LOCUS       NM_025823               4291 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus prenylcysteine oxidase 1 (Pcyox1), transcript variant
            1, mRNA.
ACCESSION   NM_025823
VERSION     NM_025823.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4291)
  AUTHORS   Banfi,C., Amadio,P., Zara,M., Brioschi,M., Sandrini,L. and
            Barbieri,S.S.
  TITLE     Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis
  JOURNAL   Int J Mol Sci 23 (5), 2831 (2022)
   PUBMED   35269975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4291)
  AUTHORS   Banfi,C., Baetta,R., Barbieri,S.S., Brioschi,M., Guarino,A.,
            Ghilardi,S., Sandrini,L., Eligini,S., Polvani,G., Bergman,O.,
            Eriksson,P. and Tremoli,E.
  TITLE     Prenylcysteine oxidase 1, an emerging player in atherosclerosis
  JOURNAL   Commun Biol 4 (1), 1109 (2021)
   PUBMED   34548610
  REMARK    GeneRIF: Prenylcysteine oxidase 1, an emerging player in
            atherosclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4291)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   4  (bases 1 to 4291)
  AUTHORS   Ghesquiere,B., Van Damme,J., Martens,L., Vandekerckhove,J. and
            Gevaert,K.
  TITLE     Proteome-wide characterization of N-glycosylation events by
            diagonal chromatography
  JOURNAL   J Proteome Res 5 (9), 2438-2447 (2006)
   PUBMED   16944957
REFERENCE   5  (bases 1 to 4291)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (bases 1 to 4291)
  AUTHORS   Beigneux,A., Withycombe,S.K., Digits,J.A., Tschantz,W.R.,
            Weinbaum,C.A., Griffey,S.M., Bergo,M., Casey,P.J. and Young,S.G.
  TITLE     Prenylcysteine lyase deficiency in mice results in the accumulation
            of farnesylcysteine and geranylgeranylcysteine in brain and liver
  JOURNAL   J Biol Chem 277 (41), 38358-38363 (2002)
   PUBMED   12151402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134528.1 and AK004799.2.
            
            On Oct 26, 2007 this sequence version replaced NM_025823.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134528.1, AK147190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AK134528.1         2-158
            158-3325            AK004799.2         113-3280
            3326-4291           AK134528.1         3327-4292
FEATURES             Location/Qualifiers
     source          1..4291
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.69 cM"
     gene            1..4291
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /note="prenylcysteine oxidase 1"
                     /db_xref="GeneID:66881"
                     /db_xref="MGI:MGI:1914131"
     exon            1..178
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1584
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /EC_number="1.8.3.5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; prenylcysteine lyase"
                     /codon_start=1
                     /product="prenylcysteine oxidase 1 isoform 1 precursor"
                     /protein_id="NP_080099.1"
                     /db_xref="CCDS:CCDS20311.1"
                     /db_xref="GeneID:66881"
                     /db_xref="MGI:MGI:1914131"
                     /translation="MGRFAAALVGSLFWLGLLLCGLGSLASAEPRAPPNRIAIVGAGI
                     GGTSSAYYLRKKFGKDVKIDVFEREEVGGRLATLKVQGHDYEAGGSVIHPLNLHMKRF
                     VKELGLSSVPASGGLVGVYNGKSLVFEESSWFVINVIKLVWRYGFQSLRMHMWVEDLL
