LOCUS       NM_001129804             465 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus Purkinje cell protein 2 (L7) (Pcp2), transcript
            variant 2, mRNA.
ACCESSION   NM_001129804
VERSION     NM_001129804.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 465)
  AUTHORS   Whittaker,D.E., Oleari,R., Gregory,L.C., Le Quesne-Stabej,P.,
            Williams,H.J., Torpiano,J.G., Formosa,N., Cachia,M.J., Field,D.,
            Lettieri,A., Ocaka,L.A., Paganoni,A.J., Rajabali,S.H.,
            Riegman,K.L., De Martini,L.B., Chaya,T., Robinson,I.C.,
            Furukawa,T., Cariboni,A., Basson,M.A. and Dattani,M.T.
  CONSRTM   GOSgene
  TITLE     A recessive PRDM13 mutation results in congenital hypogonadotropic
            hypogonadism and cerebellar hypoplasia
  JOURNAL   J Clin Invest 131 (24) (2021)
   PUBMED   34730112
REFERENCE   2  (bases 1 to 465)
  AUTHORS   Kojic,M., Gawda,T., Gaik,M., Begg,A., Salerno-Kochan,A.,
            Kurniawan,N.D., Jones,A., Drozdzyk,K., Koscielniak,A.,
            Chramiec-Glabik,A., Hediyeh-Zadeh,S., Kasherman,M., Shim,W.J.,
            Sinniah,E., Genovesi,L.A., Abrahamsen,R.K., Fenger,C.D.,
            Madsen,C.G., Cohen,J.S., Fatemi,A., Stark,Z., Lunke,S., Lee,J.,
            Hansen,J.K., Boxill,M.F., Keren,B., Marey,I., Saenz,M.S., Brown,K.,
            Alexander,S.A., Mureev,S., Batzilla,A., Davis,M.J., Piper,M.,
            Boden,M., Burne,T.H.J., Palpant,N.J., Moller,R.S., Glatt,S. and
            Wainwright,B.J.
  TITLE     Elp2 mutations perturb the epitranscriptome and lead to a complex
            neurodevelopmental phenotype
  JOURNAL   Nat Commun 12 (1), 2678 (2021)
   PUBMED   33976153
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 465)
  AUTHORS   Tsumagari,R., Maruo,K., Kakizawa,S., Ueda,S., Yamanoue,M.,
            Saito,H., Suzuki,N. and Shirai,Y.
  TITLE     Precise Regulation of the Basal PKCgamma Activity by DGKgamma Is
            Crucial for Motor Coordination
  JOURNAL   Int J Mol Sci 21 (21), 7866 (2020)
   PUBMED   33114041
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 465)
  AUTHORS   Luo,L., Ambrozkiewicz,M.C., Benseler,F., Chen,C., Dumontier,E.,
            Falkner,S., Furlanis,E., Gomez,A.M., Hoshina,N., Huang,W.H.,
            Hutchison,M.A., Itoh-Maruoka,Y., Lavery,L.A., Li,W., Maruo,T.,
            Motohashi,J., Pai,E.L., Pelkey,K.A., Pereira,A., Philips,T.,
            Sinclair,J.L., Stogsdill,J.A., Traunmuller,L., Wang,J., Wortel,J.,
            You,W., Abumaria,N., Beier,K.T., Brose,N., Burgess,H.A.,
            Cepko,C.L., Cloutier,J.F., Eroglu,C., Goebbels,S., Kaeser,P.S.,
            Kay,J.N., Lu,W., Luo,L., Mandai,K., McBain,C.J., Nave,K.A.,
            Prado,M.A.M., Prado,V.F., Rothstein,J., Rubenstein,J.L.R.,
            Saher,G., Sakimura,K., Sanes,J.R., Scheiffele,P., Takai,Y.,
            Umemori,H., Verhage,M., Yuzaki,M., Zoghbi,H.Y., Kawabe,H. and
            Craig,A.M.
  TITLE     Optimizing Nervous System-Specific Gene Targeting with Cre Driver
            Lines: Prevalence of Germline Recombination and Influencing Factors
  JOURNAL   Neuron 106 (1), 37-65 (2020)
   PUBMED   32027825
REFERENCE   5  (bases 1 to 465)
  AUTHORS   Zhuang,P., Zhang,H., Welchko,R.M., Thompson,R.C., Xu,S. and
            Turner,D.L.
  TITLE     Combined microRNA and mRNA detection in mammalian retinas by in
            situ hybridization chain reaction
  JOURNAL   Sci Rep 10 (1), 351 (2020)
   PUBMED   31942002
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 465)
  AUTHORS   Filie,J.D., Burbelo,P.D. and Kozak,C.A.
