LOCUS       NM_008787               9530 bp    mRNA    linear   ROD 02-JAN-2024
DEFINITION  Mus musculus pericentrin (kendrin) (Pcnt), transcript variant 1,
            mRNA.
ACCESSION   NM_008787 XM_290069
VERSION     NM_008787.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9530)
  AUTHORS   Ho KH, Candat A, Scarpetta V, Faucourt M, Weill S, Salio C, D'Este
            E, Meschkat M, Wurm CA, Kneussel M, Janke C, Magiera MM, Genovesio
            A, Meunier A, Sassoe-Pognetto M, Brill MS, Spassky N and Patrizi A.
  TITLE     Choroid plexuses carry nodal-like cilia that undergo axoneme
            regression from early adult stage
  JOURNAL   Dev Cell 58 (23), 2641-2651 (2023)
   PUBMED   37890489
REFERENCE   2  (bases 1 to 9530)
  AUTHORS   Majumder S, Chattopadhyay A, Wright JM, Guan P, Buja LM, Kwartler
            CS and Milewicz DM.
  TITLE     Pericentrin deficiency in smooth muscle cells augments
            atherosclerosis through HSF1-driven cholesterol biosynthesis and
            PERK activation
  JOURNAL   JCI Insight 8 (21), e173247 (2023)
   PUBMED   37937642
  REMARK    GeneRIF: Pericentrin deficiency in smooth muscle cells augments
            atherosclerosis through HSF1-driven cholesterol biosynthesis and
            PERK activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9530)
  AUTHORS   Wang D, Li H, Chandel NS, Dou Y and Yi R.
  TITLE     MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial
            and ciliary functions by controlling gene promoters
  JOURNAL   Nat Commun 14 (1), 4404 (2023)
   PUBMED   37479688
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9530)
  AUTHORS   Vinopal S, Dupraz S, Alfadil E, Pietralla T, Bendre S, Stiess M,
            Falk S, Camargo Ortega G, Maghelli N, Tolic IM, Smejkal J, Gotz M
            and Bradke F.
  TITLE     Centrosomal microtubule nucleation regulates radial migration of
            projection neurons independently of polarization in the developing
            brain
  JOURNAL   Neuron 111 (8), 1241-1263 (2023)
   PUBMED   36796357
REFERENCE   5  (bases 1 to 9530)
  AUTHORS   He S, Gillies JP, Zang JL, Cordoba-Beldad CM, Yamamoto I, Fujiwara
            Y, Grantham J, DeSantis ME and Shibuya H.
  TITLE     Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate
            mitotic and male meiotic spindle bipolarity
  JOURNAL   Nat Commun 14 (1), 1715 (2023)
   PUBMED   36973253
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9530)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 9530)
  AUTHORS   Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW and
            Walsh CA.
  TITLE     LIS1 regulates CNS lamination by interacting with mNudE, a central
            component of the centrosome
  JOURNAL   Neuron 28 (3), 665-679 (2000)
   PUBMED   11163258
REFERENCE   8  (bases 1 to 9530)
  AUTHORS   Tong JK, Hassig CA, Schnitzler GR, Kingston RE and Schreiber SL.
  TITLE     Chromatin deacetylation by an ATP-dependent nucleosome remodelling
            complex
  JOURNAL   Nature 395 (6705), 917-921 (1998)
   PUBMED   9804427
REFERENCE   9  (bases 1 to 9530)
  AUTHORS   Chen H, Gos A, Morris MA and Antonarakis SE.
  TITLE     Localization of a human homolog of the mouse pericentrin gene
            (PCNT) to chromosome 21qter
  JOURNAL   Genomics 35 (3), 620-624 (1996)
   PUBMED   8812505
REFERENCE   10 (bases 1 to 9530)
  AUTHORS   Doxsey SJ, Stein P, Evans L, Calarco PD and Kirschner M.
