LOCUS       NM_211138               4875 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus phosphate cytidylyltransferase 1, choline, beta
            isoform (Pcyt1b), transcript variant 1, mRNA.
ACCESSION   NM_211138
VERSION     NM_211138.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4875)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4875)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4875)
  AUTHORS   Ogasawara,Y., Cheng,J., Tatematsu,T., Uchida,M., Murase,O.,
            Yoshikawa,S., Ohsaki,Y. and Fujimoto,T.
  TITLE     Long-term autophagy is sustained by activation of CCTbeta3 on lipid
            droplets
  JOURNAL   Nat Commun 11 (1), 4480 (2020)
   PUBMED   32900992
  REMARK    GeneRIF: Long-term autophagy is sustained by activation of CCTbeta3
            on lipid droplets.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4875)
  AUTHORS   Strakova,J., Demizieux,L., Campenot,R.B., Vance,D.E. and Vance,J.E.
  TITLE     Involvement of CTP:phosphocholine cytidylyltransferase-beta2 in
            axonal phosphatidylcholine synthesis and branching of neurons
  JOURNAL   Biochim Biophys Acta 1811 (10), 617-625 (2011)
   PUBMED   21736954
REFERENCE   5  (bases 1 to 4875)
  AUTHORS   Marcucci,H., Elena,C., Gilardoni,P. and Banchio,C.
  TITLE     Characterization of the murine CTP:phosphocholine
            cytidylyltransferase beta gene promoter
  JOURNAL   Biochim Biophys Acta 1781 (5), 254-262 (2008)
   PUBMED   18423385
  REMARK    GeneRIF: Results suggest that the activities of alternative
            promoters provide for greater flexibility in the control of
            CTP:phosphocholine cytidylyltransferase beta isoform expression.
REFERENCE   6  (bases 1 to 4875)
  AUTHORS   Wang,L., Magdaleno,S., Tabas,I. and Jackowski,S.
  TITLE     Early embryonic lethality in mice with targeted deletion of the
            CTP:phosphocholine cytidylyltransferase alpha gene (Pcyt1a)
  JOURNAL   Mol Cell Biol 25 (8), 3357-3363 (2005)
   PUBMED   15798219
REFERENCE   7  (bases 1 to 4875)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 4875)
  AUTHORS   Jackowski,S., Rehg,J.E., Zhang,Y.M., Wang,J., Miller,K., Jackson,P.
            and Karim,M.A.
  TITLE     Disruption of CCTbeta2 expression leads to gonadal dysfunction
  JOURNAL   Mol Cell Biol 24 (11), 4720-4733 (2004)
   PUBMED   15143167
REFERENCE   9  (bases 1 to 4875)
  AUTHORS   Karim,M., Jackson,P. and Jackowski,S.
  TITLE     Gene structure, expression and identification of a new
            CTP:phosphocholine cytidylyltransferase beta isoform
  JOURNAL   Biochim Biophys Acta 1633 (1), 1-12 (2003)
   PUBMED   12842190
REFERENCE   10 (bases 1 to 4875)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB646993.1 and AK032027.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032027.1, BC048917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               BB646993.1         11-475
            466-4875            AK032027.1         168-4577
FEATURES             Location/Qualifiers
     source          1..4875
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 41.28 cM"
     gene            1..4875
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /note="phosphate cytidylyltransferase 1, choline, beta
                     isoform"
                     /db_xref="GeneID:236899"
                     /db_xref="MGI:MGI:2147987"
     exon            1..365
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1358
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /EC_number="2.7.7.15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphorylcholine transferase B; choline-phosphate
                     cytidylyltransferase B; CT B; CCT B; CCT-beta;
                     CTP:phosphocholine cytidylyltransferase B"
                     /codon_start=1
                     /product="choline-phosphate cytidylyltransferase B isoform
