LOCUS       NM_008794               3834 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus proprotein convertase subtilisin/kexin type 7 (Pcsk7),
            transcript variant 2, mRNA.
ACCESSION   NM_008794
VERSION     NM_008794.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3834)
  AUTHORS   Sachan,V., Le Devehat,M., Roubtsova,A., Essalmani,R.,
            Laurendeau,J.F., Garcon,D., Susan-Resiga,D., Duval,S., Mikaeeli,S.,
            Hamelin,J., Evagelidis,A., Chong,M., Pare,G., Chernetsova,E.,
            Gao,Z.H., Robillard,I., Ruiz,M., Trinh,V.Q., Estall,J.L., Faraj,M.,
            Austin,R.C., Sauvageau,M., Prat,A., Kiss,R.S. and Seidah,N.G.
  TITLE     PCSK7: A novel regulator of apolipoprotein B and a potential target
            against non-alcoholic fatty liver disease
  JOURNAL   Metabolism 150, 155736 (2024)
   PUBMED   37967646
  REMARK    GeneRIF: PCSK7: A novel regulator of apolipoprotein B and a
            potential target against non-alcoholic fatty liver disease.
            Erratum:[Metabolism. 2024 Dec;161:156032. doi:
            10.1016/j.metabol.2024.156032.. PMID: 39298889]
REFERENCE   2  (bases 1 to 3834)
  AUTHORS   Ashraf,Y., Duval,S., Sachan,V., Essalmani,R., Susan-Resiga,D.,
            Roubtsova,A., Hamelin,J., Gerhardy,S., Kirchhofer,D.,
            Tagliabracci,V.S., Prat,A., Kiss,R.S. and Seidah,N.G.
  TITLE     Proprotein convertase 7 (PCSK7) reduces apoA-V levels
  JOURNAL   FEBS J 287 (16), 3565-3578 (2020)
   PUBMED   31945259
REFERENCE   3  (bases 1 to 3834)
  AUTHORS   Anyetei-Anum,E.N., Blum,A., Seidah,N.G. and Beinfeld,M.C.
  TITLE     Prohormone convertase 7 is necessary for the normal processing of
            cholecystokinin in mouse brain
  JOURNAL   Biochem Biophys Res Commun 482 (4), 1190-1193 (2017)
   PUBMED   27923657
  REMARK    GeneRIF: PC7 has a critical role in normal processing of
            cholecystokinin in mouse brain
REFERENCE   4  (bases 1 to 3834)
  AUTHORS   Bessonnard,S., Mesnard,D. and Constam,D.B.
  TITLE     PC7 and the related proteases Furin and Pace4 regulate E-cadherin
            function during blastocyst formation
  JOURNAL   J Cell Biol 210 (7), 1185-1197 (2015)
   PUBMED   26416966
  REMARK    GeneRIF: PC7 and the related proteases Furin and Pace4 regulate
            E-cadherin function during blastocyst formation.
REFERENCE   5  (bases 1 to 3834)
  AUTHORS   Wetsel,W.C., Rodriguiz,R.M., Guillemot,J., Rousselet,E.,
            Essalmani,R., Kim,I.H., Bryant,J.C., Marcinkiewicz,J.,
            Desjardins,R., Day,R., Constam,D.B., Prat,A. and Seidah,N.G.
  TITLE     Disruption of the expression of the proprotein convertase PC7
            reduces BDNF production and affects learning and memory in mice
  JOURNAL   Proc Natl Acad Sci U S A 110 (43), 17362-17367 (2013)
   PUBMED   24101515
  REMARK    GeneRIF: Data show that BDNF and PC7 mRNAs are colocalized in
            hippocampus and amygdala and that mature BDNF protein levels are
            reduced in these brain areas in proprotein convertase PC7 knockout
            mice.
REFERENCE   6  (bases 1 to 3834)
  AUTHORS   Villeneuve,P., Feliciangeli,S., Croissandeau,G., Seidah,N.G.,
            Mbikay,M., Kitabgi,P. and Beaudet,A.