  TITLE     Pericentrin, a highly conserved centrosome protein involved in
            microtubule organization
  JOURNAL   Cell 76 (4), 639-650 (1994)
   PUBMED   8124707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158618.5, BC085244.1, U05823.1, AK163352.1, AK029906.1 and
            BM219062.2.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by NM_008787.4.
            
            On Apr 20, 2006 this sequence version replaced NM_008787.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               AC158618.5         136836-137024
            190-1120            BC085244.1         14-944
            1121-2156           U05823.1           1120-2155
            2157-2928           BC085244.1         1981-2752
            2929-4188           AK163352.1         292-1551
            4189-4584           U05823.1           4182-4577
            4585-9517           AK029906.1         81-5013
            9518-9530           BM219062.2         1-13                c
FEATURES             Location/Qualifiers
     source          1..9530
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.8 cM"
     gene            1..9530
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /note="pericentrin (kendrin)"
                     /db_xref="GeneID:18541"
                     /db_xref="MGI:MGI:102722"
     exon            1..348
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..9045
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /note="isoform a is encoded by transcript variant 1;
                     pericentrin 2; pericentrin-360; pericentrin-250"
                     /codon_start=1
                     /product="pericentrin isoform a"
                     /protein_id="NP_032813.3"
                     /db_xref="CCDS:CCDS23944.1"
                     /db_xref="GeneID:18541"
                     /db_xref="MGI:MGI:102722"
                     /translation="MEDEQEQRRRKVEAGRAKLANFRQRKTKGDCPNSKKKTAKRKGS
                     AVHASVQEEGSVATPNSELPQGGAVFESPSCSNTLEGTRGASAAQEQEDCELDVTDLQ
                     GQQQTQPPPPQTAHSLELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLNGR
                     RAQELALLQSRQQCELELLREQHAREKEEMALRSGQEAAELKEKLRSEMEKNAQTIET
                     LKQDWESERELCLENLRQELSLKHQSEMEGLQSQFQKELSEQKVELEKIFQAKHEAEV
                     SLKNLEAQHQAAIKKLQEDLQSEHCQYLQDLEQKFREKEKAKELELETLQASYEDLKA
                     QSQEEIRLLWSQLESMKTNREELNGSWDPVLAQASHLEELEHLRSGFAQQQQQERAQH
                     ESELEHLRVYFEKKLKDAEKTYQEDLTVFQQRLQEAREDSLESTEISSSCVLPEETSG
                     REGKEPPDPLDLQLGQPKVQESLVEDCQVKLSKAEEKIQQMKEEFQKKEAEWELSREE
                     LKREAEERLASMFLELREKAESEKLSIISRFEHRESSMRHLQDQQAAQILDLERSLME
                     QQGHLRQLEQELTRDDLLPCSQCGQEPAMAQEEKNGALLREKEDCALQLLMAQNRFLE
                     ERKEIMEKFAKEQDAFLRDAQEKHNHELQLLQQGHQQQLLALRMELETKHRSELTEQL
                     ASSESRRQALLETHVAELQVKHNAEISALEKRHLSNLDELESCYVADVQTIRDEHQQA
                     LELLRAELEEQLQKKESCHREMLTQELENLKRQHAEELQSVRDSLRMEMSAQHIENGK
