LOCUS       NM_008788               1539 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus procollagen C-endopeptidase enhancer protein (Pcolce),
            mRNA.
ACCESSION   NM_008788
VERSION     NM_008788.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1539)
  AUTHORS   Hsiao,Y.T., Yoshida,Y., Okuda,S., Abe,M., Mizuno,S., Takahashi,S.,
            Nakagami,H., Morishita,R., Kamimura,K., Terai,S., Aung,T.M., Li,J.,
            Furihata,T., Tang,J.Y., Walsh,K., Ishigami,A., Minamino,T. and
            Shimizu,I.
  TITLE     PCPE-1, a brown adipose tissue-derived cytokine, promotes
            obesity-induced liver fibrosis
  JOURNAL   EMBO J 43 (21), 4846-4869 (2024)
   PUBMED   39160276
REFERENCE   2  (bases 1 to 1539)
  AUTHORS   Sansilvestri Morel,P., Duvivier,V., Bertin,F., Provost,N.,
            Hammoutene,A., Hubert,E.L., Gonzalez,A., Tupinon-Mathieu,I.,
            Paradis,V. and Delerive,P.
  TITLE     Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice
            reduces liver fibrosis but not NASH progression
  JOURNAL   PLoS One 17 (2), e0263828 (2022)
   PUBMED   35148334
  REMARK    GeneRIF: Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in
            mice reduces liver fibrosis but not NASH progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1539)
  AUTHORS   Sansilvestri-Morel,P., Harouki-Crochemore,N., Bertin,F.,
            Bertheux,H., Vermeil de Conchard,G., Diguet,N., Desfosses,E.,
            Lecomte,M., Gonzalez,A., Diez,J., Tupinon-Mathieu,I. and
            Delerive,P.
  TITLE     Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice has No
            Major Impact on Cardiac Collagen and Function Under Basal
            Conditions
  JOURNAL   J Cardiovasc Pharmacol 78 (5), e703-e713 (2021)
   PUBMED   34369899
  REMARK    GeneRIF: Deficiency of Procollagen C-Proteinase Enhancer 1 in Mice
            has No Major Impact on Cardiac Collagen and Function Under Basal
            Conditions.
REFERENCE   4  (bases 1 to 1539)
  AUTHORS   Shpargel,K.B., Mangini,C.L., Xie,G., Ge,K. and Magnuson,T.
  TITLE     The KMT2D Kabuki syndrome histone methylase controls neural crest
            cell differentiation and facial morphology
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32541010
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1539)
  AUTHORS   Huang,G., Massoudi,D., Muir,A.M., Joshi,D.C., Zhang,C.L., Chiu,S.Y.
            and Greenspan,D.S.
  TITLE     WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for
            Mitochondrial Fusion
  JOURNAL   Cell Rep 20 (4), 923-934 (2017)
   PUBMED   28746876
REFERENCE   6  (bases 1 to 1539)
  AUTHORS   Takahara,K., Kessler,E., Biniaminov,L., Brusel,M., Eddy,R.L.,
            Jani-Sait,S., Shows,T.B. and Greenspan,D.S.
  TITLE     Type I procollagen COOH-terminal proteinase enhancer protein:
            identification, primary structure, and chromosomal localization of
            the cognate human gene (PCOLCE)
  JOURNAL   J Biol Chem 269 (42), 26280-26285 (1994)
   PUBMED   7523404
REFERENCE   7  (bases 1 to 1539)
  AUTHORS   Lecain,E., Zelenika,D., Laine,M.C., Rhyner,T. and Pessac,B.
  TITLE     Isolation of a novel cDNA corresponding to a transcript expressed
            in the choroid plexus and leptomeninges
  JOURNAL   J Neurochem 56 (6), 2133-2138 (1991)
   PUBMED   2027019
REFERENCE   8  (bases 1 to 1539)
  AUTHORS   Kessler,E., Mould,A.P. and Hulmes,D.J.
  TITLE     Procollagen type I C-proteinase enhancer is a naturally occurring
            connective tissue glycoprotein
  JOURNAL   Biochem Biophys Res Commun 173 (1), 81-86 (1990)
   PUBMED   2256940
REFERENCE   9  (bases 1 to 1539)
  AUTHORS   Rhyner,T.A., Lecain,E., Mallet,J. and Pessac,B.
