LOCUS       NM_153565               3512 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus proprotein convertase subtilisin/kexin type 9 (Pcsk9),
            mRNA.
ACCESSION   NM_153565
VERSION     NM_153565.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3512)
  AUTHORS   Weiss,U., Mungo,E., Hass,M., Benning,D., Gurke,R., Hahnefeld,L.,
            Dorochow,E., Schlaudraff,J., Schmid,T., Kuntschar,S., Meyer,S.,
            Medert,R., Freichel,M., Geisslinger,G. and Niederberger,E.
  TITLE     Knock-Out of IKKepsilon Ameliorates Atherosclerosis and Fatty Liver
            Disease by Alterations of Lipid Metabolism in the PCSK9 Model in
            Mice
  JOURNAL   Int J Mol Sci 25 (19), 10721 (2024)
   PUBMED   39409049
  REMARK    GeneRIF: Knock-Out of IKKepsilon Ameliorates Atherosclerosis and
            Fatty Liver Disease by Alterations of Lipid Metabolism in the PCSK9
            Model in Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3512)
  AUTHORS   Busnelli,M., Manzini,S., Colombo,A., Franchi,E., Laaperi,M.,
            Laaksonen,R. and Chiesa,G.
  TITLE     Effect of diet and genotype on the lipidome of mice with altered
            lipoprotein metabolism
  JOURNAL   iScience 27 (10), 111051 (2024)
   PUBMED   39568621
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3512)
  AUTHORS   Guo,H., Li,W., Yang,Z. and Xing,X.
  TITLE     E3 ubiquitin ligase MARCH1 reduces inflammation and pyroptosis in
            cerebral ischemia-reperfusion injury via PCSK9 downregulation
  JOURNAL   Mamm Genome 35 (3), 346-361 (2024)
   PUBMED   39115562
  REMARK    GeneRIF: E3 ubiquitin ligase MARCH1 reduces inflammation and
            pyroptosis in cerebral ischemia-reperfusion injury via PCSK9
            downregulation.
REFERENCE   4  (bases 1 to 3512)
  AUTHORS   Wu,M., Yoon,C.Y., Park,J., Kim,G., Nam,B.Y., Kim,S., Park,J.T.,
            Han,S.H., Kang,S.W. and Yoo,T.H.
  TITLE     The role of PCSK9 in glomerular lipid accumulation and renal injury
            in diabetic kidney disease
  JOURNAL   Diabetologia 67 (9), 1980-1997 (2024)
   PUBMED   38879617
  REMARK    GeneRIF: The role of PCSK9 in glomerular lipid accumulation and
            renal injury in diabetic kidney disease.
REFERENCE   5  (bases 1 to 3512)
  AUTHORS   Wang,Y., Li,F., Gao,X., Yu,H., Du,Z., Li,L., Du,Y., Hu,C. and
            Qin,Y.
  TITLE     miR-181d-5p ameliorates hypercholesterolemia by targeting PCSK9
  JOURNAL   J Endocrinol 262 (3), e230402 (2024)
   PUBMED   38940622
  REMARK    GeneRIF: miR-181d-5p ameliorates hypercholesterolemia by targeting
            PCSK9.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3512)
  AUTHORS   Benjannet,S., Rhainds,D., Essalmani,R., Mayne,J., Wickham,L.,
            Jin,W., Asselin,M.C., Hamelin,J., Varret,M., Allard,D.,
            Trillard,M., Abifadel,M., Tebon,A., Attie,A.D., Rader,D.J.,
            Boileau,C., Brissette,L., Chretien,M., Prat,A. and Seidah,N.G.
  TITLE     NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects
            on the low density lipoprotein (LDL) receptor and LDL cholesterol
  JOURNAL   J Biol Chem 279 (47), 48865-48875 (2004)
   PUBMED   15358785
  REMARK    GeneRIF: NARC-1 has a role in regulating both the level of LDLR and
            that of circulating apoB-containing lipoproteins in an
            LDLR-dependent and -independent fashion
REFERENCE   7  (bases 1 to 3512)
  AUTHORS   Dubuc,G., Chamberland,A., Wassef,H., Davignon,J., Seidah,N.G.,
            Bernier,L. and Prat,A.
  TITLE     Statins upregulate PCSK9, the gene encoding the proprotein
            convertase neural apoptosis-regulated convertase-1 implicated in
            familial hypercholesterolemia
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (8), 1454-1459 (2004)
   PUBMED   15178557
  REMARK    GeneRIF: Human, mouse, and rat PCSK9 promoters contain 2 typical
            conserved motifs for cholesterol regulation: a sterol regulatory
            element (SRE) and an Sp1 site.