                     DKFMRIYRYQSHDYAFSSVEKLMHAIGGDDYVRLLNQTLRENLKKAGFSETFLNEMIA
                     PVMKVNYGQSTDINAFVGAVSLTAADSNLWAVEGGNKIVCSGLLQASSSNLISGSVMS
                     IEEKTRTKQTGNPTKMYEVVYKTGSETHSDFYDIVLVAAPLNRKMSNITFRNFDPPIE
                     EFNDPYQQLVTTFIKGELNSTLFSSRPKDQFGLSAILVTDDSDMFINSLSIVASVRQK
                     EGPPPAVDGMHVWKTFSRDILTKEQISKLFLSYDYAVRKPWLSYPHYEPPQKCPSIIL
                     HDRLYYLNGIEFAASCMEMSAIAGYNAALLAYHRWNGNEDMIDQDDLYERLKTEL"
     exon            179..385
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /inference="alignment:Splign:2.1.0"
     exon            386..560
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /inference="alignment:Splign:2.1.0"
     exon            561..772
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /inference="alignment:Splign:2.1.0"
     exon            773..925
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /inference="alignment:Splign:2.1.0"
     exon            926..4291
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3306..3311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /note="hexamer: ATTAAA"
     polyA_site      3329
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /note="major polyA site"
     regulatory      3654..3659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /note="hexamer: ATTAAA"
     polyA_site      3672
                     /gene="Pcyox1"
                     /gene_synonym="1200015P13Rik; PCL1; Pcly"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgcaga cgcatagagc agggtctgct ggcggacccg cggtcagtct gcagctgcgg
       61 gaggccatgg ggcgcttcgc cgctgcattg gtgggctcac tgttctggct ggggctgctg
      121 ctatgtggtc tgggcagtct ggcgagcgcc gagccccggg ccccgccgaa caggatcgca
      181 atagtcggtg ctggaatcgg tggtacttcc tccgcctatt atctaaggaa gaaatttggg
      241 aaggacgtga agattgacgt gtttgagaga gaagaggtcg ggggccgttt ggccactttg
      301 aaggtgcaag gtcatgacta cgaggcaggg ggttcagtca ttcaccccct aaatttgcac
      361 atgaagcgat ttgtcaaaga gctgggtctc tccagtgttc ccgcttcagg tggcctggtg
      421 ggcgtgtaca atggaaagtc tctggtgttt gaggagagca gctggtttgt aatcaacgtg
      481 attaagctgg tgtggcgcta tgggtttcag tccctcagaa tgcacatgtg ggtagaagac
      541 ttgttggaca agttcatgag gatctaccgt taccagtccc atgactatgc ctttagcagt
      601 gtagaaaagt tgatgcacgc catcggaggg gatgactacg tcagactgct taaccaaact
      661 ctccgtgaaa acctgaagaa agcaggcttc tccgagacgt ttctcaacga gatgattgct
      721 cctgtcatga aggtcaatta tggccagagc acagacatca acgcctttgt gggggcggtg
      781 tcattgacgg ctgccgattc caacctctgg gcagtggaag gtggtaataa aattgtttgc
      841 tcggggctcc ttcaggcctc tagcagcaat cttatatctg gctccgtaat gtcaatagag
      901 gagaagacga ggaccaaaca gacaggaaac cccaccaaga tgtatgaagt ggtatataaa
      961 acaggatctg agacccattc tgacttctat gacattgtcc tcgtggctgc tcctttgaac
     1021 cggaagatgt ccaacataac tttccgaaat tttgatccgc ccatcgagga attcaatgac
     1081 ccatatcaac agctggtgac aactttcatc aaaggagaac tcaattccac tctcttcagc
     1141 tccagaccca aggatcagtt tggcctctcg gcaattcttg tcactgatga ctccgatatg
     1201 tttattaaca gtctgtccat tgtggcctct gtaagacaga aggagggtcc cccacccgcg
     1261 gtggatggca tgcacgtgtg gaagaccttc tccagggaca tcctcaccaa agaacaaatt
     1321 tcaaagctct tcctgtccta tgattatgct gtgcggaagc catggctgtc ctatcctcac
     1381 tatgagcctc ctcagaaatg tccctccatc atcctccacg accggctcta ttacctcaat
     1441 ggcatcgagt ttgcggccag ctgcatggaa atgagcgcca ttgccggcta caacgcagct
     1501 ctcctcgcct accaccgctg gaacggcaat gaggacatga ttgatcagga cgacctgtat
