LOCUS       NM_011048               4298 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus proprotein convertase subtilisin/kexin type 6 (Pcsk6),
            transcript variant 1, mRNA.
ACCESSION   NM_011048 XM_355911 XM_886136 XM_905687 XM_919493
VERSION     NM_011048.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4298)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4298)
  AUTHORS   Mohammad,A.H., Couture,F., Gamache,I., Chen,O., El-Assaad,W.,
            Abdel-Malak,N., Kwiatkowska,A., Muller,W., Day,R. and Teodoro,J.G.
  TITLE     Cleavage of the V-ATPase associated prorenin receptor is mediated
            by PACE4 and is essential for growth of prostate cancer cells
  JOURNAL   PLoS One 18 (7), e0288622 (2023)
   PUBMED   37463144
  REMARK    GeneRIF: Cleavage of the V-ATPase associated prorenin receptor is
            mediated by PACE4 and is essential for growth of prostate cancer
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4298)
  AUTHORS   Mei,X., Zhou,H., Song,Z., Yang,X., Liu,X., Fei,J., Shen,Y. and
            Wang,X.
  TITLE     PCSK6 mediates Th1 differentiation and promotes chronic colitis
            progression and mucosal barrier injury via STAT1
  JOURNAL   Aging (Albany NY) 15 (10), 4363-4373 (2023)
   PUBMED   37211384
  REMARK    GeneRIF: PCSK6 mediates Th1 differentiation and promotes chronic
            colitis progression and mucosal barrier injury via STAT1.
REFERENCE   4  (bases 1 to 4298)
  AUTHORS   Wu,Q. and Chen,S.
  TITLE     Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology
            and Disease
  JOURNAL   Int J Mol Sci 23 (21), 13429 (2022)
   PUBMED   36362216
  REMARK    GeneRIF: Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular
            Biology and Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4298)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4298)
  AUTHORS   Mbikay,M., Seidah,N.G., Chretien,M. and Simpson,E.M.
  TITLE     Chromosomal assignment of the genes for proprotein convertases PC4,
            PC5, and PACE 4 in mouse and human
  JOURNAL   Genomics 26 (1), 123-129 (1995)
   PUBMED   7782070
REFERENCE   7  (bases 1 to 4298)
  AUTHORS   Johnson,R.C., Darlington,D.N., Hand,T.A., Bloomquist,B.T. and
            Mains,R.E.
  TITLE     PACE4: a subtilisin-like endoprotease prevalent in the anterior
            pituitary and regulated by thyroid status
  JOURNAL   Endocrinology 135 (3), 1178-1185 (1994)
   PUBMED   8070361
REFERENCE   8  (bases 1 to 4298)
  AUTHORS   Seidah,N.G., Chretien,M. and Day,R.
  TITLE     The family of subtilisin/kexin like pro-protein and pro-hormone
            convertases: divergent or shared functions
  JOURNAL   Biochimie 76 (3-4), 197-209 (1994)
   PUBMED   7819324
  REMARK    Review article
REFERENCE   9  (bases 1 to 4298)
  AUTHORS   Nakagawa,T., Murakami,K. and Nakayama,K.
  TITLE     Identification of an isoform with an extremely large Cys-rich
            region of PC6, a Kex2-like processing endoprotease
  JOURNAL   FEBS Lett 327 (2), 165-171 (1993)
   PUBMED   8335106
REFERENCE   10 (bases 1 to 4298)
  AUTHORS   Steiner,D.F., Smeekens,S.P., Ohagi,S. and Chan,S.J.
  TITLE     The new enzymology of precursor processing endoproteases
  JOURNAL   J Biol Chem 267 (33), 23435-23438 (1992)
   PUBMED   1429684
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165968.3, AC132595.3 and AC148973.4.