REFERENCE   8  (bases 1 to 3512)
  AUTHORS   Naureckiene,S., Ma,L., Sreekumar,K., Purandare,U., Lo,C.F.,
            Huang,Y., Chiang,L.W., Grenier,J.M., Ozenberger,B.A.,
            Jacobsen,J.S., Kennedy,J.D., DiStefano,P.S., Wood,A. and Bingham,B.
  TITLE     Functional characterization of Narc 1, a novel proteinase related
            to proteinase K
  JOURNAL   Arch Biochem Biophys 420 (1), 55-67 (2003)
   PUBMED   14622975
REFERENCE   9  (bases 1 to 3512)
  AUTHORS   Maxwell,K.N., Soccio,R.E., Duncan,E.M., Sehayek,E. and Breslow,J.L.
  TITLE     Novel putative SREBP and LXR target genes identified by microarray
            analysis in liver of cholesterol-fed mice
  JOURNAL   J Lipid Res 44 (11), 2109-2119 (2003)
   PUBMED   12897189
REFERENCE   10 (bases 1 to 3512)
  AUTHORS   Seidah,N.G., Benjannet,S., Wickham,L., Marcinkiewicz,J.,
            Jasmin,S.B., Stifani,S., Basak,A., Prat,A. and Chretien,M.
  TITLE     The secretory proprotein convertase neural apoptosis-regulated
            convertase 1 (NARC-1): liver regeneration and neuronal
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 100 (3), 928-933 (2003)
   PUBMED   12552133
  REMARK    GeneRIF: NARC-1 is a proteinase K-like subtilase with a role in the
            differentiation of cortical neurons
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC038085.1 and AV027564.1.
            
            On Dec 20, 2007 this sequence version replaced NM_153565.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038085.1, SRR1660817.129220.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3504              BC038085.1         16-3519
            3505-3512           AV027564.1         290-297
FEATURES             Location/Qualifiers
     source          1..3512
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 49.67 cM"
     gene            1..3512
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /note="proprotein convertase subtilisin/kexin type 9"
                     /db_xref="GeneID:100102"
                     /db_xref="MGI:MGI:2140260"
     exon            1..631
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            632..823
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            824..947
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1081
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1223
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1420
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1604
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1778
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1927
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2105
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2287
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..3512
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3480..3485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /note="hexamer: AATAAA"
     polyA_site      3504
                     /gene="Pcsk9"
                     /gene_synonym="FH3; HCHOLA3; Narc1; PC9"
                     /note="major polyA site"
ORIGIN      
        1 tggggattaa gaggggggaa tgtaacaggt cccgtttgca gcccaattag gatttggggt
       61 tttgtcctca ctctgagcgt catttgacgc tgtctgggga gggcgaggcc gaaacctgat
      121 cctttagtac cggggcccgt taatgtttaa tcagagagga tcttccgatg gggctcgggg
      181 tggcgtgatc tcccggcccc caggcgtcca gtacccacac cccagaaggc ttccaccttc
      241 acgtggacgc gcaggctgcc ggtgggctcc cgttctctct ctctttctga ggctagagga
      301 ctgagccagt ccttggctcc ccagagacat cacggcccgc agccccggag ccaagtgccc
      361 cgagtcccag gcgtccatgt ccttcccgag gccgcgcgca cctctcctcg ccccgatggg
      421 cacccactgc tctgcgtggc tgcggtggcc gctgttgccg ctgttgccgc cgctgctgct
      481 gctgttgctg ctactgtgcc ccaccggcgc tggtgcccag gacgaggatg gagattatga