                     1"
                     /protein_id="NP_997593.1"
                     /db_xref="CCDS:CCDS30274.1"
                     /db_xref="GeneID:236899"
                     /db_xref="MGI:MGI:2147987"
                     /translation="MPVLTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAP
                     APFADESSCQCQAPHEKLTVAQARLGTPVDRPVRVYADGIFDLFHSGHARALMQAKTL
                     FPNSYLLVGVCSDDLTHKFKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEK
                     HKIDFVAHDDIPYSSAGSDDVYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYAR
                     RNLQRGYTAKELNVSFINEKKYRFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQ
                     KWEEKSREFIGNFLELFGPDGAWKQMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSP
                     SPTFSWLPNKTSPPSSPKAASASISSMSEGDEDEK"
     exon            366..465
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            466..582
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            583..734
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            735..813
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            814..956
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1145
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..4875
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4857..4862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
     polyA_site      4875
                     /gene="Pcyt1b"
                     /gene_synonym="CTTbeta"
ORIGIN      
        1 gtgctgtctg gttgttatag tgataaactg aggccctgcc tctgggcttc tccgagaaag
       61 aaaagggtgg tgtgtgcgtt gggggtgggg gtgggggtaa cctctttact tccccccagg
      121 gaagacaaaa aagaagggaa gaagaagggg gatgggtagg gaagagaaaa atacgtgaca
      181 aagaaaacat tctttgcctg ggaggagact cccagagggt gtagagctgg agggagcatt
      241 cactggccat gccagtactt accactgatg ctgagtcaga aacaggtatc ccaaaatccc
      301 tttccaatga gcctccctca gaaaccatgg aggaaataga gcacacatgc ccacagcctc
      361 gactgaccct gactgcacca gccccatttg ctgatgaatc cagctgccag tgccaagcac
      421 ctcatgaaaa actgaccgtt gcccaggccc gcttaggaac accagttgat aggcctgtta
      481 gagtgtatgc agatggaata tttgacctct tccactcagg tcacgcaagg gcacttatgc
      541 aagcaaaaac actgtttccc aacagctact tgttggtagg agtttgcagt gatgacctta
      601 ctcacaaatt caaaggtttt actgtgatga acgaggcaga gagatatgaa gctctcagac
      661 actgtcgata cgtggatgaa gtcatcagag acgcgccatg gactcttact ccagagtttc
      721 tggaaaaaca caagattgac tttgtggctc acgatgatat tccatactcc tctgctggtt
      781 ctgatgacgt ttataagcat atcaaggaag caggcatgtt tgttccaaca caaagaacag
      841 aaggcatctc aacatcagac atcatcacca gaattgtccg tgactatgat gtatatgccc
      901 ggcgtaatct ccagagaggg tacacagcca aggagctgaa cgtcagcttt ataaacgaga
      961 agaagtaccg tttccagaac caggtggaca agatgaaaga aaaggtcaag aatgtggaag
     1021 aaagatcaaa ggagtttgtt aacagagtag aagaaaagag tcatgaccta attcaaaagt
     1081 gggaagaaaa atcaagagag tttattggca acttcctgga actgtttggg ccagatggtg
     1141 catggaagca gatgttccag gagaggagta gccggatgct gcaggcatta tctccgaagc
     1201 agagtcctgt gagcagcccg acccggagcc ggtccccttc tcgctctcca tctcctacct
     1261 tctcctggct cccaaacaag acctctcccc cctcctcacc caaagcagcc tcagcctcca
     1321 tcagcagcat gagcgagggg gatgaggatg agaagtaaag gtgcctggtc aacaagagca
     1381 caccacacag gatgggaagg gctcccggga tgcctgggtg gtgttgagag ctgcagctct
     1441 gctgggagac gggagttctg ccatgggagt tactagggcc agctcttttt ccttctccat
     1501 tcagtctggc ctgggctcag catggaggtt tctgacctga aaacccacac agaccttgtt
     1561 agcatcctag aagcaccctc actttagccc tgctatggaa aggtgcagaa cactccatga
     1621 agtgggatga gttctgcttt ggtccacaca tctatctgta gccaataagc cacccgcaga
     1681 tgtggctgct gcctcgccct gccctctcca gtcctcaaag agccttgcac gttgccccct
     1741 gtcacccatg ctctcccaga atgaattccc ttcccacaat gggcaaagtt cagccttccc
     1801 agtacagcca ctaaggctgg atggaatgca ccaacccttt cccatttcag gaccctgcct