  TITLE     Altered processing of the neurotensin/neuromedin N precursor in PC2
            knock down mice: a biochemical and immunohistochemical study
  JOURNAL   J Neurochem 82 (4), 783-793 (2002)
   PUBMED   12358783
REFERENCE   7  (bases 1 to 3834)
  AUTHORS   Constam,D.B. and Robertson,E.J.
  TITLE     Regulation of bone morphogenetic protein activity by pro domains
            and proprotein convertases
  JOURNAL   J Cell Biol 144 (1), 139-149 (1999)
   PUBMED   9885250
REFERENCE   8  (bases 1 to 3834)
  AUTHORS   Yamazaki,K., Mizui,Y., Sagane,K. and Tanaka,I.
  TITLE     Assignment of a disintegrin and metalloproteinase domain 10
            (Adam10) gene to mouse chromosome 9
  JOURNAL   Genomics 46 (3), 528-529 (1997)
   PUBMED   9441766
REFERENCE   9  (bases 1 to 3834)
  AUTHORS   Constam,D.B., Calfon,M. and Robertson,E.J.
  TITLE     SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone
            morphogenetic proteins at distinct sites during embryogenesis
  JOURNAL   J Cell Biol 134 (1), 181-191 (1996)
   PUBMED   8698813
REFERENCE   10 (bases 1 to 3834)
  AUTHORS   Seidah,N.G., Hamelin,J., Mamarbachi,M., Dong,W., Tardos,H.,
            Mbikay,M., Chretien,M. and Day,R.
  TITLE     cDNA structure, tissue distribution, and chromosomal localization
            of rat PC7, a novel mammalian proprotein convertase closest to
            yeast kexin-like proteinases
  JOURNAL   Proc Natl Acad Sci U S A 93 (8), 3388-3393 (1996)
   PUBMED   8622945
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056456.1 and AK148416.1.
            
            On Aug 12, 2006 this sequence version replaced NM_008794.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U48830.1, AK148416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1572              BC056456.1         1-1572
            1573-3811           AK148416.1         1158-3396
            3812-3834           BC056456.1         3886-3908
FEATURES             Location/Qualifiers
     source          1..3834
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.32 cM"
     gene            1..3834
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /note="proprotein convertase subtilisin/kexin type 7"
                     /db_xref="GeneID:18554"
                     /db_xref="MGI:MGI:107421"
     exon            1..471
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            472..595
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            596..1072
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             608..2920
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /EC_number="3.4.21.-"
                     /note="prohormone convertase PC7; proprotein convertase
                     PC7; subtilisin/kexin-like protease PC7; subtilisin-like
                     proprotein convertase 7; prohormone convertase 7"
                     /codon_start=1
                     /product="proprotein convertase subtilisin/kexin type 7
                     precursor"
                     /protein_id="NP_032820.2"
                     /db_xref="CCDS:CCDS40609.1"
                     /db_xref="GeneID:18554"
                     /db_xref="MGI:MGI:107421"
                     /translation="MPKGRQKVPHLDAHLGLPICLWLELAIFFLVPQVMGLSEAGGLD
                     ILGTGGLSWAVHLDSLEGERKEESLTQQADAVAQAAGLVNAGRIGELQGHYLFVQPTG
                     HRQAMEVEAMRQQAEAVLARHEAVRWHSEQTLLKRAKRSIHFNDPKYPQQWHLNNRRS