  TITLE     Genetic mapping of the alpha 1 and alpha 2 (IV) collagen genes to
            mouse chromosome 8
  JOURNAL   Mamm Genome 6 (7), 487 (1995)
   PUBMED   7579895
REFERENCE   7  (bases 1 to 465)
  AUTHORS   Vandaele,S., Nordquist,D.T., Feddersen,R.M., Tretjakoff,I.,
            Peterson,A.C. and Orr,H.T.
  TITLE     Purkinje cell protein-2 regulatory regions and transgene expression
            in cerebellar compartments
  JOURNAL   Genes Dev 5 (7), 1136-1148 (1991)
   PUBMED   2065970
REFERENCE   8  (bases 1 to 465)
  AUTHORS   Fletcher,C., Norman,D.J., Germond,E. and Heintz,N.
  TITLE     A multilocus linkage map of mouse chromosome 8
  JOURNAL   Genomics 9 (4), 737-741 (1991)
   PUBMED   2037298
REFERENCE   9  (bases 1 to 465)
  AUTHORS   Nordquist,D.T., Kozak,C.A. and Orr,H.T.
  TITLE     cDNA cloning and characterization of three genes uniquely expressed
            in cerebellum by Purkinje neurons
  JOURNAL   J Neurosci 8 (12), 4780-4789 (1988)
   PUBMED   3199205
REFERENCE   10 (bases 1 to 465)
  AUTHORS   Oberdick,J., Levinthal,F. and Levinthal,C.
  TITLE     A Purkinje cell differentiation marker shows a partial DNA sequence
            homology to the cellular sis/PDGF2 gene
  JOURNAL   Neuron 1 (5), 367-376 (1988)
   PUBMED   2483097
  REMARK    Erratum:[Neuron 1989 Sep;3(3):following 385]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170806.2.
            
            On Sep 3, 2019 this sequence version replaced NM_001129804.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB522989.1, BU534335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC170806.2         151443-151477       c
            36-150              AC170806.2         151227-151341       c
            151-275             AC170806.2         150949-151073       c
            276-465             AC170806.2         149810-149999       c
FEATURES             Location/Qualifiers
     source          1..465
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..465
                     /gene="Pcp2"
                     /gene_synonym="L7; Pcp-2"
                     /note="Purkinje cell protein 2 (L7)"
                     /db_xref="GeneID:18545"
                     /db_xref="MGI:MGI:97508"
     exon            1..35
                     /gene="Pcp2"
                     /gene_synonym="L7; Pcp-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..395
                     /gene="Pcp2"
                     /gene_synonym="L7; Pcp-2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Purkinje cell-specific protein L7; retinal Purkinje cell
                     protein 2; protein PCD-5"
                     /codon_start=1
                     /product="Purkinje cell protein 2 isoform 2"
                     /protein_id="NP_001123276.1"
                     /db_xref="CCDS:CCDS52470.1"
                     /db_xref="GeneID:18545"
                     /db_xref="MGI:MGI:97508"
                     /translation="MAGSPDQEGFFNLLTHVQGDRMEEQRCSLQAGPGQNPESQGGPA
                     PEMDNLMDMLVNTQGRRMDDQRVTVNSLPGFQPIGPKDGMQKRPGTLSPQPLLTPQDP
                     AALSFRRNSSPQPQTQAP"
     exon            36..150
                     /gene="Pcp2"
                     /gene_synonym="L7; Pcp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            151..275
                     /gene="Pcp2"
                     /gene_synonym="L7; Pcp-2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..465
                     /gene="Pcp2"
                     /gene_synonym="L7; Pcp-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      437..442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcp2"
                     /gene_synonym="L7; Pcp-2"
                     /note="hexamer: AATAAA"
     polyA_site      459
                     /gene="Pcp2"
                     /gene_synonym="L7; Pcp-2"
                     /note="major polyA site"
ORIGIN      
        1 atttagagaa attctgcaga cccgtgagga ctatggcagg ttcaccggac caggaaggct
       61 tcttcaacct gctgacccac gtgcagggcg atcggatgga ggagcagcgc tgttccttgc
      121 aggctgggcc aggccagaac ccagaaagcc agggtggccc tgctccagag atggacaatc
      181 tcatggatat gctggtcaac acccagggcc gccgcatgga cgaccagcgt gtaacagtta
      241 attccctgcc tggcttccaa cctatcggcc ccaaggatgg aatgcagaaa cgacctggga
      301 ccctcagccc tcaacccctg ctcacccctc aggatcctgc tgcactcagc ttccgcagga
      361 acagcagccc ccagccccag acacaagctc cttgagagtt ctagccatcc tgggcctccc
      421 actggcccct gaaaacaata aaacacttgg cactagcaac aaaga
//