            
            On or before Jul 2, 2009 this sequence version replaced
            XM_919493.2, XM_905687.2, XM_355911.4, XM_886136.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1255436.1,
                                           SRR7652917.177905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               AC165968.3         32591-32898         c
            309-413             AC132595.3         15578-15682         c
            414-518             AC148973.4         45702-45806
            519-662             AC148973.4         46324-46467
            663-739             AC148973.4         47615-47691
            740-828             AC148973.4         50185-50273
            829-1001            AC148973.4         71427-71599
            1002-1214           AC148973.4         77605-77817
            1215-1315           AC148973.4         81412-81512
            1316-1419           AC148973.4         87476-87579
            1420-1537           AC148973.4         89050-89167
            1538-1726           AC148973.4         98655-98843
            1727-1863           AC148973.4         102221-102357
            1864-2043           AC148973.4         143736-143915
            2044-2082           AC148973.4         144074-144112
            2083-2185           AC148973.4         150257-150359
            2186-2382           AC148973.4         152258-152454
            2383-2470           AC148973.4         153689-153776
            2471-2574           AC148973.4         157489-157592
            2575-2704           AC148973.4         162023-162152
            2705-2817           AC148973.4         166065-166177
            2818-4298           AC148973.4         167414-168894
FEATURES             Location/Qualifiers
     source          1..4298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 35.36 cM"
     gene            1..4298
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /note="proprotein convertase subtilisin/kexin type 6"
                     /db_xref="GeneID:18553"
                     /db_xref="MGI:MGI:102897"
     exon            1..308
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2915
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paired basic amino acid cleaving system 4"
                     /codon_start=1
                     /product="proprotein convertase subtilisin/kexin type 6
                     isoform 1 isoform 1"
                     /protein_id="NP_035178.1"
                     /db_xref="CCDS:CCDS52267.1"
                     /db_xref="GeneID:18553"
                     /db_xref="MGI:MGI:102897"
                     /translation="MPPRAPPAPGPRPPPRAADVARGAGAAGRHGLPPLALRPWRWLL
                     LLALPAACSALPPPRPVYTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFY
                     HSKTFKRSTLSSRGPHTFLRMDPQVKWLQQQEVKRRVKRQARSDSLYFNDPIWSNMWY
                     MHCTDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVN
                     GNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDV
                     VEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWA
                     SGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGAFYERK
                     IVTTDLRQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHLKA
                     SDWKVNGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHVCVATADKRPRSIPIVQV
                     LRTTALTNACADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLL
                     DFSNEGFTNWEFMTVHCWGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTAE
                     HPYRTFSSHQSRSRMLELSVPEQEPPKAAGQPPQAETPEDEEEYTAPSIQGSPNTLQT
                     SVCHPECGDKGCDGPNADQCLNCVHFSLGNSKTNRKCVSECPLGYFGDAAARRCRRCH