                     PGRDINVTGVWERNVTGRGVTVVVVDDGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPH
                     PDEENGNHHGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKH
                     YQINDIYSCSWGPDDDGKTVDGPHQLGKAALQHGVMAGRQGFGSIFVVASGNGGQHND
                     NCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQ
                     KGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWRDVQHIIVFTAIQYEDHHADWLT
                     NEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVSPMLKENKAVPRSPHSLEVL
                     WNVSRTDLEMSGLKTLEHVAVTVSITHPRRGSLELKLFCPSGMMSLIGAPRSMDSDPN
                     GFNAWTFSTVRCWGERARGVYRLVIRDVGDEPLQMGILQQWQLTLYGSMWSPVDIKDR
                     QSLLESAMSGKYLHDGFTLPCPPGLKIPEEDGYTITPNTLKTLVLVGCFSVFWTIYYM
                     LEVCLSQRNKASTHGCRKGCCPWAPRRQNSKDAGTALESMPLCSSKDLDGVDSEHGDC
                     TTASSFLAPELDCPPHQPPDLLQGKSGQIC"
     exon            1073..1207
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1373
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1464
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1519
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1658
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1759
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1927
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2035
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2138
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2295
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2390
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2484
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2602
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..3815
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3787..3792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /note="hexamer: AATAAA"
     polyA_site      3815
                     /gene="Pcsk7"
                     /gene_synonym="PC7; SPC7"
                     /note="major polyA site"
ORIGIN      
        1 agccctgaga cccaagcgga gcccgaggga cacgcgggcc agagagacgg cggccggatg
       61 gaggcgagag cctctctgag gagtttatgg ggaagagtca aggctatggc agtccgacgg
      121 agaagagccg cgaggggtgt ttagaggtcg gaaccgggat ggtccttaca gaggacgcca
      181 tgaaggacga gggccctgtg gcggaggggg tcctgtggcg gaggacacga ggattcgagg
      241 cgccggaact cccacagccc tcacgggcct gtgacagaag ctgtcggcgg agcgcccgga
      301 gctcggcccg ctggtcaaga ggccgcaggc ccagccgctg attggctgcg gcgccgggcg
      361 gaagtgatgt cgctgtcagt ggcgcctccg gctccgggga agccgagagt ttccgtaggg
      421 tgggggctgc ggcggcagca gcagcagcga cagtagcaac agaggctgtg ggtctgcagc
      481 tgtgttccca gtcgacactc actgctcaca gtgaaggtga catctccctc cattttcaca
      541 agatgagtgt ggtatggtta cccaggccag gacctaaact tcacagagag cccagcctgc
      601 tgttctgatg ccgaaaggga ggcagaaagt cccacacttg gatgcccacc tgggcctgcc
      661 catctgcctc tggctggaat tagccatctt ctttctggtt ccccaggtca tgggcctatc
      721 agaggcaggt gggcttgaca tcttgggcac aggggggctg agctgggccg tacatctgga
      781 cagcctagaa ggtgagagga aggaagagag tctgacgcaa caggccgatg ctgtggccca
      841 ggcagcaggg cttgtgaatg ctgggcgcat tggagaactc caggggcact acctctttgt
      901 ccagcctact gggcataggc aagccatgga ggtggaggcc atgcggcaac aggcagaggc
      961 tgtgttagcc aggcatgaag ctgtgcgctg gcactcggag caaacgctgc tgaagagggc
     1021 caagcgcagt atccacttca atgatcccaa gtaccctcaa cagtggcacc tgaataatcg
     1081 gcggagccca ggaagagaca tcaatgtgac aggtgtgtgg gagcgaaatg taactgggcg
