LOCUS       NM_008792               4766 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus proprotein convertase subtilisin/kexin type 2 (Pcsk2),
            mRNA.
ACCESSION   NM_008792
VERSION     NM_008792.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4766)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 4766)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4766)
  AUTHORS   Lu,C., Zhang,J., Wang,B., Gao,Q., Ma,K., Pei,S., Li,J. and Cui,S.
  TITLE     Casein kinase 1alpha is required to maintain murine hypothalamic
            pro-opiomelanocortin expression
  JOURNAL   iScience 26 (5), 106670 (2023)
   PUBMED   37168577
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4766)
  AUTHORS   Callon,D., Guedra,A., Lebreil,A.L., Heng,L., Bouland,N., Fornes,P.,
            Berri,F. and Andreoletti,L.
  TITLE     Replication Activities of Major 5' Terminally Deleted Group-B
            Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing
            Insulin Maturation in Pancreatic Beta Cells
  JOURNAL   Viruses 14 (12), 2781 (2022)
   PUBMED   36560784
  REMARK    GeneRIF: Replication Activities of Major 5' Terminally Deleted
            Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression
            Impairing Insulin Maturation in Pancreatic Beta Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4766)
  AUTHORS   Dowsett,G.K.C., Lam,B.Y.H., Tadross,J.A., Cimino,I., Rimmington,D.,
            Coll,A.P., Polex-Wolf,J., Knudsen,L.B., Pyke,C. and Yeo,G.S.H.
  TITLE     A survey of the mouse hindbrain in the fed and fasted states using
            single-nucleus RNA sequencing
  JOURNAL   Mol Metab 53, 101240 (2021)
   PUBMED   33962048
  REMARK    GeneRIF: A survey of the mouse hindbrain in the fed and fasted
            states using single-nucleus RNA sequencing.
REFERENCE   6  (bases 1 to 4766)
  AUTHORS   Steiner,D.F., Smeekens,S.P., Ohagi,S. and Chan,S.J.
  TITLE     The new enzymology of precursor processing endoproteases
  JOURNAL   J Biol Chem 267 (33), 23435-23438 (1992)
   PUBMED   1429684
  REMARK    Review article
REFERENCE   7  (bases 1 to 4766)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Chretien,M., Seidah,N.G. and
            Jenkins,N.A.
  TITLE     Regional localization of three convertases, PC1 (Nec-1), PC2
            (Nec-2), and furin (Fur), on mouse chromosomes
  JOURNAL   Genomics 13 (4), 1356-1358 (1992)
   PUBMED   1354647
REFERENCE   8  (bases 1 to 4766)
  AUTHORS   Seidah,N.G., Mattei,M.G., Gaspar,L., Benjannet,S., Mbikay,M. and
            Chretien,M.
  TITLE     Chromosomal assignments of the genes for neuroendocrine convertase
            PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2)
            to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region)
  JOURNAL   Genomics 11 (1), 103-107 (1991)
   PUBMED   1765368
REFERENCE   9  (bases 1 to 4766)
  AUTHORS   Smeekens,S.P., Avruch,A.S., LaMendola,J., Chan,S.J. and
            Steiner,D.F.
  TITLE     Identification of a cDNA encoding a second putative prohormone
            convertase related to PC2 in AtT20 cells and islets of Langerhans
  JOURNAL   Proc Natl Acad Sci U S A 88 (2), 340-344 (1991)
   PUBMED   1988934
REFERENCE   10 (bases 1 to 4766)
  AUTHORS   Seidah,N.G., Marcinkiewicz,M., Benjannet,S., Gaspar,L.,
            Beaubien,G., Mattei,M.G., Lazure,C., Mbikay,M. and Chretien,M.
  TITLE     Cloning and primary sequence of a mouse candidate prohormone
            convertase PC1 homologous to PC2, Furin, and Kex2: distinct
            chromosomal localization and messenger RNA distribution in brain
            and pituitary compared to PC2
  JOURNAL   Mol Endocrinol 5 (1), 111-122 (1991)
   PUBMED   2017186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158598.1, BC057348.1 and AL807801.3.