                     KGCETCTGRSPAQCLSCRRGFYHHQETNTCVTLCPAGLYADESQRLCLRCHPSCQKCV
                     DEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELVKCGECHHTCRTCVGPSREECIHC
                     AKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCEENCLSCEGSSRNCSRCKAGFTQ
                     LGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQFCCRTCLLAG"
     exon            309..413
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            414..518
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            519..662
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            663..739
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            740..828
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1001
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1214
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1315
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1419
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1537
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1726
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1863
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2043
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2082
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2185
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2382
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2470
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2574
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2704
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2817
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..4298
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4228..4233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /note="hexamer: AATAAA"
     polyA_site      4255
                     /gene="Pcsk6"
                     /gene_synonym="b2b2830Clo; Pace4; SPC4"
                     /note="major polyA site"
ORIGIN      
        1 tcgccgctcg ggcgccgcgc gagcctgccg ctgccatgcc tccgcgcgcg ccgccagcgc
       61 ccgggccccg gccgccgccc cgggccgccg atgtcgcgcg gggcgcaggg gccgccggcc
      121 ggcacggact cccgccgctc gcgctgcgcc cctggcgttg gctgcttctg ctcgcgctgc
      181 ccgccgcctg ctccgcgctg ccgccgccgc gccccgtcta caccaaccac tgggcagtgc
      241 aagtgctggg cggccccggc gcggcggacc gcgtggctgc ggcgcacggc tacctcaact
      301 tgggccagat tggaaacctg gacgattact atcattttta ccacagcaag accttcaaga
      361 gatcgacctt gagcagcagg ggcccccaca ccttcctcag aatggaccca caggtaaaat
      421 ggctgcaaca acaggaagtg aagcgcagag tcaagagaca ggcgcgaagt gactctcttt
      481 atttcaatga tcccatttgg tctaacatgt ggtacatgca ttgtactgat aagaacagtc
      541 gctgtcggtc agagatgaac gtccaggcgg cgtggaagcg tggctacaca ggaaagaatg
      601 tggtcgtcac catcctcgat gacggcatag aaaggaatca cccagacctg gcccccaact
      661 acgattccta tgcaagctac gatgtcaatg gaaatgatta tgacccatcc ccgagatatg
      721 acgccagcaa cgagaacaaa catggcactc gctgtgcggg tgaagtcgct gcctcggcca
      781 acaactccta ctgcatcgtg ggcatcgcat ataatgcaaa gataggaggc atccggatgc
      841 tggacggcga tgtgaccgat gtggtggagg ccaagtctct gggcatcaga cccaactaca
      901 ttgacattta cagcgccagt tggggacccg atgatgacgg aaagacagta gatggaccag
      961 gccggctggc taaacaagct ttcgagtatg gcattaaaaa gggtcgccaa ggtctgggct
     1021 ccatttttgt ttgggcctct gggaatggtg ggagagaagg ggaccactgc tcctgtgatg
     1081 gctacaccaa cagcatctac accatctccg taagcagcac cactgagaac ggccacaaac
     1141 cctggtacct ggaagaatgc gcttccacgt tggctaccac ctacagcagc ggggccttct
     1201 atgaacggaa gatcgtcacc acagatctgc gtcagcgctg caccgacggc cacactggga
     1261 catcagtctc agcccccatg gtggctggta tcattgcctt ggctctagaa gcaaacaacc
     1321 agttgacctg gagggatgtg cagcacctgc tggtgaagac atcacggcca gctcatctga
