggtggcag agtcctgctg cgagcatggc tgcagccgcc cctggtcctg tggagttggg
       61 cttcgccgag gaggcaccgg cctggaggct gcgcagcgag cagtttccca gcaaagtggg
      121 cgggcggccc gcgtggttgg gcttggcgga gctgccgggg cccggggcgc tggcgtgtgc
      181 gcgctgcggc cgcccgctcg ccttcctgct gcaggtgtac gcaccgctgc cgggccggga
      241 cgacgccttc caccgcagcc tctttctctt ctgctgtcgc gagccgccgt gctgcgccgg
      301 cctgcgagtt tttcgtaatc agctaccaag gaacaacgca ttctactcct atgagccccc
      361 ttctgaaaca gaagctttgg gtacggaatg tgtgtgcctc cagctcaagt ctggagccca
      421 tctctgtcgg gtttgtggtt gcttggcccc tatgacatgc tctaggtgca aacaggcaca
      481 ttactgcagc aaggagcatc agacattaga ctggcggctg ggacacaagc aggcttgtac
      541 acagtcagac aaaatagacc atatggttcc agaccacaac ttcctgtttc cagaatttga
      601 aattgtaaca gaaacagaag atgaaatttt gcctgaggtt gtggaaatgg aggattattc
      661 tgaagttaca ggaagcatgg ggggaattcc tgaggaagaa ctagattcca tggcaaagca
      721 cgaatccaag gaagatcaca tattccaaaa gtttaaatct aaaatagccc ttgaaccaga
      781 gcagattctc aggtatggaa gagggattaa acccatctgg atttctggtg aaaatattcc
      841 tcaagaaaaa gatattccag attgcccgtg tggtgccaag agaatatttg aattccaggt
      901 catgcctcag ctgttgaacc acctgaaggc agacagactc ggcagaagca tcgactgggg
      961 tgtcttggct gtcttcacct gtgctgagag ctgtagcctg ggtagcggct acacagaaga
     1021 atttgtgtgg aagcaggatg tgacagatac accttaaaag gggttaaatt cttgcaaaag
     1081 atataaaata aaaacttaaa taaaaactaa aaa
//