                     GPAADLQGAHQQDPAMALHNEGHLLVEDGDAVLRSVDAEGLLHQAGPQELGDAHTVEM
                     QKSQAELAKPQELQASQDQVAQVRDKVFLLNRELEECRAELEQLQQRRERENQEGTTL
                     ICMLRADLELAQGEGKALRDALRRLLDLFGDTLKAAVTLKSRISERAGLLLDHEDAAD
                     TSDARLAAAALGDMWSDEGLLEIDRTLPEGAETSSVCEISSHVCESFFISPENTLDCE
                     QPIRRVYQSLSTAVEGLLEMALDSSKQLEEARQLHRCVEREFRHRNEEMAQAMQKQQE
                     LLERLREESAAKDRLALELHTAKGLLEGFKVEKVDLQEALGKKEESEQQLILELEDLR
                     KQLQQAARELLTLKEEKSVLWNQKETLTNEAKEREAALQEEVESLTRVQWESRKQSEK
                     DRATLLSQMRVLESELEDQLVQHRGCAQLAEEVATLKQQLAALDKHLRSQRQFMDDQA
                     AEREHEREEFQQEIQRLEGQLRQAARPRPPGPRDSQCVQLDEEVELLQEKLREKLDGF
                     NELVIKKDFADQQLLIQEEEIKRLEETNASIQRQMVQLQEELEKQKKSMEELKEKEIL
                     KQENMGDLLLTTVSRSGLDEAGCPMLPQGSSSRGPEAQPDVTERALLQHENEVVHRRN
                     SEIDELKSLIENLQENQRQLQKDKAEEIEQLHEVIEKLQSELSLMGPKVHEVSDPQAG
                     SLHSELACLRGEGLGGQALRSELQAAQAAKEVFGQLLADQAHGHSQALEALQQRLQDA
                     EEVAARHLAELEHCVALREAEVEAMASQIQEFAATLKAKEAIIEQRDLEIDAVNKWKV
                     SHSLELEAILLALAHFRHALEQQTCATPDEPPELRQLRVQCARLSHQLQVLYRPFLKC
                     RMQLDQHQPHVASIGCANPCADDELEQEGVSNRLALAPHSLAAQAKEELEDCPLGKAN
                     LMAQVRQLQEELDHRVHSVASRDTNSETCKLQQPNLSENGPRNHCCNGEESKPSPPDD
                     VLNIAKTTWDVIDIIKNQDLLVQVEMPDFPTQEKLTSQGGPFSSQASGHSGSLLPEEA
                     AEPQQDPVRALDLSSWSSPEVVRKDPSLEPQHSLPLTPGVGTVSLHSVDISPDWTDPL
                     LQADVSGLLCYPGKSASGQAPLWAVAPSAGKHHAERTATEKDVEDFIVTSFDSQELLT
                     SPSHELARRSDGSRKSDGPDIAMMLTLGSEGSETPTTDLVAAAAAAVPFSRRFVQSPG
                     AMKEKEIHAKQMKALLQMVFDESHQILALSESQDPSSALNKGEPRDPLDGFPRDSQAL
                     SEVTTDKGEKESLETHLTWSEELLRAIQEVFAREQEKAELQPRPYGSNLGDYNSLVQR
                     LEKVIQEQGDPQKVQDHLCLSDRSSLLAEIQALRAQLRMTHLQNQEKLQQLCAALTST
                     EARGSQREHQLRRQVELLAYKVEQEKCIANELQKTLSKEQETASDVRKRLVVEQNAVQ
                     DLKSELHACKQENTSLLESLDKVQQEVLRLRYGHVTWSYCGTSSASAGRAVLDGKEKE
                     LKVVLEELESERGKGQALQAQQEEQQLRYLQREGQSSRALEELKLSLEKQLAQNNQLC
                     VALKHERAAKDNLQKELQIEASRCEALLAQEKGQLSELQKSLEAERSRSLELSEALQH
                     ERLLTEQLSRNSQEACARQETQVQHALLRKLKAEKTRALELEAMLEKVQKQAAHTQQQ
                     LEAQAQERCVELRREKERELEIQRQRDEHKIEQLQRLVRELRWKEEVSGGNGPCRGSP
                     GRGSLERDQFQEQQQELEKIRQQLLCAAGLLTSFTNHTVDRTIKDWTSSNEKAVSSLM
                     RTLEELKSELSMPTSFQKKMTAELQVQLMNELLSDNDALTKAVGMATREKAELCRTVS
                     RLEKTLKHHTQKGCVLNRQSKSSLKQDGTDLQSSLRHSDPEWHSQTTSGDTNTCNIKM
                     EKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVFPSKADKKITM
                     SRPFTKFRTAVRVVIAVLRLRFLVKKWQEVDRKGALVHPKSTRHGHRTSQRQRSPSGP
                     RASLPTRDTSSGPTKASRHSPRSAAAGSPGKERSTSTPSSRLERSLTASQDPEHSLTE
                     YIHHLEMIQQRLGGLPPDSTQKSCHQKIKQ"
     exon            349..561
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..633