     1861 cagacgcagc ttcgcgttgg tcagatagaa aagtgtgacc cttaatctct cactcaaagg
     1921 acagttgtgt caaggtgaac tccacccaag gcctgccatg cttctggctg tacattttca
     1981 tctttggcat gaggagactg ttttccagaa attacctgaa ttgatgggaa tcacagcaag
     2041 gaagcccgtc ttatctaaaa aagaaataac cacacaaacc ttcttagcag gagctgcgct
     2101 gctttggctc catgtatgga agatgaaaaa tatctcttgg agcttcttaa aggatcagct
     2161 ctttccattt ctgaccacat cacagttcat agactcgaat aacagtttga tgtaacaaac
     2221 acttagtata ccgatagggg gtgctacctg cacgtatctg ttctatgtat cctccaatat
     2281 gccaccccag ggtgtatccc atatgcaata tgaatctatg gtggtggtgt tggactctag
     2341 atccctctcc tgctctcccc catgacaccc tgctgaaatg cttgatctca agaaccgcct
     2401 ggttccctca tgacttgggc actttgtcaa aagctcaatc aaatgttaga ttccggtaga
     2461 aatgttttgt cccagaaaat tcctgttgtt cttcacccat gacattttgg gtaaagggaa
     2521 ggctcaatct tttgaatggt ctgagagaca ctgaagttat ttctggccct tgcttctcca
     2581 aatgggatag agactctcag atgactggag aactacatgg ggccgctgtt ccctaatcac
     2641 atgcagggaa tgagcaggtc cagtcaaggt ttagagctaa tctcttaggt acaaatagaa
     2701 tttcctgagt atcctagtaa agacagaaag acagcactgc agcttgacta agtgaaggcc
     2761 ttaacatgta actggtgggc aaagtccaac acctccagtg acagaaacac cccctgcctt
     2821 cagaggcttt gggaacatgc attctggggg gggggtaggg agacaactca tgaagaaagg
     2881 taccctgtct ttcccctttg tgttggggtc aaactacctc cctgctcacc tgaagatcag
     2941 tggtgactgt tgctaaggca acctggagcc tccttgttcc tggtacttct tccagaagtt
     3001 tgtaaagtgc tcatgaaaga tgggggatcg ctgggaatcc agcctgcgag aaagaaactt
     3061 cttttcatag tcaaggccct cttggagaat cacaccccag aggcaagggc ttccattcct
     3121 ccacggtatc ggtttgacct cagcctccca ccatgtaccc aggacaaatt gtgcgtgtat
     3181 gccttctatt tcagccagct gacacttgtg gcagtgcagg gacaaggaga gcaactgagc
     3241 aaatgaagaa gaggagaaga gggtcctaga gagaggaaag aaagaaagct aaaaccatct
     3301 acgctcttaa gccacttctg gttgtatgtg cggagactct ctgttgagga agccttttta
     3361 aaaagttctg gctctatgac ccagggcaga taggtccact tttacctaag tcttgctctg
     3421 aggcagagaa tgtagaggtg acatatcagg tgagtataat tttgcaggcc ctacacacca
     3481 tcctgccagg tgccacatac gtgactcatc agagagtgcc actgtagctg tgaatgatgg
     3541 gaagtgacca acatcagaat catcccaggt acaaacagac acttaagtgg gtttaaactt
     3601 ccttctcagt ttgcaacagc atctcctcac cttcccaaag ccacgagctt gccaccaaga
     3661 aatggggcgg attctgctag ccaacctttg gcccttcttg accatctcac aggccttccc
     3721 agccctgacc caggtttacc accccccaca cctgggagga gccatgactg cactttgtgt
     3781 gggttcttca ggcaattctc atggtcaagg gcgagttaag gatcgaatga cagcataaca
     3841 cgtgctgcag gcttggagaa gtaagaaaag ggatagaagc cggggaatgg gctccttttc
     3901 ctccatgaaa ggaaagaagc tacttagaga acccattccc taaggttggg aatgggaaga
     3961 tggaaaaaat gacactggag ttggtgagta tgggaggatt tatattttct actttccttc
     4021 caggcatcac taggaaggag gaaggcttcc tattgtatcc ttccatggct agtggatccc
     4081 catgcagcag gtggggtcct ggcctctcca gcttctttgg catattagca attctcatat
     4141 ctctccccac ccctggaaac caagtgctga ctctccatgt aaacaacagg ggtgtagttg
     4201 taatatggtg tatggcccat gtctgccaca aattgtcagg ataacccaga gacaaagata
     4261 aaccaggctt gtgacagaca cagtgtggct tctgacatgc tgtgggtggg ggagactcag
     4321 ccattctatg acctaggcta caagatactg cggttacact ggtgggttgt ggccacagga
     4381 agaacatggc ttattttccc tcagtcttca ggacttttta aaatgcccag tcctactcca
     4441 cagatgagac tggttttcag gcatctactc agcaactcca gtcttgtcct aaccatctga
     4501 tgaggaagga aggaaggaag gaaggaagga aggaaggaag gaaggaagga aggaagtgag
     4561 caagagataa gtgagctcat taggcaaatt ttttacttct cctcttctct agttttctgt
     4621 tgtgtcgctg cagtgtgtct ggggacaaag ccataagaag cctatctact taaaattctg
     4681 ctgtacatag aagccgaggg cttgtctgga ttcaagaatg atcttatgcc caagcatttg
     4741 ctctggtgct gaatagtgca aactactgga accaccccaa ccctaccact gaaaccccta
     4801 gacccaatcc agtctcctga tccccaatgg accacagtat tcccaacttg tttataaata
     4861 aagggacgca gagtc
//