            
            On Apr 22, 2009 this sequence version replaced NM_008792.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057348.1, AK133620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AK158598.1         63-308
            247-2587            BC057348.1         202-2542
            2588-2588           AL807801.3         31220-31220
            2589-4766           BC057348.1         2543-4720
FEATURES             Location/Qualifiers
     source          1..4766
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 70.89 cM"
     gene            1..4766
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /note="proprotein convertase subtilisin/kexin type 2"
                     /db_xref="GeneID:18549"
                     /db_xref="MGI:MGI:97512"
     exon            1..532
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2272
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /EC_number="3.4.21.94"
                     /note="neuroendocrine convertase 2; proprotein convertase
                     2; NEC 2; KEX2-like endoprotease 2; prohormone convertase
                     2"
                     /codon_start=1
                     /product="neuroendocrine convertase 2 precursor"
                     /protein_id="NP_032818.1"
                     /db_xref="CCDS:CCDS16810.1"
                     /db_xref="GeneID:18549"
                     /db_xref="MGI:MGI:97512"
                     /translation="MEGGCGSQWKAAGFLFCVMVFASAERPVFTNHFLVELHKDGEEE
                     ARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPRIKMALQQEG
                     FDRKKRGYRDINEIDINMNDPLFTKQWYLFNTGQADGTPGLDLNVAEAWELGYTGKGV
                     TIGIMDDGIDYLHPDLAYNYNADASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAA
                     ASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKT
                     VDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAI
                     NDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGV
                     FALALEANLDLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGA
                     MVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKLVLTLKTNACEGKENFVRYLEHVQA
                     VITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGT
                     WTLELGFVGSAPQKGLLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKQELEEELDE
                     AVERSLQSILRKN"
     exon            533..637
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            638..751
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..860
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..898
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            899..975
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1064
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1240
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1456
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1557
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1785
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..4745
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /note="hexamer: AATATA"
     polyA_site      2491
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /note="major polyA site"
     regulatory      4723..4728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /note="hexamer: AATAAA"
     polyA_site      4745
                     /gene="Pcsk2"
                     /gene_synonym="6330411F23Rik; Nec-2; Nec2; PC2; Phpp-2;
                     SPC2"
                     /note="major polyA site"
ORIGIN      
        1 agaattggag ccgaggagga gctgaaaatg cagatttagc atcaagcaca gacacacact
       61 agctctttct ctcgggtaca cacagctccg cacattcgca cccctgccag ccagccgggc
      121 tgcgcgactc cccggcttcc ctggcagcca gctgctggtg gacagcgtac agatttgctg
      181 tttgccaagc ttcttttctg cctcttttgc tatacaaaga tttttttttt taaaaaaaaa
      241 aaaaaagaaa aacagaaaca aaaactacat acctattttt tatttgcatc ttccctcttc
      301 gtcccctgct ccaccaccct gcgcgcctca cagccccact tttcactccc aaagaaggat
      361 ggagggcggt tgtggatccc agtggaaggc ggccgggttc ctcttctgtg tgatggtttt
      421 tgcgtctgcc gagagacccg tcttcacgaa tcattttctt gtggagttgc ataaagacgg
      481 agaggaagag gctcgccaag ttgcagcaga acacggcttt ggagtccgaa agctcccctt
      541 tgcagaaggc ctgtatcact tttatcacaa tgggcttgca aaggccaaaa gaagacgcag
      601 cctacaccat aagcggcagc tagagagaga ccccaggata aagatggcgc tgcaacaaga
      661 aggatttgac cgtaaaaaga gagggtacag ggacatcaat gagattgaca tcaacatgaa
      721 tgatcctctc tttacaaagc aatggtacct gttcaacact gggcaagccg atggaactcc
      781 tgggctagac ttgaacgtgg ccgaagcctg ggagctggga tacacaggaa aaggagtgac
      841 cattggaatt atggatgatg gaattgacta tctccaccca gacctggcct acaactacaa
      901 cgctgatgca agttatgact tcagcagcaa tgacccctac ccataccctc gatacacaga