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..889
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..945
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1120
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1257
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1369
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1610
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1698
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..2156
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2721
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2928
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..3080
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3232
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3465
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3628
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3629..3841
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..4071
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            4072..4188
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4209
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4413
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            4414..4584
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            4585..5430
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            5431..6111
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            6112..6214
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            6215..6381
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            6382..6546
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            6547..6714
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            6715..6907
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            6908..7184
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            7185..7335
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            7336..7785
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            7786..8030
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            8031..8133
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            8134..8307
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            8308..8427
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            8428..8660
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            8661..8737
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            8738..8876
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            8877..9004
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     exon            9005..9530
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9499..9504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcnt"
                     /gene_synonym="KEN; kendrin; m239Asp; m275Asp; Pcnt2"
                     /note="putative"
ORIGIN      
        1 gaacgcccgc gagccccggg aacgccgcgc ctcgctcatt ggcgtggatg aagagggtgg
       61 agagcgtcgg cgtaccaatt ggggaccaga gagatggctc tccgcccttg gagcgtcagc
      121 ggagcgcgcg tgcgcaaggc cacacggggc tccggattgg cggggcgaag ctgacagttg
      181 tgtgtatggg gggtggggag gcgagtgggt gaagggaggg agtgtaaata gagcgaaggc
      241 ggtgtcgccg ccgccctgtc acctccgagc gactcgccgg gagcccaggt ggagatggaa
      301 gacgagcagg agcagcggcg caggaaggtg gaggctggga gagccaagct tgctaacttc
      361 cgacagagaa aaacaaaagg tgactgtccg aattcgaaga aaaagacggc gaagaggaag
      421 ggttcggctg tccatgcgtc tgtccaggag gagggttcgg tagccactcc caacagcgag
      481 ctcccccaag gaggggcggt ctttgaaagc ccatcatgca gcaacaccct ggaggggacc
      541 agaggggcat ctgcagctca ggaacaagaa gactgtgaac tggatgtgac tgacctgcag
      601 ggacagcagc agacacagcc accgccaccc cagacagccc acagcctgga gctagaagcg
      661 ctgcgcttga gcctgaacaa catgcacaca gcgcagctgg agctgacgca ggccaacctg
      721 cagaaggaaa aggagacagc gttgacggag cttcgggaaa tgctcaatgg ccggcgggca
      781 caggagctgg ccctgctgca aagtcggcag cagtgcgaac tggagctgct gcgagagcag
      841 cacgcccgcg agaaggaaga gatggcgctc cgcagcgggc aagaagcagc tgagctgaag
      901 gagaagttac ggtcagaaat ggagaaaaac gcccagacga tcgagaccct gaagcaagat
      961 tgggaatccg aaagagagtt atgtttggaa aacctccgcc aggaattgtc gttgaagcat
     1021 cagtcggaga tggagggttt gcagagccag tttcagaagg aattgtcaga acagaaggtt
     1081 gaattggaga agattttcca ggccaaacat gaggctgaag tttccctgaa gaacctggag
     1141 gctcaacacc aggcggccat caagaagctg caagaagacc tgcagtcaga gcactgccag
     1201 tatttacaag atctagagca gaaattccga gaaaaggaaa aagcaaaaga gttggagtta
     1261 gagacccttc aggcatccta tgaagaccta aaggcacagt cccaagaaga gatcagactc
     1321 ctttggtccc agcttgagtc tatgaaaacc aacagagagg aactgaatgg gtcatgggat
     1381 ccagtgctgg cccaggcctc tcacctggag gagctggagc acctgcggtc gggtttcgct
     1441 cagcagcagc agcaagagcg agcccagcac gagtctgagc tggagcacct gagggtctat
     1501 tttgagaaga agttgaagga tgccgagaag acataccaag aagacctgac tgtgttccag
     1561 caaaggctgc aggaggcaag ggaggattct ctggagtcta cagaaatcag ttcgtcctgt
     1621 gtgcttccgg aggagacatc tgggagagaa ggaaaggagc caccagatcc acttgatctt
     1681 cagcttgggc agccgaaggt ccaggagagt ctggttgaag actgtcaggt gaaactcagt
     1741 aaagccgagg agaagattca gcaaatgaaa gaggagttcc aaaagaagga agccgagtgg
     1801 gagctttccc gggaggaact aaagagagaa gctgaagaga gattagcctc catgtttctg
     1861 gagctgagag aaaaggctga gtctgagaaa ctgtccataa tcagcaggtt tgaacatcgg
     1921 gagtccagca tgaggcacct gcaggaccag caggccgccc agatcttaga cctggagaga
     1981 tctctgatgg agcagcaggg tcacctgagg cagctggaac aagaactcac tcgagatgac
     2041 cttctgccat gcagccagtg tggccaggag cccgccatgg cccaggagga gaagaatggc
     2101 gcgctcctcc gagagaagga agactgtgct ctgcagctgc tgatggccca gaacaggttt
     2161 ttggaagagc ggaaagagat catggagaag tttgccaagg agcaagatgc ctttcttcga
     2221 gacgcccagg agaagcacaa ccacgagctg cagctccttc agcagggaca ccagcagcag
     2281 ctcctggctc tgaggatgga gcttgaaacc aagcaccgct ctgagctcac agagcagctc
     2341 gcctcctccg agagcaggcg gcaggcgctc cttgagactc acgtggccga gctgcaggta
