LOCUS       NM_019745               1923 bp    mRNA    linear   ROD 25-SEP-2024
DEFINITION  Mus musculus programmed cell death 10 (Pdcd10), mRNA.
ACCESSION   NM_019745
VERSION     NM_019745.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Cici,M., Dilmac,S., Aytac,G. and Tanriover,G.
  TITLE     Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are
            decreased in metastatic lesions in a murine breast carcinoma model
  JOURNAL   Biotech Histochem 99 (2), 76-83 (2024)
   PUBMED   38293758
  REMARK    GeneRIF: Cerebral cavernous malformation proteins, CCM1, CCM2 and
            CCM3, are decreased in metastatic lesions in a murine breast
            carcinoma model.
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Phillips,C.M., Johnson,A.M., Stamatovic,S.M., Keep,R.F. and
            Andjelkovic,A.V.
  TITLE     20 kDa isoform of connexin-43 augments spatial reorganization of
            the brain endothelial junctional complex and lesion leakage in
            cerebral cavernous malformation type-3
  JOURNAL   Neurobiol Dis 186, 106277 (2023)
   PUBMED   37652184
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Romanos,S.G., Srinath,A., Li,Y., Xie,B., Chen,C., Li,Y., Moore,T.,
            Bi,D., Sone,J.Y., Lightle,R., Hobson,N., Zhang,D., Koskimaki,J.,
            Shen,L., McCurdy,S., Lai,C.C., Stadnik,A., Piedad,K.,
            Carrion-Penagos,J., Shkoukani,A., Snellings,D., Shenkar,R.,
            Sulakhe,D., Ji,Y., Lopez-Ramirez,M.A., Kahn,M.L., Marchuk,D.A.,
            Ginsberg,M.H., Girard,R. and Awad,I.A.
  TITLE     Circulating Plasma miRNA Homologs in Mice and Humans Reflect
            Familial Cerebral Cavernous Malformation Disease
  JOURNAL   Transl Stroke Res 14 (4), 513-529 (2023)
   PUBMED   35715588
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Beter,M., Abdollahzadeh,A., Pulkkinen,H.H., Huang,H., Orsenigo,F.,
            Magnusson,P.U., Yla-Herttuala,S., Tohka,J. and Laakkonen,J.P.
  TITLE     SproutAngio: an open-source bioimage informatics tool for
            quantitative analysis of sprouting angiogenesis and lumen space
  JOURNAL   Sci Rep 13 (1), 7279 (2023)
   PUBMED   37142637
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Fusco,C., Nardella,G., Di Filippo,L., Dejana,E., Cacchiarelli,D.,
            Petracca,A., Micale,L., Malinverno,M. and Castori,M.
  TITLE     Transcriptome Analysis Reveals Altered Expression of Genes Involved
            in Hypoxia, Inflammation and Immune Regulation in Pdcd10-Depleted
            Mouse Endothelial Cells
  JOURNAL   Genes (Basel) 13 (6), 961 (2022)
   PUBMED   35741725
  REMARK    GeneRIF: Transcriptome Analysis Reveals Altered Expression of Genes
            Involved in Hypoxia, Inflammation and Immune Regulation in
            Pdcd10-Depleted Mouse Endothelial Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1923)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   7  (bases 1 to 1923)
  AUTHORS   He,Y., Zhang,H., Yu,L., Gunel,M., Boggon,T.J., Chen,H. and Min,W.
  TITLE     Stabilization of VEGFR2 signaling by cerebral cavernous
            malformation 3 is critical for vascular development
  JOURNAL   Sci Signal 3 (116), ra26 (2010)
   PUBMED   20371769
  REMARK    GeneRIF: Stabilization of VEGFR2 signaling by cerebral cavernous
            malformation 3 (also known as PDCD10) is critical for vascular
            development.
            Erratum:[Sci Signal. 2010;3(121):er4]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1923)
  AUTHORS   Voss,K., Stahl,S., Schleider,E., Ullrich,S., Nickel,J.,
            Mueller,T.D. and Felbor,U.
  TITLE     CCM3 interacts with CCM2 indicating common pathogenesis for
            cerebral cavernous malformations
  JOURNAL   Neurogenetics 8 (4), 249-256 (2007)
   PUBMED   17657516
REFERENCE   9  (bases 1 to 1923)
  AUTHORS   Petit,N., Blecon,A., Denier,C. and Tournier-Lasserve,E.
  TITLE     Patterns of expression of the three cerebral cavernous malformation
            (CCM) genes during embryonic and postnatal brain development
  JOURNAL   Gene Expr Patterns 6 (5), 495-503 (2006)
   PUBMED   16455310
REFERENCE   10 (bases 1 to 1923)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY091056.1, AC140430.3, BC086778.1 and AK075926.1.
