LOCUS       NM_001159730            1263 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus phosducin (Pdc), transcript variant 1, mRNA.
ACCESSION   NM_001159730
VERSION     NM_001159730.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1263)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1263)
  AUTHORS   Liu,S., Liu,X., Li,S., Huang,X., Qian,H., Jin,K. and Xiang,M.
  TITLE     Foxn4 is a temporal identity factor conferring mid/late-early
            retinal competence and involved in retinal synaptogenesis
  JOURNAL   Proc Natl Acad Sci U S A 117 (9), 5016-5027 (2020)
   PUBMED   32071204
REFERENCE   3  (bases 1 to 1263)
  AUTHORS   Wei,W., Liu,B., Jiang,H., Jin,K. and Xiang,M.
  TITLE     Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the
            Differentiation and Maintenance of Non-photoreceptor Cell Types
            During Retinal Development
  JOURNAL   Mol Neurobiol 56 (3), 1719-1736 (2019)
   PUBMED   29922981
REFERENCE   4  (bases 1 to 1263)
  AUTHORS   Rodgers,H.M., Huffman,V.J., Voronina,V.A., Lewandoski,M. and
            Mathers,P.H.
  TITLE     The role of the Rx homeobox gene in retinal progenitor
            proliferation and cell fate specification
  JOURNAL   Mech Dev 151, 18-29 (2018)
   PUBMED   29665410
REFERENCE   5  (bases 1 to 1263)
  AUTHORS   Sapkota,D., Chintala,H., Wu,F., Fliesler,S.J., Hu,Z. and Mu,X.
  TITLE     Onecut1 and Onecut2 redundantly regulate early retinal cell fates
            during development
  JOURNAL   Proc Natl Acad Sci U S A 111 (39), E4086-E4095 (2014)
   PUBMED   25228773
REFERENCE   6  (bases 1 to 1263)
  AUTHORS   Sugiyama,S., Utani,A., Yamada,S., Kozak,C.A. and Yamada,Y.
  TITLE     Cloning and expression of the mouse laminin gamma 2 (B2t) chain, a
            subunit of epithelial cell laminin
  JOURNAL   Eur J Biochem 228 (1), 120-128 (1995)
   PUBMED   7882992
REFERENCE   7  (bases 1 to 1263)
  AUTHORS   Abe,T., Kikuchi,T. and Shinohara,T.
  TITLE     The sequence of the human phosducin gene (PDC) and its 5'-flanking
            region
  JOURNAL   Genomics 19 (2), 369-372 (1994)
   PUBMED   8188267
REFERENCE   8  (bases 1 to 1263)
  AUTHORS   Abe,T., Kikuchi,T., Chang,T. and Shinohara,T.
  TITLE     The sequence of the mouse phosducin-encoding gene and its
            5'-flanking region
  JOURNAL   Gene 133 (2), 179-186 (1993)
   PUBMED   8224906
REFERENCE   9  (bases 1 to 1263)
  AUTHORS   Craft,C.M., Lolley,R.N., Seldin,M.F. and Lee,R.H.
  TITLE     Rat pineal gland phosducin: cDNA isolation, nucleotide sequence,
            and chromosomal assignment in the mouse
  JOURNAL   Genomics 10 (2), 400-409 (1991)
   PUBMED   2071146
REFERENCE   10 (bases 1 to 1263)
  AUTHORS   Danciger,M., Kozak,C.A., Abe,T., Shinohara,T. and Farber,D.B.