  TITLE     Isolation of cDNAs from a mouse astroglial cell line by a
            subtracted cDNA library
  JOURNAL   J Neurosci Res 27 (2), 144-152 (1990)
   PUBMED   1701491
REFERENCE   10 (bases 1 to 1539)
  AUTHORS   Kessler,E. and Adar,R.
  TITLE     Type I procollagen C-proteinase from mouse fibroblasts.
            Purification and demonstration of a 55-kDa enhancer glycoprotein
  JOURNAL   Eur J Biochem 186 (1-2), 115-121 (1989)
   PUBMED   2689170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144392.1 and CX210896.1.
            
            On Feb 9, 2007 this sequence version replaced NM_008788.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144392.1, AK146829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-368               AK144392.1         2-369
            369-907             CX210896.1         51-589
            908-953             AK144392.1         909-954
            954-1023            CX210896.1         635-704
            1024-1539           AK144392.1         1025-1540
FEATURES             Location/Qualifiers
     source          1..1539
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.59 cM"
     gene            1..1539
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /note="procollagen C-endopeptidase enhancer protein"
                     /db_xref="GeneID:18542"
                     /db_xref="MGI:MGI:105099"
     exon            1..168
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            169..277
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..536
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..661
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..798
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1079
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1157
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1328
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1539
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1518..1523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /note="putative"
     polyA_site      1539
                     /gene="Pcolce"
                     /gene_synonym="Astt-2; Astt2; P14; PCPE-1"
                     /note="putative"
ORIGIN      
        1 atcctgctgc tgctgctgct gctgctgctg ctgctgctga actcagctgc tgcttccagc
       61 acttcccccc tacacaatgc tgcctgctgc cctaacctcc tttctggggc cattcctttt
      121 ggcctgggtg ctgcctcttg cccgaggcca gacccccaac tacacgagac ctgtgttcct
      181 gtgcggaggg gacgtgaccg gggagtcagg ttacgtggca agtgagggtt tccccaacct
      241 ctacccccca aacaagaagt gcatctggac aattacggtg cccgagggcc agactgtgtc
      301 cctgtccttc cgagtcttcg atatggagct ccacccttcc tgccgctacg atgctctgga
      361 ggtctttgct ggctctggca cctcaggcca gcgacttgga cgcttctgcg gcaccttcag
      421 gcctgcacct gtagtcgcac ctggcaacca agtgacttta aggatgacaa ctgacgaggg
      481 caccggggga cgaggcttcc tgctctggta cagcggccgg gccacttcgg gcactgagca
      541 ccagttttgt ggggggcgga tggagaaggc gcagggaacc ttgaccacgc ccaactggcc
      601 tgagtcggat tacccaccag gcatcagctg ttcctggcac atcattgcac cctcaaacca
      661 ggtgatcatg ctaacctttg ggaagtttga tgtggagcct gacacgtact gccgatatga
      721 ctctgtcagt gtgtttaacg gagctgtgag tgacgactca aagaggctgg ggaaattttg
      781 cggagacaag gcccctagcc ccatctcttc tgaagggaac gagctcctgg tccagtttgt
      841 atcagatctc agtgtcaccg cagatggctt ctcagcctcc tacaggaccc tgccacggga
      901 tgccgtagag aaggagtcag ccctgagtcc aggggaggac gtacagcgtg gtccccagtc
      961 ccgctctgac cctaagacag gaactgggcc caaagtcaaa ccacccacta aacctaaatc
     1021 ccaacctgca gagacaccag aggcttcccc tgctacccag gcaaccccag tggccccagc
     1081 tgcccccagc atcacctgcc caaagcagta caagcggtca ggcaccttgc agagcaactt
     1141 ctgttccagt agcctagtgg tgacaggaac agtgaagacc atggtccggg gccccgggga
     1201 aggcctcact gtcactgtca gtctccttgg tgtctacaaa accggaggac tggacctgcc
     1261 ctctccgccc agtggcacct ctctgaagtt gtatgtgccc tgcaggcaga tgccccccat
     1321 gaagaaagga gccagttatc tgctgatggg tcaggtggaa gaaaacagag gccccatcct
     1381 tcctccagag agcttcgtgg ttctctacag gtccaaccag gaccagatcc tcaataacct
     1441 aagcaagagg aagtgtccct cccaacctag gacagctgcc tgatgtccta gccagataca
     1501 gcctcagagc tcatccaaat aaatgtttct tgactcagg
//