            
            On Aug 15, 2013 this sequence version replaced NM_019745.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075926.1, AK077308.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY091056.1         3-81
            80-81               AC140430.3         65116-65117         c
            82-1298             BC086778.1         1-1217
            1299-1923           AK075926.1         1247-1871
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 33.76 cM"
     gene            1..1923
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /note="programmed cell death 10"
                     /db_xref="GeneID:56426"
                     /db_xref="MGI:MGI:1928396"
     exon            1..131
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /inference="alignment:Splign:2.1.0"
     exon            132..350
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /inference="alignment:Splign:2.1.0"
     exon            351..404
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /inference="alignment:Splign:2.1.0"
     exon            405..522
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /inference="alignment:Splign:2.1.0"
     exon            523..649
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /inference="alignment:Splign:2.1.0"
     exon            650..728
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /inference="alignment:Splign:2.1.0"
     exon            729..811
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1923
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1419..1424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /note="hexamer: AATAAA"
     polyA_site      1440
                     /gene="Pdcd10"
                     /gene_synonym="2410003B13Rik; Ccm3; Tfa15; Tfar15"
                     /note="major polyA site"
ORIGIN      
        1 gactcctgct gggcaggatt ccggacaacg cctggttcct ttcgggtcct tccggcgtcg
       61 ccggagtgaa ttgatccggg agttgaagag ggctccaaag gtgggaagtg aagtccgtgc
      121 ctcagttgcc gattgctgtt cttctttgtg taccagtctt tatcacatac acataaaaaa
      181 gggaagaaat tcggcagtga atgaagattc ctctgcattt tagcattgct ttttctactg
      241 tagttggctt ttgaatgagg atgacaatgg aagagatgaa gaatgaagct gagaccactt
      301 ccatggtttc tatgcctctc tatgcagtca tgtatcctgt gtttaatgag ctagaacgag
      361 taaatttgtc tgcagctcag actctgagag ccgctttcat taaggctgaa aaggaaaatc
      421 caggcctcac acaagacatc attatgaaaa tattagagaa aaaaagtgta gaagttaact
      481 tcaccgagtc cctccttcgt atggcagctg atgacgtaga agagtacatg attgagcggc
      541 cagagccaga attccaggac ctaaatgaaa aggcacgggc acttaaacag attctcagta
      601 agattcctga tgagatcaat gacagagtga ggtttctgca gacaatcaag gatatagcta
      661 gtgcaataaa agaactactt gatacagtga ataatgtctt caaaaaatat cagtaccaga
      721 accgcagggc acttgaacac caaaagaaag aatttgtaaa atactccaaa agtttcagtg
      781 acactctgaa gacttatttt aaagatggca aggcaataaa tgtgttcata agtgccaacc
      841 ggctaattca tcaaaccaac ttgatacttc agaccttcaa aactgtggcc tgaaagttgt
      901 atatgttaag agatgtactt ctcagtggca gtattaaact gcatttatct gtaaatttta
      961 aagtttgact gtataaatta tcagtccctc cggagggacc taatccagga tgttgaatgg
     1021 gattattgcc atcttacacc atatttttgt aaaatgtagc ttaatcataa tctcacaatg
     1081 aagattttgc atcacttttg ctattatcat tcttttaaga attataagcc aaaagaattt
     1141 acgccttaat gtgtcattat ataacattcc ttacaagaac tgtaaatatt ggtgtttgtt
     1201 tctgacattt taacttgaaa gcgatatgct gcaagataat gtatttaaca atatttggtg
     1261 gcaaatattc aataaatagt ttacatctgt taaacatttc tttacttgaa aaaagatgca
     1321 tatatatatg tgtgtgtgta tatatgatca gaagaccaag acaacttggt ataatgttaa
     1381 agatcttcta atgggagctt actagcagtt tatcaaataa taaaggaaca agaattccta
     1441 ttttttgtcc ttaatcactt tgagcaaaat gtagtcagtt aaaatacttt tgttagttgt
     1501 tacatatcaa gaactggata ttttttcact atttccaatc tttatagacc tgagaagaga
     1561 gatgaagcta cggggtcttc gtactgtagt aacacttcag gttcatgacg ctttctgagt
     1621 ggtagatgcg gctccacgaa attacttctg ctatactagg ccctaataag ctttgcacat
     1681 tgtccccaga gtaatcacaa tttaaaaaaa aaaaattcta atagttgtat tgagattttt
     1741 atcagtgtta atataatata tactctttaa atatgtatag tttgtttcac actagagaag
     1801 ttataagaaa actatgtatc ggtattcatg ttgagtgatt tgagttttta attataaaat
     1861 aaagggaaaa tcaggttttg ttcatgtttt ataaagaaat gaaatattaa aatttgttga
     1921 cag
//
