LOCUS       NM_021396               3415 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus programmed cell death 1 ligand 2 (Pdcd1lg2), mRNA.
ACCESSION   NM_021396 XM_993457
VERSION     NM_021396.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3415)
  AUTHORS   Ogishi,M., Kitaoka,K., Good-Jacobson,K.L., Rinchai,D., Zhang,B.,
            Wang,J., Gies,V., Rao,G., Nguyen,T., Avery,D.T., Khan,T.,
            Smithmyer,M.E., Mackie,J., Yang,R., Arias,A.A., Asano,T.,
            Ponsin,K., Chaldebas,M., Zhang,P., Peel,J.N., Bohlen,J., Levy,R.,
            Pelham,S.J., Lei,W.T., Han,J.E., Fagniez,I., Chrabieh,M., Laine,C.,
            Langlais,D., Gruber,C., Al Ali,F., Rahman,M., Aytekin,C.,
            Benson,B., Dufort,M.J., Domingo-Vila,C., Moriya,K., Shlomchik,M.,
            Uzel,G., Gray,P.E., Suan,D., Preece,K., Chua,I., Okada,S.,
            Chikuma,S., Kiyonari,H., Tree,T.I., Bogunovic,D., Gros,P., Marr,N.,
            Speake,C., Oram,R.A., Beziat,V., Bustamante,J., Abel,L.,
            Boisson,B., Korganow,A.S., Ma,C.S., Johnson,M.B., Chamoto,K.,
            Boisson-Dupuis,S., Honjo,T., Casanova,J.L. and Tangye,S.G.
  TITLE     Impaired development of memory B cells and antibody responses in
            humans and mice deficient in PD-1 signaling
  JOURNAL   Immunity 57 (12), 2790-2807 (2024)
   PUBMED   39603236
REFERENCE   2  (bases 1 to 3415)
  AUTHORS   Moriyama,R., Katsumata,Y., Okamoto,Y. and Harigai,M.
  TITLE     Upregulation of PD-1 and its ligands and expansion of T peripheral
            helper cells in the nephritic kidneys of lupus-prone BXSB-Yaa mice
  JOURNAL   Lupus 33 (8), 816-827 (2024)
   PUBMED   38622764
  REMARK    GeneRIF: Upregulation of PD-1 and its ligands and expansion of T
            peripheral helper cells in the nephritic kidneys of lupus-prone
            BXSB-Yaa mice.
REFERENCE   3  (bases 1 to 3415)
  AUTHORS   Lv,J., Jiang,Z., Yuan,J., Zhuang,M., Guan,X., Liu,H., Yin,Y.,
            Ma,Y., Liu,Z., Wang,H. and Wang,X.
  TITLE     Pan-cancer analysis identifies PD-L2 as a tumor promotor in the
            tumor microenvironment
  JOURNAL   Front Immunol 14, 1093716 (2023)
   PUBMED   37006239
  REMARK    GeneRIF: Pan-cancer analysis identifies PD-L2 as a tumor promotor
            in the tumor microenvironment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3415)
  AUTHORS   Hurrell,B.P., Helou,D.G., Howard,E., Painter,J.D.,
            Shafiei-Jahani,P., Sharpe,A.H. and Akbari,O.
  TITLE     PD-L2 controls peripherally induced regulatory T cells by
            maintaining metabolic activity and Foxp3 stability
  JOURNAL   Nat Commun 13 (1), 5118 (2022)
   PUBMED   36045140
  REMARK    GeneRIF: PD-L2 controls peripherally induced regulatory T cells by
            maintaining metabolic activity and Foxp3 stability.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3415)
  AUTHORS   Sugiura,D., Okazaki,I.M., Maeda,T.K., Maruhashi,T., Shimizu,K.,
            Arakaki,R., Takemoto,T., Ishimaru,N. and Okazaki,T.