     1381 aggcgagcga ctggaaagtc aacggagctg ggcataaagt tagccatctc tatggatttg
     1441 gcttggtgga tgcagaagct ctggtcctgg aggcgaggaa gtggacggca gtgccctccc
     1501 agcacgtatg cgtggccacc gcagacaaaa ggcccaggag catccccata gtgcaggtgc
     1561 tacggaccac agccctgacc aacgcctgtg cggaccactc agaccagcgt gtggtgtacc
     1621 tggagcatgt ggttgtccga atctctatct cacacccacg ccggggcgat ctccagatcc
     1681 acctgatttc tccctctgga accaagtctc aacttttggc aaagagattg ctggattttt
     1741 ccaatgaggg gttcacaaac tgggaattca tgaccgtcca ctgctgggga gaaaaggctg
     1801 aaggggagtg gactctggaa gtgcaggata taccatcgca ggtccgaaac ccagagaaac
     1861 aaggaaagct gaaagaatgg agcctcattt tatatggcac cgcagagcac ccatatcgca
     1921 ccttcagctc ccatcagtct cgctcacgga tgctggagct ctccgtcccg gagcaggagc
     1981 ctcccaaggc tgctggacaa ccaccccagg cagagactcc agaagacgag gaagagtaca
     2041 cagctccttc catccaaggc tctcctaata ctttacagac cagtgtgtgc catcccgagt
     2101 gtggtgacaa aggctgtgat ggtcccaatg cagaccagtg cttgaactgt gtccacttca
     2161 gcctggggaa ctccaagaca aacaggaagt gtgtgagcga gtgccccttg ggctactttg
     2221 gggatgcagc tgcaagacgc tgccgtcgct gccataaggg atgtgagacg tgcacgggca
     2281 ggagcccagc acagtgcctg tcttgtcgcc gtgggttcta tcaccaccag gagacgaaca
     2341 cgtgtgtgac cctctgtcct gccggacttt atgctgatga aagtcagaga ctctgcctca
     2401 ggtgccaccc gagctgtcag aagtgcgtgg atgaacctga gaagtgcact gtgtgtaagg
     2461 agggattcag cctggcacgg ggcagctgca ttccggactg tgaaccgggt acctacttcg
     2521 attcagagct cgtcaaatgt ggggaatgcc atcacacctg ccggacctgt gtggggccca
     2581 gcagagaaga gtgtattcac tgtgcaaaaa gcttccactt ccaagactgg aaatgtgtgc
     2641 cggcctgcgg tgagggcttc tacccggagg agatgcctgg cttaccccac aaagtgtgtc
     2701 gaagatgtga ggagaactgc ctgagctgcg agggctccag taggaactgc agcagatgta
     2761 aagccggctt cacacagctg ggaacctcct gcatcaccaa ccacacgtgc agcaatgccg
     2821 atgagacctt ctgcgagatg gtgaagtcca atcggctctg cgaacggaag ctcttcatcc
     2881 agttttgctg ccgcacctgc ctcctggctg ggtaggggca ccagctgccc gcagagggca
     2941 gggtcctcct gtctgcccgt ttgcccatct accttcctac agatggtcag ccatagcctg
     3001 ttccttgggg tagccctgca tctgacagct gtatctcccc cagagctggg ttctactgca
     3061 gcatctctga gcacctgaac aggtggaggt ggcccttaag gatatgtggc taaattgaca
     3121 aaaatcccct tgaactctgc ttgctggctg cagtctaaag ttggactcaa aacaggaaca
     3181 aaaatgaatt gtgagactca tacctgcagc ttcggagtgg cttctgggac cctagtttac
     3241 tgagacttca agaccaaagc agaaaaagcg agatgcctgg cgtcacatca cgtcctcctc
     3301 ccacatatct gtgtggccgt gacaaatctc agcgagtcgg ctggcaggac cctatgctgc
     3361 cctcacctat gatgaagggc ctcgcttcct ccctgtgcat cactggccac caaacagccg
     3421 gagggacagt ttgatcggac tgtaaataaa atgggtttca gggcataaga tgtatgacca
     3481 ctagagagag aatctatgtc tacgcagtca gctccttccg aaacggcagc cccggcctgg
     3541 acggcctagc accaaaccga aataggtcca ctcatcctct cttcagcgtt ctcttctgag
     3601 tgagccgagc tgtccacatg gctgttctac ctgtgtccct ggggcctcct gggcccgagc
     3661 caccagccat ctacagctac agagcctgtg aaggaggatc caaaggagct acttaggatt
     3721 agccaaaaga catctgatgg ccaggcagtt ccataaacat gcaaagccag cccctgaatc
     3781 actagtcgcc agccctccat ggcacacaac tgcttttcaa gtgtatttgg cctctgcact
     3841 cgggactctc tgttcttggg tggatgctgc gctggtccag tatggtacaa gcctacatga
     3901 tagagctgga ttgatttttc tgccaagcct gtgtgggcat tttataagct acgtgttcta
     3961 atttttaccg atgttaatta ttttgacaaa tatttcatat attttcattg aaatgcgcaa
     4021 atccgcttgc tcagttccct gagctaaggg aataacactt gccttaaatt tccccaacct
     4081 cgtctctctc cacatggtcc tgctctcctc tctgactgta atgtgtttgt cttgtcacct
     4141 gtaggtggca aggactcagc tgttgtctgt tgaatccaca cttcaaataa gaaatcagtg
     4201 aagcaaatct aatgttaacc ctgagttaat aaaagagtta acatcccatt gcaaaggggc
     4261 ttgtatttct tttcaagata aataaaactt tgagcctc
//