     1141 tggggtgaca gtggtggtgg tggatgacgg agtggaacac accgtccagg acatcgcacc
     1201 caactacagt ccagagggaa gttatgacct caactctaat gacccagatc ccatgcccca
     1261 ccctgatgag gagaatggta accaccatgg gacccggtgt gcaggagaaa ttgcagctgt
     1321 gcccaacaac agcttctgtg cagtgggtgt ggcctacggg agccgaatag caggtatccg
     1381 ggtgctggat ggaccactta ctgacagtat ggaggctgtg gcgttcaaca agcactatca
     1441 gatcaatgac atctacagct gcagctgggg cccagatgat gatgggaaga cagtggatgg
     1501 tcctcatcag ctcggaaagg ctgccttaca acatggagtg atggctggtc gccaaggctt
     1561 tggaagtatc tttgtggttg ccagtggtaa tgggggccag cacaatgaca actgcaacta
     1621 tgatggctat gccaactcca tctacactgt caccatagga gctgtggatg aggagggacg
     1681 gatgcctttt tatgcagagg agtgtgcctc catgctggca gtcaccttca gtggtggaga
     1741 caagatgctg cggagcattg tgaccactga ctgggacctt cagaagggca ctggctgcac
     1801 tgaaggccac acaggaacct cagctgcagc tcctctggca gctggaatga tagccctcat
     1861 gctgcaggtg cggccctgcc tcacatggcg ggatgtacag cacataattg tcttcacagc
     1921 catccagtat gaagatcatc atgcagactg gctcaccaat gaggctggct tcagccacag
     1981 ccatcagcat ggtttcggcc tgctcaacgc ttggagactt gtcaatgcag ccaagatctg
     2041 gacatctgtc ccttacttag cctcctatgt cagccccatg ctgaaagaaa ataaggctgt
     2101 tccgaggtcc ccccactctc tggaggtgct atggaatgtc agcaggacgg acctggagat
     2161 gtcggggctg aagaccttgg aacatgtggc agtgacagtc tccatcactc acccacgacg
     2221 tggcagctta gaactgaaac tgttttgtcc cagtggcatg atgtctttga tcggcgcgcc
     2281 ccgcagcatg gactcggatc ctaatggctt caatgcttgg accttttcca ctgtgcggtg
     2341 ctggggggaa agagcaagag gcgtctacag actggttatc agggatgtag gagatgagcc
     2401 gctccagatg ggcatcctcc agcagtggca gctgaccctg tatggctcca tgtggagtcc
     2461 agtagacatc aaggacagac aaagtctctt agaaagtgct atgagtggaa aatacctgca
     2521 tgatggcttc accctgcctt gcccacctgg gctgaaaatc cctgaggagg atggctacac
     2581 cattacccct aacacactca agacccttgt gctggtaggc tgcttcagtg tcttctggac
     2641 tatttactac atgctagaag tgtgcctgag ccagaggaac aaggcttcca cccatggctg
     2701 caggaaggga tgctgcccct gggccccacg aaggcaaaac tccaaggatg cagggacagc
     2761 actagaatca atgccactgt gcagcagcaa ggacctggat ggagtggatt cagagcatgg
     2821 ggactgcaca actgcatcta gcttcctggc cccagagctg gattgtcctc cacaccaacc
     2881 cccagacctg ctgcagggga agagcgggca gatttgctga ccccagagcc cagcttcccc
     2941 catgtacaac aggcacttcc taaactcggt tatgaggctt tcaatcgtgg aagctcagga
     3001 gggaatggtc ctgatagtga catctgggac cccaggcctc tgaagcattt gcagcctcct
     3061 caggagggtg agggccatct taatgcagtg gtaagggact ggtgatcatg gcttctctag
     3121 ctgaacttgg ctgagaacct ttgacaaggg attggcacca agaccaggca gcccttgatt
     3181 tcctcgctct ctggagctag tcagtgtcct agaccaccag gacctctact cattcatgag
     3241 ttagttatgc agcaagtccc tatataccta gaaatgctct tgtcagaagt gtcactgcca
     3301 agggaccaga gagaggctgc taagagcctg gacatgccta ccctgaaagc agctgccttc
     3361 attacccttt tctgtgcgcc tgttctgaag ccaacttaaa cctgtccaca tcttcactac
     3421 cattcgccct ttctgctgaa ggaatggtga cgtgttccca ggagaactgg gaggcacagg
     3481 attcccagca cccttgctgc ctcattgggg aagttggcca gctggacttc agagagctaa
     3541 gacacagcat tttcaaagat agcctgggag cactgtctct gaccacctgt cttcctctgc
     3601 accgtgctca gggaaatggc cttcattcca gaggccagct gtctgcctga cttttcctcc
     3661 gttcttggcc ttctcccctt cccatcttct gagctaattg ttaatatgaa ttttttaatg
     3721 cttaagattt gatttttact tttcaaagca acattttgtt gaattttttt ctgcacagct
     3781 ttccaaaata aaaagcagaa gtataaaaac ccaaaaaaaa aaaaaaaaaa aaaa
//