  TITLE     PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates
            autoimmunity
  JOURNAL   Nat Immunol 23 (3), 399-410 (2022)
   PUBMED   35145298
REFERENCE   6  (bases 1 to 3415)
  AUTHORS   Ozkaynak,E., Wang,L., Goodearl,A., McDonald,K., Qin,S., O'Keefe,T.,
            Duong,T., Smith,T., Gutierrez-Ramos,J.C., Rottman,J.B., Coyle,A.J.
            and Hancock,W.W.
  TITLE     Programmed death-1 targeting can promote allograft survival
  JOURNAL   J Immunol 169 (11), 6546-6553 (2002)
   PUBMED   12444166
  REMARK    GeneRIF: most normal tissues and cardiac isografts had minimal
            expression of PD-1, PD-L1, or PD-L2, but intragraft induction of
            all three molecules occurred during development of cardiac
            allograft rejection
REFERENCE   7  (bases 1 to 3415)
  AUTHORS   Yamazaki,T., Akiba,H., Iwai,H., Matsuda,H., Aoki,M., Tanno,Y.,
            Shin,T., Tsuchiya,H., Pardoll,D.M., Okumura,K., Azuma,M. and
            Yagita,H.
  TITLE     Expression of programmed death 1 ligands by murine T cells and APC
  JOURNAL   J Immunol 169 (10), 5538-5545 (2002)
   PUBMED   12421930
  REMARK    GeneRIF: B7-DC expression is inducible on macrophages and dendritic
            cells upon stimulation with IFN-gamma, GM-CSF, or IL-4.
REFERENCE   8  (bases 1 to 3415)
  AUTHORS   Ishida,M., Iwai,Y., Tanaka,Y., Okazaki,T., Freeman,G.J., Minato,N.
            and Honjo,T.
  TITLE     Differential expression of PD-L1 and PD-L2, ligands for an
            inhibitory receptor PD-1, in the cells of lymphohematopoietic
            tissues
  JOURNAL   Immunol Lett 84 (1), 57-62 (2002)
   PUBMED   12161284
  REMARK    GeneRIF: expression patterns of PD-L1 and PD-L2 with the cells of
            lymphohematopoietic tissues exclusively expressing the former
REFERENCE   9  (bases 1 to 3415)
  AUTHORS   Tseng,S.Y., Otsuji,M., Gorski,K., Huang,X., Slansky,J.E., Pai,S.I.,
            Shalabi,A., Shin,T., Pardoll,D.M. and Tsuchiya,H.
  TITLE     B7-DC, a new dendritic cell molecule with potent costimulatory
            properties for T cells
  JOURNAL   J Exp Med 193 (7), 839-846 (2001)
   PUBMED   11283156
REFERENCE   10 (bases 1 to 3415)
  AUTHORS   Latchman,Y., Wood,C.R., Chernova,T., Chaudhary,D., Borde,M.,
            Chernova,I., Iwai,Y., Long,A.J., Brown,J.A., Nunes,R.,
            Greenfield,E.A., Bourque,K., Boussiotis,V.A., Carter,L.L.,
            Carreno,B.M., Malenkovich,N., Nishimura,H., Okazaki,T., Honjo,T.,
            Sharpe,A.H. and Freeman,G.J.
  TITLE     PD-L2 is a second ligand for PD-1 and inhibits T cell activation
  JOURNAL   Nat Immunol 2 (3), 261-268 (2001)
   PUBMED   11224527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY749628.1, BC104138.1 and AC093339.17.