     2401 aaacacaatg ctgaaattag cgccttggag aagagacacc tctccaacct ggatgagtta
     2461 gagtcctgtt acgtggccga cgttcagact attcgggatg agcaccaaca ggctttggag
     2521 ctcttgcgag cggagctgga ggagcagcta cagaaaaagg agtcttgtca cagagagatg
     2581 ttgacgcagg agctggaaaa cctgaaacgc caacatgctg aagagcttca gtccgtaaga
     2641 gatagcctga gaatggaaat gagtgcccag cacatagaga acgggaaagg gccggccgct
     2701 gacttgcaag gagcacacca gcaagacccg gccatggctc tgcacaatga agggcacctg
     2761 ctggtggagg atggcgatgc agtcttgcgt agtgtggacg ctgagggcct gctgcaccaa
     2821 gctggacctc aggagctggg agacgcgcac acagttgaaa tgcagaagtc acaagcagag
     2881 ttggccaaac cccaggagct gcaggcatca caggaccagg ttgcacaggt gagagacaag
     2941 gtcttcctgc tgaaccggga gttagaagag tgccgagcgg agctggagca gctacagcag
     3001 aggcgggaac gggagaacca ggagggcacc acgctgatct gcatgctcag ggctgacctg
     3061 gagctggctc agggcgaagg gaaagccctc cgagatgccc tgaggagact tctcgatctg
     3121 tttggggaca cactgaaggc agctgtgacc ctaaagagcc ggatcagtga gcgtgcgggg
     3181 ctcctcctgg accacgagga tgctgcagat acaagtgacg cccggttagc agctgccgcc
     3241 cttggcgata tgtggtctga cgagggtcta ctggagatag acagaacgtt gccagaaggg
     3301 gcagagacat cttccgtgtg tgaaattagc agtcatgtgt gtgaaagctt cttcatcagc
     3361 cctgaaaaca cactggactg tgagcagcca attaggagag tctaccagag cctcagcacg
     3421 gccgtggagg gcctcctgga gatggccctg gactcctcca aacagctgga ggaagctcgc
     3481 cagctccatc gctgtgtcga gagagagttc cgtcacagga acgaggagat ggcccaggct
     3541 atgcagaagc agcaggagtt gctggagcgc ctgagggagg agagtgcggc caaggacagg
     3601 ctggctctgg agctgcacac ggctaagggc ctccttgaag gattcaaggt ggagaaagtg
     3661 gatctgcagg aggcgctggg caaaaaggag gagtcggaac agcagctgat cctggagcta
     3721 gaggatctgc ggaagcagct gcagcaggct gcccgcgagc tgctcactct gaaggaggag
     3781 aagtcggtct tgtggaacca gaaggaaact ttgactaatg aagcaaaaga aagagaagct
     3841 gcactgcagg aggaggtgga atctcttacc agagtccagt gggagtccag gaagcagtct
     3901 gaaaaggacc gcgccaccct actctctcag atgcgcgtct tggagtctga gttggaggac
     3961 cagcttgtgc agcaccgggg ctgtgcccag ctggctgagg aagtggctac cctgaagcag
     4021 cagctggctg ccctagacaa gcacttacgt agccagcgtc agttcatgga tgatcaagct
     4081 gccgagcgtg agcatgagcg ggaagagttc cagcaggaga tccagaggct ggaggggcag
     4141 ctccgccagg cagcccggcc acggcctccc gggccccggg acagccagtg cgtccagtta
     4201 gacgaggagg tggagttgtt acaagaaaaa ctgagagaaa aattagatgg gtttaatgaa
     4261 ttggtcataa agaaagattt tgccgatcaa caattgctaa tccaagaaga agaaattaag
     4321 cgcctcgagg agacaaatgc cagcatacaa agacaaatgg tccagctcca ggaagaactg
     4381 gaaaaacaga agaaaagcat ggaagaatta aaggaaaaag agatactaaa gcaagagaac
     4441 atgggtgact tactgctaac aactgtatca cggtccgggc tggatgaagc tgggtgtcct
     4501 atgcttcccc aaggcagctc ttctaggggt ccggaagccc aaccagatgt aacagagagg
     4561 gcactcttac agcacgagaa tgaggttgtc cacaggagaa actctgagat tgatgagctg
     4621 aaaagcctca tcgagaactt acaggaaaac cagaggcaat tacagaagga taaagcagag
     4681 gaaatcgagc agctccacga agtcattgag aagctgcaga gcgagctgag cctcatggga
     4741 cccaaggtgc acgaagtcag cgatcctcag gctggcagcc tccacagtga gctggcctgc