  TITLE     The gene for retinal rod 33-kDa protein is on mouse chromosome 1,
            near Lamb2
  JOURNAL   Cytogenet Cell Genet 56 (3-4), 202-205 (1991)
   PUBMED   1675982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK020798.1, BI738229.1, BC012507.1 and BE950243.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI736834.1, BI739848.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AK020798.1         2-10
            10-663              BI738229.1         1-654
            664-1244            BC012507.1         638-1218
            1245-1263           BE950243.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 63.84 cM"
     gene            1..1263
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /note="phosducin"
                     /db_xref="GeneID:20028"
                     /db_xref="MGI:MGI:98090"
     exon            1..84
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            85..169
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..843
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /note="PHD; 33 kDa phototransducing protein; rod
                     photoreceptor 1"
                     /codon_start=1
                     /product="phosducin"
                     /protein_id="NP_001153202.1"
                     /db_xref="CCDS:CCDS15354.1"
                     /db_xref="GeneID:20028"
                     /db_xref="MGI:MGI:98090"
                     /translation="MEEAASQSLEEDFEGQATHTGPKGVINDWRKFKLESEDGDSIPP
                     SKKEILRQMSSPQSRDDSKERMSRKMSIQEYELIHQDKEDESCLRKYRRQCMQDMHQK
                     LSFGPRYGFVYELETGEQFLETIEKEQKVTTIVVNIYEDGVRGCDALNSSLACLAVEY
                     PMVKFCKIKASNTGAGDRFSTDVLPTLLVYKGGELISNFISVAEQFAEEFFAVDVESF
                     LNEYGLLPEREIHDLEQTNMEDEDIE"
     exon            170..315
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..1247
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1216..1221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /note="hexamer: AATAAA"
     regulatory      1222..1227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /note="hexamer: AATAAA"
     polyA_site      1237
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /note="major polyA site"
     polyA_site      1244
                     /gene="Pdc"
                     /gene_synonym="Rpr-1; Rpr1"
                     /note="major polyA site"
ORIGIN      
        1 aaaggagttc agtggacagc gattctcact ccctggacat attctagaac accaggaaca
       61 gagacccaaa ctgtgagtct acaaactaca ccaaacccaa cccataaaat ggaagaagcc
      121 gccagccaaa gcttagaaga agattttgaa ggacaggcca cgcacacagg acccaaagga
      181 gtaataaatg attggagaaa gtttaaatta gaaagtgaag atggtgattc aattccaccc
      241 agcaagaagg aaatcctcag acaaatgtcc tctcctcaga gcagagatga ctcaaaagaa
      301 agaatgagca gaaagatgag cattcaagaa tatgaactca ttcatcaaga caaagaagat
      361 gagagttgcc ttcgcaaata ccggaggcag tgcatgcagg atatgcatca gaagttgagt
      421 tttgggccta ggtatgggtt tgtgtatgag ctggaaacag gggagcaatt cctggaaacc
      481 atcgagaagg agcagaaggt caccacaatt gtggttaaca tttacgagga tggtgtcagg
      541 ggctgcgatg cactcaacag cagcttagcg tgccttgcag tagagtaccc aatggtcaag
      601 ttctgtaaaa taaaagcttc taataccgga gcgggggacc gcttttccac agacgtactc
      661 cctacgttgc tggtgtacaa aggtggggaa ctcataagca attttattag tgtggctgaa
      721 caatttgctg aagaattttt tgctgtggat gtggagtctt tcctaaatga atatggatta
      781 ctaccagaaa gagagataca tgacctagag cagaccaaca tggaagacga ggacattgaa
      841 taagccttca ccatgtcagt atctcatgtc tatcctttac acagtgaaca ctgatttttt
      901 tttttggtag tatctatatt cctttagcaa acactaaata tgggcctggc tatttaaact
      961 cggggggggg gacacactaa aattatgtac atagcacttt ttagtactaa ttactcaaat
     1021 tgagataata ttttactgca aggatattgt ggtttttagc aaataactag taagcagagg
     1081 aggtgggtaa tgtcaatgtt tagatcattg taaaaatccc tttcaagttc cgtgttagat
     1141 tttgctcctc atttttccct tggcattttt atttgggctt ttcaaactga atactgctta
     1201 taaactggtt tgtacaataa aaataaaatc ctatgaagaa acaagtaaaa aaaaaaaaaa
     1261 aaa
//