      961 tgactggttc aacagccatg gaactaggtg tgcaggagaa gtttctgctg cagccagcaa
     1021 caatatctgt ggagtcggcg tagcatacaa ctccaaggtg gcagggatcc ggatgctgga
     1081 ccagcccttt atgacagaca tcatcgaagc ctcctccatc agccacatgc ctcaactgat
     1141 cgacatctac agtgcaagct ggggccccac agacaatggg aagacggttg atgggccccg
     1201 agagctcaca ctccaggcca tggctgatgg cgtgaacaag ggccgtgggg gcaaaggcag
     1261 catctatgtg tgggcctctg gggacggtgg cagctacgat gactgcaact gtgacggcta
     1321 tgcttcaagc atgtggacca tctccatcaa ctcagccatc aatgatggca ggactgcctt
     1381 gtatgatgag agttgctctt ccaccttagc atccaccttc agcaatggga ggaagaggaa
     1441 tcctgaggct ggtgtggcta ccacagactt gtatggcaac tgtactctga gacactctgg
     1501 gacatctgca gctgctccgg aggcagctgg cgtgtttgca ttagctttgg aggctaacct
     1561 ggatctgacc tggagagaca tgcaacatct gactgtgctc acctccaagc ggaaccagct
     1621 tcatgatgag gttcatcagt ggcgacggaa tggggttggc ctggaattta atcacctctt
     1681 tggctacgga gtccttgatg caggtgccat ggtgaaaatg gctaaagact ggaaaactgt
     1741 tccggagaga ttccattgtg tgggaggctc tgtgcagaac cctgaaaaaa taccacccac
     1801 cggcaagctg gtactgaccc tcaaaacaaa tgcatgtgag gggaaggaaa acttcgtccg
     1861 ctacctggag cacgtccaag ctgtcatcac agtcaacgcg accaggagag gagacctgaa
     1921 catcaacatg acctccccaa tgggcaccaa gtccattttg ctgagccggc gtcccagaga
     1981 cgacgactcc aaggtgggct ttgacaagtg gcctttcatg accacccaca cctgggggga
     2041 ggatgcccga gggacctgga ccctggagct ggggtttgtg ggcagtgcac cacagaaggg
     2101 gttgctgaag gaatggaccc tgatgcttca cggcacacag agcgccccat acatcgatca
     2161 ggtggtgagg gattaccagt ctaagctggc catgtccaag aagcaggagc tggaggaaga
     2221 gctggatgag gctgtggaga gaagcctgca aagtatcctg agaaagaact agggccacgc
     2281 ttccgccttc acctcccctt cctccccgtc tctgcctctc cttgctccac agttctggca
     2341 gccaccagcc acccagcaat tcctgttacc cccgacacaa gcaatcccag cctggtctca
     2401 agctttgctc gctgtcaatg attattttca ctacaatgga agcaaccgtt tttattctgt
     2461 agcccaaata tagcgttcct accaacatct atgtcctatg tgtgactcga cctttatttc
     2521 tgtcatgtaa atgggtggtt gtgctgcact tgaaaccagg aaagctctgc cctcgctttt
     2581 ttttttttct tttcctatct gagaagagaa gagaatgcat ctaaaaagcc acacatggtg
     2641 actcaagaat attcgtggcc tcagctgaga tgctgataga gagtgaactc cacagctcta
     2701 gcatgggggt tggagggtgg cttggattaa gcaagactag tcagggatgt aaactgaggt
     2761 gcctgatgag aaaagatgtg gtcccccagg gagccctgaa gcccaaatac tggacaggct
     2821 gaggaagttt aaaaggcacg agctttgaaa gtttaatccc tatacccaaa tcgtgtcccc
     2881 tctgctctgc caggatgaca taaaatggaa acacatggct cttctgtcac cagctactgc
     2941 tcttcactgg gactggaccc actggagcag ccaaaatgcc tcttacattg cctttatcca
     3001 cacacccgca gttttcaggt actctttaca cagccatcca agagagaaac taccaggtca
     3061 atctagctgc tgtctggcta agagcagttt accaatttta gaaataggag catccccttt
     3121 cctgagtggt tttagagttc cctgttatga cacaaccaag aggcaagagg tttttttggt
     3181 ttggtttggt ttggtttggt ttagttttga ttttgatttg gttttgacag tgtcacccac
     3241 accaaccagg gctttgattt cccaaaacta tcactggagt gcaatatctc cctccctcaa
     3301 gttgtaattt cactggtgtt ttggagaaat gagtcactgt ttgagaaggg gccagtggat
     3361 gaagggggca catcagaagg catgagttgc catacttatg tggacctcta gttgctagaa
     3421 gcttgttgca tggagagggg cccatgccac ctcattcccc ataactcgaa gccagaaggg
     3481 aagcaagaga caatctcttt caaaaaaaca catgttgtca ctttagcaac cacgagaata
     3541 tctagcaagc accccaaagg tgacagctgt caactttaaa agacatcgct tcattcccag
     3601 ttactatcta aagtaaccca ctgtcacttg gagtgcctgc ccaaggattg gcttcccact
     3661 cagatctcag tgtcccctgg tcctctcccc accctaggtt ctccccctcc cttccctgaa
     3721 gcatgtgcag agcctggagt ttctttgctg aagccagcaa ctcagaagca ctaaggttcc
     3781 gttcctgggg ggcgacttta ggagagaatt ctgggaagct tctttcattc cttttgtccc
     3841 ccattttagc ctggattttt tcttctctgg caccttgtaa cattccctgt gtcatgcttt
     3901 tgagtgtaat aatatttatg atttctaaaa gaaatttatt atttgttaca aaggtctgtt
     3961 taaaccacct tagatttaaa gaaaaaatgg caatcattga gaattcattt cacattaatg
     4021 gtctggaaat aaaaccaaag gacattctgt gtgcacatac acataaatgc acatagaaat
     4081 atatatatac atatgtagac tatatacatg tgtatatgtg tgtatatata cctgtataaa
     4141 tgtacataca cacatatacc taaatgtgtg tgtattctgt atgtattgaa gacacagacg
     4201 ccatatacat ctctaaaaga gtattcagaa aatatcaaaa tgattccggc tgagtagaag
     4261 gccggtagag attcaggtga aatgtctgtt catctcttcc catttatgac acctctgtaa
     4321 ttttgaagct ctctgtataa acattaattg tcttatatga gcagcagaaa tataaaatag
     4381 ttgtccatat tttcacattt gtggtataat ttatgaaatt agagagtaac ttatctgctt
     4441 cttaatagaa atggcaagtt ttgatatgag tatatagtat ataaagacaa atagtgctaa
     4501 gtgtaaatat ttggtctcta tttcaccttt ggcatcagta ttaacaccaa ctgtcaagct
     4561 agtgatgttt tttatgatgc ccctgagtct gatgcaagag acagtcattt attttaaaaa
     4621 ctgaaaagca agtgaataac aatcaggtta acattgttac tccctgtgac aagaattttt
     4681 aagtaaattt aaaaatatat gttgtaaatt aggaggctca acaataaaac ataccttccg
     4741 gaaaaaaaaa aaaaaaaaaa aaaaaa
//
