LOCUS       NM_011045               1260 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus proliferating cell nuclear antigen (Pcna), mRNA.
ACCESSION   NM_011045
VERSION     NM_011045.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Wada,S., Ideno,H., Nakashima,K., Komatsu,K., Demura,N.,
            Tomonari,H., Kimura,H., Tachibana,M. and Nifuji,A.
  TITLE     The histone H3K9 methyltransferase G9a regulates tendon formation
            during development
  JOURNAL   Sci Rep 14 (1), 20771 (2024)
   PUBMED   39237663
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Yoshida,S., Kawamura,A., Aoki,K., Wiriyasermkul,P., Sugimoto,S.,
            Tomiyoshi,J., Tajima,A., Ishida,Y., Katoh,Y., Tsukada,T.,
            Tsuneoka,Y., Yamada,K., Nagamori,S., Nakayama,K. and Yoshida,K.
  TITLE     Positive regulation of Hedgehog signaling via phosphorylation of
            GLI2/GLI3 by DYRK2 kinase
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2320070121 (2024)
   PUBMED   38968120
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Yoshida,S., Tsuneoka,Y., Tsukada,T., Nakakura,T., Kawamura,A.,
            Kai,W. and Yoshida,K.
  TITLE     Primary Cilia are Required for Cell-Type Determination and
            Angiogenesis in Pituitary Development
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39001875
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Valdez,B.C., Perlaky,L., Saijo,Y., Henning,D., Zhu,C., Busch,R.K.,
            Zhang,W.W. and Busch,H.
  TITLE     A region of antisense RNA from human p120 cDNA with high homology
            to mouse p120 cDNA inhibits NIH 3T3 proliferation
  JOURNAL   Cancer Res 52 (20), 5681-5686 (1992)
   PUBMED   1394192
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Surmacz,E., Nugent,P., Pietrzkowski,Z. and Baserga,R.
  TITLE     The role of the IGF1 receptor in the regulation of cdc2 mRNA levels
            in fibroblasts
  JOURNAL   Exp Cell Res 199 (2), 275-278 (1992)
   PUBMED   1371961
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Pilz,A., Le Tissier,P., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Mapping of the structural gene for S-adenosyl homocysteine
            hydrolase to mouse chromosome 2, and related sequences to
            chromosomes 8 and X
  JOURNAL   Mamm Genome 3 (11), 633-636 (1992)
   PUBMED   1450513
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Abbott,C., Pilz,A., Moseley,H. and Peter,J.
  TITLE     The gene for proliferating cell nuclear antigen (Pcna) maps to
            mouse chromosome 2
  JOURNAL   Mamm Genome 3 (5), 286-289 (1992)
   PUBMED   1353383
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Yamaguchi,M., Hayashi,Y., Hirose,F., Matsuoka,S., Moriuchi,T.,
            Shiroishi,T., Moriwaki,K. and Matsukage,A.
  TITLE     Molecular cloning and structural analysis of mouse gene and
            pseudogenes for proliferating cell nuclear antigen
  JOURNAL   Nucleic Acids Res 19 (9), 2403-2410 (1991)
   PUBMED   1674997
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL807793.7.
            
            On Nov 17, 2006 this sequence version replaced NM_011045.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005778.1, AK165217.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AL807793.7         10001-10365         c
            366-463             AL807793.7         9088-9185           c
            464-531             AL807793.7         8876-8943           c
            532-726             AL807793.7         8429-8623           c
            727-850             AL807793.7         6959-7082           c
            851-1260            AL807793.7         6471-6880           c
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.15 cM"
     gene            1..1260
                     /gene="Pcna"
                     /note="proliferating cell nuclear antigen"
                     /db_xref="GeneID:18538"
                     /db_xref="MGI:MGI:97503"
     exon            1..365
                     /gene="Pcna"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..930
                     /gene="Pcna"
                     /note="cyclin"
                     /codon_start=1
                     /product="proliferating cell nuclear antigen"
                     /protein_id="NP_035175.1"
                     /db_xref="CCDS:CCDS16771.1"
                     /db_xref="GeneID:18538"
                     /db_xref="MGI:MGI:97503"
                     /translation="MFEARLIQGSILKKVLEALKDLINEACWDVSSGGVNLQSMDSSH
                     VSLVQLTLRSEGFDTYRCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALV
                     FEAPNQEKVSDYEMKLMDLDVEQLGIPEQEYSCVIKMPSGEFARICRDLSHIGDAVVI
                     SCAKNGVKFSASGELGNGNIKLSQTSNVDKEEEAVTIEMNEPVHLTFALRYLNFFTKA
                     TPLSPTVTLSMSADVPLVVEYKIADMGHLKYYLAPKIEDEEAS"
     exon            366..463
                     /gene="Pcna"
                     /inference="alignment:Splign:2.1.0"
     exon            464..531
                     /gene="Pcna"
                     /inference="alignment:Splign:2.1.0"
     exon            532..726
                     /gene="Pcna"
                     /inference="alignment:Splign:2.1.0"
     exon            727..850
                     /gene="Pcna"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1260
                     /gene="Pcna"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1043..1048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcna"
                     /note="hexamer: AATAAA"
     polyA_site      1070
                     /gene="Pcna"
                     /note="major polyA site"
ORIGIN      
        1 attagacggt tgcgggcgca gagggttggt agttgtcgct gtaggccttc gctgccgctt
       61 ctgcatcgtg aatcggggga ccttggcagc cagacctcgt tcctcttaga gtagctctca
      121 tctagtcgcc acaactccgc caccatgttt gaggcacgcc tgatccaggg ctccatcctg
      181 aagaaggtgc tggaggctct caaagacctc atcaatgagg cctgctggga cgtcagctcg
      241 ggcggcgtga acctgcagag catggactcg tctcacgtct ccttggtaca gcttactctg
      301 cgctccgaag gcttcgacac ataccgctgc gaccgcaacc tagccatggg cgtgaacctc
      361 accagcatgt ccaaaattct aaaatgtgct ggtaatgaag acatcattac attaagggct
      421 gaagataatg cagacacctt agcactagta ttcgaagcac caaatcaaga gaaagtttca
      481 gactatgaaa tgaagttaat ggacttagat gtggagcaac ttggaatccc agaacaggag
      541 tacagctgtg taataaagat gccgtcgggt gaatttgcac gtatatgccg agaccttagc
      601 cacattggag atgctgttgt gatatcctgt gcaaagaatg gggtgaagtt ttctgcaagt
      661 ggagagcttg gcaatgggaa cattaagttg tcacaaacaa gtaatgtgga taaagaagag
      721 gaggcggtaa ccatagagat gaatgagcct gttcacctaa cgtttgctct gaggtacctg
      781 aactttttca caaaagccac tccactgtct cctacagtaa cactcagtat gtctgcagat
      841 gtgccccttg ttgtagagta taaaattgct gacatgggac acttaaagta ttatttggct
      901 cccaagattg aagatgagga agcatcttag gcattgctag aaattgagaa aactaaacct
      961 ttgaagattg ctcctgagat gccagcgtgt cctgaggtct tttctgtcac caagtttgta
     1021 cctgagtatt cttaaatatt aaaataaaat atgtagatat cttctgtaaa taacctactt
     1081 tcttttctct ccattctcca taatttgctt aaagaataag ctccaaagta aaaactagtt
     1141 ttgttaacat gaatgtttct gctttacaaa tactggtgat tttcatcaat gatcttgacg
     1201 ctaaatgcag ttttaagaaa tattgttcaa tttaaataaa gttaacaatt tgaaaagtca
//