     4801 ctccgggggg aaggcctggg tggacaggca ctacggagtg agctgcaggc tgcgcaggca
     4861 gccaaggagg tgtttggcca gctcctggca gaccaggccc acgggcacag ccaggctctg
     4921 gaggccctgc agcagcgtct ccaggacgca gaggaggttg ctgcaagaca cctggctgag
     4981 ctagaacact gtgtggccct cagagaggct gaggtggaag ccatggcctc tcagatccag
     5041 gagtttgcag ctaccctgaa ggcaaaggaa gcaatcatcg agcagagaga tttagagatt
     5101 gatgccgtga acaagtggaa agtaagccat tccctggagc tggaggccat ccttttggct
     5161 ttggctcact tccgtcatgc tctggaacag cagacctgtg ccaccccgga cgagccccct
     5221 gagctccggc agctgcgagt gcagtgtgct cgcctcagcc accagctaca agtgctgtat
     5281 cggcctttcc tcaagtgccg gatgcagttg gaccagcacc agcctcatgt ggcatctatt
     5341 ggctgtgcaa acccttgtgc agatgatgaa ctggagcagg agggagtcag caacaggctg
     5401 gccttggctc cccacagcct ggccgcacag gctaaggaag aactggaaga ctgtcccctg
     5461 ggcaaggcca atctcatggc ccaggtgaga caacttcagg aggaactgga ccaccgcgtg
     5521 cattccgtgg cctccaggga caccaactcg gaaacttgta aattacagca gccaaacctg
     5581 tcggaaaatg ggccacgtaa tcattgttgt aacggtgaag aaagtaagcc atcgcctccc
     5641 gatgatgtac ttaatattgc caaaaccaca tgggatgtaa ttgatattat taaaaatcag
     5701 gatttgttgg tccaagttga aatgccagat ttccccactc aagaaaagtt aacatcccaa
     5761 ggtggacctt tctcttccca agccagtggg cacagcggct ccctcctccc agaggaggcg
     5821 gctgagcccc agcaggaccc cgtgagggca ctggacctgt cgtcctggag ctcccctgaa
     5881 gttgtccgga aggacccatc cttggagcct cagcacagcc tgcccctgac cccgggcgtg
     5941 ggcacagtga gcctgcacag tgtggacatc tcaccagact ggacagaccc gctgctgcag
     6001 gcagacgtgt cggggctgct ttgttacccg ggcaagtctg catcaggcca ggccccactg
     6061 tgggcagtgg ccccctcggc tgggaagcac catgcggaga ggacagccac ggagaaggac
     6121 gtcgaagact ttatcgtaac atcttttgat tctcaagaat tgttaacatc cccttctcat
     6181 gagttagcga gaagaagcga tgggagcagg aaaagtgatg gcccagacat tgctatgatg
     6241 ttgaccctgg gctcagaagg gtctgagact cccaccactg acctagtcgc tgctgctgct
     6301 gctgctgttc ctttctctag aaggtttgtc cagtcaccag gagcaatgaa ggagaaggag
     6361 atccatgcaa agcaaatgaa ggctttgctg cagatggtgt ttgatgagag ccaccagata
     6421 ctggccttgt cagaaagcca ggacccctct agtgcactga acaaaggtga accacgtgac
     6481 cccctggatg gcttcccgag agacagtcag gccctttcgg aggtgacaac tgacaaagga
     6541 gagaaggaat ctttggaaac acaccttacg tggagtgagg agcttttgcg ggccatacaa
     6601 gaagtgtttg ccagggagca ggagaaggct gagctgcagc ctagacctta tggttcaaac
     6661 ctaggagatt ataactccct ggtccagagg ctggagaagg ttatccaaga gcagggagac
     6721 ccgcagaagg tccaggacca cctgtgtctg tcagacagga gcagcctgct agctgagatt
     6781 caggccctgc gtgctcagct ccgcatgaca cacttacaga accaagagaa gctgcagcaa
     6841 ttgtgtgcag ccttgacgag cacagaggcc cgagggagcc agcgggagca ccagctacga
     6901 agacaagttg aacttttggc gtacaaagtg gaacaggaaa agtgcatagc aaacgagtta
     6961 cagaaaacct tgagcaaaga acaggagacg gcgagcgacg tgcgcaagcg cctggtggtg
     7021 gagcagaatg ccgtccagga cttgaagtcc gagctgcacg cctgtaagca ggagaacacc
     7081 agcctgctgg agtcgctgga caaggtgcag caggaagtcc tgcggctcag gtatggccat