            
            On Aug 14, 2009 this sequence version replaced NM_021396.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089369.1, AK155002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                BY749628.1         4-98
            96-1335             BC104138.1         1-1240
            1336-3415           AC093339.17        69696-71775         c
FEATURES             Location/Qualifiers
     source          1..3415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 23.93 cM"
     gene            1..3415
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /note="programmed cell death 1 ligand 2"
                     /db_xref="GeneID:58205"
                     /db_xref="MGI:MGI:1930125"
     exon            1..223
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            224..291
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..980
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /note="PD-1 ligand 2; PDCD1 ligand 2; butyrophilin B7-DC;
                     programmed death ligand 2; butyrophilin-like protein"
                     /codon_start=1
                     /product="programmed cell death 1 ligand 2 precursor"
                     /protein_id="NP_067371.1"
                     /db_xref="CCDS:CCDS29736.1"
                     /db_xref="GeneID:58205"
                     /db_xref="MGI:MGI:1930125"
                     /translation="MLLLLPILNLSLQLHPVAALFTVTAPKEVYTVDVGSSVSLECDF
                     DRRECTELEGIRASLQKVENDTSLQSERATLLEEQLPLGKALFHIPSVQVRDSGQYRC
                     LVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYPLAEVSWQNVSV
                     PANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRMEPKVP
                     RTWPLHVFIPACTIALIFLAIVIIQRKRI"
     exon            292..597
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..867
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1003
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..3415
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1649
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /note="major polyA site"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
                     /note="hexamer: CATAAA"
     polyA_site      1971
                     /gene="Pdcd1lg2"
                     /gene_synonym="B7-DC; Btdc; F730015O22Rik; PD-L2"
ORIGIN      
        1 gaccacatca tttttgttcc ctttgttgga tatatcctaa tgtcaaatgt ggcatatctt
       61 tgttgtctcc ttctgtctcc caactagaga gaacacactt acggctcctg tcccgggcag
      121 gtttggttgt cggtgtgatt ggcttccagg gaacctgata caaggagcaa ctgtgtgctg
      181 ccttttctgt gtctttgctt gaggagctgt gctgggtgct gatattgaca cagaccatgc
      241 tgctcctgct gccgatactg aacctgagct tacaacttca tcctgtagca gctttattca
      301 ccgtgacagc ccctaaagaa gtgtacaccg tagacgtcgg cagcagtgtg agcctggagt
      361 gcgattttga ccgcagagaa tgcactgaac tggaagggat aagagccagt ttgcagaagg
      421 tagaaaatga tacgtctctg caaagtgaaa gagccaccct gctggaggag cagctgcccc
      481 tgggaaaggc tttgttccac atccctagtg tccaagtgag agattccggg cagtaccgtt
      541 gcctggtcat ctgcggggcc gcctgggact acaagtacct gacggtgaaa gtcaaagctt
      601 cttacatgag gatagacact aggatcctgg aggttccagg tacaggggag gtgcagctta
      661 cctgccaggc tagaggttat cccctagcag aagtgtcctg gcaaaatgtc agtgttcctg
      721 ccaacaccag ccacatcagg acccccgaag gcctctacca ggtcaccagt gttctgcgcc