      541 agagctgatg ctcgccctcc cgtcccagga ggatggcctg gctgatgagg ccgcacatgt
      601 ggccaccgcc accttccgcc gttgctccaa ggaggcctgg aggctgccag gaacctacat
      661 tgtggtgctg atggaggaga cccagaggct acagattgaa caaactgccc accgcctgca
      721 gacccgggct gcccgccggg gctatgtcat caaggttcta catatctttt atgacctctt
      781 ccctggcttc ttggtgaaga tgagcagtga cctgttgggc ctggccctga agttgcccca
      841 tgtggagtac attgaggaag actcctttgt cttcgcccag agcatcccat ggaacctgga
      901 gcgaattatc ccagcatggc accagacaga ggaagaccgc tcccctgatg gaagcagcca
      961 ggtggaggtg tatctcttag ataccagcat ccagggtgcc catcgggaga ttgagggcag
     1021 ggtcaccatc accgacttca acagcgtgcc ggaggaggat gggacacgct tccacagaca
     1081 ggcgagcaag tgtgacagcc acggcaccca cctggcaggt gtggtcagcg gccgggatgc
     1141 tggtgtggcc aagggcacca gcctgcacag cctgcgtgtg ctcaactgtc aagggaaggg
     1201 cacagtcagc ggcaccctca taggcctgga gtttattcgg aagagtcagc taatccagcc
     1261 ctcggggcca ctcgtggttc tgctgcccct ggccggtggg tatagccgca tcctcaacgc
     1321 tgcctgccgg cacctggcga ggactggggt ggtgctggtt gcagcagctg ggaacttccg
     1381 ggacgacgcc tgcctctact ccccagcttc tgctccagag gtcatcacag tcggggccac
     1441 gaatgcccag gaccagccag ttaccttggg gactttgggg actaattttg gacgctgtgt
     1501 ggatctcttt gcccccggga aggacatcat cggagcgtcc agtgactgca gcacatgctt
     1561 catgtcacag agtgggacct cacaggctgc tgcccacgtg gccggcattg tggctcggat
     1621 gctgagccgg gagcccacac ttaccctggc cgagctgcgg cagaggctga tccacttctc
     1681 taccaaagac gtcatcaaca tggcctggtt ccctgaggac cagcaggtgc tgacccccaa
     1741 cctggtggcc acactgcccc ccagcaccca tgagacaggc gggcagctgc tctgtaggac
     1801 ggtgtggtcg gcacactcgg ggcccactcg aacagctaca gctacagccc gctgtgcccc
     1861 agaagaggag ctgctgagct gctccagctt ctccaggagc gggaggcgtc gtggtgattg
     1921 gattgaggcc ataggaggcc agcaggtctg caaggccctc aatgcatttg ggggtgaggg
     1981 tgtctatgcc gtcgcgagat gctgcctggt tccccgtgcc aactgcagca tccacaacac
     2041 ccctgcagcc agagctggcc tggagaccca tgtccactgc caccagaagg accatgttct
     2101 cacaggctgc agcttccatt gggaagtgga agaccttagt gtccggaggc agcctgcgct
     2161 gaggtccaga cgtcagcctg gccagtgcgt tggccaccag gcggccagtg tctatgcttc
     2221 ctgctgccat gccccagggc tggaatgcaa aatcaaggag catgggatct caggtccttc
     2281 agagcaggtc actgtggcct gcgaagcagg atggaccctg actggatgca atgtgctccc
     2341 tggggcatcc ctcactctgg gagcctacag cgtggacaac ctgtgtgtgg caagagtcca
     2401 tgacactgcc agagcagaca ggaccagtgg agaagccaca gtagctgctg ccatctgctg
     2461 ccggagccgg ccttcagcaa aggcctcctg ggttcagtga cagcctcagg cagggatggt
     2521 gcttgaggct gggtgcagag atatgcctgc atggctctct tgtagccaaa ggtggggaga
     2581 ttctgcgtgg gagaacttgg tgtctcaccc tgggtaccca ttcctggtgt atggaagcac
     2641 ctccttcacg gtcagggggc ctgtgcttgg ctttctgcca tcagacatta agctgtagct
     2701 ggctctggcc agctgctcca gtgtaccaga acctgaggat gctcgctgca aggcctcagt
     2761 tctcaggcct tagggtgtat ttgtctttca ggaagatcat aatggacaga gatccttgga
     2821 ggttcaaaga ccaagtacca gactggaaaa ttgagtctga aagccacaag gacagtcaac
     2881 tcacagccag ctcacattgc agacaccatt ttgggctccc tgattaaatg cagatcagtt
     2941 ctgcacacct ccaggggtgg atccagctgt aaggccatac ctatatcttc cagatgtcct
     3001 catctgctgc agggctttgg ccctgctcag gataatgtgc tatgagccct catctgactc
     3061 tcagtttgta ctggagaacc atacaggact taccgcacct taccccatcc actaccatgt
     3121 gcactgactg gcctcatttt atgaaggaag agacaggacc agagaggcga tgtcacacag
     3181 ccagtgatgt caggacataa attcagagtg gctggccctg aataatgcca ggctgggcag
     3241 cgagaggaca ggctatggct tgctcctgga cctatactcc cttagcccca gtcccacaga
     3301 tcaggtggag actggagtga cagagggcga ctgtaccaag gccacaccag ctgaccagca
     3361 cacctctatc cttttgagct cttctgtctt tttatagtaa gcttcctcca cctgtgttgc
     3421 ttttgtaact tgatatttat gcagggtttt gtagttttta ttatgtagtg acttttcaga
     3481 ataaaagcag ctgatgtgac tgactgcatc cg
//