     7141 gtgacgtggt cctactgtgg aacttcttct gcttcggctg gcagagctgt gctggacggg
     7201 aaggagaagg agctgaaggt tgtgctggag gagctggagt ctgagcgcgg aaaggggcag
     7261 gccctccagg cccagcagga ggagcagcaa ctgcggtacc tgcagaggga gggccagagc
     7321 tccagggccc tggaggagtt gaaactatct ttggagaagc agcttgctca aaacaaccaa
     7381 ctgtgtgtgg ctttaaaaca cgagcgtgcg gccaaagaca acctgcagaa ggagctgcag
     7441 atcgaggcct cgcgctgcga agcgttgctg gcacaggaga agggccagct ctcagagctg
     7501 cagaagagcc tggaggctga gcggagccgc tcactcgagc tctcagaggc cctacagcac
     7561 gagcgcctcc tgacagagca gctgagccgc aactcgcagg aggcctgtgc ccgccaagag
     7621 acacaagtgc agcacgctct gctgcgaaag ctgaaggcag agaagactcg tgcgttggag
     7681 ctggaggcca tgcttgaaaa ggtgcagaaa caggctgccc acacccagca gcagctggag
     7741 gctcaggctc aggagcgctg cgtagagctc aggagagaga aggagcgaga gttggagata
     7801 cagcgtcagc gtgatgagca taagatcgag cagcttcagc gtctggtgag ggagctgagg
     7861 tggaaagagg aggtgtccgg aggaaacggc ccttgccggg gctcccccgg ccggggttct
     7921 ctggagaggg accagttcca ggagcagcaa caggaactgg agaagatccg gcagcagcta
     7981 ctgtgtgcag ctggcctcct cacaagcttt accaaccaca cggtagacag gacaattaaa
     8041 gattggacgt catcaaatga gaaggcggtg tcatccttaa tgcgcacgct ggaggagctg
     8101 aagtctgagc tgagcatgcc cacctccttt cagaaaaaga tgactgcaga actccaggtc
     8161 cagctcatga atgaactgct gagcgacaat gatgccctca caaaagctgt gggcatggca
     8221 acccgagaga aagctgagct gtgcaggacc gtctcccggc tcgagaagac cctgaagcac
     8281 cacacgcaga agggctgcgt tcttaatagg caaagcaagt cttcattgaa gcaagatggg
     8341 acagatttgc agagttctct acggcactca gacccagagt ggcactcgca gactacaagt
     8401 ggggacacaa acacctgcaa tatcaaaatg gaaaagctgt acctgcacta tctgagagca
     8461 gagagcttta ggaaagctct gatttatcaa aagaagtatc tcttactgct gattggtgga
     8521 ttccaggact cagagcagga aacgctctcc atgatcgctc acttgggggt ctttccttcc
     8581 aaagcagata agaaaattac tatgtcacgt cccttcacca agttccgcac cgccgttcga
     8641 gtggtcatcg cagtattgag gttgcggttt ttggttaaga agtggcagga agtggatcgg
     8701 aagggagccc tggtacaccc caaaagcacc cgccacggac accgaacatc ccagagacaa
     8761 cgttctccat caggacccag agcgtctctg ccaacccgag acacttcctc agggcctacc
     8821 aaggcctctc ggcacagccc cagatctgcg gcagccggct caccgggcaa ggaaagatca
     8881 acttcgacac caagttcaag gctagaaaga tccctaactg cttctcaaga tcctgagcac
     8941 tccttgacag aatacatcca tcatttagaa atgatccagc aaagacttgg ggggttgccg
     9001 ccagattcta ctcagaaatc ctgccaccag aagattaaac agtgaataaa gtccttgcgg
     9061 ctcttaacct ttgacatttc tatttgagga aagatgtttt tttttcctaa ggaaagccca
     9121 tgatatagtc tgggacacac acttcggaag tggtgacacc agcccctagg agccaccgag
     9181 agcttccacc tccacacact gctacataga gggagcccgc tgctctcatc cccaccgcac
     9241 gctcctcccc gcccagcgag caggggctgt gctgggtcct gtgcctgatg atggagctct
     9301 ctgcctcctc ccaggcagaa gctgcttgct ttcttagcgt gtcaggatgg gaaggtcagt
     9361 tgcaaatgaa cacagaggaa aagaggaatg tattttttaa agactgttgt ctgctggatg
     9421 gatggatgaa tggtcttgta ttattgttgt tgttgttttt gtaaatccat tcagtttatt
     9481 ctttttattg gcaaaacaaa taaaactatg tcaaacttgc ttctcctggc
//