      781 tcaagcctca gcctagcaga aacttcagct gcatgttctg gaatgctcac atgaaggagc
      841 tgacttcagc catcattgac cctctgagtc ggatggaacc caaagtcccc agaacgtggc
      901 cacttcatgt tttcatcccg gcctgcacca tcgctttgat cttcctggcc atagtgataa
      961 tccagagaaa gaggatctag gggaagctgt attacggaag aagatctgga cctgcggtct
     1021 tgggagttgg aaggatctga tgggaaaccc tcaagagact tctggactca aagtgagaat
     1081 cttgcaggac ctgccatttg cacttttgaa ccctttggac ggtgacccag ggctccgaag
     1141 aggagcttgt aagactgaca atcttccctc tgtctcaaga ctctctgaac agcaagaccc
     1201 caatggcact ttagacttac ccctgggatc ctggacccca gtgagggcct aaggctccta
     1261 atgactttca gggtgagaac aaaaggaatt gctctccgcc ccacccccac ctcctgcttt
     1321 ccgcagggag acatggaaat tcccagttac taaaatagat tgtcaataga gttatttata
     1381 gccctcattt cctccgggga cttggaagct tcagacaggg tttttcataa acaaagtcat
     1441 aactgatgtg ttttacagca tcctagaatc ctggcagcct ctgaagttct aattaactgg
     1501 aagcatttaa gcaacacgtt aagtaccccc actgtggtat ttgtttctac ttttctgttt
     1561 ttaaagtgtg agtcacaagg taattgttgt aacctgtgat atcactgttt cttgtgtctc
     1621 ttctttcaac tacatctttt aaaacaaaac ggtgtggggt ttggttgttt tggtggtagt
     1681 ggtagtgttt ctcagtggta tctccttaag aaaaaaaatc atcatgccag tgaattgttt
     1741 cttcagccat ttcagatggg aagctggaat agcctgtccc ccaagctaag ccttcttccc
     1801 tagctttctg cgtgatttta cattgagcat tcctgttgct ttgtttctat aactgtaatg
     1861 tggtgatgtc attgttaggg cacttgaggg tgggcgttct ggaagtcctt tcaggttagt
     1921 gtttgggggc agggttgctc agaatacata aaggtgctaa cttaaactgc agccatggag
     1981 ctcagtgaat tcactaacct tcgggctgtc caaatgtgca cattagctac tgtgacccct
     2041 gtaggttagg gagcctgaag ccagctcttt acctggtgtt tagactcagc agaatttgga
     2101 gtcaatggga ccaaatggtt gtgaaattaa gatttgaagt gtgcatctta ttttatcacc
     2161 atctgcccaa caaaacttca gaaaatgcct ttgaagcaca aaaatgtaat cgtttatgtg
     2221 aaatctctga gttgcattta gatgcccatt gcagcaaggt ggctctctca cagattccac
     2281 accttagcct aagataccag acagcaggac agagagaaaa gtccttcctg gtgtgcaaac
     2341 ttccttacac tggacctcgc ctctcaggtg tgtgattggt aggccaaatc ccgatagcca
     2401 atcggtgttg ggtgctttgt ctgctctact gggagtccag tggtacaatg gattctggca
     2461 aaatgctgcc atcttggccc tcgctgggct gctttctagg atattcatag agaaagggcc
     2521 gtccagatcc agtatcctaa aatcctgaga ggagaatata agttagtgtg tctcactata
     2581 actatctcta tgatcggtca cattactatc taacagttac caaatactat atgcctaata
     2641 ctggtaagca ttttatacac accattggat tgaatcctct caaaatcctc aaaaaggaag
     2701 ttattaatac ctccataggc aaggagccca gaacccagag aggtcaggca gtctagttat
     2761 agatgcctgc tttgtttaga agtgaacaag agcatcaaat tattaatgtg ccctggttat
     2821 taatgcgccc tggttacctg ctggatggaa catcaaggtg gacttttggc agttgcatac
     2881 acccagaggt attttggcta ttcacggatt aatttcacac gaagtgtttc agagacatgt
     2941 gtaggggaag tccgggttca gggggcctaa gattcaaact ctagcttagc tacgtctgac
     3001 ctccctaagc actaacttac tatcaaaaga atgagcagta aaagaatggt gtttactgcc
     3061 tgcctttatc aggcagtgaa cgtgcagcgg gcaacgaatg cttgataagt gtgtgtcagt
     3121 gtgaagtccc atgtaccagc cgctgtcccc actgcaaaag cagcagagcg ctcagacatc
     3181 atcagctgat ttaccagcag cagatttctt cttctagtcc catccctgaa gaagcttcca
     3241 gcctaggtac attgcatggg ctttgtgctc caggagttcc tacacagccc tcaacttcaa
     3301 cacaggcaaa gtgcttactg atcctcatgt atcttacagg gtcccctcta cccacaatac
     3361 ctcattgctg gaacttcaaa tcttcctgaa taaaagcttg cccgtggttt aatta
//