     1561 gaaaggctta agacggagct gtaactgagc actgcccctc ccccgagcgt cctgctctcg
     1621 aaggaccgag tcagcagaga ggaatttgaa cctttcctgg tactcctcat gtgggtcatg
     1681 agaaaacaca gcgttcctgt tcctcggaga atgtgttctt ctgtcagaat gtcatcactc
     1741 tggatttggg ggcggtacag gaggattgaa cctgaggccc cgtgcatgct gggcaagtgt
     1801 tcccctcttg agctgagcta tatccctagc cctcctttgt ggtttttctt ttgagactgg
     1861 gtctcactaa gttgtccagg tggaatcctc ctgcctcagt ctccggagag cctgggattt
     1921 gattccaggc cctccacatg aggcgtggct ggataactgg ggaaacattg gattttccca
     1981 ggcttgtctg gttttaagag tcacctggaa cttcataaac atctgggtta ggtcattggg
     2041 ctggtgtggg cctgggtttg tttagattgt aatcttttct tgtctctctt ttcttctttg
     2101 ggggatgtta caactagggt cttagtctgc accccaggct ggaactcatt atgcagccca
     2161 ggctggtctt gaaatcacag caatcctcct gtctcagcct cctatgtgct ggaatacaga
     2221 tgtttcccag ttcctggcag tttatactct tttgatgaga atgttctcaa agcctgaagt
     2281 cctgacttta agaatgtgac ttttgattgc ttctgcctcg gctttatcag ggatagattc
     2341 agagatagaa gcagagatag cctgtgattt ggaaccaaat atataaacta ttaacttgag
     2401 aaactattta atatataaac tattaacttg aggaggtctg tttttctata ctgtggggat
     2461 tgaacccagg accccgagta tcccagacaa atgctctacc actgagctac attgccagcc
     2521 tcaagagctt caggatcgac atccagagaa tggaatttcc taggttgaag atggggtctt
     2581 ggctctaaag ctttgtcaag atcaagttcc tcgcatgcag ccaagggtga gcaggtcctg
     2641 ggtgtcagat agagagcttt gagtgcctta aaagtgctaa gcaacacaaa tcaaaaccac
     2701 agcagaccgg tgccagaggt gactggctgc tcgatggtta atcagctgtg gtctccaagg
     2761 gaacgaacac tagagcagag gcggcctgag tgagcccaga gcagttggcc ttagaaccag
     2821 gtcttcatgg ctgcgtgagt tcagagggac gcgtatcaga tgctgggcat gcgcagtgag
     2881 gggccgttgc tgaaatctta atacagtggc gctcagttgt agctgcacat gggagtcaga
     2941 tttctcttac gtagacaagc tcaagaaatc tggtgtttag tccactgctc ataggtctcc
     3001 agtgactatc atagccacta gtattaagag ggaaaaaaag taattttgcc tgctttggtg
     3061 gtacttgcct gtcatccata cctttgtgac aaagcgagag gatcaaaagt tcagagccag
     3121 cctgggctgt ggcaacaccc tatctcaagg aataaaaatc aaaactcttc accaggttat
     3181 agcgttgctt caataaagcg gtcttaaaaa gcctgattct taaaaattat ttttccctac
     3241 tctagctgta ggaattaata atgtgtggag aaagcagcgg tgatatattt gatatggtga
     3301 cagaaattaa attcatagtt taatcagaag gttggctttt ttctaattca tttagagaca
     3361 tttgtatttt tttctgctgt ggtgttaagg aatgtggttt gtcaaaaaca caacactcag
     3421 aaatatagca ctctcgtgga ttcgtacggt ggatttgtgc agcgcgcctc ctcagagcgg
     3481 gagtgtttca tgacccctag tgggcacccg gaactgggaa gcagtgagcc ccacatgttc
     3541 tattttccac atgtacaata tacctgtggt aaagtgttaa tttataaatt tggcacagta
     3601 agagattaac aacaataatt ataaaataga agaattgtaa caattggaag tcaattaaaa
     3661 cttacaactt ctggtctgtt tctcttcttt ttcttttctt tctttctttc ttcttttttt
     3721 tttttctttt tcattttgta gacagggcct cactatgtag cgttggctgg cctcaagtca
     3781 tacagacagc ctgcttctgc ctcctgggtc ctggcattaa aggtgtgtgc cttcacatcc
     3841 accagctctt tctggtattt tccactgagt attttcagac cagcaaaagc agcagcacct
     3901 aagcgggggg ggggcgctgc agatgcaggg acatacagga taactaagtt tctaccgttt
     3961 gtggacttga tttgcaatgg gatatactta ggcttgtaat ttaaagtttt gctggtgggc
     4021 cagagagttg tctcagtggt ttagagctac aggcaaagta cacatttatg tcaatttaaa
     4081 aaattaagaa aaatctttag ccagatgtgg tggcacatgc ctttaatccc agggcttggg
     4141 agacagaggc agacaaatct cctgagttca atatagaggc aggtggatct ttgtgagtgc
     4201 aaggccagcc tggtctacat agtgagttcc atccaggaca gccagggtaa cacactgagt
     4261 ccttgtctaa attaataata gtaggagtag c
//
